Food and Humanity, Journal Year: 2023, Volume and Issue: 1, P. 809 - 816
Published: Aug. 2, 2023
Language: Английский
Materials Today Bio, Journal Year: 2023, Volume and Issue: 21, P. 100729 - 100729
Published: July 11, 2023
Infectious disease is one of the top 10 causes death worldwide, especially in low-income countries. The extensive use antibiotics has led to an increase antibiotic resistance, which poses a critical threat human health globally. Natural products such as polyphenolic compounds and their derivatives have been shown positive therapeutic effects antibacterial therapy. However, inherent physicochemical properties limit pharmaceutical effects, short half-lives, chemical instability, low bioavailability, poor water solubility. Nanoformulations promising advantages improving activity by controlling release drugs enhancing bioavailability polyphenols. In this review, we listed classification mechanisms compounds. More importantly, nanoformulations for delivery polyphenols agent were summarized, including different types nanoparticles (NPs) polymer-based NPs, metal-based lipid-based nanoscaffolds nanogels, nanofibers, nanoemulsions. At same time, also presented potential biological applications nano-system enhance ability polyphenols, aiming provide new perspective antibiotic-free treatment infectious diseases.
Language: Английский
Citations
50
Catalysts, Journal Year: 2023, Volume and Issue: 13(7), P. 1138 - 1138
Published: July 22, 2023
The use of catalytic membranes as microstructured reactors without a separative function has proved effective. High activity is possible with minimal mass transport resistances if the reactant mixture pushed to flow through pores membrane that been impregnated catalyst. In this study, n-heptane (C7H16) was hydrocracked and hydro-isomerized within plug-flow zeolitic membrane-packed bed reactor. metallic cobalt (Co) precursor at 3 wt.% loaded onto support mesoporous materials MCM-48 synthesize heterogeneous catalysis. prepared characterized by utilizing characterization techniques such scanning electron microscopy (SEM), X-ray diffraction (XRD), energy dispersive analysis (EDAX), Fourier transform infrared (FTIR), nitrogen adsorption–desorption isotherms, Brunauer–Emmett–Teller (BET) surface area. structural textural characteristics after encapsulation Co were also investigated. analyses performed before metal loading. According results, Co/MCM-48 catalyst in fixed reactor (MR) appears have an excellent ~83% during converting C7H16 400 °C, whereas maximum selectivity approximately ~65% 325 °C. our findings, synthesized exhibits acceptable isomers multiple branches, while making low aromatic components. addition, good stability noticed for over reaction. Use led highest isomerization well conversion. Therefore, catalysis promising option/ alternative traditional hydrocracking hydro-isomerization processes.
Language: Английский
Citations
38
Antioxidants, Journal Year: 2023, Volume and Issue: 12(4), P. 951 - 951
Published: April 18, 2023
Lonicera caerulaea L. and Aronia melanocarpa (Michx.) Elliot fruits are frequently used for their health benefits as they rich in bioactive compounds. They recognized a source of natural valuable phytonutrients, which makes them superfood. caerulea presents antioxidant activity three to five times higher than other berries more commonly consumed, such blackberries or strawberries. In addition, ascorbic acid level is the highest among fruits. The species A. considered one richest known sources antioxidants, surpassing currants, cranberries, blueberries, elderberries, gooseberries, contains amounts sorbitol. non-edible leaves genus became extensively analyzed byproduct waste material due high polyphenol, flavonoid, phenolic content, along with small amount anthocyanins, ingredients nutraceuticals, herbal teas, bio-cosmetics, cosmeceuticals, food by pharmaceutical industry. These plants vitamins, tocopherols, folic acid, carotenoids. However, remain outside mainstream fruit consumption, being well only audience. This review aims shed light on compounds healthy superfoods antioxidant, anti-inflammatory, antitumor, antimicrobial, anti-diabetic effects, hepato-, cardio-, neuro-protective potential. this view, we hope promote cultivation processing, increase commercial availability, also highlight ability these be potential nutraceutical sources, helpful human health.
Language: Английский
Citations
37
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 660 - 660
Published: Feb. 16, 2023
Two types of mesoporous materials, MCM-41 and MCM-48, were functionalized by the soft-template method using (3-aminopropyl)triethoxysilane (APTES) as a modifying agent. The obtained silica materials loaded with trans-ferulic acid (FA). In order to establish morphology structure series specific techniques used such as: X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Brunauer-Emmet-Teller (BET), Fourier Transform Infrared Spectroscopy (FTIR) thermogravimetric analysis (TGA). We monitored in vitro release FA at two different pH values, simulated gastric fluid (SGF) intestinal (SIF). Additionally, Staphylococcus aureus ATCC 25923, Escherichia coli 25922, Pseudomonas aeruginosa 27853 Candida albicans 10231 evaluate antimicrobial activity materials. conclusion can be employed controlled systems for polyphenols extracted from natural sources.
