Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(13), P. 1147 - 1147
Published: July 4, 2024
In
this
work,
AgNPs
were
synthesized
using
an
anthocyanin
extract
from
Peruvian
purple
potato
INIA
328—Kulli
papa.
The
was
obtained
through
a
conventional
extraction
with
acidified
ethanolic
aqueous
solvent.
This
acted
as
both
reducing
and
stabilizing
agent
for
the
reduction
of
silver
ions.
Optimization
synthesis
parameters,
including
pH,
reaction
time,
nitrate
(AgNO3)
concentration,
led
to
optimal
formation
at
pH
10,
time
30
min
AgNO3
concentration
5
mM.
Characterization
techniques
such
X-ray
diffraction
(XRD)
dynamic
light
scattering
(DLS)
revealed
that
had
crystallite
size
9.42
nm
hydrodynamic
diameter
21.6
nm,
zeta
potential
−42.03
mV,
indicating
favorable
colloidal
stability.
Fourier
Transform
Infrared
(FTIR)
analysis
confirmed
presence
functional
groups
on
surface
AgNPs,
contributing
their
Furthermore,
bacterial
activity
evaluated
by
determining
minimum
inhibitory
(MIC)
bactericidal
(MBC).
For
E.
coli,
MIC
0.5
mM
(0.05
mg/mL)
MBC
4.5
(0.49
mg/mL).
Similarly,
S.
aureus,
4.0
(0.43
These
results
highlight
benefits
extract,
in
biomedical
environmental
contexts.
Journal of Composites Science,
Journal Year:
2024,
Volume and Issue:
8(2), P. 43 - 43
Published: Jan. 24, 2024
Silver
nanoparticles
(AgNPs)
are
widely
recognized
as
a
prominent
antimicrobial
agent
and
have
found
applications
in
the
field
of
medicine.
This
study
focuses
on
synthesis
AgNPs
utilizing
natural
reducing
Ceylon
olive
(Elaeocarpus
serratus),
presenting
an
economically
viable
ecologically
friendly
approach.
For
first
time,
this
research
demonstrated
using
phytochemicals
extracted
from
olive,
serving
both
stabilizing
agents.
The
synthesized
were
characterized
with
UV–visible
spectroscopy,
particle
size
analyzer
(PSA),
X-ray
diffraction
(XRD),
Fourier
transform
infrared
spectroscopy
(FTIR),
scanning
electron
microscopy
(SEM)
coupled
energy
dispersive
spectrometer
(EDX).
spectra
primarily
indicated
formation
by
surface
plasmon
resonance
band
around
434
nm.
SEM
analysis
confirmed
presence
silver
within
range
50–110
nm,
average
approximately
70
FTIR
determined
that
proteins,
phenols,
flavonoids
may
acted
capping
Experimental
parameters
optimized
to
improve
yield
eventually
evaluate
their
antibacterial
properties.
well
diffusion
method
exhibits
significantly
larger
zone
inhibition
for
Gram-negative
bacterial
strains
(18.4
±
0.55
mm
Pseudomonas
aeruginosa
14.4
Escherichia
coli)
compared
Gram-positive
(11.6
Staphylococcus
aureus
10.4
epidermidis)
50
µg/mL
AgNPs.
These
findings
demonstrate
potential
develop
into
novel
materials
bacterial-mediated
diseases.
Antibiotics,
Journal Year:
2024,
Volume and Issue:
13(2), P. 154 - 154
Published: Feb. 4, 2024
Urinary
tract
infections
(UTIs)
are
prevalent
bacterial
in
both
community
and
healthcare
settings.
They
account
for
approximately
40%
of
all
require
around
15%
antibiotic
prescriptions.
Although
antibiotics
have
traditionally
been
used
to
treat
UTIs
several
decades,
the
significant
increase
resistance
recent
years
has
made
many
previously
effective
treatments
ineffective.
Biofilm
on
medical
equipment
settings
creates
a
reservoir
pathogens
that
can
easily
be
transmitted
patients.
catheter
frequently
observed
hospitals
caused
by
microbes
form
biofilm
after
is
inserted
into
bladder.
