Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: May 15, 2024
This
study
aimed
to
investigate
the
potential
anti-fibrotic
activity
of
vinpocetine
in
an
experimental
model
pulmonary
fibrosis
by
bleomycin
and
MRC-5
cell
line.
Pulmonary
was
induced
BALB/c
mice
oropharyngeal
aspiration
a
single
dose
(5
mg/kg).
The
remaining
animals
received
daily
pirfenidone
(as
standard
drug)
(300
mg/kg/PO)
(20
on
day
7
induction
till
end
experiment
(day
21).
results
revealed
that
managed
alleviate
fibrotic
endpoints
statistically
improving
(P
≤
0.05)
weight
index,
histopathological
score,
reduced
expression
fibrotic-related
proteins
immune-stained
lung
sections,
as
well
markers
measured
serum
samples.
It
also
alleviated
tissue
levels
oxidative
stress
inflammatory
pro-fibrotic
mediators
significantly
elevated
bleomycin-only
0.05).
Vinpocetine
express
remarkable
attenuating
effect
both
vivo
vitro
either
directly
interfering
with
classical
TGF-β1/Smad2/3
signaling
pathway
or
indirectly
upregulating
Nrf2
enhancing
antioxidant
system,
activating
PPAR-γ
downregulating
NLRP3/NF-κB
making
it
candidate
for
further
clinical
investigation
cases
fibrosis.
Chemico-Biological Interactions,
Journal Year:
2025,
Volume and Issue:
unknown, P. 111489 - 111489
Published: March 1, 2025
Oxidative
stress
and
chronic
inflammation
are
important
drivers
in
the
pathogenesis
progression
of
many
diseases,
such
as
cancers
breast,
kidney,
lung,
others,
autoimmune
diseases
(rheumatoid
arthritis),
cardiovascular
(hypertension,
atherosclerosis,
arrhythmia),
neurodegenerative
(Alzheimer's
disease,
Parkinson's
Huntington's
disease),
mental
disorders
(depression,
schizophrenia,
bipolar
disorder),
gastrointestinal
(inflammatory
bowel
colorectal
cancer),
other
disorders.
With
increasing
demand
for
less
toxic
more
tolerable
therapies,
flavonoids
have
potential
to
effectively
modulate
responsiveness
conventional
therapy
radiotherapy.
Flavonoids
polyphenolic
compounds
found
fruits,
vegetables,
grains,
plant-derived
beverages.
Six
twelve
structurally
different
flavonoid
subgroups
dietary
significance
include
anthocyanidins
(e.g.
pelargonidin,
cyanidin),
flavan-3-ols
epicatechin,
epigallocatechin),
flavonols
quercetin,
kaempferol),
flavones
luteolin,
baicalein),
flavanones
hesperetin,
naringenin),
isoflavones
(daidzein,
genistein).
The
health
benefits
related
their
structural
characteristics,
number
position
hydroxyl
groups
presence
C2=C3
double
bonds,
which
predetermine
ability
chelate
metal
ions,
terminate
ROS
radicals
formed
by
Fenton
reaction),
interact
with
biological
targets
trigger
a
response.
Based
on
these
can
exert
both
antioxidant
or
prooxidant
properties,
activity
ROS-scavenging
enzymes
expression
activation
proinflammatory
cytokines
(e.g.,
interleukin-1beta
(IL-1β),
interleukin-6
(IL-6),
tumor
necrosis
factor-alpha
(TNF-α)),
induce
apoptosis
autophagy,
target
key
signaling
pathways,
nuclear
factor
erythroid
2-related
2
(Nrf2)
Bcl-2
family
proteins.
This
review
aims
briefly
discuss
mutually
interconnected
aspects
oxidative
inflammatory
mechanisms,
lipid
peroxidation,
protein
oxidation,
DNA
damage,
mechanism
resolution
inflammation.
major
part
this
article
discusses
role
alleviating
inflammation,
two
common
components
human
diseases.
results
epidemiological
studies
also
presented.
Journal of Veterinary Internal Medicine,
Journal Year:
2025,
Volume and Issue:
39(1)
Published: Jan. 1, 2025
Abstract
Background
Oxidative
injury
occurs
in
septic
people,
but
the
role
of
oxidative
stress
and
antioxidants
has
rarely
been
evaluated
foals.
Objectives/Hypothesis
To
measure
reactive
oxygen
species
(ROS),
biomarkers
injury,
neonatal
We
hypothesized
that
ill
foals
would
have
higher
blood
concentrations
ROS
lower
compared
to
healthy
Animals
Seventy‐two
hospitalized
21
Methods
Prospective
cohort
study.
Reactive
(hydrogen
peroxide
[H
2
O
]),
(malondialdehyde
[MDA],
protein
carbonyl),
(superoxide
dismutase
[SOD],
catalase
[CAT],
glutathione,
glutathione
reductase
[GR]
peroxidase
[GPx])
were
measured
from
at
admission.
Measured
variables
between
using
a
1‐way
ANOVA
by
Tukey's
multiple
comparisons
test.
Results
Ill
(n
=
51)
had
significantly
mean
H
(healthy
2.6
±
1.4
nmol/mL,
6.8
4.6
L
nmol/mL;
95%
CI),
MDA
31.2
14.4
114.3
94.0
carbonyl
0.07
0.01
nmol/mg
protein,
0.12
0.02
CI).
