Atmospheric
pressure
Microplasma
is
a
simple,
cost-effective,
efficient,
and
eco-friendly
procedure,
which
superior
to
the
traditional
nanomaterials
synthesis
techniques.
It
generates
high
yields
allows
for
controlled
growth
rate
morphology
of
nanomaterials.
The
silver
(Ag)
nanomaterials,
with
their
unique
physical
chemical
properties,
exhibit
outstanding
antibacterial
anti-fungal
properties.
Similarly,
zinc
oxide
(ZnO)
known
low
toxicity
relatively
lower
cost,
find
wide
applications
in
wound
repair,
bone
healing,
anticancer
applications.
use
core-shell
certain
situations
where
some
nanoparticles
can
cause
serious
harm
host
tissues
or
organs
testament
potential.
A
benign
material
coated
over
core
reduce
these
cases.
This
review
compares
numerous
configurations
microplasma
systems
used
synthesizing
producing
Ag,
ZnO,
(Ag-ZnO)
biomedical
summary
also
includes
effect
control
parameters,
including
cathode
diameter,
gas
flow
rate,
precursor
concentration,
voltage,
current,
on
nanomaterial's
characteristics
In
addition,
it
provides
research
gap
shall
by
this
technique,
as
well
development
limitations
technique
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 5842 - 5842
Published: May 27, 2024
This
study
provides
a
brief
discussion
of
the
major
nanopharmaceuticals
formulations
as
well
impact
nanotechnology
on
future
pharmaceuticals.
Effective
and
eco-friendly
strategies
biofabrication
are
also
highlighted.
Modern
approaches
to
designing
pharmaceutical
nanoformulations
(e.g.,
3D
printing,
Phyto-Nanotechnology,
Biomimetics/Bioinspiration,
etc.)
outlined.
paper
discusses
need
use
natural
resources
for
“green”
design
new
with
therapeutic
efficiency.
Nanopharmaceuticals
research
is
still
in
its
early
stages,
preparation
nanomaterials
must
be
carefully
considered.
Therefore,
safety
long-term
effects
not
overlooked.
The
testing
represents
an
essential
point
their
further
applications.
Vegetal
scaffolds
obtained
by
decellularizing
plant
leaves
represent
valuable,
bioinspired
model
nanopharmaceutical
that
avoids
using
animals.
Nanoformulations
critical
various
fields,
especially
pharmacy,
medicine,
agriculture,
material
science,
due
unique
properties
advantages
over
conventional
allows
improved
solubility,
bioavailability,
targeted
drug
delivery,
controlled
release,
reduced
toxicity.
have
transitioned
from
experimental
stages
being
vital
component
clinical
practice,
significantly
improving
outcomes
medical
fields
cancer
treatment,
infectious
diseases,
neurological
disorders,
personalized
advanced
diagnostics.
Here
key
points
highlighting
importance.
significant
challenges,
opportunities,
directions
mentioned
final
section.
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(2), P. 422 - 422
Published: Feb. 10, 2025
The
intricate
relationship
between
anticancer
drugs
and
the
gut
microbiome
influences
cancer
treatment
outcomes.
This
review
paper
focuses
on
role
of
integrity
in
enhancing
efficacy
safety
drug
therapy,
emphasizing
pharmacokinetic
interactions
microbiota.
It
explores
how
disruptions
to
composition,
or
dysbiosis,
can
alter
metabolism,
immune
responses,
side
effects.
By
examining
mechanisms
disruption
caused
by
drugs,
this
highlights
specific
case
studies
like
cyclophosphamide,
5-fluorouracil,
irinotecan,
their
impact
microbial
diversity
clinical
also
discusses
microbiome-targeted
strategies,
including
prebiotics,
probiotics,
postbiotics,
fecal
microbiota
transplantation
(FMT),
as
promising
interventions
enhance
treatment.
Furthermore,
potential
profiling
personalizing
therapy
integrating
these
into
practice
is
explored.
Finally,
proposes
future
research
directions,
developing
novel
biomarkers
a
deeper
comprehension
drug-microbiome
interactions,
respond
current
gaps
knowledge
improve
patient
outcomes
care.
Frontiers in Oncology,
Journal Year:
2025,
Volume and Issue:
14
Published: Jan. 8, 2025
Colorectal
cancer
(CRC)
is
one
of
thes
most
prevalent
malignant
tumors
worldwide.
Current
therapeutic
strategies
for
CRC
have
limitations,
while
nanomaterials
show
significant
potential
diagnosing
and
treating
CRC.
This
study
utilizes
bibliometric
analysis
to
evaluate
the
current
status
trends
in
this
field.
Research
on
from
2003
2024
was
retrieved
Web
Science
Core
Collection
(WOSCC).
Tools
such
as
CiteSpace,
VOSviewer,
RStudio,
GraphPad
Prism,
Excel
were
used
analyze
hotspots,
covering
publication
trends,
countries,
institutions,
authors,
journals,
co-citation
analysis,
keywords.
Visual
maps
created
forecast
future
developments.
The
includes
3,683
publications
by
17,261
authors
3,721
institutions
across
100
countries/regions,
published
840
journals.
Global
steadily
increased,
particularly
since
2018.
China
leads
volume
citations,
with
six
top
ten
research
seven
cited
United
States
excels
citation
impact
academic
centrality.
Both
countries
currently
dominate
field,
underscoring
urgent
need
enhanced
international
collaboration.
Ramezani
M
Abnous
K
lead
H-index,
Siegel
RL
highly
cited.
International
Journal
Nanomedicine
has
highest
volume,
Controlled
Release
In
addition
"colorectal
cancer"
"nanoparticles,"
common
keyword
"drug
delivery."
