Nanogenerator with L-Arginine loading: new choices as cascaded and synergistic nitric oxide/photodynamic antitumor agents DOI
Yue Huang, Ziwei Wu, Hanyang Wang

et al.

Materials Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 9(2), P. 204 - 222

Published: Nov. 27, 2024

In this review, the design idea, synergistic mechanism and application prospects of l -arginine-loaded nanogenerators with cascade NO/PDT for anti-tumor applications are summarized.

Language: Английский

Nature's weapons: Bioactive compounds as anti-cancer agents DOI Creative Commons
Amogh Auti,

Madhura S. Tathode,

Maria Michela Marino

et al.

AIMS Public Health, Journal Year: 2024, Volume and Issue: 11(3), P. 747 - 772

Published: Jan. 1, 2024

Cancer represents a major global health burden, prompting continuous research for effective therapeutic strategies. Natural compounds derived from plants have emerged as potential strategies preventing cancer and treatment because of their inherent pharmacological properties. This comprehensive review aimed to evaluate the five key natural compounds: apigenin, quercetin, piperine, curcumin, resveratrol in prevention therapy. By examining molecular mechanisms preclinical evidence, this seeks elucidate role adjuvants or stand-alone therapies management. The exploration therapeutics offers several advantages, including low toxicity, wide availability, compatibility with conventional chemotherapeutic agents. We highlighted current understanding anticancer clinical applications advancing personalized care improve patient outcomes. discussed empirical findings vitro, vivo, studies reporting biological activity efficacy antioxidant, immunomodulatory, anti-carcinogenic, chemo-sensitizing modes. Innovative delivery systems approaches may further enhance bioavailability utility synergistic approach chemo- radiotherapeutic disease underscores importance treatment, promoting multidisciplinary development innovative

Language: Английский

Citations

4
Apigenin inhibits tumor angiogenesis by hindering microvesicle biogenesis via ARHGEF1 DOI
Wei Zhang,

Xiangjin Zhuang,

Chenlong Wu

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 596, P. 216961 - 216961

Published: May 31, 2024

Language: Английский

Citations

3
Layer-by-layer nanocomposite based on zein and hyaluronic acid for tumor-targeted gene delivery DOI
Liang Liu, Tiange Wang,

Yanlin Sun

et al.

Industrial Crops and Products, Journal Year: 2024, Volume and Issue: 222, P. 119445 - 119445

Published: Aug. 28, 2024

Language: Английский

Citations

2
Edoxaban enfolded beta-1,4-Poly-D-glucosamine nanoparticles for targeting ponym Stuart–Prower factor for treatment of venous thrombosis DOI

Pavazhaviji Pazhani,

Jose Prakash Dharmian,

Somasundaram Arumugam

et al.

Journal of drug targeting, Journal Year: 2024, Volume and Issue: 32(9), P. 1125 - 1138

Published: July 11, 2024

The present research looked for ways to develop shielded nanoparticles (NPs)-drug transporters made of chitosan (CS) enhance the bioavailability edoxaban tosylate monohydrate (ETM) oral administration by examining correlation among design aspects and data from experiments using response surface methodology (RSM). ETM-loaded CS (ETM-CS-NPs) were developed ionic gelation with tripolyphosphate (TPP). Utilising Zeta-sizer scanning electron microscopy, ETM-CS-NPs evaluated particle size (PS), zeta potential (ZP), morphology, polydispersity index (PDI), entrapment efficiency (EE) drug loading (DL). Drug polymer interactions in NPs assessed Fourier transform infra-red spectroscopy. approach Design-Expert software optimised ETM-CS-NPs. Using RSM, effects independent variables such as amount CS, TPP, glacial acetic acid on PS, PDI ZP analysed. optimal combination PS (354.8 nm), (0.509), (43.7 + mV), % EE (70.3 ± 1.3) DL (9.1 0.4) has been identified ETM-CS-NPs' anticoagulant activity was activated partial thromboplastin time (aPTT), prothrombin (PT) thrombin (TT) assays. In conclusion, a practical consistent method established, its application proven

Language: Английский

Citations

0
Nanogenerator with L-Arginine loading: new choices as cascaded and synergistic nitric oxide/photodynamic antitumor agents DOI
Yue Huang, Ziwei Wu, Hanyang Wang

et al.

Materials Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 9(2), P. 204 - 222

Published: Nov. 27, 2024

In this review, the design idea, synergistic mechanism and application prospects of l -arginine-loaded nanogenerators with cascade NO/PDT for anti-tumor applications are summarized.

Language: Английский

Citations

0