Journal of Nanoparticle Research, Journal Year: 2022, Volume and Issue: 24(11)
Published: Nov. 1, 2022
Language: Английский
Microporous and Mesoporous Materials, Journal Year: 2024, Volume and Issue: 372, P. 113096 - 113096
Published: March 20, 2024
Antimicrobial photodynamic therapy (aPDT) shows promise as a complementary or alternative approach to conventional antimicrobial treatments. Despite possessing some key advantages, many challenges remain, such optimizing the delivery of photosensitizers, improving light penetration into tissues, and determining most effective combinations photosensitizers wavelengths for different infections. Moreover, addressing associated with aggregation tendency poor solubility squaraine dyes (SQs) in particular, is crucial unlocking their full potential biomedical applications. This contribution focuses on designing innovative nanophotosensitizers properties using mesoporous silica nanoparticles (MSNs) loaded SQ dye (i.e. Br-SQ). MSNs before after Br-SQ loading were deeply characterized techniques, proving successful incorporation nanocarriers. Upon visible (640 nm) irradiation, these nanosystems demonstrated remarkable antibacterial activities against both Gram-positive Staphylococcus aureus (S. aureus) Gram-negative Escherichia coli (E. coli). Our results confirmed that are valuable nanocarriers hydrophobic Br-SQ, bringing up new opportunities develop antibiotic-free nanoformulations treat bacterial infection while minimizing risk resistance.
Language: Английский
Citations
8
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 22, 2025
Abstract Therapeutic strategy for efficiently targeting cancer cells needs an in‐depth understanding of the cellular and molecular interplay in tumor microenvironment (TME). TME comprises heterogeneous clustered together to translate initiation, migration, proliferation. The mainly proliferating cells, stromal blood vessels, lymphatic cancer‐associated fibroblasts (CAFs), extracellular matrix (ECM), stem (CSC). heterogeneity genetic evolution metastatic tumors can substantially impact clinical effectiveness therapeutic agents. Therefore, shall target all stages. Since advent nanotechnology, smart drug delivery strategies are employed deliver effective formulations directly into tumors, ensuring controlled sustained efficacy. state‐of‐the‐art nano‐drug systems shown have innocuous modes action players TME. this review provides insight mechanism metastasis involving invasion, intravasation, systemic transport circulating (CTCs), extravasation, colonization, angiogenesis. Further, novel perspectives associated with current nanotherapeutic highlighted on different stages metastasis.
Language: Английский
Citations
1
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 24, 2025
The liver performs crucial roles in energy metabolism, detoxification, and immune regulation. Hepatic diseases, including hepatitis, fibrosis, cancer, have posed a significant threat to global health, emphasizing the critical need for development of novel effective treatment approaches. Nanotechnology, an emerging technology, has been extensively researched medicine. Among many types nanomaterials, polymeric nanoparticles (NPs) are widely used drug delivery systems. Compared traditional therapies, they offer advantages disease by improving outcomes reducing side effects. This review introduced discussed application natural polymers synthetic their management. Furthermore, this paper reviewed -mainly chitosan (CS), hyaluronic acid (HA), polyethylene glycol (PEG) poly (lactic-co-glycolic acid) (PLGA)-in treatment, focusing on use various systems pure bioactive compounds origin, drugs, nucleic acids, peptides, others. Finally, challenges future perspectives NPs were provide guidance further research directions, with aim promoting clinical nanotherapeutics treating hepatic diseases.
Language: Английский
Citations
1
Drug Discovery Today, Journal Year: 2022, Volume and Issue: 28(1), P. 103393 - 103393
Published: Oct. 5, 2022
Language: Английский
Citations
34
Journal of Pharmaceutical Investigation, Journal Year: 2022, Volume and Issue: 53(1), P. 35 - 57
Published: Dec. 21, 2022
Language: Английский
Citations
32
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2867 - 2867
Published: Feb. 2, 2023
Synthetic antimicrobial and antibiofilm peptide (SAAP-148) commits significant activities against resistant (AMR) planktonic bacteria biofilms. However, SAAP-148 is limited by its low selectivity index, i.e., ratio between cytotoxicity activity, as well bioavailability at infection sites. We hypothesized that formulation of in PLGA nanoparticles (SAAP-148 NPs) improves the index due to sustained local release peptide. The aim this study was investigate physical functional characteristics NPs compare formulated with solution. displayed favorable physiochemical properties [size = 94.1 ± 23 nm, polydispersity (PDI) 0.08 0.1, surface charge 1.65 0.1 mV, encapsulation efficiency (EE) 86.7 0.3%] for up 21 days PBS 37 °C. antibacterial studies showed drastically increased, 10-fold, regarding AMR
Language: Английский
Citations
17
Nanomedicine Nanotechnology Biology and Medicine, Journal Year: 2023, Volume and Issue: 52, P. 102695 - 102695
Published: June 30, 2023
Chitosan-functionalized magnetite/poly(ε-caprolactone) nanoparticles were formulated by interfacial polymer disposition plus coacervation, and loaded with gemcitabine. That (core/shell)/shell nanostructure was confirmed electron microscopy, elemental analysis, electrophoretic, Fourier transform infrared characterizations. A short-term stability study proved the protection against particle aggregation provided chitosan shell. Superparamagnetic properties of characterized in vitro, while definition longitudinal transverse relaxivities an initial indication their capacity as T2 contrast agents. Safety particles demonstrated vitro on HFF-1 human fibroblasts, ex vivo SCID mice. The pH- heat-responsive gemcitabine release capabilities. In magnetic resonance imaging studies Prussian blue visualization iron deposits tissue samples defined improvement nanoparticle targeting into tumor when using a field. This tri-stimuli (magnetite/poly(ε-caprolactone))/chitosan could find theranostic applications (biomedical & chemotherapy) tumors.
