Emerging Trends in the Application of Green Synthesized Biocompatible ZnO Nanoparticles for Translational Paradigm in Cancer Therapy

Journal of Nanotheranostics, Journal Year: 2023, Volume and Issue: 4(3), P. 248 - 279

Published: July 1, 2023

Zinc oxide nanomaterials have been the cynosure of this decade because their immense potential in different biomedical applications. It includes usage prognosis and treatment infectious cellular diseases, owing to peculiar physiochemical properties such as variable shape, size, surface charge etc. Increasing demand ZnO raise concerns about molecular toxicity biocompatibility with human cells. This review comprehensively details for Furthermore, toxicological types systems reviewed. Moreover, biocompatible efficacy cancer specific pathways has discussed. offers insights into current scenario signifies future extension on environmental

Language: Английский

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Facile synthesis of novel ZnO-MgO nanohybrids and its photocatalytic degradation of toxic pollutants

Desalination and Water Treatment, Journal Year: 2024, Volume and Issue: 317, P. 100125 - 100125

Published: Jan. 1, 2024

The development of high receptive photocatalysts for the degradation dye from water is an implication route to unravel complications contamination. ZnO-MgO nanocomposite was successfully prepared by egg albumin-assisted route. crystallinity, morphological, optical characteristics, and photocatalytic performance composite were investigated XRD, FTIR, SEM with EDS, UV-DRS. results XRD study affirmed that comprises hexagonal cubic stages a normal crystalline size 34 nm. FTIR demonstrates distinctive vibrational frequencies at 454 524 cm−1. micrographs represented nanoparticles flower-like structure. bandgap value (Eg) found as 4.5 eV nanocomposite. efficiency has been photodegradation Congo red under daylight illumination. obtained showed good solar light irradiation. antibacterial properties have assessed versus G+ G- bacteria. outcomes designated bacteriostatic behavior Staphylococcus aureus, Aeromonashydrophila Escherichia coli, Micrococcus luteus, Shigella, Staphylococcustyphi, epidermis, Vibrio cholera, Pseudomonas aeruginosa. Furthermore, this work (ZnO-MgO nanocomposite) offers significant insights into more efficient environmental biomedical applications.

Language: Английский

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ZnO based 0–3D diverse nano-architectures, films and coatings for biomedical applications

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(12), P. 2950 - 2984

Published: Jan. 1, 2024

This review highlights the design and engineering of ZnO based 0–3D nano-architectures, thin films coatings with tunable characteristics for multifunctional biomedical applications.

Language: Английский

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Fe3O4@SiO2/Schiff-base/Zn (II) nanocomposite functioning as a versatile antimicrobial agent against bacterial and fungal pathogens

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 17, 2025

Antimicrobial resistance (AMR) presents a critical global health issue, necessitating novel therapeutic strategies to manage bacterial and fungal infections. This study explores the development evaluation of multifunctional Fe3O₄@SiO₂/Schiff-base/Zn (II) magnetic nanocomposite (MNC) with enhanced antimicrobial properties. The synthesized MNC combines characteristics Fe₃O₄ nanoparticles (MNPs) properties Schiff-base ligand functionalized Zn ions. preparation involved coprecipitation Fe₃O₄, coating SiO₂ via modified Stöber method, subsequent functionalization Schiff-base/Zn complex. Comprehensive characterization using FT-IR, XRD, SEM, TEM, DLS, EDX, VSM, TGA confirmed successful synthesis, structural integrity, superparamagnetic behavior MNPs MNC. antifungal antibacterial activities were assessed against six Candida species four strains broth microdilution methods. Fe₃O₄@SiO₂/Schiff-base/Zn exhibited significant inhibitory effects, MIC values 8–64 µg/mL for 64–512 bacteria, demonstrating potent efficacy. MTT assay indicated biocompatibility across various concentrations, except slight cytotoxicity at 256 after five days. To our knowledge, this is first report integrating ligands into achieve versatile platform both biofilm inhibition applications.

