The effect of carbon nanotubes on osteogenic functions of adipose-derived mesenchymal stem cells in vitro and bone formation in vivo compared with that of nano-hydroxyapatite and the possible mechanism DOI Creative Commons
Zhipo Du, Xinxing Feng,

Guangxiu Cao

et al.

Bioactive Materials, Journal Year: 2020, Volume and Issue: 6(2), P. 333 - 345

Published: Sept. 1, 2020

It has been well recognized that the development and use of artificial materials with high osteogenic ability is one most promising means to replace bone grafting exhibited various negative effects. The biomimetic features unique physiochemical properties nanomaterials play important roles in stimulating cellular functions guiding tissue regeneration. But efficacy degree some promote specific formation still not clear. We hereby comparatively studied our treated multi-walled carbon nanotubes (MCNTs) main inorganic mineral component natural bone, nano-hydroxyapatite (nHA) same system, tried tell related mechanism. In vitro culture human adipose-derived mesenchymal stem cells (HASCs) on MCNTs nHA demonstrated although there was no significant difference cell adhesion amount between nHA, attachment strength proliferation were better. Most importantly, could induce differentiation HASCs better than possible mechanism which found be activate Notch involved signaling pathways by concentrating more proteins, including bone-inducing ones. Moreover, ectopic vivo while not, might because stimulate inducible tissues form inductive proteins ones secreted from M2 macrophages. Therefore, effective for accelerating even nHA.

Language: Английский

Carbon nanotubes in biomedical applications: current status, promises, and challenges DOI Open Access

Bhushan O. Murjani,

Parikshit S. Kadu,

Manasi Bansod

et al.

Carbon letters, Journal Year: 2022, Volume and Issue: 32(5), P. 1207 - 1226

Published: July 4, 2022

Language: Английский

Citations

138
Electrospun Biomimetic Nanofibrous Scaffolds: A Promising Prospect for Bone Tissue Engineering and Regenerative Medicine DOI Open Access

Shabnam Anjum,

Farheen Rahman, Prashant Pandey

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(16), P. 9206 - 9206

Published: Aug. 16, 2022

Skeletal-related disorders such as arthritis, bone cancer, osteosarcoma, and osteoarthritis are among the most common reasons for mortality in humans at present. Nanostructured scaffolds have been discovered to be more efficient regeneration than macro/micro-sized because they sufficiently permit cell adhesion, proliferation, chemical transformation. Nanofibrous mimicking artificial extracellular matrices provide a natural environment tissue owing their large surface area, high porosity, appreciable drug loading capacity. Here, we review recent progress possible future prospective electrospun nanofibrous engineering. Electrospun demonstrated promising potential using variety of nanomaterials. This focused on crucial role biological applications, including drug/growth factor delivery regeneration. Natural synthetic polymeric extensively inspected regenerate tissue. We mainly significant impact composite adhesion function, different composites organic/inorganic nanoparticles with nanofiber scaffolds. analysis provides an overview scaffold-based strategies; however, same concepts can applied other organ tactics.

Language: Английский

Citations

100
Biomaterials for diabetic bone repair: Influencing mechanisms, multi-aspect progress and future prospects DOI
Bingbing Wang, Yong Huang,

Qiang Cai

et al.

Composites Part B Engineering, Journal Year: 2024, Volume and Issue: 274, P. 111282 - 111282

Published: Feb. 5, 2024

Language: Английский

Citations

17
Engineering biomimetic scaffolds for bone regeneration: Chitosan/alginate/polyvinyl alcohol-based double-network hydrogels with carbon nanomaterials DOI
Saeed Seifi,

Amir Shamloo,

Ali Kheirkhah Barzoki

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 339, P. 122232 - 122232

Published: May 3, 2024

Language: Английский

Citations

17
A Comprehensive Review on Recent Progress in Carbon Nanotubes for Biomedical Application DOI Open Access

S. Sameera Shabnum,

Siranjeevi Ravichandran,

C. Krishna Raj

et al.

Environmental Quality Management, Journal Year: 2025, Volume and Issue: 34(3)

Published: Jan. 16, 2025

ABSTRACT Carbon nanotubes (CNTs) have been considered as the prototypical nanomaterials, propelling them to forefront of nanoscience and nanotechnology. offer potential therapeutic uses in drug transport, diagnostics, biosensing, tissue engineering. Fluorescence imaging across NIR‐II range with increased penetration into tissues spatial precision has shown significant promise recent years an effective approach, harnessing intrinsic band‐gap luminescence semiconducting CNTs. They can penetrate through membranes, delivering medicines, vaccinations, nucleic acids previously inaccessible destinations. Thus, development innovative delivery methods CNTs improve pharmacological properties many types medication. Furthermore, simplicity which may be surface functionalized led their application gene vectors for illnesses such cancer. These include plasmid DNA, miRNA, siRNA. CNTs, among other carbon are inherently strong electrical conductors, making great candidates interfacing electrically excitable conducting brain interface investigations. CNT‐based hydrogels commonly utilized wound healing antimicrobial purposes. antimicrobial, antibacterial, adhesive, antioxidant, mechanical capabilities, all aids healing. In field biomedicine, being hailed promising prospects both diagnostic treatment. When it comes medication distribution, help overcome some drawbacks “free” drugs by helping formulate less water‐soluble medications better, enabling targeted delivery, even facilitating co‐delivery more than one combination therapy. Currently, two attaching substance delivered exterior sidewalls or encapsulating within interior cavities investigated medicinal chemicals using This article discusses most developments use including single‐walled (SWCNTs) well multi‐walled (MWCNTs), multipurpose nanoprobes biomedical applications.

