Environmental Research, Journal Year: 2023, Volume and Issue: 228, P. 115912 - 115912
Published: April 15, 2023
Language: Английский
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(8), P. 2064 - 2064
Published: July 31, 2023
Cancer is one of the most common lethal diseases and leading cause mortality worldwide. Effective cancer treatment a global problem, subsequent advancements in nanomedicine are useful as substitute management for anti-cancer agents. Nanotechnology, which gaining popularity, enables fast-expanding delivery methods science curing site-specific approach, utilizing natural bioactive substances because several studies have established that plant-based compounds can improve effectiveness chemotherapy. Bioactive, combination with nanotechnology, an exceptionally alluring recent development fight against cancer. Along their nutritional advantages, chemicals may be used chemotherapeutic medications to manage Alginate, starch, xanthan gum, pectin, guar hyaluronic acid, gelatin, albumin, collagen, cellulose, chitosan, other biopolymers been employed successfully medicinal products particular sites. Due biodegradability, polymeric nanobiocomposites garnered much interest developing novel drug methods. There techniques create biopolymer-based nanoparticle systems. However, these systems must created affordable environmentally sustainable way more readily available, selective, less hazardous increase effectiveness. Thus, extensive comprehension various facets developments utilized deliver drugs imperative. The present article provides overview latest research nanobiocomposites, particularly emphasizing applications controlled targeted drugs.
Language: Английский
Citations
33
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 505 - 505
Published: Feb. 2, 2023
Primary malignant brain tumors are the most common solid neoplasm in childhood. Despite recent advances, many children affected by aggressive or metastatic still present poor prognosis, therefore development of more effective therapies is urgent. Cancer stem cells (CSCs) have been discovered and isolated both pediatric adult patients with (e.g., medulloblastoma, gliomas ependymoma). CSCs a small clonal population cancer responsible for tumor initiation, maintenance progression, displaying resistance to conventional anticancer therapies. characterized specific repertoire surface markers intracellular pathways. These unique features biology offer opportunity build therapeutic approaches specifically target these complex bulk. Treatment classical chemotherapeutic regimen poses challenges location presence blood-brain barrier (BBB). Lastly, application chemotherapy developing followed long-term sequelae, especially on cognitive abilities. Novel avenues emerging panorama taking advantage nanomedicine. In this review we will summarize nanoparticle-based efficacy that NPs intrinsically demonstrated how they also decorated biomolecules. Furthermore, propose novel cargoes together advances nanoparticle design/synthesis final aim insidious
Language: Английский
Citations
30
Drug Delivery, Journal Year: 2023, Volume and Issue: 30(1), P. 1 - 18
Published: Jan. 3, 2023
Cancer is a very heterogeneous disease, and uncontrolled cell division the main characteristic of cancer. Cancerous cells need high nutrition intake to enable aberrant growth survival. To do so, cancer modify metabolic pathways produce energy anabolic precursors preserve redox balance. Due importance in tumor malignant transformation, have also been given promising perspectives for treatment, providing more effective treatment strategies, target-specific with minimum side effects. Metabolism-based therapeutic nanomaterials targeted are option. Numerous types nanoparticles (NPs) employed research analysis various therapies. The current review focuses on cutting-edge strategies therapy methods based that target metabolisms. Additionally, it highlighted primacy NPs-based therapies over traditional ones, challenges, future potential.
Language: Английский
Citations
29
ACS Applied Bio Materials, Journal Year: 2023, Volume and Issue: 6(6), P. 2266 - 2276
Published: June 5, 2023
Fruits are safe, toxin-free, and biomolecule-rich raw materials that may be utilized to decrease metal ions stabilize nanoparticles. Here, we demonstrate the green synthesis of magnetite nanoparticles which were first capped with a layer silica, followed by decoration silver nanoparticles, termed Ag@SiO2@Fe3O4, using lemon fruit extract as reducing agent in size range ∼90 nm. The effect stabilizer on characteristics was examined via different spectroscopy techniques, elemental composition multilayer-coated structures verified. saturation magnetization bare Fe3O4 at room temperature recorded 78.5 emu/g, whereas it decreased 56.4 43.8 emu/g for silica coating subsequent All displayed superparamagnetic behavior almost zero coercivity. While further processes, specific surface area increased from 67 180 m2 g–1 after addition reached 98 g–1, can explained organization an island-like model. Zeta potential values also −18 −34 mV coating, indicating enhanced stabilization silver. antibacterial tests against Escherichia coli (E. coli) Staphylococcus aureus (S. aureus) revealed SiO2@Fe3O4 did not show sufficient effect, while even low concentrations (≤ 200 μg/mL), high activity due existence atoms Furthermore, vitro cytotoxicity assay Ag@SiO2@Fe3O4 toxic HSF-1184 cells μg/mL concentration. Antibacterial during consecutive magnetic separation recycling steps investigated, offered more than 10 cycles recycling, making them potentially useful biomedical fields.
