Polymer Engineering and Science,
Journal Year:
2024,
Volume and Issue:
64(11), P. 5831 - 5841
Published: Sept. 24, 2024
Abstract
Calcium
phosphate
hydroxyapatite
(HA)
was
successfully
incorporated
into
poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate)/gelatin
(PHBV/GEL)
nanofibers
through
an
electrospinning
process
in
a
hexafluoroisopropanol
solvent
(HFIP).
The
PHBV/GEL
electrospun
and
collected
using
rotating
metallic
network
to
develop
highly
ordered
nonwoven
mats.
effects
of
HA
addition
on
the
morphologies
obtained
fibers
were
investigated
SEM.
average
diameter
ranged
around
700–900
nm,
depending
content.
From
mechanical
perspective,
nanoparticles
showed
variations
tensile
strength
elastic
modulus
values.
lowest
measured
for
neat
0.37
±
0.08
MPa
with
9.45
0.65
MPa,
whereas
highest
reported
5%
HA‐loaded
mats
1.1
0.4
16.9
0.39
MPa.
In
addition,
cell
viability,
mineral
deposition
also
studied
MC3T3‐E1
pre‐osteoblasts.
vitro
experiment
results
that
loaded‐PHBV/GEL
provide
optimal
conditions
growth
osteogenic
differentiation
cells.
This
study
reveals
potential
PHBV/GEL/HA
matrices
development
novel
guided
bone‐regeneration
(GBR)
membranes
orthopedic
craniomaxillofacial
surgery,
by
providing
favorable
structural
features
attachment,
growth,
osteoblast
Highlights
Simple
cheap
strategy
toward
network‐like
fibrous
Microstructure,
mechanical,
biological
evaluated.
Electrospun
promoted
calcium
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
12
Published: Jan. 6, 2025
The
bladder
is
a
dynamic
organ
located
in
the
lower
urinary
tract,
responsible
for
complex
and
important
physiological
activities
human
body,
including
collecting
storing
urine.
Severe
diseases
or
injuries
often
lead
to
tissue
destruction
loss
of
normal
function,
requiring
surgical
intervention
reconstruction.
rapid
development
innovative
biomaterials
has
brought
revolutionary
opportunities
modern
urology
overcome
limitations
transplantation.
This
article
first
summarized
latest
research
progress
processing
approaches
functionalization
acellular
matrix,
hydrogels,
nanomaterials,
porous
scaffolds
repairing
reconstructing
structure
function
damaged
bladder.
Then,
we
discussed
emerging
strategies
regeneration
functional
recovery,
such
as
cell
therapy,
organoids,
etc.
Finally,
outlined
issues
future
prospects
inspire
directions.
By
reviewing
these
technologies,
hope
provide
appropriate
insights
achieve
ultimate
goal
designing
manufacturing
artificial
substitutes
with
ideal
performance
all
aspects.
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(6), P. 1592 - 1592
Published: May 30, 2023
Oxygen
is
one
of
the
essential
requirements
for
cell
survival,
retention,
and
proliferation.
The
field
regenerative
medicine
tissue
engineering
(TE)
has
realized
considerable
achievements
regeneration
tissues.
However,
still
lacks
full
functionality
solid
organ
implantations;
limited
survival
retention
due
to
oxidative
stress
hypoxia
in
deeper
parts
tissues
remains
a
perpetual
challenge.
Especially
prior
neovascularization,
major
limiting
factor,
since
oxygen
delivery
becomes
crucial
throughout
tissue-engineered
construct.
diffusion
generally
range
100-200
μm
thickness
scaffold,
cells
located
beyond
this
distance
face
deprivation,
which
ultimately
leads
hypoxia.
Furthermore,
before
achieving
functional
anastomosis,
implanted
will
be
depleted
oxygen,
resulting
(<5%
dissolved
oxygen)
followed
by
anoxic
(<0.5%
microenvironments.
Different
types
approaches
have
been
adopted
establish
sustained
supply
both
vitro
vivo.
In
review,
we
summarized
recent
developments
oxygen-generating
and/or
releasing
biomaterials
enhancing
vitro,
as
well
promoting
soft
hard
repair,
including
skin,
heart,
nerve,
pancreas,
muscle,
bone
addition,
redox-scavenging
oxygenated
scaffolds
also
highlighted.
surveyed
results
shown
significant
promise
oxygen-producing
carriers
TE
applications.
Taken
together,
review
provides
detailed
overview
newer
technologies
production,
their
applications
bio-related
disciplines.
Nanomaterials,
Journal Year:
2023,
Volume and Issue:
13(7), P. 1252 - 1252
Published: April 1, 2023
This
work
analyzes
on
nanoscale
spatial
domains
the
mechanical
features
of
electrospun
membranes
Polycaprolactone
(PCL)
loaded
with
Functionalized
Magnetite
Nanoparticles
(FMNs)
produced
via
an
electrospinning
process.
