Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(5)

Published: May 1, 2024

Abstract Gliomas are the most common primary tumors of central nervous system, with glioblastoma multiforme (GBM) having highest incidence, and their therapeutic efficacy depends primarily on extent surgical resection postoperative chemotherapy. The role intracranial blood–brain barrier occurrence drug‐resistant gene O6‐methylguanine‐DNA methyltransferase have greatly limited chemotherapeutic agents in patients GBM made it difficult to achieve expected clinical response. In recent years, rapid development nanotechnology has brought new hope for treatment tumors. Nanoparticles (NPs) shown great potential tumor therapy due unique properties such as light, heat, electromagnetic effects, passive targeting. Furthermore, NPs can effectively load drugs, significantly reduce side effects improve efficacy, showing chemotherapy glioma. this article, we reviewed mechanisms glioma drug resistance, physicochemical NPs, advances resistance. We aimed provide perspectives

Language: Английский

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Salvia coccinea Buc'hoz ex Etl. Leaf extract mediated synthesis of zinc oxide nanoparticles: Assessment of antimicrobial, antioxidant and anticancer activity

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 96, P. 105662 - 105662

Published: April 16, 2024

Language: Английский

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Navigating the future of cancer management through carbon nanodots: A review

Nano-Structures & Nano-Objects, Journal Year: 2024, Volume and Issue: 39, P. 101217 - 101217

Published: June 17, 2024

Language: Английский

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Revolution in Cancer Treatment: How Are Intelligently Designed Nanostructures Changing the Game?

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5171 - 5171

Published: May 9, 2024

Nanoparticles (NPs) are extremely important tools to overcome the limitations imposed by therapeutic agents and effectively biological barriers. Smart designed/tuned nanostructures can be effective for cancer treatment. The selection design of adjustment size surface properties important, especially some precision treatments drug delivery (DD). By designing specific methods, an era opened in biomedical field personalized precise Here, we focus on advances nanostructures, as well how structure shape, size, charge, fluids (BFs) affected. We discussed applications specialized therapy head neck (HNC), which is a difficult aggressive type treat, give impetus novel treatment approaches this field. also comprehensively touched shortcomings, current trends, future perspectives when using cancer.

Language: Английский

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Nanotechnology and nanobots unleashed: pioneering a new era in gynecological cancer management – a comprehensive review

Cancer Chemotherapy and Pharmacology, Journal Year: 2025, Volume and Issue: 95(1)

Published: Jan. 4, 2025

Language: Английский

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Development of PLGA-SPC3 functionalized Gefitinib mesoporous silica nano-scaffolds for breast cancer targeting: Biodistribution and Cytotoxicity analysis

Pharmaceutical Development and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 26

Published: Jan. 31, 2025

The exploration of novel carriers for cancer treatments is on the rise, as drugs are often hindered by ineffective delivery to tumor site. In present study, Mesoporous silica nano scaffolds were developed heat assisted hydrolysis (HAH) technique, and functionalized using PLGA. These further loaded with nanosized Gefitinib (GTB). surface properties MSNs (GTB-PEG-PLGA-MSN) enhanced SPC3. characterized pore volume, particle size, zeta potential (ZP), area, entrapment efficiency (%EE), drug content.The invitro release kinetics, cytotoxicity analysis invivo biodistribution studies performed in optimized MSN Albino Wistar rats. result shows an increase %EE, loading MSN. vitro F5-GTB-PEG-PLGA-SPC3-MSN demonstrated a higher antitumor activity (43.84 ± 0.63%, p<0.05) comparison free drug. A accumulation GTB was detected liver (29,415 126 ng) indicating significant (p > 0.05). MCF-7 cell line signify viability demonstrating its efficacy breast cancer. Optimized offers improved cellular uptake, suppression less toxicity. To conclude, HAH technique produced stable MSNs, PLGA-SPC3 could be ideal carrier delivery.