Language: Английский
Citations
27
Environmental Research, Journal Year: 2023, Volume and Issue: 225, P. 115673 - 115673
Published: March 10, 2023
Language: Английский
Citations
23
Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)
Published: March 22, 2025
Cancer stem cells (CSCs), are a critical subpopulation within tumours, and defined by their capacity for self-renewal, differentiation, tumour initiation. These unique traits contribute to progression, metastasis, resistance conventional treatments like chemotherapy radiotherapy, often resulting in cancer recurrence poor patient outcomes. As such, CSCs have become focal points developing advanced therapies. This review highlights progress CSC-targeted treatments, including chimeric antigen receptor T-cell (CAR-T) therapy, immunotherapy, molecular targeting, nanoparticle-based drug delivery systems. Plant-derived compounds gene-editing technologies, such as clustered regularly interspaced short palindromic repeats (CRISPR), explored potential enhance precision minimize side effects. Metabolic pathways integral CSC survival, mitochondrial dynamics, mitophagy (regulated dynamin-related protein 1 [DRP1] the PINK1/Parkin pathway), one-carbon metabolism, amino acid metabolism (involving enzymes glutaminase (GLS) glutamate dehydrogenase (GDH]), lipid hypoxia-induced metabolic reprogramming mediated hypoxia-inducible factors (HIF-1α HIF-2α), examined therapeutic targets. The adaptability of through autophagy, flexibility, epigenetic regulation metabolites α-ketoglutarate, succinate, fumarate is discussed. Additionally, extracellular vesicles nicotinamide adenine dinucleotide (NAD⁺) identified pivotal redox balance, DNA repair, modifications. Addressing challenges heterogeneity, immune evasion, treatment durability requires interdisciplinary collaboration. Advancing therapies essential overcoming preventing relapse, paving way transformative treatments. underscores importance leveraging innovative technologies fostering collaboration revolutionize treatment.
Language: Английский
Citations
1
Pharmaceutics, Journal Year: 2021, Volume and Issue: 14(1), P. 18 - 18
Published: Dec. 22, 2021
Cancer represents one of the leading causes morbidity and mortality worldwide, imposing an urgent need to develop more efficient treatment alternatives. In this respect, much attention has been drawn from conventional cancer treatments modern approaches, such as use nanotechnology. Extensive research done for designing innovative nanoparticles able specifically target tumor cells ensure controlled release anticancer agents. To avoid potential toxicity synthetic materials, natural started attract increasing scientific interest. context, paper aims review most important used active ingredients (e.g., polyphenols, polysaccharides, proteins, sterol-like compounds) or carriers viral nanoparticles, exosomes) various moieties, focusing on their recent applications in treating diverse malignancies.
Language: Английский
Citations
41
Stem Cell Reviews and Reports, Journal Year: 2022, Volume and Issue: 18(7), P. 2209 - 2233
Published: July 25, 2022
The physiological state of the tumor microenvironment (TME) plays a central role in cancer development due to multiple universal features that transcend heterogeneity and niche specifications, like promoting progression metastasis. As result their preponderant involvement growth maintenance through several microsystemic alterations, including hypoxia, oxidative stress, acidosis, TMEs make for ideal targets both diagnostic therapeutic ventures. Correspondingly, methodologies target have been investigated this past decade as stratagems significant potential genre focused treatment. Within targeted oncotherapy, nanomedical derivates-nanocarriers (NCs) especially-have emerged present notable prospects enhancing targeting specificity. Yet, one major issue application NCs microenvironmental directed therapy is are too broad spectrum possibilities these carriers be effectively employed. However, stem cells (CSCs) might portend solution above conundrum: aside from being quite heavily invested tumorigenesis resistance, CSCs also show self-renewal fluid clonogenic properties often define specific TME niches. Further scrutiny relationship between points towards mechanisms underly tumoral characteristics metastasis, malignancy, even resistance. This review summarizes recent advances NC-enabled more holistic strikes against discusses current challenges hinder clinical strategies well avenues can further CSC-targeting initiatives. Central regulation cellular components within TME.
Language: Английский
Citations
30
Pharmacological Research, Journal Year: 2022, Volume and Issue: 186, P. 106535 - 106535
Published: Nov. 2, 2022
Language: Английский
Citations
29
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 8401 - 8401
Published: May 7, 2023
Osteosarcoma is a highly malignant bone tumor derived from mesenchymal cells that contains self-renewing cancer stem (CSCs), which are responsible for progression and chemotherapy resistance. Understanding the signaling pathways regulate CSC self-renewal survival crucial developing effective therapies. The Notch, Hedgehog, Wnt/β-Catenin developmental pathways, essential differentiation of normal cells, have been identified as important regulators osteosarcoma CSCs also in resistance to anticancer Targeting these their interactions with embryonic markers microenvironment may be promising therapeutic strategy overcome chemoresistance improve prognosis patients. This review focuses on role regulating self-renewal, pluripotency, chemoresistance, potential targets anti-cancer We discuss relevance markers, including SOX-2, Oct-4, NANOG, KLF4, association aforementioned overcoming drug
Language: Английский
Citations
20