Within
the
field
of
nanomedicine,
which
is
revolutionizing
cancer
treatment,
solid
lipid
nanoparticles
(SLNs)
have
shown
advantages
over
conventional
chemotherapy
when
tested
on
cells
in
preclinical
studies.
SLNs
proven
to
be
an
innovative
strategy
for
treatment
tri-ple-negative
breast
cells,
providing
greater
efficiency
than
existing
treatments
various
The
encapsulation
antineoplastic
drugs
has
facilitated
a
sustained,
controlled,
and
targeted
release,
enhances
therapeutic
reduces
adverse
effects.
Moreover,
surface
can
modified
increase
efficiency.
For
instance,
coating
these
particles
with
polyethylene
glycol
(PEG)
decreases
their
opsonization,
resulting
longer
life
circulatory
system.
creation
positively
charged
cationic
(cSLNs),
achieved
by
utilization
surfactants
or
ionic
lipids
structural
groups,
increases
affinity
cell
membranes
plasma
proteins.
Hyaluronic
acid
been
added
SLNs,
so
that
distinct
pH
tumor
would
stimulate
release
drug
and/or
genetic
materi-al.
current
revision
summarizes
recent
research
focusing
transport
agents
cytotoxic
effect
triple-negative
cancer.
Nano-Structures & Nano-Objects,
Journal Year:
2023,
Volume and Issue:
36, P. 101053 - 101053
Published: Oct. 1, 2023
According
to
WHO,
cancer
is
a
deadly
disease
and
the
second
cause
of
death
globally.
Conventional
treatment
methods,
such
as
chemotherapy,
surgery,
radiography,
etc.,
have
been
bedeviled
with
numerous
adverse
effects.
Hence,
efforts
made
find
suitable
technique
little
or
no
side
effects
for
diagnoses
treatment.
In
searching
an
alternative
medicine,
using
magnetic
nanoparticles
(MNPs)
in
diagnosis
has
recently
gained
lot
interest
among
researchers.
This
due
their
excellent
properties,
biocompatibility,
non-toxic
nature,
stability,
mention
few.
this
review,
we
extensively
discussed
various
methods
synthesis
MNPs,
comparing
merits
demerits.
The
functionalization
MNPs
reason
it
were
detailedly
described.
Also
covered
review
application
diagnosis,
including
MRI
MPI.
explained
strategies,
hyperthermia,
magnetic-guided
drug
delivery,
theranostic
platforms.
Furthermore,
use
modeling
simulation
predicting
optimizing
performance
ensure
effectiveness
was
discussed.
Finally,
looked
at
toxicity-related
concerns
future
perspective
on
applications
these
MNPs.
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(11), P. 12408 - 12419
Published: May 23, 2024
Integrating
imaging
and
therapeutic
capabilities
into
a
single
entity
can
offer
enhanced
diagnostic
accuracy
treatment
efficacy
in
clinically
effective
formulations.
Due
to
the
diversity
of
chemical
structures
and/or
limited
solubility
inhibitors
or
fluorophores,
it
is
essential
employ
robust
delivery
carrier
that
facilitate
drug
absorption
distribution
during
its
circulation
blood.
This
study
explores
potential
hollow
gadolinium
oxide
(Gd2O3)
nanocarriers
applications.
The
citric
acid
(CA)-capped
were
synthesized
via
urea-assisted
precipitation
hydrothermal
methods
using
carbon
spheres
as
sacrificial
templates.
resulting
nanosized
displayed
spherical
morphology
demonstrated
relaxation
rates
longitudinal
transverse
directions,
indicated
by
their
r1
r2
values
1.8
5.3
s–1
mM–1,
respectively.
To
mimic
physiological
conditions,
loaded
separately
with
antibiotic
sparfloxacin
azo
dye
Congo
red
at
neutral
pH
(7.4)
body
temperature
(37
°C).
CR-loaded
nanospheres
exhibited
time-dependent
internalization
behavior
HeLa
cells,
suggesting
for
intracellular
delivery.
Furthermore,
SP-loaded
antimicrobial
activity
against
both
Gram-positive
Gram-negative
bacteria,
demonstrating
bacterial
infections.
mitigate
risk
leaching
Gd3+
ions
inherent
toxicity,
CA
coating
was
applied
surface
which
resulted
outstanding
cell
viability
functionalized
nanocarriers.
In
addition,
offered
additional
support
increased
encapsulation
continuous
release
molecules
until
1
week
(168
h).
characterization
data
provide
evidence
CA-capped
positive
MR
contrast
agents
applicability
safe
controlled
carriers.
Deleted Journal,
Journal Year:
2025,
Volume and Issue:
7(4)
Published: April 7, 2025
Abstract
Porphyrin-based
metal–organic
frameworks
can
encapsulate
various
therapeutic
agents
and
their
unique
structural
properties.
These
two
features
have
led
to
the
use
of
these
materials
as
drug
delivery
for
cancer
treatment.
Due
porous
nature
MOFs,
controlled
release
is
associated
with
minimizing
systemic
toxicity
increasing
effectiveness
In
addition,
this
type
MOF
takes
advantage
ability
absorb
light
produce
reactive
oxygen
species,
which
an
inherent
characteristic
porphyrins,
in
photodynamic
therapy
(PDT).
Of
course,
due
recent
developments
observed
methods
production
modification
Multifunctional
substrates
(combining
techniques
such
immunotherapy
or
chemotherapy)
overcome
limitations
common
treatments
been
created
individually.
The
surface
performance
structure
adaptive
are
high.
This
feature
makes
it
possible
target
a
population
all
types
cancers
other
words,
there
also
possibility
customizing
compounds.
imaging
porphyrin-based
leads
real-time
monitoring
treatment
results
personalization
strategies.
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(12), P. 1634 - 1634
Published: Nov. 21, 2023
Nucleic
acid-based
therapies
have
the
potential
to
address
numerous
diseases
that
pose
significant
challenges
more
traditional
methods.
RNA-based
emerged
as
a
promising
avenue,
utilizing
nanoformulation
treatments
target
range
of
pathologies.
Nanoformulation
offers
several
advantages
compared
other
treatment
modalities,
including
targeted
delivery,
low
toxicity,
and
bioactivity
suitable
for
drug
loading.
At
present,
various
types
nanoformulations
are
available,
such
liposomes,
polymeric
nanoparticles
(NPs),
magnetic
NPs,
nanoshells,
solid
lipid
(SLNs).
therapy
utilizes
intracellular
gene
with
messenger
RNA
(mRNA)
emerging
prominently
in
cancer
immunotechnology
against
infectious
diseases.
The
approval
mRNA-based
technology
opens
doors
future
technological
advancements,
particularly
self-amplifying
replicon
(repRNA).
RepRNA
is
novel
platform
therapy,
comprising
viral
unique
molecular
property
enables
amplification
all
encoded
genetic
information
countless
times.
As
result,
repRNA-based
achieved
levels
expression.
In
this
context,
primary
objective
study
furnish
comprehensive
review
repRNA
its
applications
treatments,
specific
focus
on
encapsulated
nanoparticles.
overarching
goal
provide
an
extensive
overview
use
conjunction
across
therapies.
