The role of alpha-fetoprotein in the tumor microenvironment of hepatocellular carcinoma

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: April 10, 2024

Hepatocellular carcinoma (HCC) is a prevalent malignant cancer worldwide, characterized by high morbidity and mortality rates. Alpha-fetoprotein (AFP) glycoprotein synthesized the liver yolk sac during fetal development. However, serum levels of AFP exhibit significant correlation with onset progression HCC in adults. Extensive research has demonstrated that tumor microenvironment (TME) plays crucial role transformation HCC, key factor TME, promoting The objective this review was to analyze existing knowledge regarding TME. Specifically, focused on effect various cells immune evasion, clinical application diagnosis treatment HCC. These findings offer valuable insights into

Language: Английский

Comprehensive review and updated analysis of DNA methylation in hepatocellular carcinoma: From basic research to clinical application

Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(11)

Published: Oct. 27, 2024

Abstract Hepatocellular carcinoma (HCC) is a primary malignant tumour, ranking second in global mortality rates and posing significant health threats. Epigenetic alterations, particularly DNA methylation, have emerged as pivotal factors associated with HCC diagnosis, therapy, prognosis progression. However, comprehensive analysis of the methylation mechanism driving progression its potential therapeutic biomarker remains lacking. This review attempts to comprehensively summarise various aspects such mechanism, detection methods biomarkers aiding treatment prognostic assessment HCC. It also explores role regulating HCC's sorafenib resistance, alongside elaborating effects methyltransferase inhibitors on A detailed examination these underscores research tumour cells elucidate mechanisms, identify diagnostic markers develop new tumour‐specific for Key points summary diagnosis treatment. The hepatocellular carcinoma's inhibitors. Deep critical discovering novel

Language: Английский

Development of cancer-associated fibroblasts-targeting polymeric nanoparticles loaded with 8-O-methylfusarubin for breast cancer treatment

International Journal of Pharmaceutics X, Journal Year: 2024, Volume and Issue: 8, P. 100294 - 100294

Published: Oct. 17, 2024

Language: Английский