Cumin (Cuminum cyminum): Traditional Uses and Modern Scientific Aspects - A Review DOI Open Access

Sundus Hameed Ahmed

South Asian Research Journal of Biology and Applied Biosciences, Journal Year: 2024, Volume and Issue: 6(06), P. 262 - 264

Published: Dec. 24, 2024

Cumin (Cuminum cyminum) is an herbaceous plant that belongs to the Umbelliferae family, widely known for its use as a spice in Indian, Middle Eastern, and other global cuisines. This aromatic contains powerful active compounds such thymoquinone cuminaldehyde, which have been linked numerous health benefits. Recent scientific research has highlighted cumin's positive effects on digestion, inflammation reduction, blood sugar regulation, even potential anticancer properties. These attributes make cumin important natural remedy various concerns. Furthermore, possesses antibacterial antifungal properties, making it effective combating skin infections microbial ailments. Laboratory studies revealed additional promising findings regarding extract. demonstrated ability inhibit tumor growth, reduce intestinal inflammation, enhance gut animal models. Such results indicate therapeutic agent addressing chronic complex conditions. Despite these encouraging findings, essential note most so far conducted laboratory settings or animals. To fully understand cumin’s medicinal confirm benefits human health, further clinical trials humans are necessary. will provide more comprehensive insights into safety, efficacy, dosage of cumin-based therapies. In addition culinary appeal, stands out functional with significant health-promoting Its multifaceted nature highlights importance integrating remedies modern healthcare practices, though solidify role applications.

Language: Английский

Nigella sativa: A Comprehensive Review of Its Therapeutic Potential, Pharmacological Properties, and Clinical Applications DOI Open Access

A. S. Alberts,

Elena-Theodora Moldoveanu,

Adelina-Gabriela Niculescu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13410 - 13410

Published: Dec. 14, 2024

Nigella sativa (NS) is an annual herb belonging to the Ranunculaceae family, also known as black cumin or seed. This plant has been used since ancient times due its therapeutic properties and proven effective in gastrointestinal, respiratory, cardiovascular, infectious, inflammatory conditions. In this review, aim highlight effects of Arab countries “the that cures any disease”, which are provided by phytochemical compounds composition, such thymoquinone, p-cymene, α-thujene, longifolene, β-pinene, α-pinene, carvacrol. These confer antioxidant effect seeds, leading a significant decrease ROS potent anti-inflammatory effect. Also, NS seeds may have synergistic with other drugs, chemotherapeutic agents antibiotics, lead reduction dose, improved effect, could overcoming obstacles drug resistance. The studies review showed potential be agent both monotherapy adjuvant. Although there demonstrating NS, need for much more extensive research clinical trials clearly established objectives so mechanism action active substances better understood. With data far, can food production small quantities administered short periods. Further investigations understanding profile most mode administration, well clearer perspective on toxicological NS.

Language: Английский

Citations

4
An updated review on the phytochemistry and pharmacological activity of black cumin (Nigella sativa L.) DOI Creative Commons
Raghvendra Pandey, Brijesh Pandey, Atul Bhargava

et al.

Advanced Chinese Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 23, 2025

Abstract In this review, a comprehensive and systematic evaluation of the phytochemical constituents, traditional medicinal applications, current pharmacological research, toxicity, nanobiotechnology black cumin has been undertaken. An exhaustive database retrieval was conducted to collect scientific information about Nigella sativa L. from 1956 2025 using PubMed, Scopus, ISI Web Science, SciFinder, CABI. Search carried out keywords “ ,” oil,” “Ethnobotany,” “Phytochemistry,” “Pharmacological activity,” “Toxicity,” “Nanotechnology.” Several important phytochemicals are found in seeds N . L., many which seem have good impact on human health put use Ayurvedic, Unani, Siddha systems medicine. Among active compounds, thymoquinone is most important, forming 30%–48% oil fraction. Besides thymoquinone, wide range such as thymohydroquinone, dithymoquinone, p ‐cymene, sabinene, carvacrol, 4‐terpineol, kaempferol (glucoside) t ‐anethol, longifolene (sesquiterpene), α ‐pinene, ‐hederin (pentacyclic triterpene), thymol also reported. Current research provided evidence for uses cumin, especially antioxidant, anti‐inflammatory, antibacterial, antifungal, antiviral, anticancer, antidiabetic, neuroprotective, gastroprotective, antiarthritic effects. The review provides an in‐depth analysis phytochemistry, well potential properties Since plant being extensively investigated its properties, valuable up‐to‐date status will act reference future applications plant.