Thermal
and
structural
analyses
demonstrate
that
FMNs
affect
PCL
crystallinity
its
melting
temperature.
HarmoniX-Atomic
Force
Microscopy
(H-AFM),
a
modality
suitable
to
map
elastic
modulus
nanometric
sample
surface,
evidences
local
properties
membranes.
The
increases
when
tip
reveals
magnetite
nanoparticles.
That
allows
accurate
mapping
distribution
along
nanofibers
mat
through
analysis
parameter.
Local
values
are
also
affected
by
degree
influenced
filler
content.
for
low
percentage
(<5
wt.%),
while,
higher
amounts
tend
hinder
crystallization
polymer,
which
manifests
lower
crystallinity.
H-AFM
confirms
this
trend,
showing
is
function
amount
fibers
hosting
filler.
bulk
membranes,
evaluated
tensile
tests,
strictly
related
complex
nanocomposite
system.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(7), P. 1613 - 1613
Published: July 19, 2024
Stiffness
and
adhesions
following
rotator
cuff
tears
(RCTs)
are
common
complications
that
negatively
affect
surgical
outcomes
impede
healing,
thereby
increasing
the
risk
of
morbidity
failure
interventions.
Tissue
engineering,
particularly
through
use
nanofiber
scaffolds,
has
emerged
as
a
promising
regenerative
medicine
strategy
to
address
these
complications.
This
review
critically
assesses
efficacy
limitations
nanofiber-based
methods
in
promoting
(RC)
regeneration
managing
postrepair
stiffness
adhesions.
It
also
discusses
need
for
multidisciplinary
approach
advance
this
field
highlights
important
considerations
future
clinical
trials.
Advances in chemical and materials engineering book series,
Journal Year:
2024,
Volume and Issue:
unknown, P. 351 - 378
Published: Oct. 22, 2024
The
use
of
nanomaterials
in
biomedical
applications
has
revolutionized
drug
delivery,
biosensing,
and
tissue
engineering.
These
materials
offer
improved
bioavailability,
targeted
controlled
release,
enhancing
therapeutic
efficacy
reducing
side
effects.
They
are
also
used
cancer
therapy,
gene
vaccination.
Nanomaterial-based
biosensors
detect
biomolecules
at
ultra-low
concentrations,
disease
diagnosis
monitoring.
In
engineering,
create
scaffolds
mimicking
the
extracellular
matrix,
promoting
cell
adhesion,
proliferation,
differentiation.
Techniques
like
electrospinning
3D
printing
to
bioactive
for
regenerative
medicine.
This
chapter
highlights
transformative
potential
applications,
addressing
challenges
future
directions
this
rapidly
evolving
field.
Advances in chemical and materials engineering book series,
Journal Year:
2024,
Volume and Issue:
unknown, P. 125 - 150
Published: Oct. 22, 2024
In
this
chapter,
the
authors
present
nanomaterials
for
biomedical
application
as
promising
technology
of
drug
delivery,
biosensors,
and
tissue
engineering.
Nanomaterials
have
revolutionized
field
applications
because
they
provide
sophisticated
solutions
engineering,
biosensing,
administration
through
treating
diagnosing
a
variety
human
ailments,
including
cancer,
heart
disease,
dental
conditions,
disorders
central
peripheral
nervous
systems.
play
crucial
role
in
achieving
sustainable
development
goals
by
offering
innovative
across
various
health
sectors.
author
discussion
attempts
to
indicate
revolutionary
impact
on
research
clinical
practice
an
extensive
recent
developments
problems
areas
applications:
Journal of the Textile Institute,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 10
Published: April 18, 2024
Recent
advancements
in
nanofiber
production
technology
have
opened
up
exciting
possibilities
for
highly
sophisticated
applications
nanofiber-based
structures,
particularly
the
realm
of
yarns.
These
yarns
serve
as
fundamental
components
various
fabric
designs,
encompassing
woven,
knitted,
braided,
and
nonwoven
patterns.
Additionally,
these
fabrics
can
reinforcement
nanocomposites
with
a
polymeric
matrix.
This
study
aims
to
investigate
reinforcing
effect
micro/nanofibers
such
nonwoven,
knitted
fabrics.
Apart
from
depositing
micro/nanofibers,
we
successfully
manufactured
micro/nanofiber
yarn
made
polyamide-6.
was
achieved
by
employing
two
nozzles
equipped
opposite
charges
flat-tipped
needles.
Furthermore,
created
both
woven
weft-knitted
using
this
yarn.
Subsequently,
utilized
reinforce
epoxy
resin.
The
results
indicated
that
nanocomposite
reinforced
warp
direction,
featuring
volume
fraction
12%,
exhibited
highest
Young's
modulus
(7500
MPa,
5.47
times
more
compared
epoxy)
ultimate
strength
(112
5.09
epoxy).
represents
pioneering
step
towards
development
reinforcements
promising
potential
applications.
