Hydrophilic Components as Key Active Ingredients in Adipose‐Derived Matrix Bioscaffolds for Inducing Fat Regeneration DOI Creative Commons

Xiaomu Ma,

Yue Qiang,

Qian Wang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(31)

Published: Aug. 27, 2024

Decellularized adipose-derived matrix (DAM) has emerged as a promising biomaterial for soft tissue reconstruction. However, due to lack of research on its complex composition, the understanding key components in DAM remains limited, leading inconsistent adipogenic properties and challenges optimizing preparation methods purposefully. In this study, it is proposed first time that comprises two distinct components: hydrophilic (H-DAM) lipophilic (L-DAM), each with markedly different effects fat regeneration. It confirmed H-DAM component inducing regeneration enhanced cell-cell cell-scaffold interactions, primarily mediated by Hedgehog signaling pathway. contrast, L-DAM exhibits poor cell adhesion contains more antigenic components, higher immunoinflammatory response reduced adipogenesis. addition, found intracellular proteins, which are abundant H-DAM, can be retained beneficial their hydrophilicity, contrary conventional view they shall removed. Accordingly, purified bioscaffold unprecedented efficacy immunogenicity. This finding provides insights developing scaffolds promotes realization xenotransplantation.

Language: Английский

Molecular principles underlying aggressive cancers DOI Creative Commons
Ruth Nussinov, Bengi Ruken Yavuz, Hyunbum Jang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 16, 2025

Language: Английский

Citations

3
Hydrophilic Components as Key Active Ingredients in Adipose‐Derived Matrix Bioscaffolds for Inducing Fat Regeneration DOI Creative Commons

Xiaomu Ma,

Yue Qiang,

Qian Wang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(31)

Published: Aug. 27, 2024

Decellularized adipose-derived matrix (DAM) has emerged as a promising biomaterial for soft tissue reconstruction. However, due to lack of research on its complex composition, the understanding key components in DAM remains limited, leading inconsistent adipogenic properties and challenges optimizing preparation methods purposefully. In this study, it is proposed first time that comprises two distinct components: hydrophilic (H-DAM) lipophilic (L-DAM), each with markedly different effects fat regeneration. It confirmed H-DAM component inducing regeneration enhanced cell-cell cell-scaffold interactions, primarily mediated by Hedgehog signaling pathway. contrast, L-DAM exhibits poor cell adhesion contains more antigenic components, higher immunoinflammatory response reduced adipogenesis. addition, found intracellular proteins, which are abundant H-DAM, can be retained beneficial their hydrophilicity, contrary conventional view they shall removed. Accordingly, purified bioscaffold unprecedented efficacy immunogenicity. This finding provides insights developing scaffolds promotes realization xenotransplantation.

Language: Английский

Citations

1