Language: Английский

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Functionalized ZnO-Based Nanocomposites for Diverse Biological Applications: Current Trends and Future Perspectives

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(5), P. 397 - 397

Published: Feb. 21, 2024

The wide array of structures and characteristics found in ZnO-based nanostructures offers them a versatile range uses. Over the past decade, significant attention has been drawn to possible applications these materials biomedical field, owing their distinctive electronic, optical, catalytic, antimicrobial attributes, alongside exceptional biocompatibility surface chemistry. With environmental degradation an aging population contributing escalating healthcare needs costs, particularly developing nations, there's growing demand for more effective affordable devices with innovative functionalities. This review delves into particular essential facets different synthetic approaches (chemical green) that contribute production multifunctional nano-ZnO particles applications. Outlining conjugation ZnO nanoparticles highlights enhancement capacity while lowering toxicity. Additionally, recent progress study nano-biomaterials tailored purposes is explored, including biosensing, bioimaging, tissue regeneration, drug delivery, as well vaccines immunotherapy. final section focuses on particles' toxicity mechanism special emphasis neurotoxic potential, primary pathways, providing overall up-to-date development future perspectives biomedicine field.

Language: Английский

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A comprehensive review on crosslinked network systems of zinc oxide-organic polymer composites

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 274, P. 133250 - 133250

Published: June 20, 2024

Language: Английский

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Advances in agar-based composites: A comprehensive review

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 346, P. 122619 - 122619

Published: Aug. 19, 2024

Language: Английский

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Green Synthesis of Zinc Oxide Nanoparticles: Preparation, Characterization, and Biomedical Applications - A Review

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 12889 - 12937

Published: Dec. 1, 2024

Abstract: Over the last decade, biomedical nanomaterials have garnered significant attention due to their remarkable biological properties and diverse applications in biomedicine. Metal oxide nanoparticles (NPs) are particularly notable for wide range of medicinal uses, including antibacterial, anticancer, biosensing, cell imaging, drug/gene delivery. Among these, zinc (ZnO) NPs stand out versatility effectiveness. Recently, ZnO become a primary material various sectors, such as pharmaceutical, cosmetic, antimicrobials, construction, textile, automotive industries. can generate reactive oxygen species induce cellular apoptosis, thus underpinning potent anticancer antibacterial properties. To meet growing demand, numerous synthetic approaches been developed produce NPs. However, traditional manufacturing processes often involve economic environmental costs, prompting search more sustainable alternatives. Intriguingly, synthesis methods utilizing plants, plant extracts, or microorganisms emerged ideal producing These green production techniques offer medicinal, economic, environmental, health benefits. This review highlights latest advancements applications, showcasing potential revolutionize field with eco-friendly cost-effective solutions. Keywords: antimicrobial, antioxidant, synthesis, nanomedicine, nanoparticle,

Language: Английский

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Morphological effect of green and chemically synthesized nano-ZnO for evaluation of antimicrobial and photo-catalytic activity

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141822 - 141822

Published: Feb. 1, 2025

Language: Английский

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Zinc Oxide Nanoparticles Affect Early Seedlings’ Growth and Polar Metabolite Profiles of Pea (Pisum sativum L.) and Wheat (Triticum aestivum L.)

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14992 - 14992

Published: Oct. 8, 2023

The growing interest in the use of zinc oxide nanoparticles (ZnO NPs) agriculture creates a risk soil contamination with ZnO NPs, which can lead to phytotoxic effects on germinating seeds and seedlings. In present study, susceptibility seeds/seedlings pea wheat NPs various sizes (≤50 ≤100 nm) applied at concentrations range 100–1000 mg/L was compared. Changes metabolic profiles seedlings were analyzed by GC GC-MS methods. size-dependent harmful effect seedling’s growth revealed. more toxic (50 lowest concentration (100 mg/L) caused 2-fold decrease length roots. peas, root elongation slowed down 20–30% only 1000 NPs. response common for all tested cultivars wheat, significant increase sucrose (in roots shoots) GABA roots). seedlings, an increased content metabolites involved aspartate–glutamate pathway TCA cycle (citrate, malate) found, while total amino acids tissues) malate roots) decreased. Moreover, products starch hydrolysis (maltose glucose) endosperm indicates disturbances mobilization.

Language: Английский

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