bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 4, 2024
An unusual family of bifunctional terpene synthases has been discovered in which both catalytic domains - a prenyltransferase and cyclase are connected by long, flexible linker. These enzymes unique to fungi catalyze the first committed steps biosynthesis complex terpenoid natural products: assembles 5-carbon precursors form C
Language: Английский
Fermentation, Journal Year: 2024, Volume and Issue: 10(6), P. 275 - 275
Published: May 23, 2024
It is widely known that mushrooms present several properties with applications in the medicinal and pharmaceutical sectors, including antimicrobial, immunomodulatory, antioxidant, hypotensive, neuroprotective, anti-inflammatory activities. This article aims to review examples of bioactive metabolites responsible for those activities, such as polysaccharides, phenols polyphenols, terpenes, peptides, alkaloids, steroids, which are produced by relevant mushroom species. also discusses their production through solid-state fermentation submerged fermentation, well processes obtention extracts considerations on stability aiming industrial applications. In addition, examines patent landscape surrounding mushroom-derived bioactives, shedding light intellectual property history innovations driving this field forward. Examples recently deposited patents highlighted, main depositors. China United States major depositor countries (52% 35% patents, respectively), principal compounds polysaccharides alkaloids. The provides insights into current market landscape, showcasing products available consumers. From dietary supplements skincare formulations, offerings reflect growing interest harnessing health benefits bioactives.
Language: Английский
Citations
4
eFood, Journal Year: 2025, Volume and Issue: 6(1)
Published: Jan. 20, 2025
ABSTRACT Mushrooms have long been an integral part of human culture and health are valued for their nutritional therapeutic properties. Often referred to as a superfood, mushrooms rich in bioactive compounds that provide range benefits including antioxidant, antimicrobial, anticancer, prebiotic, antidiabetic, anti‐inflammatory effects. This review focussed on the diversity mushrooms, emphasizing medicinal significance, explores secondary metabolites with potential applications nutraceuticals pharmaceuticals. It underscores role vital agents developing value‐added products. An overview compounds, such polysaccharides, peptides, proteins, terpenoids, phenolic identified numerous mushroom species. Additionally, addresses advancements fungal biotechnology, particularly use fungi efficient industrial cell factories, influence food quality sustainability. By critically analyzing recent studies, summarizes diverse roles biomolecules pharmaceutical industries highlights significant contribution modern medicine health‐related fields.
Language: Английский
Citations
0
Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 512 - 512
Published: Jan. 23, 2025
The rise of antibiotic-resistant Staphylococcus aureus strains, particularly MRSA, complicates the management skin and soft tissue infections. This review highlights ultrasonic methodologies as adjunctive therapies to combat S. aureus-driven infections prevent progression biofilm formation chronic wounds. Low- high-frequency ultrasound (LFU HFU) demonstrate potential in disrupting biofilms, enhancing drug delivery, promoting repair through cavitation microbubble activity. These approaches integrate frequencies with microbubbles therapeutics, such antibiotics affimers, minimize resistance improve healing. Tailoring bioeffects on structures localized delivery technologies, including microneedle patches piezoelectric systems, presents promising solutions for early intervention structure (SSSIs).
Language: Английский
Citations
0
Mycology: An International Journal on Fungal Biology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12
Published: Feb. 2, 2025
Different species of fungi usually share many common pathways but they also have some unique metabolic (e.g. those for specialised metabolites). It is not clear how gene expression patterns significantly contribute to the creation diverse volatile compounds. Based on research most VOCs, functions different fungal compounds are mainly as follows: inhibitory or synergistic effects other microorganisms, promoting growth in plants inducing a defensive response crops, and participating material cycle affecting interactions between organisms ecosystem. Approximately three hundred VOCs been identified from fungi. According their chemical properties, major categories terpenoids, aromatic compounds, alcohols, alkanes, esters, aldehydes, ketones, heterocyclic The eight-carbon alcohol (1-octen-3-ol) one characteristic VOC. This abundantly produced VOC results breakdown linoleic acid causes distinctive mushroom-like odour. Consequently, its presence has utilised signal growth. by certain semiochemical numerous arthropods. use Drosophila melanogaster (fruit flies) model testing toxicity showed that delayed metamorphosis and/or caused fly death at concentrations. When was cultivated an atmosphere shared with mixtures released growing cultures several medically important fungi, including Aspergillus fumigatus, observed. Additionally, we propose components genetic immune system D. engaged via elicitation Toll pathway. 1-octen-3-ol, example, associated higher levels fruit bioassay. In this review, summarise (1) diversity (2) biosynthesis bioactive characteristics (3) assess health impacts VOCs.
Language: Английский
Citations
0
Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 247 - 247
Published: Feb. 12, 2025
Although not frequently lethal, dermatological diseases represent a common cause of consultation worldwide. Due to the natural and non-invasive approach phytotherapy, research for novel alternatives, such as polyphenols, treat skin disorders is subject interest in modern medicine. Polyphenols, particular, have been considered because their anti-inflammatory, antitumoral, antimicrobial, antioxidant properties, low molecular weight, lipophilic nature that enables passage these compounds through barrier. This review discusses treatment acne vulgaris, fungal infections, dermatitis, alopecia, cancer, using polyphenols therapeutic prophylactic options. The specific molecules each disorder, mechanisms action, current clinical trials, proposed applications are also reviewed.
Language: Английский
Citations
0
Journal of Agriculture and Food Research, Journal Year: 2025, Volume and Issue: unknown, P. 101791 - 101791
Published: March 1, 2025
Language: Английский
Citations
0
Medicine in Microecology, Journal Year: 2025, Volume and Issue: unknown, P. 100125 - 100125
Published: March 1, 2025
Language: Английский
Citations
0
Published: Jan. 1, 2025
Citations
0
Springer eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 31
Published: Jan. 1, 2025
Language: Английский
Citations
0
Journal of Plant Pathology, Journal Year: 2025, Volume and Issue: unknown
Published: April 23, 2025
Language: Английский
Citations
0