Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 20, 2024
Postoperative
infections
in
artificial
joints
provide
considerable
difficulties
the
field
of
orthopedics,
especially
after
joint
replacement
procedures.
These
rank
among
most
severe
postoperative
consequences,
frequently
leading
to
treatment
ineffectiveness
and
reduced
quality
life
for
surgery
patients.
Consequently,
it
is
crucial
acquire
knowledge
about
worldwide
research
trends
this
area
order
educate
clinical
practices
improve
therapeutic
techniques.
This
work
exploits
bibliometric
analysis
investigate
present
state,
developing
patterns,
main
areas
focus
on
infection.
Antibiotic-loaded
bone
cement
has
been
traditionally
advocated
as
a
key
step
for
the
success
of
one-stage
hip
revision
surgery,
while
cementless
techniques
have
recently
proposed
with
and
without
use
local
antibacterials
an
equally
successful
alternative.
Aim
this
review
is
to
investigate
effective
role
antimicrobial
protection
cemented
surgery.
Twelve
studies
reporting
results
single-stage
procedure
at
minimum
two
years
follow-up
were
reviewed.
When
pooling
together
data,
no
infection
recurrence
was
observed
on
average
in
83.3%
patients
(range
75.0%
100%).
Only
papers,
both
from
same
French
group,
included
treated
antibiotic-loaded
cement,
control
95.9%
total
195
patients.
This
figure
appears
better
that
80.7%
obtained
by
all
remaining
studies.
Concerning
revision,
17
studies,
521
patients,
showed
90.0%
56.8%
100%)
recurrence,
follow-up.
Eight
papers
reported
outcomes
implants
any
antibacterial
nine
more
described
four
different
implant
protection.
No
comparative
study
investigated
or
Pooled
data
86.7%,
application
antibacterials,
compared
90.1%
100%
protection,
depending
technology
used.
However,
due
relatively
low
number
each
statistical
difference
could
be
found,
either
considering
strategies
alone
pooled
together.
side
effect
had
technique.
points
out
although
safe
largely
performed
clinical
setting,
still
rely
mainly
experts’
opinion
observational
series
prospective
trial,
hence
definitive
conclusion
can
drawn
concerning
its
Frontiers in Chemistry,
Journal Year:
2024,
Volume and Issue:
12
Published: Aug. 29, 2024
In
this
study,
zeolitic
imidazolate
framework
8
(ZIF-8)
was
coated
on
porous
Ti6Al4V
scaffolds,
either
bare
or
previously
modified
using
hydroxyapatite
(HA)
HA
and
gelatin
(HAgel),
via
a
growing
single-step
method
in
aqueous
media
two
contact
times
at
6
h
24
h.
The
scaffolds
termed
ZIF-8@Ti,
ZIF-8@HA/Ti,
ZIF-8@HAgel/Ti
were
characterized
scanning
electron
microscopy
(SEM),
powder
X-ray
diffraction
(PXRD),
attenuated
total
reflectance-Fourier
transform
infrared
(ATR-FTIR),
molecular
plasma-atomic
emission
spectroscopy
(MP-AES).
order
to
assess
the
cell
proliferation
rate,
cytocompatibility
of
evaluated
primary
osteoblasts
(hOBs)
alamarBlue
assay,
while
osteoconductivity
analyzed
hOBs
real-time
approach,
evaluating
expression
secreted
phosphoprotein
1
(SPP1).
Osteopontin,
which
is
protein
encoded
by
gene,
represents
major
non-collagenous
bone
that
binds
tightly
HA.
shown
be
non-cytotoxic
based
hOB
all
time
points
analysis
(24
72
h).
cultures,
induced
upregulation
SPP1
with
different
fold
changes.
Some
selected
assayed
vitro
for
their
antibacterial
potential
against
Staphylococcus
epidermidis
;
ZIF-8
crystals,
regardless
presence
gelatin,
strongly
inhibited
bacterial
adhesion
materials
reduced
culture
medium,
demonstrating
suitable
release
bioactive
form.
These
experiments
suggest
innovative
tested
herein,
provide
good
microenvironment
adhesion,
viability,
osteoconduction
effective
prevention
S.
adhesion.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(19), P. 10269 - 10269
Published: Sept. 24, 2024
Ventilator-associated
pneumonia
(VAP)
remains
one
of
the
most
common
hospital-acquired
infections
(HAI).
Considering
complicated
diagnosis
and
lack
effective
treatment,
prophylactic
measures
are
suggested
as
new
standard
to
prevent
disease.
Although
VAP
often
manifests
a
polymicrobial
nature,
Pseudomonas
aeruginosa
pathogens
associated
with
highest
morbidity
mortality
rates
within
these
mechanically
ventilated
patients.
In
this
paper,
we
report
on
development
an
antibacterial
hydrogel
coating
using
polymyxin
B
(PMB)
peptide
bacterial
adhesion
polymeric
substrate.
We
fully
characterized
properties
atomic
force
microscopy
(AFM),
scanning
electron
(SEM),
wettability
analyses
Fourier-transform
infrared
(FTIR)
Raman
spectroscopy.
Furthermore,
several
biological
assays
confirmed
anti-biofilm
effect
tubing
for
at
least
8
days
against
P.
aeruginosa.
On
top
that,
produced
is
compliant
requirements
regarding
cytocompatibility
stated
in
ISO
(International
Organization
Standardization)
10993
guidelines
extended
release
PMB
over
period
42
was
detected.
conclusion,
study
serves
foundation
peptide-releasing
formulas
prevention
VAP.
Antibiotics,
Journal Year:
2024,
Volume and Issue:
13(11), P. 1060 - 1060
Published: Nov. 7, 2024
The
aim
of
this
review
is
to
investigate
the
effective
role
local
antimicrobial
protection
for
one-stage
cemented
and
cementless
hip
revision
surgery.
Twelve
studies
reporting
results
single-stage
procedures
with
a
minimum
two-year
follow-up
were
reviewed.
When
pooling
together
data,
no
infection
recurrence
was
observed
on
average
in
83.3%
patients
(a
range
75.0%
100%).
Only
two
papers
included
treated
without
use
antibiotic-loaded
bone
cement,
an
control
95.9%
total
195
patients.
This
figure
appears
be
better
than
80.7%
obtained
by
all
remaining
studies.
Concerning
revision,
17
studies,
521
patients,
showed
90.0%
(range
56.8%
100%)
at
follow-up.
No
comparative
study
investigated
or
antibacterial
protection.
pooled
data
86.7%,
application
antibacterials,
compared
90.1%
100%
protection,
depending
technology
used.
statistical
difference
could
found,
either
considering
strategies
alone
together.
side
effects
had
been
reported
any
technique.
Local
surgery,
although
safe
largely
performed
clinical
setting,
still
rely
mainly
experts'
opinions
prospective
trial,
hence
definitive
conclusion
can
drawn
concerning
its
