Cited by Metallodrugs: Synthesis, mechanism of action and nanoencapsulation for targeted chemotherapy

Experimental and Computational Studies on the Interaction of DNA with Hesperetin Schiff Base CuII Complexes DOI

Federico Pisanu, Anna Sykuła, Giuseppe Sciortino

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5283 - 5283

Published: May 13, 2024

The interactions with calf thymus DNA (CT-DNA) of three Schiff bases formed by the condensation hesperetin benzohydrazide (HHSB or L1H3), isoniazid (HIN L2H3), thiosemicarbazide (HTSC L3H3) and their CuII complexes (CuHHSB, CuHIN, CuHTSC general formula [CuLnH2(AcO)]) were evaluated in aqueous solution both experimentally theoretically. UV–Vis studies indicate that ligands exhibit hypochromism, which suggests helical ordering helix. intrinsic binding constants (Kb) Cu compounds CT-DNA, range (2.3–9.2) × 106, from to CuHHSB, higher than other copper-based potential drugs, suggesting π–π stacking interaction due presence aromatic rings favors binding. Thiazole orange (TO) assays confirmed displace TO site, quenching fluorescence emission. DFT calculations allow for an assessment equilibrium between [Cu(LnH2)(AcO)] [Cu(LnH2)(H2O)]+, tautomer binds CuII, amido (am) not imido (im), coordination mode HTSC (O−, N, S), instead NH2). docking intercalative is preferred over minor groove CT-DNA order [Cu(L1H2am)(AcO)] > [Cu(L2H2am)(AcO)] ≈ L1H3 [Cu(L3H2am)(AcO)], line experimental Kb constants, obtained spectroscopy. Moreover, dockings predict strength larger [Cu(L1H2am)(H2O)]+. Overall, results suggest when different enantiomers, tautomers, donor sets are possible a metal complex, computational approach should be recommended type and, general, macromolecules.

Language: Английский

Citations

Metal-Based Drug–DNA Interactions and Analytical Determination Methods DOI

Adriana Corina Hangan,

L. Oprean,

Lucia Dican

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(18), P. 4361 - 4361

Published: Sept. 13, 2024

DNA structure has many potential places where endogenous compounds and xenobiotics can bind. Therefore, bind along the sites of nucleic acid with aim changing its structure, genetic message, and, implicitly, functions. Currently, there are several mechanisms known to be involved in binding. These covalent non-covalent interactions. The interaction or metal base coordination is an irreversible binding it represented by intra-/interstrand cross-link. generally a reversible intercalation between pairs, insertion, major and/or minor groove binding, electrostatic interactions sugar phosphate backbone. In present review, we focus on types DNA-metal complex (including some representative examples) presenting methods currently used study them.

Language: Английский

Citations

Novel Erodium glaucophyllum (L.) Aiton growing in arid environment: Phytochemical characterization, antimicrobial, antioxidant, and anticancer potential DOI

Amr H. Hashem, Bahaa Badr, Fathy M. Elkady

et al.

Electronic Journal of Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

Coordinative Compounds Based on Unsaturated Carboxylate with Versatile Biological Applications DOI

Gina Vasile Scăeţeanu, Mihaela Badea, Rodica Olar

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(10), P. 2321 - 2321

Published: May 15, 2024

This review presents an overview of the biological applications coordinative compounds based on unsaturated carboxylates accompanied by other ligands, usually N-based heterocyclic species. The interest in these arises from valuable antimicrobial and antitumor activities evidenced some species, as well their ability to generate metal-containing polymers suitable for various medical purposes. Therefore, we describe recently discovered aspects related synthesis, structure, activity a wide range carboxylate-containing species metal ions, originating mostly 3d series. encountered are acrylate, methacrylate, fumarate, maleate, cinnamate, ferulate, coumarate, itaconate. Regarding properties investigated compounds, it is worth mentioning good inhibit development resistant strains or microbial biofilms inert surfaces or, even more, exert against cells. intercalate into DNA strands scavenge ROS also addressed.

Language: Английский

Citations

Synthesis of Novel Cu(II), Co(II), Fe(II), and Ni(II) Hydrazone Metal Complexes as Potent Anticancer Agents: Spectroscopic, DFT, Molecular Docking, and MD Simulation Studies DOI

Eyüp Başaran, Hatice Gamze Soğukömeroğulları, Muhammed Tılahun Muhammed

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Metal complexes [FeL], [NiL]·H

Citations

Cobalt(II) and Manganese(II) Complexes of Sodium Monensinate A Bearing Nitrate Co-Ligands DOI

Nikolay Petkov,

Miroslav Boyadzhiev,

Nikita Bozhilova

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12129 - 12129

Published: Nov. 12, 2024

Monensic acid is a natural polyether ionophore and therapeutic of first choice in veterinary medicine for the control coccidiosis. Although known as sodium-binding ligand, it can also form variety coordination species depending on experimental conditions applied. In this study, we present crystal structures properties Co(II) Mn(II) complexes sodium monensinate (MonNa) derived from reaction MonNa with cobalt or manganese dinitrates. The newly obtained compounds have same composition [M(MonNa)

Language: Английский

Citations

Metallodrugs: Synthesis, mechanism of action and nanoencapsulation for targeted chemotherapy DOI

Jéssica Andreza Oliveira Rodrigues,

Neelakanta Sarvashiva Kiran,

Ankita Chatterjee

et al.

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 231, P. 116644 - 116644

Published: Nov. 20, 2024

Language: Английский

Citations