Archives of Oral Biology, Journal Year: 2024, Volume and Issue: unknown, P. 106116 - 106116
Published: Oct. 1, 2024
Language: Английский
Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)
Published: Feb. 20, 2025
Language: Английский
Citations
1
Ukrainian Journal of Veterinary and Agricultural Sciences, Journal Year: 2025, Volume and Issue: 8(1), P. 49 - 61
Published: April 23, 2025
Melatonin is a multifunctional hormone with diverse physiological roles, particularly in immune regulation and reproductive health. While primarily synthesized by the pineal gland response to circadian rhythm, melatonin also produced extrapineal tissues such as placenta, gastrointestinal tract, organs, highlighting its systemic significance. Beyond role sleep-wake cycle regulation, exhibits potent antioxidant, anti-inflammatory, immunomodulatory properties, making it essential for maintaining cellular homeostasis overall stability. In system, contributes both innate adaptive immunity modulating cytokine production, reducing oxidative stress, enhancing cell activity. It plays protective against infections inflammatory diseases suppressing pro-inflammatory mediators interleukin-6 (IL-6) tumor necrosis factor-alpha (TNF-α) while promoting anti-inflammatory cytokines like interleukin-10 (IL-10). Additionally, influences tolerance, which critical preventing autoimmune responses ensuring successful pregnancy. females, improves oocyte quality, embryo development, pregnancy outcomes protecting ovarian follicles from damage, regulating steroidogenesis, supporting placental function. Its fetal development significant, maternal-fetal signaling, vascularization, epigenetic modifications that influence gene expression. men, spermatogenesis sperm quality boosting mitochondrial activity, decreasing safeguarding DNA damage. helps regulate production testes, optimal Given pleiotropic effects, holds substantial therapeutic potential addressing dysfunction, disorders, complications. Future research should focus on clinical applications of supplementation treating infertility, pregnancy-related complications, immune-mediated diseases. Understanding intricate relationship between melatonin, immunity, reproduction may pave way innovative strategies human veterinary medicine. roles well-known function rhythm exerts effects. function, thereby offering protection disorders. reproduction, key processes maturation, maintenance. supports fertility improving gonadotropin secretion, melatonin's involvement highlights significance gestation. widespread presents promising immune-related exploring lead novel success resilience
Language: Английский
Citations
0
Published: Jan. 1, 2024
The chemical known as melatonin, N-acetyl-5-methoxytryptamine, is widely dispersed and very versatile in its functional aspects. processes involving the retina biological clock that regulate pineal gland's circadian melatonin production are quickly being discovered, mechanisms governing synthesis within gland have been thoroughly studied. According to research, both endogenous exogenous, plays a significant role promoting physiological molecular adaptations domestic animals wildlife. Seasonally polyestrous subject of substantial research. Herds housed photoperiodic aberrations their circannual cycles corrected by supplementation procedures. One defining characteristics range techniques uses alter cell physiology biology. However, antioxidant immunostimulatory properties may be able mitigate these effects. During cycle, livestock undergo several metabolic adaptation impair immune system result chronic sickness, weight loss, or decreased productivity. Melatonin has an impact on heart blood vessels. It can vasodilate vasoconstrictor numerous systemic arteries, depending kind location receptors. This modulates animal's total nutrient partitioning through vascular resistance. physiological, cellular, impacts well-being illnesses domesticated food main topics this review, along with recent developments subject.
Language: Английский
Citations
2
Theriogenology, Journal Year: 2024, Volume and Issue: 226, P. 95 - 103
Published: June 12, 2024
Language: Английский
Citations
2
Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11
Published: Sept. 2, 2024
Melatonin (N-acetyl-5-methoxytryptamine) is an essential small molecule with diverse biological functions. It plays several key roles, including regulating the secretion of reproductive hormones and cycle, enhancing functionality organs, improving quality sperm eggs, mitigating oxidative stress in system. effectively inhibits scavenges excess free radicals while activating antioxidant enzyme system reduces production inflammatory factors alleviates tissue damage caused by inflammation pathways. Additionally, melatonin contributes to repairing intestinal barrier gut microbiota, thereby reducing bacterial toxin permeation. The use as endogenous hormone animal husbandry has garnered considerable attention because its positive effects on performance, outcomes, adaptation, disease treatment, environmental sustainability. This review explores characteristics functions melatonin, along current applications production. Our findings may serve a reference for farming future developmental directions.
