The potential use of nanozymes as an antibacterial agents in oral infection, periodontitis, and peri-implantitis

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 25, 2024

Abstract Several studies suggest that oral pathogenic biofilms cause persistent infections. Among these is periodontitis, a prevalent condition brought on by plaque biofilm. It can even result in tooth loss. Furthermore, the accumulation of germs around dental implant may lead to peri-implantitis, which damages surrounding bone and gum tissue. bacterial biofilm contamination causes soft tissue irritation adjacent resorption, severely compromising health. On decontaminated surfaces, however, re-osseointegration cannot be induced standard removal techniques such as mechanical cleaning antiseptic treatment. A family nanoparticles known nanozymes (NZs) comprise highly catalytically active multivalent metal components. The most often employed NZs with antibacterial activity are those have peroxidase (POD) activity, among other types NZs. Since less expensive, more easily produced, stable than natural enzymes, they hold great promise for use various applications, including treating microbial significantly contributed studying success rates periodontal health maintenance periodontics implantology. An extensive analysis research their applications managing conditions, caries, pulp disorders, ulcers, infections mouth. To combat bacteria, this review concentrates imitate enzymes implantology periodontology. With view future, there several ways might used treat disorders antibacterially. Graphical

Language: Английский

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Progress in dental materials: application of natural ingredients

Russian Chemical Reviews, Journal Year: 2024, Volume and Issue: 93(3), P. RCR5108 - RCR5108

Published: March 1, 2024

The existing additives for dental restorative materials used in therapeutic dentistry, dentures, orthodontic appliances and adhesives (for example, metal oxide nanoparticles) also to root canal irrigants endodontics mouthwashes can be toxic humans, cause allergic reactions accumulate organs tissues. Today, a relevant trend is development of that have an antimicrobial effect are non-toxic humans. A promising alternative the above-mentioned phyto-components, including plant propolis extracts, since they cheap non-toxic. This review devoted natural orthodontics, dentistry endodontics. makes recommendations regarding additional research required practical implementation considered (filling materials, mouthwashes, orthopaedic products), examines influence on physicochemical physicomechanical properties polymer outlines advantages disadvantages compared synthetic ones. main challenges this area narrow range microorganisms which was studied (which mainly <i>S. mutans, E. faecalis, C. albicans</i>) predominance <i>in vitro</i> studies over clinical studies. covers published data past five years.<br> bibliography includes 123 references.

Language: Английский

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How Will Nanomedicine Revolutionize Future Dentistry and Periodontal Therapy?

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 592 - 592

Published: Jan. 12, 2025

Periodontitis is a prevalent inflammatory disease affecting the supporting structures of teeth, leading to gum recession, tooth loss, and systemic health complications. Traditional diagnostic methods treatments, such as clinical evaluation scaling, often fall short in early detection targeted therapy, particularly complex or advanced cases. Recent advancements nanomedicine offer promising solutions for improving both diagnosis treatment periodontitis. Nanoparticles, liposomes, quantum dots, nanorods, have demonstrated potential enhancing accuracy by enabling more precise periodontal pathogens biomarkers at molecular level. Furthermore, nanotechnology-based therapies, including drug delivery systems antimicrobial agents, localized controlled release therapeutic efficacy reducing side effects compared conventional treatments. This study reviews current applications periodontitis, highlighting its revolutionize care detection, times, outcomes.

Language: Английский

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Emerging Applications of Nanotechnology in Dentistry

Dentistry Journal, Journal Year: 2023, Volume and Issue: 11(11), P. 266 - 266

Published: Nov. 15, 2023

Dentistry is a branch of healthcare where nanobiotechnology reverberating in multiple ways to produce beneficial outcomes. The purpose this review bring into the awareness readers various practical dimensions nano-dental complex (nanodentistry) and how novelties linked with field are revolutionizing dentistry. A methodological approach was adopted collect latest data on nanotechnology dentistry from sources, including PubMed, Google Scholar, Scopus, official websites like WHO. Nanodentistry an emerging that involves use nanomaterials, nanorobots, diagnose, treat, prevent dental diseases. results summarize descriptive analyses uses nanodentistry within orthodontics, preventive dentistry, prosthodontics, restorative periodontics, surgeries, restoration technologies, other areas future directions nano-industries nano-healthcare have been included link them oral sector, treatment plans, improved medical services which could be explored for advanced regulation. major limitations nanoproducts their cost-effectiveness accessibility, especially financially constrained countries. These will help experience detailed analysis comprehensive covering diverse achievements past analyses, present scenarios, implications.

Language: Английский

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Nanotechnology for Dentistry: Prospects and Applications

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(14), P. 2130 - 2130

Published: July 22, 2023

In the XXI century, application of nanostructures in oral medicine has become common. medicine, using for treatment dental caries constitutes a great challenge. There are extensive studies on implementation nanomaterials to composites order improve their properties, e.g., adhesive strength. Moreover, helpful implant applications as well maxillofacial surgery accelerated healing, promoting osseointegration, and others. Dental personal care products an important part where increasingly used, toothpaste hypersensitivity. Nowadays, nanoparticles such macrocycles used different formulations early cancer diagnosis area. Cancer cavity—human squamous carcinoma—is sixth leading cause death. Detection stage offers best chance at total cure. Along with diagnosis, photodynamic mechanism-based treatments, which possess many advantages, protecting healthy tissues producing good cosmetic results. Application carries potential risks, like long-term influence toxicity body, need be studied further. The introduction development nanotechnologies no longer hypothetical future, but element today’s medicine.

