Sensitive detection of gallic acid in food by electrochemical sensor fabricated by integrating nanochannel film with nanocarbon nanocomposite DOI Creative Commons
Jiasheng Li,

Jiahui Lin,

Tao Luo

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 12, 2024

Sensitive detection of gallic acid (GA) in foods is great significance for assessing the antioxidant properties products and ensuring consumer health. In this work, a simple electrochemical sensor was conveniently fabricated by integrating vertically-ordered mesoporous silica film (VMSF) with electrochemically reduced graphene oxide (ErGO) nitrogen quantum dots (NGQDs) nanocomposite, enabling sensitive GA food sample. A water-soluble mixture (GO) NGQDs drop-cast onto common carbon electrode, glassy electrode (GCE), followed rapid growth VMSF using an assisted self-assembly method (EASA). The negative voltage applied during facilitated situ reduction GO to ErGO. synergistic effects ErGO, NGQDs, nanochannels led nearly tenfold enhancement signal compared that obtained on electrodes modified either ErGO or alone. realized linear concentration range from 0.1 10 μM, 100 μM. limit (LOD), determined based signal-to-noise ratio three ( S / N = 3), found be 81 nM. Combined size-exclusion property VMSF, demonstrated high selectivity, making it suitable samples.

Language: Английский

Sensitive Detection of Biomarker in Gingival Crevicular Fluid Based on Enhanced Electrochemiluminescence by Nanochannel-Confined Co3O4 Nanocatalyst DOI Creative Commons
Changfeng Zhu,

Yujiao Zhao,

Jiyang Liu

et al.

Biosensors, Journal Year: 2025, Volume and Issue: 15(1), P. 63 - 63

Published: Jan. 19, 2025

The sensitive detection of inflammatory biomarkers in gingival crevicular fluid (GCF) is highly desirable for the evaluation periodontal disease. Luminol-based electrochemiluminescence (ECL) immunosensors offer a promising approach fast and convenient biomarkers. However, luminol’s low ECL efficiency under neutral conditions remains challenge. This study developed an immunosensor by engineering immunorecognition interface on outer surface mesoporous silica nanochannel film (SNF) confining Co3O4 nanocatalyst within SNF nanochannels to improve luminol efficiency. was grown indium tin oxide (ITO) electrode using simple Stöber solution growth method. A successfully confined through situ electrodeposition, confirmed X-ray photoelectron spectroscopy (XPS) electrochemical measurements. demonstrated excellent electrocatalytic activity, effectively enhancing H2O2 oxidation boosting signal conditions. Using interleukin-6 (IL-6) as proof-of-concept demonstration, epoxy functionalization enabled covalent immobilization capture antibodies, forming specific interface. IL-6 binding induced immunocomplex formation, which reduced allowed quantitative detection. showed linear range from 1 fg mL−1 10 ng mL−1, with limit (LOD) 0.64 mL−1. It also good selectivity anti-interference capabilities, enabling successful artificial GCF samples.

Language: Английский

Citations

4
Homogeneous Aptasensor with Electrochemical and Electrochemiluminescence Dual Detection Channels Enabled by Nanochannel-Based Probe Enrichment and DNase I Cleavage for Tumor Biomarker Detection DOI Creative Commons
Jiong Gao, Shiyue Zhang, Fengna Xi

