Biosynthesis, characterization, magnetic hyperthermia, and in vitro toxicity evaluation of quercetin-loaded magnetoliposome lipid bilayer hybrid system on MCF-7 breast cancer

Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2023, Volume and Issue: 1868(3), P. 130543 - 130543

Published: Dec. 14, 2023

Language: Английский

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Dual-loaded liposomal carriers to combat chemotherapeutic resistance in breast cancer

Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: 21(2), P. 309 - 324

Published: Jan. 29, 2024

The resistance to chemotherapy is a significant hurdle in breast cancer treatment, prompting the exploration of innovative strategies. This review discusses potential dual-loaded liposomal carriers combat chemoresistance and improve outcomes for patients.

Language: Английский

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Lipid Nanoparticle Delivery System for Normalization of Tumor Microenvironment and Tumor Vascular Structure

Biomaterials Research, Journal Year: 2025, Volume and Issue: 29

Published: Jan. 1, 2025

Tumors grow by receiving oxygen and nutrients from the surrounding blood vessels, leading to rapid angiogenesis. This results in functionally structurally abnormal vasculature characterized high permeability irregular flow, causing hypoxia within tumor microenvironment (TME). Hypoxia exacerbates secretion of pro-angiogenic factors such as vascular endothelial growth factor (VEGF), further perpetuating vessel formation. environment compromises efficacy radiotherapy, immunotherapy, chemotherapy. In this study, we developed a pH-sensitive liposome (PSL) system, termed OD_PSL@AKB, co-deliver (OD) razuprotafib (AKB-9778) tumors. system rapidly responds acidic TME alleviate inhibit VEGF secretion, restoring VE-cadherin expression hypoxic cell/cancer cell cocultures. Our findings highlight potential OD_PSL@AKB normalizing improving therapeutic efficacy.

Language: Английский

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Mechanism and application prospect of magnesium-based materials in cancer treatment

Journal of Magnesium and Alloys, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Bovine Lactoferrin Loaded Magnetic-Responsive Plasmonic Lipo-Somes for Therapeutic Applications

Published: May 26, 2023

Bovine lactoferrin (bLf) is a milk-derived protein that exhibits multiple biological activities and has been explored towards different therapeutic applications. Since this molecule susceptible to degradation some of its properties depend on tertiary structure, the encapsulation bLf in stimuli-responsive formulations provides an added value potentiate when administered. Plasmonic magnetoliposomes emerge as promising nanosystems for dual hyperthermia (magneto-photothermia) local therapy, since combination magnetic gold nanoparticles (NPs) single nanosystem (multifunctional liposomes) enables targeting controlled release encapsulated drugs. In work, plasmonic (PMLs) containing manganese ferrite (28 nm size) (~ 5 functionalized with 11-mercaptoundecanoic acid or octadecanethiol, were synthesized loaded bLf. The structural, optical measured by TEM, SQUID UV/vis/NIR absorption spectroscopy. Specific Absorption Rate was determined assess capabilities photothermal hyperthermia. Finally, Saccharomyces cerevisiae used eukaryotic cellular model activity mechanism entry bLf-loaded PMLs, through counting colony forming units fluorescence microscopy, respectively. results demonstrate PMLs are mainly internalized energy- temperature-dependent endocytic process, though contribution diffusion component cannot be discarded. Most notably, only exhibit cytotoxicity efficiency similar free bLf, attesting their potential delivery context interventions.

Language: Английский

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Magnetoliposomes with Calcium-Doped Magnesium Ferrites Anchored in the Lipid Surface for Enhanced DOX Release

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(18), P. 2597 - 2597

Published: Sept. 20, 2023

Nanotechnology has provided a new insight into cancer treatment by enabling the development of nanocarriers for encapsulation, transport, and controlled release antitumor drugs at target site. Among these nanocarriers, magnetic nanosystems have gained prominence. This work presents design, development, characterization magnetoliposomes (MLs), wherein superparamagnetic nanoparticles are coupled to lipid surface. For this purpose, dimercaptosuccinic acid (DMSA)-functionalized Ca0.25Mg0.75Fe2O4 were prepared first time. The demonstrated cubic shape with an average size 13.36 nm. Furthermore, their potential photothermal hyperthermia was evaluated using 4 mg/mL, 2 1 mg/mL concentrations NPs@DMSA, which maximum temperature variation 20.4 °C, 11.4 7.3 respectively, during 30 min NIR-laser irradiation. Subsequently, surface DPPC/DSPC/CHEMS DPPC/DSPC/CHEMS/DSPE-PEG-based MLs synthesis methodology, exhibiting sizes 153 ± 8 nm 136 nm, respectively. Doxorubicin (DOX) encapsulated high efficiency, achieving 96% 2% encapsulation in non-PEGylated 98.0% 0.6% stealth MLs. Finally, drug assays DOX-loaded performed under different conditions (37 °C 42 °C) pH (5.5 7.4), simulating physiological therapeutic conditions. results revealed higher rate acidic pH. Release rates significantly increased when introducing stimulus laser-induced 808 (1 W/cm2) 5 min. After 48 h testing, 5.5, 67.5% 0.5% DOX released, while 7.4, only modest 27.0% 0.1% achieved. demonstrate developed stimulation environments maintain sustained reduced profile 7.4.