Language: Английский
Citations
2
Theriogenology, Journal Year: 2024, Volume and Issue: 234, P. 64 - 72
Published: Dec. 2, 2024
Language: Английский
Citations
2
Animals, Journal Year: 2023, Volume and Issue: 13(20), P. 3219 - 3219
Published: Oct. 15, 2023
Cryopreserved semen is widely used in assisted reproductive techniques. Post-thawing spermatozoa endure oxidative stress due to the high levels of reactive oxygen and nitrogen species, which are produced during freezing/thawing process, depletion antioxidants. To counteract this depletion, supplementation sperm preparation medium with antioxidants has been applied. Melatonin a hormone diverse biological roles potent antioxidant, an ameliorative effect on spermatozoa. In present study, we assessed melatonin thawed bovine their handling. were incubated for 60 min presence or absence 100 μΜ melatonin. Also, was further challenged by addition hydrogen peroxide. Spermatozoa evaluated terms kinematic parameters (CASA), viability (trypan blue staining) antioxidant capacity (glutathione NBT assay, determination iNOS Western blot analysis). melatonin, presented better parameters, as percentage motile rapid higher group. They also status, determined increased cellular glutathione decreased protein levels.
Language: Английский
Citations
5
Published: Sept. 6, 2023
Cryopreserved semen is widely used in Assisted Reproductive Technologies (ART) enabling the conservation and broad use of genetically superior semen. The quality post-thawing determines success ART despite great advances cryopreservation methods, frozen/thawed still sub-optimal. Post-thawing spermatozoa endure oxidative stress (OS) due to high levels reactive oxygen nitrogen species, which are produced during freezing/thawing process, depletion antioxidants. To counteract this depletion, supplementation sperm preparation medium with antioxidants has been applied. Melatonin a hormone diverse biological roles potent antioxidant, an ameliorative effect on spermatozoa. In present study, melatonin bovine was evaluated vitro handling under conditions terms parameters antioxidant capacity. (100 μΜ) improved kinematic spermatozoa, enhanced viability reinforced status by increasing cellular GSH inhibiting iNOS protein expression.
Language: Английский
Citations
4
Annals of Animal Science, Journal Year: 2024, Volume and Issue: 24(4), P. 1139 - 1151
Published: May 10, 2024
Abstract Cattle are among the animals with diurnal activity, which is due to specific animal–environment relationship and natural role wild cattle play in ecosystem. As humans began domesticating, breeding these animals, they became an integral part of this relationship. This review article addresses most important current issues: 1) a characterisation contemporary knowledge on biological determinants vision abilities dairy cattle, 2) discussion between animal health performance, 3) light–animal under husbandry conditions. The intricate link anatomical physiological aspects visual function their circadian rhythms was emphasised. connection directly influences growth development, as well performance cows during long/short day photoperiods. also considers possibility managing cows’ photoperiod light quality enhance overall well-being.
Language: Английский
Citations
1
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: July 17, 2024
ABSTRACT Reproduction is a highly demanding biological process that occurs at the optimal time of year and day to ensure success spawn offspring. Melatonin hormone that, secreted mainly by pineal gland, plays critical role in integration photoneuroendocrine information from environment (annual daily variations) modulate reproductive activity gonadal development fish. In this study we assessed effect exogenous melatonin on circadian levels sex steroids gonadotropins pubertal 2 yr-old male sea bass during their cycle including, pre-spermatogenesis (Pspg), spermiation (Spm) post-spermiation (PSpm) stages. Our results demonstrated all hormones displayed variations along entire Circulating luteinizing (Lh) were affected both injection timing administration Spm PSpm stages, thus evoking Lh night. also significantly rhythms Fsh stage. Overall, 11-Kt T plasma which not prevented melatonin. However, showed significant decrease 1h after dusk Pspg stage, while it increased those 5 h These findings provide new insights into fish reproduction as key factor regulation variation involved development. This circumstance may have implications control gametogenesis management aquaculture. Highlights Plasma Fsh, Lh, show bass. evokes changes cycle. yields level differences elicits depending stage time.
Language: Английский
Citations
0