Harnessing the Power of Polyphenols: A New Frontier in Disease Prevention and Therapy

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 692 - 692

Published: May 27, 2024

There are a wide variety of phytochemicals collectively known as polyphenols. Their structural diversity results in broad range characteristics and biological effects. Polyphenols can be found foods drinks, including fruits, cereals, tea, coffee. Studies both vitro vivo, well clinical trials, have shown that they possess potent antioxidant activities, numerous therapeutic effects, health advantages. Dietary polyphenols demonstrated the potential to prevent many problems, obesity, atherosclerosis, high blood sugar, diabetes, hypertension, cancer, neurological diseases. In this paper, protective effects mechanisms behind them investigated detail, citing most recent available literature. This review aims provide comprehensive overview current knowledge on role preventing managing chronic The cited publications derived from vitro, human-based studies trials. A more complete understanding these naturally occurring metabolites will pave way for development novel polyphenol-rich diet drug programs. This, turn, provides further evidence their benefits.

Language: Английский

---

The state of the art in anti-aging: plant-based phytochemicals for skin care

Immunity & Ageing, Journal Year: 2025, Volume and Issue: 22(1)

Published: Jan. 31, 2025

Phytochemicals help mitigate skin aging by scavenging free radicals, modulating key enzymatic pathways, and promoting the skin's structural integrity. Carotenoids, vitamins, essential fatty acids, phenolic compounds work acting as antioxidants, inhibiting enzymes like hyaluronidase, collagenase, elastase, which degrade structure, reducing levels of inflammatory markers (IL-6, IL-8, etc.) matrix metalloproteinases (MMP-1, MMP-2) linked to aging. Recent research highlights that plant-based phytochemicals can improve elasticity, reduce hyperpigmentation, prevent breakdown important proteins, support wound healing, making them valuable components for care treatments. This review explores multifaceted roles in maintaining improving health, highlighting their mechanisms action potential anti-aging innovations.

Language: Английский

---

Nanoparticle-Encapsulated Plant Polyphenols and Flavonoids as an Enhanced Delivery System for Anti-Acne Therapy

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 209 - 209

Published: Feb. 4, 2025

This study conducted a literature review by searching for articles related to the treatment of skin infections/wrinkles using nano-delivery systems containing natural compounds. The search was in various databases published last 10 years, with strict inclusion and exclusion criteria. Of 490 found, 40 were considered relevant. Acne vulgaris is common dermatological disorder characterised inflammation sebaceous glands, often resulting development pimples, cysts, scarring. Conventional treatments, including antibiotics topical retinoids, frequently demonstrate limitations such as side effects, resistance, insufficient absorption. Recent advancements nanotechnology have enabled creation innovative drug-delivery that enhance effectiveness reduce adverse effects anti-acne medications. Polyphenols flavonoids, bioactive compounds notable anti-inflammatory, antioxidant, antibacterial properties, are recognised their therapeutic acne treatment. However, practical application hindered solubility, stability, bioavailability. incorporation these into nanoparticle-based delivery has shown promise resolving challenges. Various nanoparticle platforms, lipid-based nanoparticles, polymeric solid lipid evaluated ability improve controlled release, targeted polyphenols flavonoids skin. advent polyphenol flavonoid-loaded nanoparticles marks new therapy era.

Language: Английский

---

Formulation and Evaluation of the Antioxidant Activity of an Emulsion Containing a Commercial Green Tea Extract

Molecules, Journal Year: 2025, Volume and Issue: 30(1), P. 197 - 197

Published: Jan. 6, 2025

The addition of an extract to emulsion is intended improve its fragrance and care qualities. Green tea a beverage known all over the world. It tasty has beneficial effects on human health due high polyphenol content. compounds present in this variety have also made it interesting cosmetic ingredient. polyphenols contained green antioxidant properties can delay ageing process skin. Various preparations with ingredient be found market-from creams hair products. Making one's own cosmetics trend. In following study, three containing extracts from different manufacturers were prepared, total (TP) contents, phenolic profile used activity these examined using two methods: DPPH• ABTS•+ cationic radicals. study showed that glycerin-water measured by selected methods was higher than oil extract. Among creams, product Firm 2 (glycerin-water extract) best properties.