Language: Английский

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Circular RNAs in cancer

MedComm, Journal Year: 2025, Volume and Issue: 6(2)

Published: Feb. 1, 2025

Abstract Circular RNA (circRNA), a subtype of noncoding RNA, has emerged as significant focus in research due to its distinctive covalently closed loop structure. CircRNAs play pivotal roles diverse physiological and pathological processes, functioning through mechanisms such miRNAs or proteins sponging, regulation splicing gene expression, serving translation templates, particularly the context various cancers. The hallmarks cancer comprise functional capabilities acquired during carcinogenesis tumor progression, providing conceptual framework that elucidates nature malignant transformation. Although numerous studies have elucidated role circRNAs cancers, their functions development chemoradiotherapy resistance remain unexplored clinical applications circRNA‐based translational therapeutics are still infancy. This review provides comprehensive overview circRNAs, covering biogenesis, unique characteristics, functions, turnover mechanisms. We also summarize involvement relevance biomarkers therapeutic targets, especially thyroid (TC). Considering potential fascination therapeutics, “Ying‐Yang” dynamic regulations TC warrant vastly dedicated investigations.

Language: Английский

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Nanoparticle-Based Delivery Systems for Phytochemicals in Cancer Therapy: Molecular Mechanisms, Clinical Evidence, and Emerging Trends

Drug Development and Industrial Pharmacy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 31

Published: March 21, 2025

This review examines recent advancements in nanoparticle-based delivery systems for phytochemicals, focusing on their role overcoming multidrug resistance, improving therapeutic efficacy, and facilitating clinical translation. highlights advances nanoparticle-enabled phytochemical to enhance bioavailability, improve outcomes, enable targeted applications. By comparing various nanoparticle systems, formulation methods, efficacy data, it identifies gaps current research guides the development of more effective, next-generation phytochemical-loaded nanocarriers. A systematic literature published between 2000 2024 was conducted using PubMed, Scopus, Web Science. Articles cancer therapy were included. Compounds such as curcumin, resveratrol, quercetin, epigallocatechin gallate demonstrate enhanced anti-cancer when encapsulated nanoparticles, leading improved increased tumor cell targeting, reduced toxicity. Clinical trials indicate regression fewer adverse effects. Emerging approaches-such nanogels, hybrid combination therapies with immune checkpoint inhibitors-further refine treatment efficacy. Nanoparticle-based significantly potential making them promising candidates safer, effective treatments. However, challenges related regulatory guidelines, scalability, long-term safety must be addressed fully realize potential.

Language: Английский

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Nanoparticle troopers: Infiltrating cancer cells for targeted therapies

Nano-Structures & Nano-Objects, Journal Year: 2025, Volume and Issue: 41, P. 101453 - 101453

Published: Feb. 1, 2025

Language: Английский

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Moringa oleifera mediated green synthesis of gold nanoparticles and their anti-cancer activity against A549 cell line of lung cancer through ROS/ mitochondrial damage

Frontiers in Chemistry, Journal Year: 2025, Volume and Issue: 13

Published: March 5, 2025

Gold nanoparticles (Au-NPs) hold significant promise in lung cancer treatment due to their unique physicochemical properties, enabling targeted drug delivery, enhanced therapeutic efficacy, and reduced systemic toxicity. This study is aimed produce the Au-NPs utilising Moringa oleifera evaluate effectiveness of cancer, with a specific focus on A549 cell lines. The synthesis was carried out by combining 10 mL an aqueous extract M. 190 1 mM HAuCl4 solution. synthesized were characterised using several microscopic spectroscopic techniques. evaluation median inhibitory concentration (IC50) its impact apoptosis conducted through measurement caspase activation formation reactive oxygen species (ROS). Anti-cancer characteristics employing DAPI staining. Furthermore, influence ROS production mitochondrial membrane potential evaluated at IC50 fluorescence microscopy, DCFH-DA Rhodamine 123 dyes. confirmed UV-Vis spectroscopy, absorbance peak 540 nm. FTIR, TEM results showed that mediated had spherical morphology, mean size approximately 30 nm, as determined DLS. exhibited value 50 μg/mL against cells. staining revealed both concentrations AuNP, 25 μg/mL, noteworthy anti-cancer apoptotic properties. demonstrates oleifera-mediated exhibit cytotoxic effects cells, μg/mL. Both tested substantial specifically line, sets this apart from others address broader spectrum types. These findings suggest for clinical applications treatment, providing new application.

Language: Английский

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