Partial Cell Fate Transitions to Promote Cardiac Regeneration DOI Creative Commons

Jianchang Yang

Cells, Journal Year: 2024, Volume and Issue: 13(23), P. 2002 - 2002

Published: Dec. 4, 2024

Heart disease, including myocardial infarction (MI), remains a leading cause of morbidity and mortality worldwide, necessitating the development more effective regenerative therapies. Direct reprogramming cardiomyocyte-like cells from resident fibroblasts offers promising avenue for regeneration, but its efficiency consistency in generating functional cardiomyocytes remain limited. Alternatively, induced cardiac progenitor (iCPCs) could generate essential lineages, existing methods often involve complex procedures. These limitations underscore need advanced mechanistic insights refined strategies to improve reparative outcomes heart. Partial cellular fate transitions, while still relatively less well-defined area primarily explored longevity neurobiology, hold remarkable promise repair. It enables or rejuvenation into stem progenitor-like state with enhanced cardiogenic potential, lineages necessary comprehensive recovery reducing safety risks. As an emerging strategy, partial transitions play pivotal role reversing damage offer substantial potential therapeutic innovation. This review will summarize current advances these areas, recent findings involving two transcription factors that critically regulate stemness cardiogenesis. also explore considerations further refining approaches enhance their safety.

Language: Английский

Nanotechnology in healthcare, and its safety and environmental risks DOI Creative Commons
Xiaohan Ma,

Yaxin Tian,

Yang Ren

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 15, 2024

Abstract Nanotechnology holds immense promise in revolutionising healthcare, offering unprecedented opportunities diagnostics, drug delivery, cancer therapy, and combating infectious diseases. This review explores the multifaceted landscape of nanotechnology healthcare while addressing critical aspects safety environmental risks associated with its widespread application. Beginning an introduction to integration we first delved into categorisation various materials employed, setting stage for a comprehensive understanding potential. We then proceeded elucidate diverse applications nanotechnology, spanning medical tissue engineering, targeted gene development antimicrobial agents. The discussion extended current situation surrounding clinical translation commercialisation these cutting-edge technologies, focusing on nanotechnology-based products that have been approved globally date. also discussed considerations nanomaterials, both terms human health impact. presented vivo nanomaterial exposure, relation transport mechanisms, oxidative stress, physical interactions. Moreover, highlighted risks, acknowledging potential implications ecosystems biodiversity. Lastly, strived offer insights regulatory governing across different regions globally. By synthesising perspectives, underscore imperative balancing innovation stewardship, charting path forward responsible healthcare. Graphical abstract

Language: Английский

Citations

26
Navigating the intricate in-vivo journey of lipid nanoparticles tailored for the targeted delivery of RNA therapeutics: a quality-by-design approach DOI Creative Commons

Ehsan Bitaraf Haghighi,

Samira Sadat Abolmaali, Ali Dehshahri

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 14, 2024

RNA therapeutics, such as mRNA, siRNA, and CRISPR–Cas9, present exciting avenues for treating diverse diseases. However, their potential is commonly hindered by vulnerability to degradation poor cellular uptake, requiring effective delivery systems. Lipid nanoparticles (LNPs) have emerged a leading choice in vivo delivery, offering protection against degradation, enhanced facilitation of endosomal escape. LNPs encounter numerous challenges targeted vivo, demanding advanced particle engineering, surface functionalization with targeting ligands, profound comprehension the biological milieu which they function. This review explores structural physicochemical characteristics LNPs, in-vivo fate, customization therapeutics. We highlight quality-by-design (QbD) approach beyond liver, focusing on biodistribution, immunogenicity, toxicity. In addition, we explored current strategies associated ensuring repeated-dose efficacy, safety, tissue-specific gene delivery. Furthermore, provide insights into clinical applications various classes diseases finally prospects

Language: Английский

Citations

6
Injectable polyplex-loaded glycol chitosan thermogel for efficient and safe inner ear gene delivery DOI
Thi Phuc Le, Lê Thị Thanh Thủy, Sheng Chih Jin

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Recent Advances and Challenges for Biological Materials in Micro/Nanocarrier Synthesis for Bone Infection and Tissue Engineering DOI
Qinglin Xia,

Shuyan Zhou,

Jingya Zhou

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Roughly 1.71 billion people worldwide suffer from large bone abnormalities, which are the primary cause of disability. Traditional grafting procedures have several drawbacks that impair their therapeutic efficacy and restrict use in clinical settings. A great deal work has been done to create fresh, more potent strategies. Under these circumstances, a crucial technique for regeneration major lesions emerged: tissue engineering (BTE). BTE involves biomaterials can imitate natural design bone. To yet, no biological material able fully meet parameters perfect implantable material, even though varieties created investigated regeneration. Against this backdrop, researchers focused interest over past few years on subject nanotechnology nanostructures regenerative medicine. The ability nanoengineered particles overcome current constraints strategies─such as decreased cell proliferation differentiation, insufficient mechanical strength materials, production extrinsic factors required effective osteogenesis revolutionized field engineering. effects nanoparticles characteristics application materials main topics our review, summarizes most recent vitro vivo research context BTE.