Language: Английский

Citations

0
Identification of novel inhibitors targeting Mycobacterium abscessus InhA through virtual screening, docking, and molecular dynamic simulations DOI Creative Commons

M Hasnain Abbas,

Abdullah R. Alanzi, Kashif Iqbal Sahibzada

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 14, 2025

Language: Английский

Citations

0
Thymoquinone enhances efficacy of cervical Cancer therapeutic vaccines via modulating CD8+ T cells DOI

Yuxin Che,

Bing Song, Yingjie Song

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 114605 - 114605

Published: May 1, 2025

Language: Английский

Citations

0
Artificial intelligence and complex natural products for cardiovascular infection prevention and oxidative damage mitigation DOI Creative Commons
Josè M. Prieto

Exploration of Medicine, Journal Year: 2025, Volume and Issue: 6

Published: May 9, 2025

The cardiovascular system remains vulnerable to a multitude of threats, including infections, inflammation, and oxidative stress. These factors contribute significantly the development progression diseases, pressing global health concern. Historically, research into natural medicines has primarily focused on isolated compounds. However, complex entities like essential oils, rich in diverse chemical constituents, offer superior therapeutic potential. We discuss here how their inherent variability can lead unpredictable synergistic antagonistic effects, hindering consistent outcomes. This inconsistency is particularly problematic addressing rising incidence perioperative infections need combat radical-mediated damage subclinical inflammation. scoping review departs from hypothesis “Can we leverage products for discovery new clinical approaches diseases encompassing inflammation infection?”. Therefore, delve potential products, preventing mitigating damage, emphasizing crucial role artificial neural networks (ANNs) advancing this field. emphasizes multidisciplinary collaboration generate quality data effective ANN analysis, envisioning future integration omics technologies with ANNs more precise predictions product activities. It addresses challenges translating AI-designed oils practice, intellectual property protection standardization issues due regional variability, suggesting World Health Organization establishing guidelines oil specifications ensure efficacy while enabling accessibility. author concludes by stressing address ethical considerations at intersection technology, science, regarding proprietary status versus making them freely available worldwide.

Language: Английский

Citations

0
Foliar application of nano NPK fertilizer improves physiological activities and essential oil production in Coleus aromaticus Benth. (Ajwain Patta) DOI Creative Commons

Sufina Akhter,

Theodore R. Sana, Rashid Mir

et al.

Plant Nano Biology, Journal Year: 2025, Volume and Issue: unknown, P. 100160 - 100160

Published: May 1, 2025

Language: Английский

Citations

0
Molecular Docking of Key Compounds from Acacia Honey and Nigella sativa Oil and Experimental Validation for Colitis Treatment in Albino Mice DOI Creative Commons

M Bibi,

Irfan Baboo,

Hamid Majeed

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(12), P. 1035 - 1035

Published: Dec. 11, 2024

Colitis, an inflammatory condition of the colon that encompasses ulcerative colitis (UC) and Crohn's disease, presents significant challenges due to limitations side effects current treatments. This study investigates potential natural products, specifically AH NSO, as organic therapeutic agents for colitis. Molecular docking studies were conducted identify binding affinities interaction mechanisms between bioactive compounds in NSO proteins implicated colitis, such those involved inflammation oxidative stress pathways. An vivo experiment was performed using albino mouse model with clinical symptoms, histopathological assessments, biochemical analyses evaluate both individually combination. Results from molecular revealed promising interactions fructose Prostaglandin G/H synthase 2 (Ptgs2) cellular tumor antigen p53, energy measured at -6.0 kcal/mol -5.1 kcal/mol, respectively. Meanwhile, presence glucose molecule glucokinase chain A (-6.3 kcal/mol) B (-5.8 indicated efficacy modulating Experimental data demonstrated treatment significantly reduced inflammation, improved gut health, ameliorated symptoms. Histopathological evaluations confirmed mucosal damage immune cell infiltration, while showed normalization markers levels. provides compelling evidence natural, complementary treatments suggesting their future role integrative strategies. However, further research into long-term safety, optimal dosing, action is warranted translate these findings applications.

Language: Английский

Citations

0
Cumin (Cuminum cyminum): Traditional Uses and Modern Scientific Aspects - A Review DOI Open Access

Sundus Hameed Ahmed

South Asian Research Journal of Biology and Applied Biosciences, Journal Year: 2024, Volume and Issue: 6(06), P. 262 - 264

Published: Dec. 24, 2024

Cumin (Cuminum cyminum) is an herbaceous plant that belongs to the Umbelliferae family, widely known for its use as a spice in Indian, Middle Eastern, and other global cuisines. This aromatic contains powerful active compounds such thymoquinone cuminaldehyde, which have been linked numerous health benefits. Recent scientific research has highlighted cumin's positive effects on digestion, inflammation reduction, blood sugar regulation, even potential anticancer properties. These attributes make cumin important natural remedy various concerns. Furthermore, possesses antibacterial antifungal properties, making it effective combating skin infections microbial ailments. Laboratory studies revealed additional promising findings regarding extract. demonstrated ability inhibit tumor growth, reduce intestinal inflammation, enhance gut animal models. Such results indicate therapeutic agent addressing chronic complex conditions. Despite these encouraging findings, essential note most so far conducted laboratory settings or animals. To fully understand cumin’s medicinal confirm benefits human health, further clinical trials humans are necessary. will provide more comprehensive insights into safety, efficacy, dosage of cumin-based therapies. In addition culinary appeal, stands out functional with significant health-promoting Its multifaceted nature highlights importance integrating remedies modern healthcare practices, though solidify role applications.

Language: Английский

Citations

0