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 746 - 746

Published: Feb. 6, 2025

Homogeneous aptasensors that eliminate the need for probe labeling or immobilization hold significant potential rapid detection of tumor biomarkers. Herein, a homogeneous aptasensor with electrochemical (EC) and electrochemiluminescence (ECL) dual channels was developed by integrating nanochannel-based enrichment DNase I cleavage selective biomarker, carbohydrate antigen 125 (CA125). A two-dimensional (2D) composite prepared assembling CA125-specific aptamer cationic tris(2,2′-bipyridyl)Ru(II) (Ru(bpy)32+), which exhibited both EC ECL properties, onto graphene oxide (GO) nanosheets (Ru(bpy)32+/Apt@GO). vertically ordered mesoporous silica film (VMSF) ultrasmall, uniform, aligned nanochannel arrays rapidly grown on inexpensive disposable indium tin (ITO) electrode, forming interface. Due to size exclusion effect ultrasmall nanochannels in VMSF, Ru(bpy)32+/Apt@GO unable penetrate nanochannels, resulting no detectable Ru(bpy)32+ signal electrode. Upon specific recognition CA125 aptamer, an aptamer-CA125 complex formed subsequently detached from GO. then cleaved complex, releasing allowing dissociate into solution. This enzymatic enabled re-enter binding cycle, amplifying release The electrostatic adsorption VMSF significantly enhanced signals. constructed linear range 0.1 U/mL 100 ng/mL, limit (LOD) 91 mU/mL. For detection, detected over 0.001 U/mL, LOD as low 0.4 demonstrated excellent selectivity successfully applied dual-mode EC/ECL fetal bovine serum samples.

Language: Английский

Citations

1
CA 15-3-specific molecularly imprinted polymer nanoparticles-based voltammetric sensor for breast cancer monitoring DOI

Chutimon Akkapinyo,

Peter A. Lieberzeit, Peter Wolschann

et al.

Talanta, Journal Year: 2025, Volume and Issue: 288, P. 127746 - 127746

Published: Feb. 16, 2025

Language: Английский

Citations

0
Heteroepitaxial Growth of Narrow Band Gap Carbon-Rich Carbon Nitride Using In Situ Polymerization to Empower Sunlight-Driven Photoelectrochemical Water Splitting DOI
Narendra Chaulagain, Kazi M. Alam, John Garcia

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

We describe an in situ-polymerized conformal thin layer coating of narrow band gap carbon-rich carbon nitride (NBG-CRCN) on titania nanorod arrays to design a binary semiconductor heterojunction photocatalyst. The situ polymerization creates strong interaction between the TiO2 substrate and film, which prevents leaching CRCN liquid electrolytes. A unique aspect our work is developing easy inexpensive technique for heteroepitaxial growth mechanically photochemically stable films with intimate contact at CN:TNR interface. This method aids overcoming one main problems (CN), namely, inability produce evenly distributed CN substrate. synthesized NBG-CRCN@TNR extends visible light absorption 700 nm (Eg = 1.7 eV) red-shifts photoluminescence (PL) emission peak 580 nm. shifts broadening Raman spectra hybrid compared those TNR confirm unusually NBG-CRCN. An heteroepitaxially grow (002) rutile (110) confirmed by advanced characterization. High-resolution transmission electron microscopy (HRTEM), selected-area diffraction (SAED), grazing-incidence wide-angle X-ray scattering (GIWAXS) suggest (110). Under AM1.5G solar illumination, shows superior performance photoelectrochemical water splitting, generating photocurrent density as high 4.3 mA cm-2 1 M KOH under 0.6 V external bias, rising 8.4 presence hole scavenger (methanol). impressive hydrogen evolution rate 26.51 μmol h-1 88.12% Faradaic efficiency recorded. Establishing high-quality interface g-C3N4 permits effective charge carrier separation, leading enhanced photocatalytic activity.

Language: Английский

Citations

0
Enhanced Electrochemiluminescence of Luminol and-Dissolved Oxygen by Nanochannel-Confined Au Nanomaterials for Sensitive Immunoassay of Carcinoembryonic Antigen DOI Creative Commons
Weibin Li,

Ruliang Yu,

Fengna Xi

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(20), P. 4880 - 4880

Published: Oct. 15, 2024

Simple development of an electrochemiluminescence (ECL) immunosensor for convenient detection tumor biomarker is great significance early cancer diagnosis, treatment evaluation, and improving patient survival rates quality life. In this work, demonstrated based on enhanced ECL signal boosted by nanochannel-confined Au nanomaterial, which enables sensitive the biomarker-carcinoembryonic antigen (CEA). Vertically-ordered mesoporous silica film (VMSF) with a nanochannel array amine groups was rapidly grown simple low-cost indium tin oxide (ITO) electrode using electrochemically assisted self-assembly (EASA) method. nanomaterials were confined in situ VMSF through electrodeposition, catalyzed both conversion dissolved oxygen (O

Language: Английский

Citations

2
Amino-functionalized vertically ordered mesoporous silica film on electrochemically polarized screen-printed carbon electrodes for the construction of gated electrochemical aptasensors and sensitive detection of carcinoembryonic antigens DOI Creative Commons

Ke He,

Hongxin Wang, T. Luo

et al.

