Oxometallate-Based Ionic Liquid Catalyzed CO2-Promoted Hydration of Propargylic Alcohols for α-Hydroxy Ketones Synthesis DOI Open Access

Yuankun Wang,

C.-J. Wang,

Weidong Lin

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 62 - 62

Published: Dec. 25, 2024

α-Hydroxy ketones are a crucial class of organic compounds prevalent in natural products and pharmaceutical molecules. The CO2-promoted hydration propargylic alcohols is an efficient method for the synthesis α-hydroxy ketones. Herein, ionic liquid (IL) was designed to catalyze this reaction individually under atmospheric CO2 pressure, volatile solvents, additives. This IL, constructed from molybdate anion, can be recycled industrial (NH4)2MoO4 production wastewater, demonstrating its high tolerance catalytic environments significant potential practical applications. To our knowledge, first instance oxometallate-based IL catalyst being utilized alcohols. Further mechanistic studies revealed bifunctionality activating both substrates.

Language: Английский

Designing Effective Antimicrobial Agents: Structural Insights into the Antibiofilm Activity of Ionic Liquids DOI

Alexey D. Tikhomirov,

Ksenia S. Egorova, Valentine P. Ananikov

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Research concerning biofilm control is critical due to the pervasive and resilient nature of biofilms, which pose significant challenges across industrial, environmental, healthcare sectors. Traditional antimicrobial treatments are often ineffective against these robust structures. Here, we explore properties ionic liquids (ILs) their efficacy in disruption. By examining structural variations ILs, highlight key role hydrophobicity, noting that longer alkyl side chains IL cations enhance disruption bacterial death. However, upon reaching a certain optimal chain length─usually C12 C14─the activity ILs starts decrease. Furthermore, symmetry size anions significantly impact elimination. This Perspective addresses gap research, revealing structure–activity relationships providing foundation for designing more effective biofilm-disrupting agents.

Language: Английский

Citations

0
Interactions of Laurylated and Myristoylated KR12 Fragment of the LL37 Peptide with Polyoxidovanadates DOI Creative Commons

Martyna Kapica,

Elżbieta Kamysz, Ola Grabowska

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(7), P. 1589 - 1589

Published: April 2, 2025

Isothermal titration calorimetry (ITC), circular dichroism (CD) spectroscopy, and molecular dynamics simulations were applied to describe interactions between lipopeptides decavanadate ions ([V10O28]6−). The selected are conjugates of the amide KR12 peptide, smallest antimicrobial peptide derived from human cathelicidin LL-37, with lauric acid (C12-KR12) myristic (C14-KR12). smaller sizes C12-KR12 C14-KR12 compared proteins allow for rigorous characterization their non-covalent highly negatively charged [V10O28]6− ions. stoichiometry resulting decavanadate–peptide complexes thermodynamic parameters (ΔG, ΔH, TΔS) determined. ITC results, supported by MD simulation, showed that binding cationic is rather non-specific driven enthalpic contributions electrostatic positively residues peptides anionic decavanadate. Furthermore, influence temperature on stability α-helical structure assessed based CD spectra. Under experimental conditions (50 mM sodium cacodylate buffer, pH 5), adopt an conformation, showing greater thermal stability. vanadium species disrupt reduce its

Language: Английский

Citations

0
In Situ Reducible Ionic Frameworks for Dual‐Site and Photothermal Catalysis DOI
Jinghan Yang, Ming‐Feng Wei, Jiaxu Wang

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

Abstract Ionic frameworks (IFs), characterized by ionic bonds and periodic framework structures, find extensive applications in several fields. However, the inherent high bond energy of often leads to formation close‐packed structures rather than open frameworks. Consequently, selection suitable building units is pivotal for successful synthesis IFs. Utilizing large size negative charge polyoxometalates (POMs), along with their combination metal cations, offers an effective approach constructing In this study, 2D IFs are fabricated using {Na 4 O 18 } cluster formed sodium ions Anderson‐type polyanions. Polyoxovanadates integrated into voids, resulting a uniform distribution two clusters. The catalytic performance evaluated through reactions, revealing that clusters act as dual‐site catalysts, thereby enhancing reaction efficiency. presence strong reductants, polyoxovanadates undergo partial reduction, inducing single‐crystal‐to‐single‐crystal transformation. reduced display pronounced photothermal conversion capabilities serve efficient photothermal‐catalytic agents cycloaddition epoxides carbon dioxide. This research not only enhances structural diversity achieves but also pioneeringly demonstrates situ reduction application near‐infrared catalysis.

Language: Английский

Citations

0
Rapid fabrication of polyoxometalate-enhanced photo responsive films from ethyl cellulose (EC) and polyvinylpyrrolidone (PVP) DOI
Tanveer Hussain, Mulenga Kalulu, Zaheer Ahmad

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 280, P. 136051 - 136051

Published: Sept. 26, 2024

Language: Английский

Citations

1
Experimental investigation on the desorption of CO2 enriched liquids based on ceramic membranes DOI
Dan Gao, Yuanyuan Cao, Zhao-Hao Li

et al.

Separation and Purification Technology, Journal Year: 2024, Volume and Issue: unknown, P. 130592 - 130592

Published: Nov. 1, 2024

Language: Английский

Citations

1
Tailorable Ionic Frameworks for Selective Gas Adsorption and Separation: Bridging Experimental Insights with Mechanistic Understanding DOI Open Access

Luyun Xuan,

Hongxue Wang,

Ming‐Feng Wei

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

The selective adsorption and separation of gases using solid adsorbents represent a crucial method for the treatment toxic preparation high-purity gases. interaction forces between gas molecules are influenced by various factors, making precise design to achieve specific pressing issue that requires urgent attention. In this study, series ionic frameworks constructed from Na

Language: Английский

Citations

0
Oxometallate-Based Ionic Liquid Catalyzed CO2-Promoted Hydration of Propargylic Alcohols for α-Hydroxy Ketones Synthesis DOI Open Access

Yuankun Wang,

C.-J. Wang,

Weidong Lin

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 62 - 62

Published: Dec. 25, 2024

α-Hydroxy ketones are a crucial class of organic compounds prevalent in natural products and pharmaceutical molecules. The CO2-promoted hydration propargylic alcohols is an efficient method for the synthesis α-hydroxy ketones. Herein, ionic liquid (IL) was designed to catalyze this reaction individually under atmospheric CO2 pressure, volatile solvents, additives. This IL, constructed from molybdate anion, can be recycled industrial (NH4)2MoO4 production wastewater, demonstrating its high tolerance catalytic environments significant potential practical applications. To our knowledge, first instance oxometallate-based IL catalyst being utilized alcohols. Further mechanistic studies revealed bifunctionality activating both substrates.

Language: Английский

Citations

0