Language: Английский

---

Dietary Interventions, Supplements, and Plant-Derived Compounds for Adjunct Vitiligo Management: A Review of the Literature

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 357 - 357

Published: Jan. 20, 2025

Vitiligo is a chronic autoimmune pigmentation disorder shaped by complex interplay of genetic predispositions and environmental triggers. While conventional therapies—phototherapy, corticosteroids, immunosuppressants—can be effective, their benefits are often partial temporary, with recurrence common once treatment stops. As such, there increasing interest in exploring complementary approaches that may offer more sustainable impact. Emerging evidence suggests macronutrient micronutrient-level changes could beneficial for managing progression and, some cases, facilitating repigmentation. Antioxidant-rich foods, such as apples, green tea, Indian gooseberry, onions, peppers, help mitigate oxidative stress, while inflammatory gluten high-phenol nuts berries, exacerbate the condition. Certain supplements, including high-dose vitamin D, C, E, selenium, enhance phototherapy outcomes. Omega-3 other unsaturated fatty acids, addition to prebiotics probiotics, under active investigation roles gut health immune regulation. Notably, plant-derived compounds, i.e., Ginkgo biloba, have demonstrated promise promoting repigmentation disease progression. However, it must emphasized these nutritional interventions remain exploratory, research needed establish efficacy, safety, optimal usage before they can recommended part standard regimen.

Language: Английский

---

Polyphenol Microneedles for Dermatological Therapy

Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Abstract Dermatological diseases represent one of the most prevalent health concerns globally, with associated care and treatment costs having consistently increased over past decade. Current therapeutic modalities, including topical medications, oral pharmaceuticals, physical therapies, frequently face challenges such as inadequate drug absorption substantial adverse effects. Microneedles, recognized minimally invasive delivery systems, effectively penetrate cutaneous barrier to enhance permeability efficacy. Polyphenols—abundant in botanical marine sources—demonstrate diverse pharmacological properties encompassing anti‐inflammatory antioxidant activities. The integration polyphenols microneedle technology has emerged a promising strategy for dermatological conditions, demonstrating significant clinical potential. This review examines multifunctional capabilities polyphenol‐incorporated microneedles elucidates their mechanisms action managing disorders. Furthermore, it synthesizes recent progress polyphenol‐based applications various pathologies, acne vulgaris, psoriasis, atopic dermatitis. Finally, current is discussed proposed future research directions optimizing polyphenol systems therapeutics.

Language: Английский

---

In Vitro Studies of the Effect of Oil Emulsions from Transgenic Flax Varieties on the Treatment of Wound Healing and Care of Human Skin with the Tendency to Inflammation

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2544 - 2544

Published: March 12, 2025

Excessive amounts of free-oxygen radicals produced during inflammation induce oxidative stress and lead to cell damage, thus delaying the transition into proliferation in wound healing process. Oxidative on skin cells also plays an important role pathogenesis inflammatory diseases. The aim planned vitro studies was assess mechanisms regenerative action protection against three oil emulsions from transgenic (GMO) flax varieties M, B, MB a linseed emulsion traditional NIKE oil. Antioxidant gene-protective properties were identified for tested healthy model under stress. wound-healing potential these assessed proliferation, cycle, migration, apoptosis necrosis assays. conducted research presented that are safe human because they do not cancer and, at same time, migration processes normal cells. Additionally, their use increases ability eliminate damaged Transgenic oils provide effect increased antioxidant effect, resulting stress, which atopic dermatitis psoriasis. Linen B has best protective epidermis cancer, is probably due presence amount stigmasterol its composition along with appropriate content polyphenol compounds, as well oleic linoleic acids.

