Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 11375 - 11402
Published: Dec. 1, 2024
Systemic lupus erythematosus is a heterogeneous autoimmune disease. A burst of reactions in various systems can lead to severe clinical conditions closely associated with mortality. T cells serve as mediators that drive the occurrence and maintenance inflammatory processes.
Language: Английский
Microorganisms, Journal Year: 2025, Volume and Issue: 13(2), P. 282 - 282
Published: Jan. 27, 2025
This paper explores various aspects of microbiology and immunology, with a particular focus on the epidemiology molecular characterisation infectious diseases in Caribbean South America. Key areas investigation include tuberculosis (TB), experimental vaccines, bloodborne pathogens. A retrospective study conducted Jamaica highlights significance early HIV screening, timely diagnosis, inte-grated care. The also examines challenges posed by nosocomial infections, particularly those caused antibiotic-resistant Gram-negative bacteria methicillin-resistant Staphylococcus aureus (MRSA), emphasising critical importance infection control measures. Additionally, it regional microbiome, global response to diseases, immune responses patients immunodeficiency disorders such as severe combined (SCID) chronic granulomatous disease (CGD), underscoring their heightened susceptibility wide range infections.
Language: Английский
Citations
1
Behavioural Brain Research, Journal Year: 2025, Volume and Issue: 483, P. 115465 - 115465
Published: Feb. 6, 2025
Language: Английский
Citations
1
Diagnostics, Journal Year: 2024, Volume and Issue: 14(11), P. 1186 - 1186
Published: June 5, 2024
Systemic lupus erythematosus (SLE) is a chronic autoimmune condition that can seriously impair multiple organs including the nervous system, causing neuropsychiatric SLE (NPSLE), which encompasses broad range of symptoms. Pathogenesis not completely understood but thought to involve inflammatory and vascular pathways. This comprehensive review discusses complex nature heterogeneity NPSLE challenges in diagnosis treatment result from it. Diagnosis often requires multidisciplinary approach with assessments, laboratory testing, imaging, neuropsychological evaluations. Current treatments focus on managing symptoms through immunosuppressive anti-thrombotic therapies tailored or specific manifestations. paper emphasizes necessity for interdisciplinary approaches further research enhance diagnostic accuracy effectiveness. It also highlights importance understanding underlying mechanisms develop more targeted therapies, citing need high-quality studies novel agents.
Language: Английский
Citations
6
World Journal of Psychiatry, Journal Year: 2025, Volume and Issue: 15(2)
Published: Jan. 14, 2025
BACKGROUND Not all neuropsychiatric (NP) manifestations in patients with systemic lupus erythematosus (SLE) are secondary to lupus. The clarification of the cause NP symptoms influences therapeutic strategies for SLE. AIM To understand attribution psychiatric a cohort Chinese METHODS This retrospective single-center study analyzed 160 inpatient medical records. Clinical diagnosis, which is considered gold standard, was used divide subjects into SLE (PSLE) group (G1) and (G2). features were compared between these two groups. sensitivity specificity Italian model explored. RESULTS A total 171 syndromes recorded 138 patients, including 87 cases acute confusional state, 40 cognitive dysfunction, 18 psychosis, 13 each depressive disorder mania or hypomania. 141 (82.5%) attributed In contrast G2 G1 had higher Disease Activity Index-2000 scores (21 vs 12, P = 0.001), lower prevalence anti-beta-2-glycoprotein 1 antibodies (8.6% 25.9%, 0.036), anti-ribosomal ribonucleoprotein particle (rRNP) (39.0% 22.2%, 0.045). exhibited 95.0% 70.0% when threshold value set at 7. CONCLUSION Patients PSLE increased disease activity. There correlation anti-rRNP antibodies. effectively assesses multiple who present symptoms.