Language: Английский

Citations

3
Enhancing the Biological Characteristics of Aminolysis Surface-Modified 3D Printed Nanocomposite Polycaprolactone/Nanohydroxyapatite Scaffold via Gelatin Biomacromolecule Immobilization: An In Vitro and In Vivo Study DOI

Mohammadhasan Farnaghi,

Seyed Ali Poursamar, Mahour Farzan

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 249, P. 114505 - 114505

Published: Jan. 9, 2025

Language: Английский

Citations

2
Polyetheretherketone and Its Composites for Bone Replacement and Regeneration DOI Open Access
Chengzhu Liao, Yuchao Li, S. C. Tjong

et al.

Polymers, Journal Year: 2020, Volume and Issue: 12(12), P. 2858 - 2858

Published: Nov. 29, 2020

In this article, recent advances in the development, preparation, biocompatibility and mechanical properties of polyetheretherketone (PEEK) its composites for hard soft tissue engineering are reviewed. PEEK has been widely employed fabricating spinal fusions due to radiolucency, chemical stability superior sterilization resistance at high temperatures. can also be tailored into patient-specific implants treating orbital craniofacial defects combination with additive manufacturing process. However, is bioinert, lacking osseointegration after implantation. Accordingly, several approaches including surface roughening, thin film coating technology, addition bioactive hydroxyapatite (HA) micro-/nanofillers have adopted improve performance. The elastic modulus 3.7-4.0 GPa, being considerably lower than that human cortical bone ranging from 7-30 GPa. Thus, not stiff enough sustain applied stress load-bearing orthopedic implants. Therefore, HA micro-/nanofillers, continuous discontinuous carbon fibers incorporated enhancing stiffness applications. Among these, more effective providing additional capabilities. particular, tensile composite 30wt% short resemble those bone. Hydrophobic shows no degradation behavior, thus hampering use making porous scaffolds. blended hydrophilic polymers such as polyglycolic acid polyvinyl alcohol produce biodegradable scaffolds

Language: Английский

Citations

111
Hybrid Gelatin Hydrogels in Nanomedicine Applications DOI
Bidita Salahuddin, Shuo Wang, Danial Sangian

et al.

ACS Applied Bio Materials, Journal Year: 2021, Volume and Issue: 4(4), P. 2886 - 2906

Published: March 9, 2021

Gelatin based hydrogels are often incorporated with supporting materials such as chitosan, poly(vinyl alcohol), alginate, carbon nanotubes, and hyaluronic acid. These hybrid specifically of interest in diversified nanomedicine fields they exhibit unique physicochemical properties, antimicrobial activity, biodegradability, biocompatibility. The applications include drug delivery, wound healing, cell culture, tissue engineering. This paper reviews the various up-to-date methods to fabricate gelatin-based hydrogels, including UV photo-cross-linking, electrospinning, 3D bioprinting. also includes physical, chemical, mechanical, biocompatibility characterization studies several gelatin discusses their relevance applications. Challenges associated fabrication for nanotechnology implementation, development, critically discussed, some future recommendations provided.

Language: Английский

Citations

93
Recent Progress on Biodegradable Tissue Engineering Scaffolds Prepared by Thermally-Induced Phase Separation (TIPS) DOI Open Access
Reza Zeinali, Luís J. del Valle, Juan Torras

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(7), P. 3504 - 3504

Published: March 28, 2021

Porous biodegradable scaffolds provide a physical substrate for cells allowing them to attach, proliferate and guide the formation of new tissues. A variety techniques have been developed fabricate tissue engineering (TE) scaffolds, among most relevant is thermally-induced phase separation (TIPS). This technique has widely used in recent years three-dimensional (3D) TE scaffolds. Low production cost, simple experimental procedure easy processability together with capability produce highly porous controllable architecture justify popularity TIPS. paper provides general overview TIPS methodology applied preparation 3D The advances fabrication through this technique, terms technology material selection, reviewed. In addition, how properties can be effectively modified serve as ideal substrates specific target specifically addressed. Additionally, examples are offered respect changes parameters, combination other innovations polymer or filler selection.

Language: Английский

Citations

88
Conductive Scaffolds for Bone Tissue Engineering: Current State and Future Outlook DOI Creative Commons
Damion T. Dixon, Cheryl T. Gomillion

Journal of Functional Biomaterials, Journal Year: 2021, Volume and Issue: 13(1), P. 1 - 1

Published: Dec. 21, 2021

Bone tissue engineering strategies attempt to regenerate bone lost due injury or disease. Three-dimensional (3D) scaffolds maintain structural integrity and provide support, while improving regeneration through amplified cellular responses between implanted materials native tissues. Through this, that show great osteoinductive abilities as well desirable mechanical properties have been studied. Recently, scaffolding for engineered bone-like tissues evolved with the use of conductive increased scaffold bioactivity. These make several characteristics shown be useful in applications combine them hope improved stimulation (i.e., electrical). With addition materials, these bioactive synthetic substitutes could result outcomes by reducing current factors limiting effectiveness existing materials. This review seeks overview challenges associated state engineering, need produce new grafting substitutes, promising future present towards alleviating issues repair regeneration.

Language: Английский

Citations

81