Electrospun Nanofibers Encapsulated with Natural Products: A Novel Strategy to Counteract Skin Aging DOI Open Access

Diletta Serra,

Giuseppe Garroni, Sara Cruciani

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1908 - 1908

Published: Feb. 5, 2024

The skin is the primary tissue affected by wounds and aging, significantly impacting its protective function. Natural products are widely used in cosmetics, representing a new approach to preventing age-related damage. Nanomedicine combines nanotechnology traditional treatments create innovative drugs. main targets of nanotechnological approaches wound healing, regeneration, rejuvenation tissue. barrier not easily permeable, creation modern nanodevices way improve passive penetration substances. In this study, Helichrysum italicum oil (HO) was combined with different types electrospun nanofibers study their activity on evaluate future application for topical treatments. present research, we biodegradable polymers, including polyvinyl alcohol (PVA) polyvinylpyrrolidone (PVP), which were characterized scanning electron microscope (SEM). All results show positive trend cell proliferation viability human stem cells (SSCs) BJ fibroblasts pre-treated then exposed UV stress. Gene expression analysis revealed activation molecular program SSCs treated functionalized before exposure. Understanding mechanisms involved changes during aging allows nanomaterials HO directly patients.

Language: Английский

Recent trends in preparation and biomedical applications of iron oxide nanoparticles DOI Creative Commons

Yu Qing Meng,

Ya Nan Shi,

Yong Zhu

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 8, 2024

Abstract The iron oxide nanoparticles (IONPs), possessing both magnetic behavior and semiconductor property, have been extensively used in multifunctional biomedical fields due to their biocompatible, biodegradable low toxicity, such as anticancer, antibacterial, cell labelling activities. Nevertheless, there are few IONPs clinical use at present. Some approved for withdrawn insufficient understanding of its applications. Therefore, a systematic summary IONPs’ preparation applications is crucial the next step entering practice from experimental stage. This review summarized existing research past decade on biological interaction with animal/cells models, human. aims provide cutting-edge knowledge involved effects vivo vitro, improve smarter design application clinic trials. Graphical

Language: Английский

Citations

51
Functionalized nanoparticles: Tailoring properties through surface energetics and coordination chemistry for advanced biomedical applications DOI
Yogendra Kumar,

Amit Sinha,

K.D.P. Nigam

et al.

Nanoscale, Journal Year: 2023, Volume and Issue: 15(13), P. 6075 - 6104

Published: Jan. 1, 2023

Significant advances in nanoparticle-related research have been made the past decade, and amelioration of properties is considered utmost importance for improving nanoparticle bioavailability, specificity, catalytic performance. Nanoparticle can be tuned through in-synthesis post-synthesis functionalization operations, with thermodynamic kinetic parameters playing a crucial role. In spite robust techniques based on surface chemistry, scalable technologies not explored well. The coordination enhancement via organic/inorganic/biomolecules material has attracted much attention morphology modification shape tuning, which are indispensable aspects colloidal phase during biomedical applications. It envisioned that influences anchoring nano interfaces immobilization functional groups biomolecules. this work, various nanostructure methodologies discussed, aiming to exploit their full potential precision engineering Simultaneous discussions emerging characterization strategies functionalized assemblies gain insights into chemistry. An overview current prospects nanoparticles presented, an emphasis controllable attributes such as size, shape, morphology, functionality, features, Debye Casimir interactions.

Language: Английский

Citations

48
Emerging Trends in the Application of Green Synthesized Biocompatible ZnO Nanoparticles for Translational Paradigm in Cancer Therapy DOI Creative Commons
Shaikh Sheeran Naser, Basab Ghosh, Faizan Zarreen Simnani

et al.

Journal of Nanotheranostics, Journal Year: 2023, Volume and Issue: 4(3), P. 248 - 279

Published: July 1, 2023

Zinc oxide nanomaterials have been the cynosure of this decade because their immense potential in different biomedical applications. It includes usage prognosis and treatment infectious cellular diseases, owing to peculiar physiochemical properties such as variable shape, size, surface charge etc. Increasing demand ZnO raise concerns about molecular toxicity biocompatibility with human cells. This review comprehensively details for Furthermore, toxicological types systems reviewed. Moreover, biocompatible efficacy cancer specific pathways has discussed. offers insights into current scenario signifies future extension on environmental

Language: Английский

Citations

42
Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration DOI Creative Commons
Amal George Kurian, Rajendra K. Singh,

Varsha Sagar

et al.

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)

Published: Feb. 6, 2024

Inflammatory skin disorders can cause chronic scarring and functional impairments, posing a significant burden on patients the healthcare system. Conventional therapies, such as corticosteroids nonsteroidal anti-inflammatory drugs, are limited in efficacy associated with adverse effects. Recently, nanozyme (NZ)-based hydrogels have shown great promise addressing these challenges. NZ-based possess unique therapeutic abilities by combining benefits of redox nanomaterials enzymatic activity water-retaining capacity hydrogels. The multifaceted effects include scavenging reactive oxygen species other inflammatory mediators modulating immune responses toward pro-regenerative environment enhancing regenerative potential triggering cell migration differentiation. This review highlights current state art NZ-engineered (NZ@hydrogels) for regeneration applications. It also discusses underlying chemo-mechano-biological mechanisms behind their effectiveness. Additionally, challenges future directions this ground, particularly clinical translation, addressed. insights provided aid design engineering novel hydrogels, offering new possibilities targeted personalized skin-care therapies.