Significant
CAT
0.4
0.3
mU/mg
238.5
101.9
μg/mL,
110.7
37.8
CI;
P
<
.0001),
GR
1.6
1.8
0.5
GPx
0.003
0.007
0.002
CI)
also
noted.
Conclusions
Clinical
Importance
antioxidant
occur
bacteremic
These
should
be
considered
during
treatment
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(4), P. 1693 - 1693
Published: Feb. 16, 2025
Tetraselmis
chuii
(T.
chuii)
is
a
green,
marine,
eukaryotic,
microalgae
that
was
authorized
in
the
European
Union
(EU)
as
novel
food
for
human
consumption
2014,
and
supplement
2017.
This
narrative
review
will
provide
an
overview
of
preclinical
clinical
trials
assessing
efficacy
T.
chuii-derived
ingredient,
characterized
by
high
superoxide
dismutase
(SOD)
activity
(SOD-rich
chuii),
to
improve
various
aspects
cellular
health.
Collectively,
results
from
vitro,
more
importantly
vivo
research,
support
SOD-rich
potential
promoter
Principally,
ingredient
appears
function
indirect
antioxidant
boosting
intracellular
systems.
Moreover,
it
can
positively
modulate
inflammatory
status
up-regulating
anti-inflammatory
down-regulating
pro-inflammatory
cytokines
factors.
In
addition,
promote
health
though
protecting
DNA
damage,
immune
function,
strengthening
cell
structure
integrity,
modulating
signaling
pathways.
There
also
some
evidence
suggest
may
mitochondrial
through
up-regulation
genes
linked
biogenesis
ATP
synthesis.
From
conducted
date,
transcriptional
activation
nuclear
factor
erythroid
2-related
2
(NRF2)
sirtuin
1
(SIRT1)
appear
be
important
mediating
effects
on
These
exciting
preliminary
observations
represent
natural
blue
with
enhance
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(7), P. 3148 - 3148
Published: March 28, 2025
Oxidative
stress
(OS)
and
gut
microbiota
are
crucial
factors
influencing
human
health,
each
playing
a
significant
role
in
the
development
progression
of
chronic
diseases.
This
review
provides
comprehensive
analysis
complex
interplay
between
these
two
factors,
focusing
on
how
an
imbalance
reactive
oxygen
species
(ROS)
antioxidants
leads
to
OS,
disrupting
cellular
homeostasis
contributing
range
conditions,
including
metabolic
disorders,
cardiovascular
diseases,
neurological
cancer.
The
microbiota,
diverse
community
microorganisms
residing
gastrointestinal
tract,
is
essential
for
regulating
immune
responses,
pathways,
overall
health.
Dysbiosis,
composition,
closely
associated
with
inflammation,
dysfunction,
various
highlights
influences
influenced
by
complicating
pathophysiology
many
conditions.
Furthermore,
emerging
evidence
has
identified
extracellular
vesicles
(EVs)
as
critical
facilitators
crosstalk
OS
microbiota.
EVs
also
play
signaling
host
tissues,
modulating
processes.
function
holds
promise
targeted
therapies
aimed
at
restoring
microbial
balance
mitigating
OS.
Personalized
therapeutic
approaches,
probiotics,
antioxidants,
fecal
transplantation-based
strategies,
can
be
used
address
OS-related
diseases
improve
health
outcomes.
Nonetheless,
further
research
needed
study
molecular
mechanisms
underlying
interactions
potential
innovative
interventions
offer
novel
strategies
managing
enhancing
Abstract
Osteoarthritis
(OA)
is
the
most
common
degenerative
joint
disorder
that
causes
disability
in
aged
individuals,
caused
by
functional
and
structural
alterations
of
knee
joint.
To
investigate
whether
metabolic
drivers
might
be
harnessed
to
promote
cartilage
repair,
a
liquid
chromatography–mass
spectrometry
(LC–MS)
untargeted
metabolomics
approach
was
carried
out
screen
serum
biomarkers
osteoarthritic
rats.
Based
on
correlation
analyses,
α-ketoglutarate
(α-KG)
has
been
demonstrated
have
antioxidant
anti-inflammatory
properties
various
diseases.
These
make
α-KG
prime
candidate
for
further
investigation
OA.
Experimental
results
indicate
significantly
inhibited
H
2
O
-induced
cell
matrix
degradation
apoptosis,
reduced
levels
reactive
oxygen
species
(ROS)
malondialdehyde
(MDA),
increased
superoxide
dismutase
(SOD)
glutathione
(GSH)/glutathione
disulfide
(GSSG)
levels,
upregulated
expression
ETV4,
SLC7A11
GPX4.
Further
mechanistic
studies
observed
α-KG,
like
Ferrostatin-1
(Fer-1),
effectively
alleviated
Erastin-induced
apoptosis
ECM
degradation.
Fer-1
SLC7A11,
GPX4
at
mRNA
protein
decreased
ferrous
ion
(Fe
2+
)
accumulation,
preserved
mitochondrial
membrane
potential
(MMP)
ATDC5
cells.
In
vivo,
treatment
ferroptosis
OA
rats
activating
ETV4/SLC7A11/GPX4
pathway.
Thus,
these
findings
inhibits
via
signaling
pathway,
thereby
alleviating
observations
suggest
exhibits
therapeutic
prevention
OA,
having
clinical
applications
future.
