Extracellular vesicle-loaded hydrogels for tissue repair and regeneration

Materials Today Bio, Journal Year: 2022, Volume and Issue: 18, P. 100522 - 100522

Published: Dec. 21, 2022

Extracellular vesicles (EVs) are a collective term for nanoscale or microscale secreted by cells that play important biological roles. Mesenchymal stem class of with the potential self-healing and multidirectional differentiation. In recent years, numerous studies have shown EVs, especially those mesenchymal cells, can promote repair regeneration various tissues and, thus, significant in regenerative medicine. However, due to rapid clearance capacity circulatory system, EVs barely able act persistently at specific sites target tissues. Hydrogels good biocompatibility loose porous structural properties allow them serve as EV carriers, thereby prolonging retention certain areas slowing release EVs. When needed function sites, EV-loaded hydrogels stand an excellent approach. this review, we first introduce sources, roles, extraction characterization methods describe their current application status. We then review different types discuss factors influencing abilities carry summarize several strategies loading into characterizing hydrogels. Furthermore, applications tissue repair. This article concludes summary state research on outlook future directions, which hope will provide promising ideas researchers.

Language: Английский

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Novel Trends in Hydrogel Development for Biomedical Applications: A Review

Polymers, Journal Year: 2022, Volume and Issue: 14(15), P. 3023 - 3023

Published: July 26, 2022

Nowadays, there are still numerous challenges for well-known biomedical applications, such as tissue engineering (TE), wound healing and controlled drug delivery, which must be faced solved. Hydrogels have been proposed excellent candidates these they promising properties the mentioned including biocompatibility, biodegradability, great absorption capacity tunable mechanical properties. However, depending on material or manufacturing method, resulting hydrogel may not up to specific task it is designed, thus different approaches enhance performance requirements of application in question. The main purpose this review article was summarize most recent trends technology, going through used polymeric materials popular synthesis methods years, strategies enhancing hydrogels' properties, cross-linking manufacture composite hydrogels. In addition, secondary objective briefly discuss other novel applications hydrogels that past few years drawn a lot attention.

Language: Английский

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Preparation, properties, and applications of gelatin-based hydrogels (GHs) in the environmental, technological, and biomedical sectors

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 218, P. 601 - 633

Published: July 25, 2022

Language: Английский

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Are Natural Compounds a Promising Alternative to Synthetic Cross-Linking Agents in the Preparation of Hydrogels?

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(1), P. 253 - 253

Published: Jan. 11, 2023

The main aim of this review is to assess the potential use natural cross-linking agents, such as genipin, citric acid, tannic epigallocatechin gallate, and vanillin in preparing chemically cross-linked hydrogels for biomedical, pharmaceutical, cosmetic industries. Chemical one most important methods that commonly used form mechanically strong based on biopolymers, alginates, chitosan, hyaluronic collagen, gelatin, fibroin. Moreover, properties agents their advantages disadvantages are compared relative known synthetic counterparts. Nowadays, advanced technologies can facilitate acquisition high-purity biomaterials from unreacted components with no additional purification steps. However, while planning designing a chemical process, energy water consumption should be limited order reduce risks associated global warming. many N,N′-methylenebisacrylamide, ethylene glycol dimethacrylate, poly (ethylene glycol) diacrylates, epichlorohydrin, glutaraldehyde, harmful both humans environment. One solution problem could bio-cross-linking obtained resources, which would eliminate toxic effects ensure safety

Language: Английский

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Perspectives on recent advancements in energy harvesting, sensing and bio-medical applications of piezoelectric gels

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(17), P. 6191 - 6220

Published: Jan. 1, 2023

This review highlights the recent progress in piezoelectric gels (also known as PiezoGels) comprised of polymers, ceramic oxides and supramolecular materials used for energy harvesting, sensing wound dressing.

Language: Английский

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pH‐responsive polymers for drug delivery: Trends and opportunities

Journal of Polymer Science, Journal Year: 2023, Volume and Issue: 61(22), P. 2828 - 2850

Published: Aug. 23, 2023

Abstract Polymer science has applications in biomedical engineering, prosthetics, surgical implants, and prospective pharmaceutical excipients for drug delivery. “Intelligent or Smart Polymers” are created targeting either by derivatization of natural polymers controlled radical polymerization electrolytes. Their mode action is governed the environmental stimuli viz. temperature, pH, ionic concentration, magnetism, so on. pH‐responsive polymers, because their self‐assembling behavior, alter solubility, conformation, surface activity, hydrophilicity when exposed to a specific pH. The physiological pH varies from acidic nuclei alkaline cytoplasm highly gastric juice slightly plasma; thus, various under study delivering small molecules, genes, peptides, enzymes, growth factors, antibodies. non‐invasive delivery routes like oral, ocular, nasal, pulmonary, transdermal, rectal can be explored recombinant proteins, monoclonal antibodies, molecules with particular emphasis on individual's pathological state. Further, these designed into architectures dendrimers, liposomes, micelles, metallic nanoparticles that serve as reservoirs sustaining release. challenges this field selection biocompatible ease synthesis scale‐up, ensuring effective drug‐loading, stability aspects, producing robust pharmacological data, timely regulatory approvals. This review exclusively explores physicochemical characteristics categorization, architectural entities, recent studies patents, emerging concerning diseases.