Language: Английский

Citations

38
Role of long non-coding RNAs in cancer: From subcellular localization to nanoparticle-mediated targeted regulation DOI Creative Commons

Chunfang Wei,

XU Ya,

Qian Shen

et al.

Molecular Therapy — Nucleic Acids, Journal Year: 2023, Volume and Issue: 33, P. 774 - 793

Published: July 16, 2023

Long non-coding RNAs (lncRNAs) are a class of RNA transcripts more than 200 nucleotides in length that play crucial roles cancer development and progression. With the rapid high-throughput sequencing technology, considerable number lncRNAs have been identified as novel biomarkers for predicting prognosis patients and/or therapeutic targets therapy. In recent years, increasing evidence has shown biological functions regulatory mechanisms closely associated with their subcellular localization. More importantly, based on important regulating progression (e.g., growth, resistance, metastasis) specific ability nucleic acids siRNA, mRNA, DNA) to regulate expression any target genes, much effort exerted recently develop nanoparticle (NP)-based acid delivery systems

Language: Английский

Citations

24
Nanomedicine for drug resistant pathogens and COVID-19 using mushroom nanocomposite inspired with bacteriocin – A review DOI Open Access

Moovendran Srinivash,

Raman Krishnamoorthi,

Pambayan Ulagan Mahalingam

et al.

Inorganic Chemistry Communications, Journal Year: 2023, Volume and Issue: 152, P. 110682 - 110682

Published: April 3, 2023

Language: Английский

Citations

23
Nanoscale strides: exploring innovative therapies for breast cancer treatment DOI Creative Commons
Sruthi Laakshmi Mugundhan, M. Mothilal

RSC Advances, Journal Year: 2024, Volume and Issue: 14(20), P. 14017 - 14040

Published: Jan. 1, 2024

Nanotechnology revolutionizes breast cancer treatment by improving drug delivery, overcoming barriers, and reducing side effects. This review highlights its potential superiority over conventional methods, transforming management.

Language: Английский

Citations

13
Bioprinting of self-healing materials and nanostructures for biomedical applications: Recent advances and progresses on fabrication and characterization techniques DOI
Babak Mikaeeli Kangarshahi, Seyed Morteza Naghib, Gelareh Mikaeeli Kangarshahi

et al.

Bioprinting, Journal Year: 2024, Volume and Issue: 38, P. e00335 - e00335

Published: Feb. 1, 2024

Language: Английский

Citations

10
Designing Green Synthesis-Based Silver Nanoparticles for Antimicrobial Theranostics and Cancer Invasion Prevention DOI Creative Commons

Taghrid S. Alomar,

Najla AlMasoud, Manal A. Awad

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 4451 - 4464

Published: May 1, 2024

Introduction: Researchers are increasingly favouring the use of biological resources in synthesis metallic nanoparticles. This process is quick and affordable. The current study examined antibacterial anticancer effects silver nanoparticles (AgNPs) derived from Neurada procumbens plant. Biomolecules natural sources can be used to coat AgNPs make them biocompatible. Methods: UV-Vis spectroscopy was verify plant extract, while transmission electron microscopy (TEM), photoluminescence (PL) spectroscopy, dynamic light scattering (DLS), Fourier transform infrared (FTIR) were characterize their morphology, crystalline structure, stability, coating. Results: UV-visible spectrum shows an absorption peak at 422 nm, indicating isotropic nature these As a result emergence 804.53 615.95 cm − 1 emitted by atoms sample, FTIR demonstrated that Ag stretching vibration mode metal-oxygen (M-O). Electron dispersive X-ray (EDX) spectral analysis elementary has 3 keV. Irradiating surface with electrons, photons, or laser beams triggers illumination. emission locations have been found between 300 550 nm. DLS analysis, suspended particles showed bimodal size distribution, Z-average particle being 93.38 Conclusion: findings action substantially ( p ≤ 0.05) more evident against Gramme-positive strains (S. aureus B. cereus) than E. coli . biosynthesis environmentally friendly method for making nanostructures antimicrobial properties. Keywords: Silver nanoparticles, peak,

Language: Английский

Citations

10
Posterity of nanoscience as lipid nanosystems for Alzheimer's disease regression DOI Creative Commons
Shaikh Sheeran Naser, Dibyangshee Singh, Subham Preetam

et al.

Materials Today Bio, Journal Year: 2023, Volume and Issue: 21, P. 100701 - 100701

Published: June 17, 2023

Alzheimer's disease (AD) is a type of dementia that affects vast number people around the world, causing great deal misery and death. Evidence reveals relationship between presence soluble Aβ peptide aggregates severity in patients. The BBB (Blood Brain Barrier) key problem because it prevents therapeutics from reaching desired places. To address issue, lipid nanosystems have been employed to deliver therapeutic chemicals for anti-AD therapy precise targeted manner. applicability clinical significance (Galantamine, Nicotinamide, Quercetin, Resveratrol, Curcumin, HUPA, Rapamycin, Ibuprofen) will be discussed this review. Furthermore, implications aforementioned compounds treatment examined. Thus, review pave way researchers fashion therodiagnostics approaches based on nanomedicine overcome problems delivering molecules across blood brain barrier (BBB).

Language: Английский

Citations

18