Language: Английский

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Elastic Liposomes Containing Calcium/Magnesium Ferrite Nanoparticles Coupled with Gold Nanorods for Application in Photothermal Therapy

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(8), P. 679 - 679

Published: April 15, 2024

This work reports on the design, development, and characterization of novel magneto-plasmonic elastic liposomes (MPELs) DPPC:SP80 (85:15) containing Mg0.75Ca0.25Fe2O4 nanoparticles coupled with gold nanorods, for topical application photothermal therapy (PTT). Both magnetic plasmonic components were characterized regarding their structural, morphological, properties. The display a cubic shape size (major axis) 37 ± 3 nm, while longitudinal transverse sizes nanorods are 46 7 nm 12 1.6 respectively. A new methodology was employed to couple nanostructures, using cysteine as bridge. potential photothermia evaluated nanoparticles, magnetic/plasmonic which demonstrated maximum temperature variation 28.9 °C, 33.6 °C 37.2 respectively, during 30 min NIR-laser irradiation 1 mg/mL dispersions. Using fluorescence anisotropy studies, phase transition (Tm) 35 estimated MPELs, ensures an enhanced fluidity crucial effective crossing skin layers. this nanostructure corresponds specific absorption rate (SAR) 616.9 W/g increase 33.5 °C. These findings point development thermoelastic nanocarriers suitable features act hyperthermia agents.

Language: Английский

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Economic and Accessible Portable Homemade Magnetic Hyperthermia System: Influence of the Shape, Characteristics and Type of Nanoparticles in Its Effectiveness

Materials, Journal Year: 2024, Volume and Issue: 17(10), P. 2279 - 2279

Published: May 11, 2024

Currently, one of the main causes death in world is cancer; therefore, it urgent to obtain a precocious diagnosis, as well boost research and development new potential treatments, which should be more efficient much less invasive for patient. Magnetic hyperthermia (MH) an emerging cancer therapy using nanoparticles, has proved effective when combined with chemotherapy, radiotherapy and/or surgery, or even by itself, depending on type location tumor’s cells. This article presents results obtained previously developed economic homemade device different types magnetite sizes ranging between 12 ± 5 36 11 nm presenting shapes (spherical cubic particles). These magnetic nanoparticles (MNPs) were synthesized three methods (co-precipitation, solvothermal hydrothermal processes), their final form being naked, possessing kinds covering layers (polyethylene glycol (PEG) citric acid (CA)). The parameters used characterize heating hyperthermia, namely Specific Absorption Rate (SAR) intrinsic loss power (ILP), have been two methods. Among other results, these experiments allowed determination MNPs showed best performance concerning hyperthermia. From may concluded that, expected, shape important factor, time that can remain suspended solution (which directly related concentration layer MNPs). gave terms SAR particles covered PEG, while total spherical better.

Language: Английский

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Bovine Lactoferrin-Loaded Plasmonic Magnetoliposomes for Antifungal Therapeutic Applications

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(8), P. 2162 - 2162

Published: Aug. 19, 2023

Bovine lactoferrin (bLf) is a milk-derived protein that exhibits potent broad-spectrum antifungal activity against multiple fungi. bLf susceptible to degradation, while some of its properties depend on the tertiary structure. So, encapsulation in stimuli-responsive therapeutic formulations provides an added value enhance biological activities. Plasmonic magnetoliposomes (PMLs) arise as promising nanocarriers for dual hyperthermia (magneto-photothermia) and local chemotherapy, since combination magnetic gold nanoparticles (NPs) single nanosystem (multifunctional liposomes) enables targeting controlled release loaded drugs. In this work, plasmonic containing manganese ferrite (28 nm size) (5–7.5 size), functionalized with 11-mercaptoundecanoic acid or octadecanethiol, were prepared bLf. The NPs’ optical, structural measured via UV/vis/NIR absorption spectroscopy, SQUID TEM, respectively. Specific Absorption Rate (SAR) was calculated assess capabilities photothermal hyperthermia. Finally, potential bLf-loaded PMLs their mechanism internalization assessed Saccharomyces cerevisiae by counting colony forming units using fluorescence microscopy. results demonstrate are mainly internalized through energy- temperature-dependent endocytic process, though contribution diffusion component cannot be discarded. Most notably, only display cytotoxicity efficiency similar free bLf, attesting delivery context interventions.

Language: Английский

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Nanotechnology in Reproduction

Özgür Yayınları eBooks, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 15, 2023

Advancements in technology and science have facilitated the development of various materials for use different industries. These can range from large sizes to even nanometer dimensions. Nanomaterials or nanoparticles, which fall within size 1 100 nanometers, emerged as a prominent aspect nanotechnology. Nanotechnology, known one fastest-growing technologies today, has found applications wide array fields such health, energy, metallurgy, physics, chemistry, engineering. be produced using diverse methods, including chemical synthesis utilization biological structures. Biocompatible nanomaterials, they are commonly referred to, particularly significance medical science, oncology, tissue engineering, drug delivery. While certain areas made remarkable progress terms nanobiotechnology, there other that comparatively new realm Reproductive biotechnologies among slowly cautiously exploring nanomaterials. Similar baby's crawling, this field is being gradually, each day brings forth surprising developments through ongoing studies. In book, prepared our esteemed readers, uses nanotechnology reproduction been compiled. It covers bioengineering studies explores its functions embryo manipulation, semen purification, infertility treatments, well effects nanomaterials on mammalian aquatic organisms. I would like express my gratitude all colleagues who contributed aimed at explaining reproductive biotechnologies. With expectation it beneficial scientific community... Assist. Prof. Ali Erdem ÖZTÜRK

Language: Английский

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