Language: Английский
Citations
17
Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(6), P. 2713 - 2726
Published: May 6, 2024
Breast cancer is one of the leading causes mortality in women globally. The efficacy breast treatments, notably chemotherapy, hampered by inadequate localized delivery anticancer agents to tumor site, resulting compromised and increased systemic toxicity. In this study, we have developed redox-sensitive poly(lactic-co-glycolic acid) (PLGA) nanoparticles for smart palbociclib (PLB) cancer. particle size formulated PLB@PLGA-NPs (nonredox-sensitive) RS-PLB@PLGA-NPs (redox-sensitive) NPs were 187.1 ± 1.8 nm 193.7 1.5 nm, respectively. zeta potentials nonredox-sensitive +24.99 2.67 mV +9.095 1.87 mV, characterized morphological various physicochemical parameters such as SEM, TEM, XRD, DSC, TGA, XPS, etc. % entrapment efficiency was found be 85.48 1.29% 87.72 1.55%, displayed a rapid drug release at acidic pH higher GSH concentration compared PLB@PLGA-NPs. cytotoxicity assay MCF-7 cells suggested that 5.24-fold 14.53-fold cytotoxic free PLB, Further, cellular uptake study demonstrated had significantly Coumarin 6 dye. Additionally, AO/EtBr reactive oxygen species analysis confirmed superior activity over PLB. vivo dimethyl-benz(a)anthracene-induced rats depicted highly effective reducing size, hypoxic tumor, vascularity hemocompatibility reveals nonhemolytic human blood. Moreover, an histopathology both safe nontoxic vital organs.
Language: Английский
Citations
6
Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1090 - 1090
Published: Aug. 30, 2024
Nanotechnology, now established as a transformative technology, has revolutionized medicine by enabling highly targeted drug delivery. The use of organic nanocarriers in delivery systems significantly enhances the bioavailability vitamins and their analogs, thereby improving cellular therapeutic effects. Vitamin D, known for its crucial role bone health, also influences various metabolic functions, such proliferation, differentiation, immunomodulation, is increasingly explored anticancer potential. Given versatile properties biocompatibility, vitamin D an attractive candidate encapsulation within systems. This review provides comprehensive overview synthesis, metabolism, signaling, well applications customized Moreover, it examines design engineering that incorporate discusses advances this field, including synergistic effects achieved through combination with other agents. By highlighting these innovations, valuable insights into development advanced potential to enhance outcomes.
Language: Английский
Citations
6
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(1), P. 88 - 88
Published: Jan. 9, 2024
Clinical drug administration aims to deliver drugs efficiently and safely target tissues, organs, cells, with the objective of enabling their therapeutic effects. Currently, main approach enhance a drug’s effectiveness is ensuring its efficient delivery intended site. Due fact that there are still various drawbacks traditional methods, such as high toxicity side effects, insufficient specificity, poor targeting, pharmacokinetic performance, nanocarriers have emerged promising alternative. Nanocarriers possess significant advantages in due size tunability surface modifiability. Moreover, nano-drug systems demonstrated strong potential terms prolonging circulation time, improving bioavailability, increasing retention at tumor site, decreasing resistance, well reducing undesirable effects anticancer drugs. Numerous studies focused on utilizing polysaccharides nanodelivery carriers, developing based polysaccharides, or exploiting tumor-targeting ligands precision nanoparticle delivery. These types investigations become commonplace academic literature. This review elucidate preparation methods principles polysaccharide gold nanocarriers. It also provides an overview factors affect loading different kinds Additionally, it outlines strategies employed by improve efficiency The provide reference for further development research systems.
Language: Английский
Citations
5