Toxicity of Carbon Nanomaterials: A model to predict ROS production from easily measurable surface characteristics

Carbon, Journal Year: 2025, Volume and Issue: unknown, P. 119997 - 119997

Published: Jan. 1, 2025

Language: Английский

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Ecotoxicological assessment of a graphene-based commercial ink toward freshwater ecosystems: from single-species tests to a microcosm approach

Carbon, Journal Year: 2025, Volume and Issue: 234, P. 120012 - 120012

Published: Jan. 17, 2025

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The Toxicological Profile of Active Pharmaceutical Ingredients–Containing Nanoparticles: Classification, Mechanistic Pathways, and Health Implications

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(5), P. 703 - 703

Published: May 9, 2025

Nanotechnology is the manipulation of matter on an atomic and molecular scale, producing a lot new substances with properties that are not necessarily easily expected based present knowledge. produces unique can be beneficial or harmful depending their biocompatibility distribution. Understanding nanomaterial toxicity essential to ensure safe application in biological environmental applications. This review aims provide comprehensive overview nanoparticle toxicity, focusing physicochemical properties, mechanisms cellular uptake, potential health risks. Key factors influencing include particle size, shape, concentration, aspect ratio, crystallinity, surface charge, dissolution, agglomeration. Nanoparticles induce oxidative stress inflammation, contributing adverse effects when inhaled, ingested, applied skin. However, may limited just these pathways, as they also exhibit other toxic such activation apoptotic pathway mitochondrial damage. By summarizing current knowledge aspects, this article intends support development nanoparticles safer way for future

Language: Английский

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Role of Chemical Reduction and Formulation of Graphene Oxide on Its Cytotoxicity towards Human Epithelial Bronchial Cells

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(15), P. 2189 - 2189

Published: July 27, 2023

Graphene-based materials may pose a potential risk for human health due to occupational exposure, mainly by inhalation. This study was carried out on bronchial epithelial 16HBE14o− cells evaluate the role of chemical reduction and formulation graphene oxide (GO) its cytotoxic potential. To this end, effects GO were compared chemically reduced form (rGO) stable water dispersion (wdGO), means cell viability reduction, reactive oxygen species (ROS) generation, pro-inflammatory mediators release genotoxicity. These induced concentration-dependent with following potency rank: rGO > >> wdGO. After 24 h an EC50 4.8 μg/mL (eight-fold lower than that GO) most potent material in inducing ROS contrast Cytokines genotoxicity (DNA damage micronucleus induction) appeared low all materials, wdGO showing lowest effect, especially former. results suggest key increasing potential, probably structure alterations resulting from process. In contrast, formulated seems be material, presumably cellular internalization damaging capacity.

Language: Английский

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Graphene‐Based Engineered Living Materials

Small Methods, Journal Year: 2023, Volume and Issue: 8(1)

Published: Oct. 8, 2023

Abstract With the rise of engineered living materials (ELMs) as innovative, sustainable and smart systems for diverse engineering biological applications, global interest in advancing ELMs is on rise. Graphene‐based nanostructures can serve effective tools to fabricate ELMs. By using graphene‐based building units microorganisms designers end materials, next‐generation be with structural properties inherent microorganisms. However, some challenges need addressed fully take advantage design This work covers latest advances fabrication application Fabrication strategies are first categorized, followed by a systematic investigation advantages disadvantages within each category. Next, potential applications covered. Moreover, associated identified discussed. Based comprehensive overview literature, primary challenge limiting integration nanotoxicity arising from synthetic parameters. Finally, we present possible principles potentially address these challenges.

Language: Английский

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Biological Effects of Small Sized Graphene Oxide Nanosheets on Human Leukocytes

Biomedicines, Journal Year: 2024, Volume and Issue: 12(2), P. 256 - 256

Published: Jan. 23, 2024

Since the discovery of graphene, there has been a wide range literature dealing with its versatile structure and easy binding biomolecules as well large loading capacity. In emerging field immunotherapy, graphene derivatives have potential uses drug delivery platforms directly into tumour sites or adjuvants in cancer vaccines, they are internalized by monocytes which turn may activate adaptive anti-tumoral immune responses. this study, we expose cells innate system human acute monocytic leukemia cell line (THP-1) to low doses small-sized GO nanosheets functionalized bovine serum albumin (BSA) fluorescein isothiocyanate (FITC), study their response after internalization. We show flow cytometry, uptake GO-BSA-FITC reaches 80% viability ROS production both unaffected exposure nanoparticles. On contrary, GO-BSA seem an inhibitory effect on production, probably due antioxidant properties. also provided results chemotaxis macrophages derived from peripheral blood treated GO-BSA. conclusion, showed size nanosheets, concentration used degree functionalization were important factors for biocompatibility cells. Its cytotoxicity high adaptability make it good candidate deployment particular delivering protein antigens immunity.

Language: Английский

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MicroRNA-Dependent Mechanisms Underlying the Function of a β-Amino Carbonyl Compound in Glioblastoma Cells

ACS Omega, Journal Year: 2024, Volume and Issue: 9(29), P. 31789 - 31802

Published: July 15, 2024

Glioblastoma (GB) is an aggressive brain malignancy characterized by its invasive nature. Current treatment has limited effectiveness, resulting in poor patients' prognoses. β-Amino carbonyl (β-AC) compounds have gained attention due to their potential anticancerous properties.

Language: Английский

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Screening the micronucleus assay for reliable estimation of the genotoxicity of graphene and other 2D materials

Carbon, Journal Year: 2023, Volume and Issue: 215, P. 118426 - 118426

Published: Aug. 30, 2023

Language: Английский

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Graphene Oxide Nanotoxicity: A Comprehensive Analysis

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: June 26, 2024

Graphene oxide (GO) has emerged as a promising nanomaterial with physicochemical properties that make it candidate for wide range of applications. However, the potential toxicity GO is significant threat must be addressed before GO’s safe use in biomedical and environmental applications can fully realized. Numerous studies have demonstrated ability to induce oxidative stress, inflammation, genotoxicity, cytotoxicity cell types animal models. Importantly, influenced by its size, morphology, charge, surface functional groups. The current review summarizes recent research findings on focusing cellular uptake, biodistribution, biological effects. It provides an overview understanding nanotoxicity highlights need additional assess safety various By addressing these concerns developing appropriate measures, we exploit while ensuring utilization settings. Thus, comprehensive evaluation risks crucial full exploitation utilization.

Language: Английский

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State-of-the-art developments in surface functionalized carbon-based bio/nanocomposites for theranostic antibacterials, advanced bioimaging, and molecular bioelectronics inspired biosensing platforms

Journal of Industrial and Engineering Chemistry, Journal Year: 2024, Volume and Issue: 140, P. 103 - 145

Published: June 1, 2024

Language: Английский

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