Language: Английский
Citations
0
Cytokine, Journal Year: 2025, Volume and Issue: 188, P. 156874 - 156874
Published: Feb. 3, 2025
Language: Английский
Citations
0
Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 503 - 503
Published: Feb. 18, 2025
Background: Fibromyalgia, depression, and autoimmune diseases represent a triad of interconnected conditions characterized by overlapping biological pathways, including chronic inflammation, immune dysregulation, neurochemical imbalances. Understanding their shared mechanisms offers opportunities for innovative therapeutic approaches. Objective: This systematic review explores the common inflammatory- immune-related pathways among these conditions, emphasizing implications biomarker development novel strategies. Methods: Following PRISMA guidelines, comprehensive literature search was conducted in databases PubMed, Scopus, Web Science, Cochrane Library. Studies examining relationship between fibromyalgia, with focus on responses, inflammatory biomarkers, interventions were included. The quality selected studies assessed using Risk Bias tool. Results: From 255 identified studies, 12 met inclusion criteria. Evidence supports role pro-inflammatory cytokines (e.g., IL-6, TNF-α) dysregulation serotonin, dopamine) as key factors pathophysiology conditions. Pilot highlight potential immune-modulating therapies, low-dose IL-2 anti-inflammatory agents such N-acetylcysteine minocycline, alleviating both physical psychological symptoms. Emerging cytokine profiles platelet serotonin activity, show promise personalized treatment Conclusions: linking underscore need integrated Although pilot provide preliminary insights, validation through large-scale, multicenter trials is essential. Future research should standardizing methodologies leveraging biomarker-driven precision medicine to improve outcomes patients complex, multifactorial
Language: Английский
Citations
0
Neuroglia, Journal Year: 2025, Volume and Issue: 6(1), P. 10 - 10
Published: March 1, 2025
Vestibular disorders significantly affect individuals by impairing balance, spatial orientation, and quality of life. Despite the focus on neuronal mechanisms, emerging research emphasizes importance neuroglia—astrocytes, microglia, oligodendrocytes, Schwann cells—in onset, progression, resolution these conditions. This narrative review explores roles neuroglia in vestibular disorders, including migraines unilateral bilateral vestibulopathies. It discusses established facts, challenges, future perspectives, offering insights into their pathophysiological therapeutic implications, limitations current research. By understanding interplay between function, this aims to advance diagnostic treatment strategies for
Language: Английский
Citations
0
Cureus, Journal Year: 2025, Volume and Issue: unknown
Published: March 5, 2025
This systematic review comprehensively analyzes the neurological complications associated with Sjögren's Syndrome (SS), focusing on peripheral neuropathy, central nervous system (CNS) involvement, cognitive dysfunction, and autonomic dysregulation. Eight studies, published between 2010 2024, were meticulously selected, encompassing a range of study designs, patient populations, diagnostic methodologies. The findings highlight substantial burden manifestations in SS, neuropathy identified as most prevalent complication, followed by impairment CNS vasculitis. underscores critical need for standardized criteria outcome measures to facilitate early detection effective intervention. Although some studies report promising results regarding efficacy immunotherapy other therapeutic approaches, absence randomized controlled trials (RCTs) significantly hampers ability establish definitive treatment guidelines. Additionally, this highlights importance accounting confounding factors, such comorbid conditions, understanding disease progression efficacy. It calls further research investigate innovative options develop personalized plans tailored specific needs SS patients complications.
Language: Английский
Citations
0
Molecular Immunology, Journal Year: 2025, Volume and Issue: 181, P. 66 - 74
Published: March 12, 2025
Language: Английский
Citations
0
Diagnostics, Journal Year: 2025, Volume and Issue: 15(7), P. 824 - 824
Published: March 25, 2025
Background: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder. Neuropsychiatric manifestations are frequently observed and associated with increased morbidity reduced quality of life. Magnetic resonance imaging (MRI) the neuroimaging procedure choice for investigation. High-resolution vessel wall (HRVWI) methodology that allows active mapping pathophysiological processes involving brain walls. Methods: To exemplify importance HRVWI its usefulness in patients SLE, we carried out scoping review (following PRISMA guidelines) using PubMed Embase databases. Results: We retrieved 10 studies utilized neuropsychiatric including total 69 patients. The majority, 84% (58/69), were women, ages ranging between 16 80 years (average 38.4 years). Approximately 46.3% (32/69) had white matter lesions at time investigation, 77% (53/69) normal magnetic angiography. Treatment immunosuppressants led to resolution majority findings. Conclusions: Imaging plays an important role investigating SLE. analysis gaining more importance, ability identify inflammation even if angiographic MRI sequences (3D TOF) normal, allowing institution early immunosuppressant treatment symptoms.
Language: Английский
Citations
0