Managing
biofilms
challenging
due
emergence
resistance.
Biofilms
enable
evade
host’s
innate
immune
defences,
resulting
long-term
persistence.
The
incidence
sepsis
spread
bloodstream
increasing,
drug-resistant
may
even
more
prevalent.
While
availability
upcoming
tests
identify
cause
infection
its
spectrum
critical,
it
alone
will
not
solve
problem;
innovative
treatment
approaches
also
needed.
This
review
analyses
main
characteristics
formation
drug
recurrent
uropathogen-induced
UTIs.
importance
alternative
therapies
combatting
biofilm-caused
UTI
emphasised.
Nanomaterials,
Journal Year:
2022,
Volume and Issue:
12(11), P. 1841 - 1841
Published: May 27, 2022
Metallic
nanoparticles
(MNPs)
produced
by
green
synthesis
using
plant
extracts
have
attracted
huge
interest
in
the
scientific
community
due
to
their
excellent
antibacterial,
antifungal
and
antibiofilm
activities.
To
evaluate
these
pharmacological
properties,
several
methods
or
protocols
been
successfully
developed
implemented.
Although
were
mostly
inspired
guidelines
from
national
international
regulatory
bodies,
they
suffer
a
glaring
absence
of
standardization
experimental
conditions.
This
situation
leads
lack
reproducibility
comparability
data
different
study
settings.
minimize
problems,
for
antimicrobial
evaluation
MNPs
should
be
specialists
field.
Being
aware
immensity
workload
efforts
required
achieve
this,
we
set
out
undertake
meticulous
literature
review
laboratory
conditions
used
that
could
as
basis
future
guidelines.
also
brings
together
all
discrepancies
resulting
designs
emphasizes
impact
on
biological
activities
well
interpretation.
Finally,
paper
proposes
general
overview
requires
extensive
investigations
stage
development
effective
synthesis.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(10), P. 4146 - 4146
Published: May 17, 2023
Quercetin
(QtN)
displays
low
systemic
bioavailability
caused
by
poor
water
solubility
and
instability.
Consequently,
it
exerts
limited
anticancer
action
in
vivo.
One
solution
to
increase
the
efficacy
of
QtN
is
use
appropriate
functionalized
nanocarriers
that
preferentially
target
deliver
drug
tumor
location.
Herein,
a
direct
advanced
method
was
designed
develop
water-soluble
hyaluronic
acid
(HA)-QtN-conjugated
silver
nanoparticles
(AgNPs).
HA-QtN
reduced
nitrate
(AgNO3)
while
acting
as
stabilizing
agent
produce
AgNPs.
Further,
HA-QtN#AgNPs
served
an
anchor
for
folate/folic
(FA)
conjugated
with
polyethylene
glycol
(PEG).
The
resulting
PEG-FA-HA-QtN#AgNPs
(further
abbreviated
PF/HA-QtN#AgNPs)
were
characterized
both
vitro
ex
Physical
characterizations
included
UV-visible
(UV-Vis)
spectroscopy,
Fourier
transform
infrared
(FTIR)
transmission
electron
microscopy
(TEM),
particle
size
(PS)
zeta
potential
(ZP)
measurements,
biopharmaceutical
evaluations.
evaluations
analyses
cytotoxic
effects
on
HeLa
Caco-2
cancer
cell
lines
using
MTT
assay;
cellular
intake
into
cells
flow
cytometry
confocal
microscopy;
blood
compatibility
automatic
hematology
analyzer,
diode
array
spectrophotometer,
enzyme-linked
immunosorbent
assay
(ELISA).
prepared
hybrid
delivery
nanosystem
hemocompatible
more
oncocytotoxic
than
free,
pure
QtN.
Therefore,
PF/HA-QtN#AgNPs
represent
smart
nano-based
system
(NDDS)
could
be
promising
oncotherapeutic
option
if
data
are
validated