Language: Английский

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Nanotechnology in toothpaste: Fundamentals, trends, and safety

Heliyon, Journal Year: 2024, Volume and Issue: 10(3), P. e24949 - e24949

Published: Jan. 21, 2024

Several studies have revealed that healthcare nanomaterials are widely used in numerous areas of dentistry, including prevention, diagnosis, treatment, and repair. Nanomaterials dental cosmetics utilized to enhance the efficacy toothpaste other mouthwashes. Nanoparticles added toothpastes for a variety reasons, decay remineralization, hypersensitivity reduction, brightening, antibacterial qualities. In this review, benefits uses many common found outlined. Additionally, capacity clinical applications nanoparticles as anti-bacterial, whitening, hypersensitivity, remineralizing agents treatment problems periodontitis discussed.

Language: Английский

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Bioresponsive nanotechnology in pediatric dental drug delivery

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 93, P. 105436 - 105436

Published: Feb. 1, 2024

Nanotechnology in the field of pediatric dentistry offers innovative solutions to challenges. In this literature review, nanomaterials application dentistry, addressing critical concerns, such as toxicity and regulatory hurdles, is discussed. Also, unique physicochemical properties nanomaterials, including size, biocompatibility, drug delivery capabilities are explored. The safety efficacy nanoscale therapeutics were found be before their use dentistry. Polymer-based systems, especially those using natural polysaccharides, demonstrate great potential prevalent dental issues children. These systems can perform targeted therapy, reduce dosages, minimize side effects, making them beneficial for addition, future personalized treatments While advantages applying nanotechnology readily apparent, ongoing research should performed maximize its address

Language: Английский

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Water desalination, and energy consumption applications of 2D nano materials: hexagonal boron nitride, graphenes, and quantum dots

Reviews in Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 44(4), P. 619 - 636

Published: May 29, 2024

Abstract In this article, we explore the role of nanotechnology in addressing water scarcity through desalination. The scope treatment is discussed, emphasizing potential 2D nanomaterials such as hexagonal boron nitride (h-BN), graphene, and quantum dots revolutionizing desalination technologies. Various techniques, including membrane distillation (MD), solar-powered multi-stage flash (MSF), multi-effect (MED), are analyzed context nanomaterial applications. review highlights energy-intensive nature conventional methods underscores nanomaterials’ to enhance efficiency sustainability processes. Challenges facing desalination, scalability environmental impact, acknowledged, setting stage for future research directions.

Language: Английский

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On the Use of Nanoparticles in Dental Implants

Materials, Journal Year: 2024, Volume and Issue: 17(13), P. 3191 - 3191

Published: June 29, 2024

Results obtained in physics, chemistry and materials science on nanoparticles have drawn significant interest the use of nanostructures dental implants. The main focus concerns nanoscale surface modifications titanium-based implants order to increase roughness provide a better bone-implant interfacial area. Surface coatings via sol-gel process ensure deposition homogeneous layer or mixtures titanium substrate. Nanotubular structures created by anodic oxidation yield an interesting nanotopography for drug release. Carbon-based nanomaterials hold great promise field dentistry account their outstanding mechanical properties structural characteristics. Carbon that include carbon nanotubes, graphene its derivatives (graphene oxide quantum dots) can be used as implant surface. Their antibacterial well ability functionalized with adequate chemical groups make them particularly useful improving biocompatibility promoting osseointegration. Nevertheless, evaluation possible toxicity is required before being exploited clinical trials.

Language: Английский

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Evaluation of Cell Proliferation and Wound Healing Effects of Vitamin A Palmitate-Loaded PLGA/Chitosan-Coated PLGA Nanoparticles: Preparation, Characterization, Release, and Release Kinetics

ACS Omega, Journal Year: 2023, Volume and Issue: 8(2), P. 2658 - 2668

Published: Jan. 6, 2023

In this study, vitamin A palmitate (VAP)-loaded poly(lactic-co-glycolic acid) (PLGA)/chitosan-coated PLGA nanoparticle (NP) systems were prepared by the nanoprecipitation technique. The characterized parameters such as particle size, polydispersity index (PDI), ζ-potential, encapsulation efficiency, in vitro dissolution, and release kinetic study. Then, cytotoxicity wound healing profiles of designed NP formulations HaCaT (human keratinocyte skin cell lines) determined. size VAP-loaded NPs was obtained between 196.33 ± 0.65 669.23 5.49 nm. PDI data proved that all high quality monodisperse. While negative ζ-potential values Blank-NP-1 NP-1 encoded obtained, positive chitosan-coated NPs. studies observed rapid dissolution first 1-6 h, but prolonged VAP after dissolution. As a result culture activity studies, it determined NP-7 most effective. It thought reason for coded formulation with smallest concluded efficiency increased its structure. This study demonstrated similar effects systems, particular NP-7, which increases proliferation at lower concentrations (10 μg·mL-1) than alone (100 μg·mL-1). nanocarriers can be used pharmaceutical industry have been successfully produced results evaluated promising industry.

Language: Английский

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