DNA Damage of Iron-Gold Nanoparticle Heterojunction Irradiated by kV Photon Beams: A Monte Carlo Study

Applied Sciences, Journal Year: 2023, Volume and Issue: 13(15), P. 8942 - 8942

Published: Aug. 3, 2023

This study aims to evaluate the dependence of DNA damage on proportion iron and gold in iron-gold nanoparticle heterojunctions using Monte Carlo simulations. The simulation setup included a spherical with varying percentages gold, irradiated by photon beams different energies (50–150 keV). Geant4-DNA code was utilized for accurate tracking radiation transport. results reveal that increases higher percentage volume heterojunction, primarily due photoelectric enhancement. Furthermore, lower beam energy 50 keV induces greater compared 100 150 keV. findings suggest effective cancer cell eradication through damage, should be equal or than 50% heterojunction. In conclusion, from this will shed light potential enhancing radiotherapy outcomes. investigation resulting combination contrast agents radiosensitizers is crucial advancing research treatment. knowledge gained aid development personalized approaches, ultimately improving patient outcomes

Language: Английский

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Amelioration of breast cancer therapies through normalization of tumor vessels and microenvironment: paradigm shift to improve drug perfusion and nanocarrier permeation

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 15(2), P. 389 - 406

Published: July 15, 2024

Language: Английский

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Variations in Gold Nanoparticle Size on DNA Damage: A Monte Carlo Study Based on a Multiple-Particle Model Using Electron Beams

Applied Sciences, Journal Year: 2023, Volume and Issue: 13(8), P. 4916 - 4916

Published: April 14, 2023

Research is currently focused on maximizing cancer cell death while minimizing harm to healthy cells. Gold nanoparticles (GNPs) have been extensively studied as a radiosensitizer improve sparing normal tissue. Previous research and simulations demonstrated that the presence of single GNP increases DNA damage dose. In this study, Monte Carlo simulation using Geant4-DNA code was used investigate effects multiple GNPs when exposed electron beams with energies 50, 100, 150, 200 keV. The study examined caused by 1–4 same total volume analyzing both single- double-strand breaks. results indicate increasing number decreasing beam energy strand Although increased, proportion breaks remained unchanged in relation

Language: Английский

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Recent advances of nanocrystals in cancer theranostics

Nanoscale Advances, Journal Year: 2023, Volume and Issue: 5(16), P. 4018 - 4040

Published: Jan. 1, 2023

This review summarizes the examples of cancer theranostic applications different NCs.

Language: Английский

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Nanoparticles for imaging-guided photothermal therapy of colorectal cancer

Heliyon, Journal Year: 2023, Volume and Issue: 9(11), P. e21334 - e21334

Published: Oct. 20, 2023

Colorectal cancer (CRC) is one of the most common malignancies with a high mortality rate worldwide. While surgery, chemotherapy, and radiotherapy have shown some effectiveness in improving survival rates, they come drawbacks such as side effects harm to healthy tissues. The theranostic approach, which integrates processes diagnosis treatment, can minimize biological effects. Photothermal therapy (PTT) an emerging treatment method that usages light-sensitive agents generate heat at tumor site induce thermal erosion. development nanotechnology for CRC using imaging-guided PTT has garnered significant. Nanoparticles suitable physical chemical properties enhance efficiency PTT. This approach enables monitoring progress safeguards In this article, we concisely introduce application metal nanoparticles, polymeric carbon nanoparticles colorectal cancer.

Language: Английский

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