Language: Английский

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Gelatin Methacryloyl (GelMA)-Based Biomaterial Inks: Process Science for 3D/4D Printing and Current Status

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(4), P. 2156 - 2221

Published: March 20, 2024

Tissue engineering for injured tissue replacement and regeneration has been a subject of investigation over the last 30 years, there considerable interest in using additive manufacturing to achieve these goals. Despite such efforts, many key questions remain unanswered, particularly area biomaterial selection applications as well quantitative understanding process science. The strategic utilization biological macromolecules provides versatile approach meet diverse requirements 3D printing, printability, buildability, biocompatibility. These molecules play pivotal role both physical chemical cross-linking processes throughout biofabrication, contributing significantly overall success printing process. Among several bioprintable materials, gelatin methacryloyl (GelMA) widely utilized applications, with some degree success. In this context, review will discuss bioengineering approaches identify gelation strategies that are appropriate control rheology, buildability inks. This focus on GelMA structural (scaffold) different tissues potential carrier vehicle transport living cells their maintenance viability physiological system. Recognizing importance printability toward shape fidelity biophysical properties, major qualitative impact factors, including microrheological, viscoelastic, gelation, shear thinning properties inks, parameters, particular, reference extrusion GelMA-based Specifically, we emphasize possibilities regulate mechanical, swelling, biodegradation, cellular functionalities bio(material) by hybridization techniques, synthetic natural biopolymers, inorganic nanofillers, microcarriers. At close, possibility integration experimental data sets artificial intelligence/machine learning is emphasized predict fidelity, or inks clinically relevant tissues.

Language: Английский

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Engineered Bio‐Based Hydrogels for Cancer Immunotherapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(21)

Published: Feb. 16, 2024

Immunotherapy represents a revolutionary paradigm in cancer management, showcasing its potential to impede tumor metastasis and recurrence. Nonetheless, challenges including limited therapeutic efficacy severe immune-related side effects are frequently encountered, especially solid tumors. Hydrogels, class of versatile materials featuring well-hydrated structures widely used biomedicine, offer promising platform for encapsulating releasing small molecule drugs, biomacromolecules, cells controlled manner. Immunomodulatory hydrogels present unique capability augmenting immune activation mitigating systemic toxicity through encapsulation multiple components localized administration. Notably, based on biopolymers have gained significant interest owing their biocompatibility, environmental friendliness, ease production. This review delves into the recent advances bio-based immunotherapy synergistic combinatorial approaches, highlighting diverse applications. It is anticipated that this will guide rational design field immunotherapy, fostering clinical translation ultimately benefiting patients.

Language: Английский

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Recent progress of electrospun nanofibers as burning dressings

RSC Advances, Journal Year: 2024, Volume and Issue: 14(20), P. 14374 - 14391

Published: Jan. 1, 2024

Burns are a global public health problem, which brings great challenges to and the economy.

Language: Английский

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Biomimetic Scaffolds—A Novel Approach to Three Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(6), P. 531 - 531

Published: March 16, 2024

Biomimetic scaffolds imitate native tissue and can take a multidimensional form. They are biocompatible influence cellular metabolism, making them attractive bioengineering platforms. The use of biomimetic adds complexity to traditional cell cultivation methods. most commonly used technique involves cultivating cells on flat surface in two-dimensional format due its simplicity. A three-dimensional (3D) provide microenvironment for surrounding cells. There two main techniques obtaining 3D structures based the presence scaffolding. Scaffold-free consist spheroid technologies. Meanwhile, scaffold contain organoids all constructs that various types scaffolds, ranging from decellularized extracellular matrix (dECM) through hydrogels one extensively studied forms potential culture up 4D bioprinted biomaterials. bioprinting is important create scaffolds. versatility this allows many different inks, mainly hydrogels, as well inorganic substances. Increasing amounts data evidence vast usage engineering personalized medicine, with area application being regeneration skin musculoskeletal systems. Recent papers also indicate increasing vivo tests products which further strengthen importance branch emphasize need extensive research safe humansbiomimetic tissues organs. In review article, we recent advancements field preceded by an overview technologies led development complex type culture.

Language: Английский

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