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 11, 2024

Disposable electrochemical biosensors with high sensitivity are very fit for point-of-care testing in clinical diagnosis. Herein, amino-functionalized, vertically ordered mesoporous silica films (NH

Language: Английский

Citations

2
Nanochannel confined graphene quantum dots/platinum nanoparticles boosts electrochemiluminescence of luminal-O2 system for sensitive immunoassay DOI
Yucheng Zhou, Chaoyan Zhang, Jiyang Liu

et al.

Talanta, Journal Year: 2024, Volume and Issue: 285, P. 127223 - 127223

Published: Nov. 20, 2024

Language: Английский

Citations

2
Solid-phase electrochemiluminescence immunosensing platform based on bipolar nanochannel array film for sensitive detection of carbohydrate antigen 125 DOI Creative Commons
Shun Lü,

Jiayi Wu,

T. Luo

et al.

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12

Published: Oct. 25, 2024

Development of simple solid-phase electrochemiluminescence (ECL) immunosensor with convenient fabrication for high-performance detection tumor biomarkers is crucial. Herein, a ECL immunoassay was constructed based on bipolar silica nanochannel film (bp-SNA) modified electrode highly sensitive carbohydrate antigen 125 (CA 125). Inexpensive and readily available indium tin oxide (ITO) used as the supporting growth bp-SNA. bp-SNA consists bilayer SNA different functional groups charge properties, including negatively charged inner layer (n-SNA) positively outer (p-SNA). The nanochannels were immobilization emitter tris(bipyridine)ruthenium(II), while surface utilized constructing immunorecognition interface. Due to dual electrostatic interaction composed attraction from n-SNA repulsion p-SNA, could be stably confined within bp-SNA, providing stable high signals electrode. After amino derivatized aldehyde groups, recognition antibodies covalently immobilized, an obtained after blocking nonspecific sites. When CA binds interface, formed complex reduces diffusion co-reactant tripropylamine (TPrA) electrode, decreasing signal. Based this mechanism, can achieve 125. linear range 0.01 100 U/mL, limit 4.7 mU/mL. in serum also achieved. construction has advantages fabrication, stability immobilized emitter, selectivity, making it suitable detection.

Language: Английский

Citations

1
Sensitive detection of gallic acid in food by electrochemical sensor fabricated by integrating nanochannel film with nanocarbon nanocomposite DOI Creative Commons
Jiasheng Li,

Jiahui Lin,

Tao Luo

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 12, 2024

Sensitive detection of gallic acid (GA) in foods is great significance for assessing the antioxidant properties products and ensuring consumer health. In this work, a simple electrochemical sensor was conveniently fabricated by integrating vertically-ordered mesoporous silica film (VMSF) with electrochemically reduced graphene oxide (ErGO) nitrogen quantum dots (NGQDs) nanocomposite, enabling sensitive GA food sample. A water-soluble mixture (GO) NGQDs drop-cast onto common carbon electrode, glassy electrode (GCE), followed rapid growth VMSF using an assisted self-assembly method (EASA). The negative voltage applied during facilitated situ reduction GO to ErGO. synergistic effects ErGO, NGQDs, nanochannels led nearly tenfold enhancement signal compared that obtained on electrodes modified either ErGO or alone. realized linear concentration range from 0.1 10 μM, 100 μM. limit (LOD), determined based signal-to-noise ratio three ( S / N = 3), found be 81 nM. Combined size-exclusion property VMSF, demonstrated high selectivity, making it suitable samples.

Language: Английский

Citations

0