Research progress on medicinal components and pharmacological activities of polygonatum sibiricum

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 328, P. 118024 - 118024

Published: March 13, 2024

Language: Английский

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Physicochemical characterization and protective effects of raw and nine-steamed Polygonatum cyrtonema polysaccharides on cyclophosphamide-induced immunosuppression in mice

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141911 - 141911

Published: March 1, 2025

Language: Английский

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Recent advances in polysaccharide-based drug delivery systems for cancer therapy: a comprehensive review

Artificial Cells Nanomedicine and Biotechnology, Journal Year: 2024, Volume and Issue: 52(1), P. 564 - 586

Published: Dec. 5, 2024

Cancer has a high rate of incidence and mortality throughout the world. Although several conventional approaches have been developed for treatment cancer, such as surgery, chemotherapy, radiotherapy thermal therapy, they remarkable disadvantages which result in inefficient cancer. For example, immunogenicity, prolonged treatment, non-specificity, metastasis cost are considered major drawbacks chemotherapy. Therefore, there is fundamental requirement development breakthrough technologies cancer suppression. Polysaccharide-based drug delivery systems (DDSs) most reliable carriers therapy. Polysaccharides, kind practical biomaterials, divided into types, including chitosan, alginates, dextran, hyaluronic acid, cyclodextrin, pectin, etc. Polysaccharides extracted from different natural resources (like herbal, marine, microorganisms, etc.). The potential features polysaccharides made them candidates therapeutics to sites; simple purification, ease modification functionalization, hydrophilicity, serum stability, appropriate loading capacity, biocompatibility, bioavailability, biodegradability stimuli-responsive sustained release manner considerable aspects these biopolymers. This review highlights applications polysaccharides-based DDSs pharmaceutical science

Language: Английский

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Switching from deep eutectic solvents to deep eutectic systems for natural product extraction

Green Chemical Engineering, Journal Year: 2024, Volume and Issue: 6(1), P. 36 - 53

Published: June 1, 2024

This article presents a comprehensive overview of recent advancements in natural product extraction, focusing on the evolution from deep eutectic solvents (DESs) to systems (DESys) for extraction. DESs, known their environmentally friendly properties, have become crucial extracting various products plants, including micromolecules, lignin, and polysaccharides. Research into extraction mechanism reveals that target compounds typically form hydrogen bonds with effectively becoming part solvent system. insight has led development DESys method, where bond acceptors (HBAs) donors (HBDs) are directly mixed sample system containing compounds. The shift DES-based DESys-based introduces innovative approaches integral system, allowing one-step dissolution methodology eliminates need pre-prepared simplifying processes enhancing efficiency. Additionally, strategies DESs recycling reuse contribute sustainability efforts, offering cost-effective solutions. expanding applications cosmetics, food, industry, environmental fields highlight promising potential. By delineating transition products, this review offers valuable insights advancing practice green chemical engineering.

Language: Английский

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Fractionation of lignin from corncob with high−yield p − coumaric acid production in deep eutectic solvents followed by pyrolysis to produce monophenols

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138331 - 138331

Published: Dec. 1, 2024

Language: Английский

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Evolutionary research trends of polysaccharides from Polygonatum genus: A comprehensive review of its isolation, structure, health benefits, and applications

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141566 - 141566

Published: Feb. 1, 2025

Language: Английский

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Ionic Liquid‐Based Polarity‐Adjustable Deep Eutectic Solvent Extraction Followed by High‐Performance Liquid Chromatography‐Diode‐Array Detection for the Determination of Liposoluble Anthraquinones in Salvia miltiorrhiza Bge. Root

Journal of Separation Science, Journal Year: 2025, Volume and Issue: 48(3)

Published: March 1, 2025

A simple, green, and efficient ultrasound-assisted deep eutectic solvents (DESs) extraction followed by high-performance liquid chromatography-diode array detector was established to detect four liposoluble anthraquinones in Salvia miltiorrhiza Bge. root. In this study, a series of polarity-adjustable DESs were prepared using n-hexanol tetrabutylammonium chloride, their structure, density, viscosity, pH, thermal stability determined. The conditions for optimized through single-factor experiments response surface methodology. kinetic thermodynamic properties associated with the investigated. results showed that standard curves excellent linearity from 0.018 150 µg mL-1 (r > 0.9998). detection quantification limits varied 5.04 5.60 ng 16.81 18.67 mL-1, respectively. recoveries measured as 84.1%-95.1%, relative deviations not exceeded 4.6%.

Language: Английский

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Comparison of Polygonatum sibiricum Polysaccharides Found in Young and Mature Rhizomes

Foods, Journal Year: 2024, Volume and Issue: 13(13), P. 2010 - 2010

Published: June 25, 2024

The main active component of Polygonatum sibiricum (P. sibiricum) rhizome is Polysaccharide (PsP) with antioxidant function. At present, only the mature P. used to extract PsP, while young by-product discarded directly as waste, resulting in significant wastage resources. We ultrasound-assisted extraction-deep eutectic solvents (UAE-DESs) method PsP and rhizomes, respectively. extraction rate, structure composition ability between rhizomes were compared, so provide references for comprehensive utilization rate (33.88 ± 1.95%) was close that (45.08 1.92%) rhizomes. (PsP-2) contained six kinds monosaccharides, which belonged acidic polysaccharides. above characteristics similar those rhizome. also exhibited biological activity rhizome, indicated even more advantages DPPH free radical scavenging ability. results this study support utility consequently helping avoid unnecessary waste reference sibiricum.

Language: Английский

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Polygonatum Sibiricum Polysaccharides: A Promising Strategy in the Treatment of Neurodegenerative Disease

Neurochemistry International, Journal Year: 2024, Volume and Issue: 181, P. 105902 - 105902

Published: Nov. 13, 2024

Language: Английский

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Research Progress on the Extraction, Structure Elucidation, Biological Activities, and Drug Carrier Applications of Polygonati Rhizom Polysaccharides

Journal of Food Biochemistry, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

As widely used in traditional Chinese medicine and nutritional food, Polygonati Rhizom is known for its diverse pharmacological properties, including hematopoiesis, immune enhancement, antitumor, anti‐inflammatory, antioxidant, antiaging, antiviral, hepatoprotection. polysaccharides (PRPs) are primary bioactive compounds that water‐soluble mainly comprise fructose (Fru), glucose (Glc), galactose (Gal), arabinose (Ara), rhamnose (Rha), fucose (Fuc), xylose (Xyl), glucuronic acid (GlcA), galacturonic (GalA). Meanwhile, different extraction methods, such as hot water ultrasonic extractions, can significantly affect the yield of PRPs, Additionally, PRPs were also reported to hold promising potential a drug carrier. Herein, extraction, structure elucidation, biological activities, carrier applications systematically summarized, providing reference further research development Rhizom.

Language: Английский

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