Emerging
areas
"metal-organic
frameworks
(MOFs)"
"green
synthesis"
are
gaining
attention
leading
hotspots.
offers
an
in-depth
application
CRC,
promoting
interdisciplinary
collaboration
advancing
scientific
progress
Small Science,
Journal Year:
2024,
Volume and Issue:
4(11)
Published: Sept. 17, 2024
Advancing
therapeutic
progress
is
centered
on
developing
drug
delivery
systems
(DDS)
that
control
molecule
release,
ensuring
precise
targeting
and
optimal
concentrations.
Targeted
DDS
enhances
treatment
efficacy
minimizes
off-target
effects,
but
struggles
with
degradation.
Over
the
last
three
decades,
nanopharmaceuticals
have
evolved
from
laboratory
concepts
into
clinical
products,
highlighting
profound
impact
of
nanotechnology
in
medicine.
Despite
advancements,
effective
therapeutics
remains
challenging
because
biological
barriers.
Nanocarriers
offer
a
solution
small
size,
high
surface-to-volume
ratios,
customizable
properties.
These
address
physiological
challenges,
such
as
shear
stress,
protein
adsorption,
quick
clearance.
They
allow
targeted
to
specific
tissues,
improve
outcomes,
reduce
adverse
effects.
exhibit
controlled
decreased
degradation,
enhanced
efficacy.
Their
size
facilitates
cell
membrane
penetration
intracellular
delivery.
Surface
modifications
increase
affinity
for
types,
allowing
This
study
also
elucidates
potential
integration
artificial
intelligence
nanoscience
innovate
future
nanocarrier
systems.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(6), P. 734 - 734
Published: May 29, 2024
Fluoropyrimidine
(FP)
drugs
are
central
components
of
combination
chemotherapy
regimens
for
the
treatment
colorectal
cancer
(CRC).
FP-based
has
improved
survival
outcomes
over
last
several
decades
with
much
therapeutic
benefit
derived
from
optimization
dose
and
delivery.
To
provide
further
advances
in
efficacy,
next-generation
prodrugs
nanodelivery
systems
FPs
being
developed.
This
review
focuses
on
recent
innovative
approaches
FP
that
display
promise.
We
summarize
established,
clinically
useful
prodrug
strategies,
including
capecitabine,
which
exploit
tumor-specific
enzyme
expression
optimal
anticancer
activity.
then
describe
use
DNA-based
polymers
(e.g.,
CF10)
delivery
activated
nucleotides
as
a
approach
proven
activity
pre-clinical
models
clinical
potential.
Multiple
show
promise
CRC
we
albumin-mediated
delivery,
development
mesoporous
silica
nanoparticles,
emulsion-based
metal
hydrogel-based
liposomes
lipid
nanoparticles
particular
development.
Nanodelivery
is
anticipated
to
impact
coming
years
improve
patients.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(2), P. 205 - 205
Published: Feb. 6, 2025
Cancer
represents
a
significant
societal,
public
health,
and
economic
challenge.
Conventional
chemotherapy
is
based
on
systemic
administration;
however,
it
has
current
limitations,
including
poor
bioavailability,
high-dose
requirements,
adverse
side
effects,
low
therapeutic
indices,
the
development
of
multiple
drug
resistance.
These
factors
underscore
need
for
innovative
strategies
to
enhance
delivery
directly
tumours.
However,
local
treatment
also
presents
challenges,
penetration
through
endothelial
layers,
tissue
density
in
tumour
microenvironment,
interstitial
fluid
pressure,
physiological
conditions
within
tumour,
permanence
at
site
action.
Nanotechnology
promising
alternative
addressing
these
challenges.
This
narrative
review
elucidates
potential
nanostructured
formulations
cancer
treatment,
providing
illustrative
examples
an
analysis
advantages
challenges
associated
with
this
approach.
Among
nanoformulations
developed
breast,
bladder,
colorectal,
oral,
melanoma
cancer,
polymeric
nanoparticles,
liposomes,
lipid
nanohydrogels
have
demonstrated
particular
efficacy.
systems
permit
mucoadhesion
enhanced
penetration,
thereby
increasing
concentration
(bioavailability)
consequently
improving
anti-tumour
efficacy
potentially
reducing
effects.
In
addition
studies
indicating
chemotherapy,
nanocarriers
can
be
used
as
theranostic
approach
combination
irradiation
methods.
Surfaces,
Journal Year:
2024,
Volume and Issue:
7(3), P. 680 - 697
Published: Sept. 2, 2024
Atmospheric
pressure
microplasma
is
a
simple,
cost-effective,
efficient,
and
eco-friendly
procedure,
which
superior
to
the
traditional
nanomaterials
synthesis
techniques.
It
generates
high
yields
allows
for
controlled
growth
rate
morphology
of
nanomaterials.
The
silver
(Ag)
nanomaterials,
with
their
unique
physical
chemical
properties,
exhibit
outstanding
antibacterial
antifungal
properties.
Similarly,
zinc
oxide
(ZnO)
known
low
toxicity
relatively
lower
cost,
find
wide
applications
in
wound
repair,
bone
healing,
anticancer
applications.
use
core–shell
certain
situations
where
some
nanoparticles
can
cause
serious
harm
host
tissues
or
organs
testament
potential.
A
benign
material
coated
over
core
reduce
these
cases.
This
review
compares
numerous
configurations
systems
used
synthesizing
producing
Ag,
ZnO,
(Ag-ZnO)
biomedical
summary
also
includes
effect
control
parameters,
including
cathode
diameter,
gas
flow
rate,
precursor
concentration,
voltage,
current,
on
nanomaterial’s
characteristics
In
addition,
it
provides
research
gap
by
this
technique,
as
well
development
limitations
technique
