Scale-up of Electrospinning: Market Overview of Products and Devices for Pharmaceutical and Biomedical Purposes

Pharmaceutics, Journal Year: 2021, Volume and Issue: 13(2), P. 286 - 286

Published: Feb. 22, 2021

Recently, the electrospinning (ES) process has been extensively studied due to its potential applications in various fields, particularly pharmaceutical and biomedical purposes. The production rate using typical ES technology is usually around 0.01–1 g/h, which lower than industry requirements. Therefore, different companies have worked develop equipment, technological solutions, electrospun materials into large-scale production. Different approaches explored scale-up mainly by increasing nanofiber jet through multiple needles, free-surface technologies, hybrid methods that use an additional energy source. Among them, needleless centrifugal gained most attention applications. Besides, reached (450 g/h some cases) makes these feasible industry. present study overviews compares recent successfully developed for nanofibers’ accompanying challenges with examples of applied drug delivery systems. types commercial products devices released markets mentioned.

Language: Английский

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Review of advances in electrospinning-based strategies for spinal cord regeneration

Materials Today Chemistry, Journal Year: 2022, Volume and Issue: 24, P. 100944 - 100944

Published: May 13, 2022

Language: Английский

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Plasma-controlled surface wettability: recent advances and future applications

International Materials Reviews, Journal Year: 2022, Volume and Issue: 68(1), P. 82 - 119

Published: March 8, 2022

Materials with the desirable surface wettability are of key importance in diverse applications. However, most existing chemical processes used for control often energy-inefficient, pollute environment, and rely on harsh processing conditions. Therefore, highly-selective, green, low-cost alternative fabrication techniques urgent demand. Low-temperature plasma is one such promising approach that satisfies above requirements. In this review, we present recent advances to emerging applications energy, biomedicine fields. The underlying mechanisms engineering, features processes, water-surface interactions discussed. This review aims guide further development effectively various surfaces. effort poised contribute advanced functional materials targeting a broad range

Language: Английский

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Recent trends on biomaterials for tissue regeneration applications: review

Journal of Materials Science, Journal Year: 2023, Volume and Issue: 58(2), P. 527 - 558

Published: Jan. 1, 2023

Abstract Tissue engineering is approach of replacing or regeneration biological functions tissues organs by using combination biomaterials, biomolecules and cells. mainly depends scaffold biomaterials fabrication methods. Therefore, there have been progressive investigation development new with different formulations to help achieve necessary requirements in the tissue applications. This review briefly representing features associated biomaterial type design required for applications, presenting earlier research field trends future implementation. It focusing on generations discovery field. As well as, types such as bioceramics, bioactive glasses, synthetic natural polymers their derived composites, used scaffolds (as a main part engineering) are demonstrated this review. Scaffold methods also reviewed here. Moreover, it showing recent achievements bone, skin, cartilage, neural, cardiac pre-clinical procedure repair injured diseased organs. Finally, challenges presented Graphical abstract

Language: Английский

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Recent Advances in Designing Fibrous Biomaterials for the Domain of Biomedical, Clinical, and Environmental Applications

ACS Biomaterials Science & Engineering, Journal Year: 2022, Volume and Issue: 8(9), P. 3690 - 3716

Published: Aug. 29, 2022

Unique properties and potential applications of nanofibers have emerged as innovative approaches opportunities in the biomedical, healthcare, environmental, biosensor fields. Electrospinning centrifugal spinning strategies gained considerable attention among all kinds to produce nanofibers. These techniques with high porosity surface area, adequate pore architecture, diverse chemical compositions. The extraordinary characteristics unveiled new gates nanomedicine establish fiber-based formulations for biomedical use, a wide range other applications. present review aims provide comprehensive overview their broad applications, including drug delivery, scaffolds, tissue/bone-tissue engineering, dental environmental remediation single place. begins brief introduction followed by Finally, future perspectives current challenges are demonstrated. This will help researchers engineer more efficient multifunctional improved effective use areas. We strongly believe this is reader's delight dealing fundamental principles nanofiber-based scaffolds. assist students scientific communities understand significance several domains nanotechnology, nanomedicine, biotechnology, remediation, which set benchmark further research.

