Recent advances in polysaccharide-based drug delivery systems for cancer therapy: a comprehensive review

Artificial Cells Nanomedicine and Biotechnology, Journal Year: 2024, Volume and Issue: 52(1), P. 564 - 586

Published: Dec. 5, 2024

Cancer has a high rate of incidence and mortality throughout the world. Although several conventional approaches have been developed for treatment cancer, such as surgery, chemotherapy, radiotherapy thermal therapy, they remarkable disadvantages which result in inefficient cancer. For example, immunogenicity, prolonged treatment, non-specificity, metastasis cost are considered major drawbacks chemotherapy. Therefore, there is fundamental requirement development breakthrough technologies cancer suppression. Polysaccharide-based drug delivery systems (DDSs) most reliable carriers therapy. Polysaccharides, kind practical biomaterials, divided into types, including chitosan, alginates, dextran, hyaluronic acid, cyclodextrin, pectin, etc. Polysaccharides extracted from different natural resources (like herbal, marine, microorganisms, etc.). The potential features polysaccharides made them candidates therapeutics to sites; simple purification, ease modification functionalization, hydrophilicity, serum stability, appropriate loading capacity, biocompatibility, bioavailability, biodegradability stimuli-responsive sustained release manner considerable aspects these biopolymers. This review highlights applications polysaccharides-based DDSs pharmaceutical science

Language: Английский

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Production of PEGylated Vancomycin-Loaded Niosomes by a Continuous Supercritical CO2 Assisted Process

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(10), P. 846 - 846

Published: May 13, 2024

Niosomes are arousing significant interest thanks to their low cost, high biocompatibility, and negligible toxicity. In this work, a supercritical CO2-assisted process was performed at 100 bar 40 °C produce niosomes different Span 80/Tween 80 weight ratios. The formulation of cholesterol 80:20 selected encapsulate vancomycin, used as model active compound, perform drug release rate comparison between PEGylated non-PEGylated niosomes. both cases, nanometric vesicles were obtained, i.e., 214 ± 59 nm 254 73 for niosomes, respectively, that characterized by encapsulation efficiency (95% 98% niosomes). However, only able prolong the vancomycin time up 20-fold with respect untreated powder, resulting in powerful strategy control rate.

Language: Английский

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Drug delivery using gold nanoparticles

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 216, P. 115481 - 115481

Published: Nov. 29, 2024

Language: Английский

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Advances in polysaccharide‐based materials for biomedical and pharmaceutical applications: A comprehensive review

Archiv der Pharmazie, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Polysaccharides, the most abundant biopolymers in nature, have attracted attention of researchers and clinicians due to its practicality biomedical pharmaceutical sciences. These biomaterials high bioavailability play structural functional roles living organisms. Polysaccharides are classified into several groups based on their origin, including plant polysaccharides marine (like chitosan, hyaluronic acid, dextran, alginates, etc.) with specific applications. possess unique physicochemical (such as surface groups, solubility, stability), mechanical strength tensile), antioxidant activity, biocompatibility, biodegradability, renewability, non-immunogenicity) characteristics which made them excellent platforms for a wide variety Ease extraction different preparation approaches mentioned other potential properties that further improved They drug/bioactive encapsulation capacity sustained/controlled release manner vivo microenvironments. The anti-inflammatory immunomodulation, stimuli-responsive release, passive active delivery considered features these indicated practical applications sciences, biosensors, tissue engineering, implantation, wound healing, vascular grafting, vaccines. This review highlights advances polysaccharide-based materials

Language: Английский

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Approved natural products-derived nanomedicines for disease treatment

Chinese Journal of Natural Medicines, Journal Year: 2024, Volume and Issue: 22(12), P. 1100 - 1116

Published: Dec. 1, 2024

Language: Английский

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