Language: Английский
Citations
23
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: Oct. 31, 2023
Antimicrobial photodynamic therapy (aPDT) has become a potent contender in the fight against microbial infections, especially context of rising antibiotic resistance crisis. Recently, there been significant interest polyphenolic natural products as potential photosensitizers (PSs) aPDT, given their unique chemical structures and inherent antimicrobial properties. Polyphenolic products, abundant readily obtainable from sources, are generally regarded safe highly compatible with human body. This comprehensive review focuses on latest developments future implications using polyphenols PSs aPDT. Paramount compounds, including curcumin, hypericin, quercetin, hypocrellin, celastrol, riboflavin, resveratrol, gallic acid, aloe emodin, elaborated upon respect to structural characteristics, absorption properties, effects. Furthermore, aPDT mechanism, specifically its targeted action cells biofilms, is also discussed. demonstrate immense representing promising alternate approach counteract antibiotic-resistant bacteria biofilm-related infections.
Language: Английский
Citations
23
Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12
Published: Jan. 18, 2024
Gene therapy is a technique that rectifies defective or abnormal genes by introducing exogenous into target cells to cure the disease. Although gene has gained some accomplishment for diagnosis and of inherited acquired cardiovascular diseases, how efficiently specifically deliver targeted lesion sites without being cleared blood system remains challenging. Based on nanotechnology development, non-viral vectors provide promising strategy overcoming difficulties in therapy. At present, according physicochemical properties, nanotechnology-based include polymers, liposomes, lipid nanoparticles, inorganic nanoparticles. Non-viral have an advantage safety, efficiency, easy production, possessing potential clinical application value when compared with viral vectors. Therefore, we summarized recent research progress diseases based commonly used vectors, hopefully providing guidance orientation future relevant research.
Language: Английский
Citations
9
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(4), P. 525 - 525
Published: April 10, 2024
Melissa officinalis is an important medicinal plant that used and studied intensively due to its numerous pharmacological effects. This has active compounds with biomedical potential; some are volatile, while others sensitive heat or oxygen. Therefore, increase stability prolong biological activities, the natural extract can be loaded into various nanostructured systems. In this study, different loading systems were obtained from mesoporous silica, like Mobile Composition of Matter family (MCM) a hexagonal (MCM-41) cubic (MCM-48) pore structure, simple functionalized amino groups (using 3-aminopropyl) such as triethoxysilane (APTES). Thus, four materials characterized morphological structural points view by scanning electron microscopy, BET analysis adsorption–desorption isotherms, Fourier-transform infrared spectroscopy (FTIR) thermogravimetric coupled differential calorimetry. Natural was concentrated analyzed High-Performance Liquid Chromatography identify polyphenolic compounds. The tested against Gram-negative bacteria yeasts both reference strains clinical belonging Gram-positive previously isolated intra-hospital infections. highest antimicrobial efficiency found fungal strains. Good activity also recorded methicillin-resistant S. aureus, inhibiting production virulence factors.
Language: Английский
Citations
8
Environmental Pollution, Journal Year: 2024, Volume and Issue: 348, P. 123745 - 123745
Published: March 16, 2024
Language: Английский
Citations
7
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(9), P. 1202 - 1202
Published: Sept. 13, 2024
Gallic acid (GA) is a well-known herbal bioactive compound found in many herbs and foods like tea, wine, cashew nuts, hazelnuts, walnuts, plums, grapes, mangoes, blackberries, blueberries, strawberries. GA has been reported for several pharmacological activities, such as antioxidant, inflammatory, antineoplastic, antimicrobial, etc. Apart from its incredible therapeutic benefits, it associated with low permeability bioavailability issues, limiting their efficacy. belongs to BCS (Biopharmaceutics classification system) class III (high solubility probability). In this context, novel drug delivery approaches played vital role resolving these issues. Nanocarrier systems help improve moiety’s physical chemical stability by encapsulating them into lipidic or polymeric matrix core system. regard, researchers have developed wide range of nanocarrier GA, including liposomes, transfersomes, niosomes, dendrimers, phytosomes, micelles, nanoemulsions, metallic nanoparticles, solid lipid nanoparticles (SLNs), nanostructured carriers, polymer conjugates, the present review, different search engines Scopus, PubMed, ScienceDirect, Google Scholar referred acquiring recent information on theme work. Therefore, review paper aims emphasize systems, patents, clinical updates GA.
Language: Английский
Citations
6
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(6), P. 1728 - 1728
Published: June 14, 2023
The production of highly porous and three-dimensional (3D) scaffolds with biomimicking abilities has gained extensive attention in recent years for tissue engineering (TE) applications. Considering the attractive versatile biomedical functionality silica (SiO2) nanomaterials, we propose herein development validation SiO2-based 3D TE. This is first report on fibrous architectures, using tetraethyl orthosilicate (TEOS) polyvinyl alcohol (PVA) during self-assembly electrospinning (ES) processing (a layer flat fibers must be created before fiber stacks can develop mat). compositional microstructural characteristics obtained materials were evaluated by complementary techniques, both pre-ES aging period post-ES calcination. Then, vivo evaluation confirmed their possible use as bioactive bone
Language: Английский
Citations
11