Language: Английский

---

Unveiling the Biological Properties of Rosa rubiginosa L. Leaf Extract as a Bio-Functional Ingredient Based on 2D Cell-Based Models and In Vitro Assessments

Cosmetics, Journal Year: 2025, Volume and Issue: 12(2), P. 62 - 62

Published: March 31, 2025

Natural ingredients have long been utilized to enhance human health. While Rosa rubiginosa L. has relatively understudied, it is known for its antioxidant and anti-inflammatory properties. This study explores diverse bioactivity on primary keratinocytes fibroblasts, highlighting potential as a bio-functional agent in cosmeceuticals or nutraceuticals. The leaf extract demonstrated strong scavenging activity high phenolic content protection while also preventing DNA breakage. At the molecular level, ATP determination revealed that confers cell viability even under oxidative stress. Gene expression analysis uncovered protective effects fibroblasts due response stress induced by UVA irradiation. These findings suggest provides significant vitro biological properties cell-based models, offering new insights into benefits underscoring role.

Language: Английский

---

Effects of Yeast Products on the Apparent Total Tract Macronutrient Digestibility, Oxidative Stress Markers, Skin Measures, and Fecal Characteristics and Microbiota Populations of Healthy Adult Dogs

Animals, Journal Year: 2025, Volume and Issue: 15(7), P. 1046 - 1046

Published: April 4, 2025

Brewer's yeast has high nutritional value and contains bioactive compounds that may promote health. Functionalized canola meal (FCM) is a high-fiber ingredient been proposed as carrier for brewer's yeast. The objective of this experiment was to determine the apparent total tract digestibility (ATTD) diets containing yeast-enriched FCM test their effects on fecal characteristics microbiota, skin measures, serum oxidative stress markers adult dogs. Twelve dogs were fed four extruded kibble (control (no or yeast), + low dose, medium dose) in replicated 4x4 LSD. Dogs had greater wet output (~15% than control). ATTD DM, OM, fat lower FCM, although values remained >80% all macronutrients. altered relative abundance few bacterial genera (Eubacterium brachy, Peptoclostridium, Ruminococcus gnavus) phenol indole concentrations. Other characteristics, metabolites, diversity indices, not affected. These findings suggest can be incorporated into canine without compromising stool quality nutrient affect microbial metabolism.

Language: Английский

---

Biological Activity of Horehound (Marrubium vulgare L.) Herb Grown in Poland and Its Phytochemical Composition

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 780 - 780

Published: June 14, 2024

Marrubium vulgare (Lamiaceae) is a plant which has long been known and used in traditional medicine for various purposes. However, few recent studies have documented its chemical composition biological properties. The present study investigated the phytochemical of horehound, as well protective, antioxidant, antimicrobial potential. GC-MS analysis revealed that major components horehound essential oil are E-caryophyllene (35.7%), germacrene D (25.2%), bicyclogermacrene (10.6%). activity hydroethanolic herb extract derives from multiple compounds, including polyphenols (55.72 mg/mL), flavonoids (11.01 phenolic acids (4.33 tannins (4.46 mg/mL). Chromatographic analyses identified 12 ferulic acid, catechin, quercetin, protocatechuic rutin, syringic acid (35.42, 24.69, 20.65, 18.70, 14.46, 12.69 mg/mL, respectively) were main constituents. Its DPPH radical scavenging ability was 68.29%, while antioxidant properties, determined by FRAP method, at level 1.22 mmol/L. Moreover, M. decreased intracellular reactive oxygen species fibroblasts keratinocytes vitro, achieving strongest effect concentration 2.5% case both types skin cells. Extracts showed significant anti-biofilm activity, confirming plant’s potential therapeutic applications against microbial pathogens (gram-positive gram-negative bacteria fungi). research results demonstrate protective on viability vitro. To sum up, vulgare, valuable natural material with high preventive effectiveness, candidate new pharmaceutical cosmetics industries.

Language: Английский

---