The Potential of Cannabidiol for Treating Canine Atopic Dermatitis

Veterinary Sciences, Journal Year: 2025, Volume and Issue: 12(2), P. 159 - 159

Published: Feb. 12, 2025

Atopic dermatitis is prevalent in humans (hAD) and dogs (cAD) profoundly impacts the patients’ quality of life. The increasing number new drugs development for atopic indicates both need potential precision medicine to generate an optimised benefit–risk therapeutic plan. Cannabidiol (CBD), known its anti-inflammatory antipruritic properties, shows promise hAD cAD management, prompting exploration cannabinoids (CBs) CBD as tools. In fact, encouraging results on benefits using have been published, along with safety evaluations that reveal generally well tolerated dogs. However, limited placebo-controlled trials dosage variations pose barriers hinder definitive conclusions. Challenges product stability, inconsistent formulations, legal ambiguities highlight standardised CBD-based products research commercial uses. complex landscape further complicates accessibility regulation. Despite these challenges, emerging a avenue urging high-quality research, clarity. This brief review provides valuable insights into CBs cAD, compared hAD, emphasising importance rigorous unambiguous regulation successful integration veterinary dermatology.

Language: Английский

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GC–MS as a valuable tool for analysing cannabinoid-containing gummies and identifying the synthetic process used for their production

Forensic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 100672 - 100672

Published: May 1, 2025

Language: Английский

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Fragmentation and Isomerization Pathways of Natural and Synthetic Cannabinoids Studied via Higher Collisional Energy Dissociation Profiles

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 717 - 717

Published: Feb. 5, 2025

Cannabinoid molecules are the family of that bind to cannabinoid receptors (CB1 and CB2) human body cause changes in numerous biological functions including motor coordination, emotion, pain reception. Cannabinoids occur either naturally Cannabis Sativa plant or can be produced synthetically laboratory. The need for accurate analytical methods analyzing is considerable current importance due demands detecting illegal cannabinoids monitoring manufacture popular, non-illegal products. Mass spectrometry has been shown an optimum technique identifying cannabinoids. In this work, we perform Higher Collisional Dissociation (HCD) mass spectrometric measurements on Orbitrap Fusion Tribrid Spectrometer measure collision-energy-dependent molecular fragmentation pathways a group key their metabolites (cannabidiol, Δ9-Tetrahydrocannabinol, 11-Hydroxy-Δ9-tetrahydrocannabinol, 11-nor-9-Carboxy-Δ9-tetrahydrocannabinol, cannabidiolic acid, tetrahydrocannabinolic acid), along with two synthetic (JWH-018 MDMB-FUBINACA). This first time have studied using energy-resolved HCD methods. We identified number common, primary pathways, loss water, other small neutral molecule units (e.g., butene), rupture central C-C bond links aromatic alkyl ring groups. Quantum chemical calculations presented provide insights into preferred protonation sites characterize isomerization protonated open-ring [CBDA + H]+) closed-ring analogues [THCA H]+). A result emerge from our study particularly valuable isomerization, since isobaric pairs ions here H]+ associated identical profiles indicating one structure occurred during electrospray–mass process. important as it will general applicability tautomeric thus demonstrates application tool tautomerization proclivity.

Language: Английский

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Exploring the Potential of Nonpsychoactive Cannabinoids in the Development of Materials for Biomedical and Sports Applications

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

This Perspective explores the potential of nonpsychoactive cannabinoids (NPCs) such as CBD, CBG, CBC, and CBN in developing innovative biomaterials for biomedical sports applications. It examines their physicochemical properties, anti-inflammatory, analgesic, neuroprotective effects, integration into various hydrogels, sponges, films, scaffolds. also discusses current challenges standardizing formulations, understanding long-term intrinsical regulatory landscapes. Further, it promising applications NPC-loaded materials bone regeneration, wound management, drug delivery systems, emphasizing improved biocompatibility, mechanical therapeutic efficacy demonstrated

Language: Английский

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