Language: Английский

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<p>Growth Factor and Its Polymer Scaffold-Based Delivery System for Cartilage Tissue Engineering</p>

International Journal of Nanomedicine, Journal Year: 2020, Volume and Issue: Volume 15, P. 6097 - 6111

Published: Aug. 1, 2020

Abstract: The development of biomaterials, stem cells and bioactive factors has led to cartilage tissue engineering becoming a promising tactic repair defects. Various polymer three-dimensional scaffolds that provide an extracellular matrix (ECM) mimicking environment play important role in promoting regeneration. In addition, numerous growth have been found the regenerative process. However, it elucidated uncontrolled delivery these cannot fully exert potential can also elicit undesired side effects. Considering complexity ECM, neither nor independently obtain successful outcomes engineering. Therefore, collectively, appropriate combination great promote effectively; this approach become area considerable interest recent investigations. Of late, increasing trend was observed towards develop controlled system provides adequate physical support for neo-cartilage formation enables spatiotemporally precisely their chondrogenic potential. This review will discuss various involved Several factor strategies based on be discussed, with examples from studies highlighting importance spatiotemporal single or multiple applications. Keywords: scaffold, factor, delivery,

Language: Английский

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Electrospun conductive nanofiber yarns for accelerating mesenchymal stem cells differentiation and maturation into Schwann cell-like cells under a combination of electrical stimulation and chemical induction

Acta Biomaterialia, Journal Year: 2020, Volume and Issue: 139, P. 91 - 104

Published: Nov. 30, 2020

Language: Английский

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Bioactive electrospun scaffolds for wound healing applications: A comprehensive review

Polymer Testing, Journal Year: 2020, Volume and Issue: 93, P. 106952 - 106952

Published: Nov. 11, 2020

Skin tissue engineering is a promising approach to resorb skin layers and regenerate appendages through biomedical scaffold design. A plethora of techniques have been employed fabricate clinically effective scaffolds among which electrospinning(ES) has gained tremendous attention due its outstanding potential in fabrication nanoscale structures similar the native extracellular matrix (ECM). Furthermore, electrospun dressings open many opportunities enable delivery drugs bioactive agents wound site. Given physical biochemical signaling cues, ES technology found extensive applications for providing template environment promote cellular functions restore damaged tissue. In this review, we discuss recently developed that yielded acute chronic treatment development. introduce requirements navigate excellent

Language: Английский

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Poly (ε-caprolactone)-based electrospun nano-featured substrate for tissue engineering applications: a review

Progress in Biomaterials, Journal Year: 2021, Volume and Issue: 10(2), P. 91 - 117

Published: June 1, 2021

Language: Английский

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The translational paradigm of nanobiomaterials: Biological chemistry to modern applications

Materials Today Bio, Journal Year: 2022, Volume and Issue: 17, P. 100463 - 100463

Published: Oct. 17, 2022

Recently nanotechnology has evolved as one of the most revolutionary technologies in world. It now become a multi-trillion-dollar business that covers production physical, chemical, and biological systems at scales ranging from atomic molecular levels to wide range industrial applications, such electronics, medicine, cosmetics. Nanobiomaterials synthesis are promising approaches produced various elements be it plants, bacteria, peptides, nucleic acids, etc. Owing better biocompatibility approach synthesis, they have gained immense attention biomedical field. Moreover, due their scaled-down sized property, nanobiomaterials exhibit remarkable features which make them potential candidate for different domains tissue engineering, materials science, pharmacology, biosensors, Miscellaneous characterization techniques been utilized nanobiomaterials. Currently, commercial transition research level form nano-scaffolds, implants, biosensors is stimulating whole field starting bio-mimetic nacres 3D printing, multiple nanofibers like silk fibers functionalizing drug delivery cancer therapy. The contribution single quantum dot nanoparticles tagging typically discipline genomics proteomics noteworthy. This review focuses on diverse emerging applications mechanistic advancements owing physiochemical properties leading growth industries measures. Alongside implementation several gene approaches, optical coding, photodynamic therapy, vapor sensing elaborately discussed this review. Different parameters based current challenges future perspectives also here.

Language: Английский

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