Language: Английский

Citations

0
Nanotheranostics Revolutionizing Gene Therapy: Emerging Applications in Gene Delivery Enhancement DOI Creative Commons
Paula Guzmán-Sastoque, Cristian F. Rodríguez,

María Camila Monsalve

et al.

Journal of Nanotheranostics, Journal Year: 2025, Volume and Issue: 6(2), P. 10 - 10

Published: April 9, 2025

Nanotheranostics—where nanoscale materials serve both diagnostic and therapeutic functions—are rapidly transforming gene therapy by tackling critical delivery challenges. This review explores the design engineering of various nanoparticle systems (lipid-based, polymeric, inorganic, hybrid) to enhance stability, targeting, endosomal escape genetic payloads. We discuss how real-time imaging capabilities integrated into these platforms enable precise localization controlled release genes, improving treatment efficacy while reducing off-target effects. Key strategies overcome barriers (such as proton sponge effect photothermal disruption) achieve nuclear are highlighted, along with recent advances in stimuli-responsive that facilitate spatiotemporal control expression. Clinical trials preclinical studies demonstrate expanding role nanotheranostics managing cancer, inherited disorders, cardiovascular neurological diseases. further address regulatory manufacturing hurdles must be for widespread clinical adoption nanoparticle-based therapies. By synthesizing progress ongoing challenges, this underscores transformative potential effective, targeted, image-guided delivery.

Language: Английский

Citations

0
Layer-by-layer nanocomposite based on zein and hyaluronic acid for tumor-targeted gene delivery DOI
Liang Liu, Tiange Wang,

Yanlin Sun

et al.

Industrial Crops and Products, Journal Year: 2024, Volume and Issue: 222, P. 119445 - 119445

Published: Aug. 28, 2024

Language: Английский

Citations

2
mRNA Technologies Danger DOI Creative Commons

M. V. Supotnitskiy

Journal of NBC Protection Corps, Journal Year: 2024, Volume and Issue: 8(3), P. 205 - 231

Published: Nov. 19, 2024

Highlights. The impact that the technologies may exert on human genome is underestimated. mRNA represent a particular danger for genome. Relevance. are quite widespread in Western world. They also gaining popularity Russia and why we should control safety of such technologies. Purpose study – to determine potential hazard Study base sources full English academic periodicals available Internet. Method study. Analytical. author used suggestions Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA). Discussion. paper dwells essence scope technologies, discusses their way functioning, identifies shortcomings provoke pathological consequences humans; determines approaches permit use these genes. article proves nowadays imperfect, now it impossible predict near long-term they bring health. technology itself dual purpose can be under other names unleash biological war with new final goal population decline. newer agents influence will be, more dangerous become. methods application sophisticated. All this accompanied by media eliminate alternative opinions. This result decline general level knowledge about threats. Conclusion. We maintain rigid state over development any potentially ensure not names. It worth limiting them only oncology approximately 10 years. help identify range possible adverse application. injection drugs go from abroad checked nano objects "storage".

Language: Английский

Citations

0
Partial Cell Fate Transitions to Promote Cardiac Regeneration DOI Creative Commons

Jianchang Yang

Cells, Journal Year: 2024, Volume and Issue: 13(23), P. 2002 - 2002

Published: Dec. 4, 2024

Heart disease, including myocardial infarction (MI), remains a leading cause of morbidity and mortality worldwide, necessitating the development more effective regenerative therapies. Direct reprogramming cardiomyocyte-like cells from resident fibroblasts offers promising avenue for regeneration, but its efficiency consistency in generating functional cardiomyocytes remain limited. Alternatively, induced cardiac progenitor (iCPCs) could generate essential lineages, existing methods often involve complex procedures. These limitations underscore need advanced mechanistic insights refined strategies to improve reparative outcomes heart. Partial cellular fate transitions, while still relatively less well-defined area primarily explored longevity neurobiology, hold remarkable promise repair. It enables or rejuvenation into stem progenitor-like state with enhanced cardiogenic potential, lineages necessary comprehensive recovery reducing safety risks. As an emerging strategy, partial transitions play pivotal role reversing damage offer substantial potential therapeutic innovation. This review will summarize current advances these areas, recent findings involving two transcription factors that critically regulate stemness cardiogenesis. also explore considerations further refining approaches enhance their safety.

Language: Английский

Citations

0