Active herbal ingredients and drug delivery design for tumor therapy: a review DOI
Jing Han,

Y. Shen,

Ruiying Cao

et al.

Chinese Journal of Natural Medicines, Journal Year: 2024, Volume and Issue: 22(12), P. 1134 - 1162

Published: Dec. 1, 2024

Language: Английский

Plant-derived paclitaxel-loaded ultra-small Fe₃O₄ nanoparticles for MR imaging-mediated antitumor therapy DOI Creative Commons

Xixi Lai,

Yili Zhao, Zhiyuan Shi

et al.

Industrial Crops and Products, Journal Year: 2025, Volume and Issue: 228, P. 120902 - 120902

Published: March 25, 2025

Language: Английский

Citations

6
Progress in the Treatment of Central Nervous System Diseases Based on Nanosized Traditional Chinese Medicine DOI Creative Commons
Jing Li,

Qingyin Long,

Huang Ding

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(16)

Published: Feb. 28, 2024

Abstract Traditional Chinese Medicine (TCM) is widely used in clinical practice to treat diseases related central nervous system (CNS) damage. However, the blood‐brain barrier (BBB) constitutes a significant impediment effective delivery of TCM, thus substantially diminishing its efficacy. Advances nanotechnology and applications TCM (also known as nano‐TCM) can deliver active ingredients or components across BBB targeted brain region. This review provides an overview physiological pathological mechanisms systematically classifies common CNS types nanocarriers that effectively brain. Additionally, drug strategies for nano‐TCMs utilize vivo properties vitro devices bypass cross are discussed. further focuses on application treatment various diseases. Finally, this article anticipates design strategy with higher efficiency probes their potential treating wider range

Language: Английский

Citations

12
Correlation Analysis of Secondary Metabolism and Endophytic Fungal Assembles Provide Insights Into Screening Efficient Taxol‐Related Fungal Elicitors DOI Creative Commons
Mingshuang Wang,

Xueshuang Liang,

Ruoyun Ma

et al.

Plant Cell & Environment, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

ABSTRACT The efficacy of Taxol, a natural anticancer drug, in the treatment various types cancers has been certified globally. Fungal elicitors have reported as an impressive strategy for enhancing Taxol biosynthesis. We investigated effect twig age on biosynthesis and communities endophytic fungi. A negative correlation between content complexity fungal community twigs was predicted. Endogenous taxoids, similar to balancing valves, might specific controlling microbiota assembly Taxus twigs. Utilising special correlation, 11 isolates age‐associated fungi were used screen new involved Two efficient elicitors, L01 ( Guignardia ) J02 Diaporthe ), identified, increasing contents by 5.91‐ 4.83‐folds, respectively. It is confirmed that effective may be negatively correlated with tissues. Furthermore, significantly induced jasmonic acid (JA) content, speculating involvement MYC2a‐controlled JA signalling elicitor‐activated Our data revealed provided novel approach

Language: Английский

Citations

1
Elucidation of the final steps in Taxol biosynthesis and its biotechnological production DOI

Feiyan Liang,

Yuman Xie, Chi Zhang

et al.

Nature Synthesis, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Language: Английский

Citations

1
Post-genomic illumination of paclitaxel biosynthesis DOI
Alisdair R. Fernie, Fang Liu, Youjun Zhang

et al.

Nature Plants, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Language: Английский

Citations

4
Gas bubble-assisted extraction method for efficient recovery of paclitaxel from Taxus chinensis DOI

Yeji Kang,

Da-Yeon Kang,

Jin-Hyun Kim

et al.

Biotechnology and Bioprocess Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Language: Английский

Citations

0
Phenolics: An Unmatched and Invaluable Natural Molecules with Outstanding Potential in Drug Development, Health Benefits, and Industrial Applications DOI
Zahed Mahmood,

Z. Lubabah

Springer eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 42

Published: Jan. 1, 2025

Language: Английский

Citations

0
Efficacy of drug-coated balloon versus uncoated balloon for dysfunctional dialysis access: a systematic review and meta-analysis DOI

Aarij Elahi,

M Ashraf Qamar,

Fasih Mand Khan

et al.

Clinical and Experimental Nephrology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Language: Английский

Citations

0
Self-assembly of paclitaxel derivative and fructose as a potent inducer of immunogenic cell death to enhance cancer immunotherapy DOI Creative Commons

Manzhen Li,

Likang Lu,

Yaoyao Guo

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101793 - 101793

Published: April 23, 2025

Immunotherapy shows promise for tumor control but is limited by low response rates. Paclitaxel (PTX) induces immunogenic cell death (ICD), yet conventional delivery systems face challenges like drug loading and insufficient intracellular accumulation, reducing ICD efficacy. Small-molecule self-assembled PTX nanoparticles offer a promising solution due to high dose delivery. In this study, was conjugated with phenylboronic acid (PBA) form the derivative PTX-PBA, which spontaneously fructose into (PTX-PBA-Fru NPs). These exhibited uniform size of 107.8 ± 2.9 nm, PDI 0.064 0.042, zeta potential -12.2 0.9 mV, spherical morphology. 4T1 tumor-bearing mice, PTX-PBA-Fru NPs significantly enhanced inhibition (p < 0.001) increased body weight 0.05). No allergic reactions in healthy Balb/c mice maximum tolerated intravenous reached 200 mg/kg, underscoring its favorable safety profile NPs. The effects induced NPs, when combined immunomodulator resiquimod (R848), elicited robust anti-tumor immune response. This combination therapy effectively remodeled immunosuppressive microenvironment achieved 37.5 % eradication rate. Moreover, it established long-term memory, providing protection against re-challenge. novel formulation demonstrates strong effects, safety, clinical R848-based immunotherapy.

Language: Английский

Citations

0
Natural product-based nanotechnological formulations for colorectal cancer treatment DOI

Lan-Fang Wu,

Jiali Wu, Xinyu Wang

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Language: Английский

Citations

0