Obstetric outcomes associated with antipsychotic treatment during pregnancy: A narrative review DOI Open Access
Jessica Patricia Sanchez Guanilo, Angie Ximena Sánchez Yepez, José André Seminario Asmat

et al.

Revista Médica de Trujillo, Journal Year: 2022, Volume and Issue: 17(3), P. 103 - 107

Published: Sept. 30, 2022

Antipsychotics are increasingly prescribed for various disorders including bipolar disorder, schizophrenia, other psychotic and to a lesser extent depression, anxiety, insomnia even nausea during pregnancy. The full knowledge about its possible effects due exposure pregnancy is still limited, although some studies refer degree of relationship with the appearance such as gestational diabetes, premature birth, congenital malformations, our review did not find sufficiently clear them. In addition safety profile, another aspect consider assessment that untreated psychiatric could also represent risk factor poor outcomes. Therefore, lack highly significant data on these aspects pregnancy, more needed provide detail risks benefits drugs at this stage.

Language: Английский

Sex differences in the blood–brain barrier: Implications for mental health DOI Creative Commons
Laurence Dion‐Albert, Luisa Bandeira Binder, Béatrice Daigle

et al.

Frontiers in Neuroendocrinology, Journal Year: 2022, Volume and Issue: 65, P. 100989 - 100989

Published: March 8, 2022

Prevalence of mental disorders, including major depressive disorder (MDD), bipolar (BD) and schizophrenia (SZ) are increasing at alarming rates in our societies. Growing evidence points toward sex differences these conditions, high treatment resistance support the need to consider novel biological mechanisms outside neuronal function gain mechanistic insights that could lead innovative therapies. Blood-brain barrier alterations have been reported MDD, BD SZ. Here, we provide an overview sex-specific immune, endocrine, vascular transcriptional-mediated changes affect neurovascular integrity possibly contribute pathogenesis disorders. We also identify pitfalls current literature highlight promising biomarkers. Better understanding how adaptations can health status is essential not only context SZ but cardiovascular diseases stroke which associated with higher prevalence conditions.

Language: Английский

Citations

63
Association of In Utero Antipsychotic Medication Exposure With Risk of Congenital Malformations in Nordic Countries and the US DOI
Krista F. Huybrechts, Loreen Straub, Pär Karlsson

et al.

JAMA Psychiatry, Journal Year: 2022, Volume and Issue: 80(2), P. 156 - 156

Published: Dec. 7, 2022

Psychiatric disorders are common among female individuals of reproductive age. While antipsychotic medication use is increasing, the safety such medications in pregnancy an area with large evidence gaps.To evaluate risk first-trimester exposure respect to congenital malformations, focusing on individual drugs and specific malformation subtypes.This cohort study used data from nationwide health registers 5 Nordic countries US spanned 1996 2018. The included all pregnancies resulting singleton live-born infants, consisted publicly insured mothers linked their infants nested Medicaid Analytic eXtract. Data were analyzed November 2020 April 2022.One or more dispensing any atypical, typical, drugs.Any major subtypes previously suggested be associated utero: cardiovascular oral clefts, neural tube defects, hip dysplasia, limb reduction anorectal atresia/stenosis, gastroschisis, hydrocephalus, other brain anomalies, esophageal disorders. Propensity score stratification was control for potential confounders. Pooled adjusted estimates calculated using indirect standardization.A total 6 455 324 unexposed (mean maternal age range across countries: 24-31 years), 21 751 exposed atypical range, 26-31 6371 typical 27-32 years) cohort. Prevalence 2.7% (95% CI, 2.7%-2.8%) 4.3% 4.1%-4.6%) drug exposure, 3.1% 2.7%-3.5%) utero. Among most prevalent exposure-outcome combinations, relative risks (aRR) generally close null. One exception olanzapine cleft (aRR, 2.1 [95% 1.1-4.3]); however, varied sensitivity analyses. moderately increased observed gastroschisis anomalies after 1.5 0.8-2.6] 1.9 1.1-3.0]) cardiac malformations chlorprothixene 1.6 1.0-2.7]). association direction consistent analyses, confidence intervals wide, prohibiting firm conclusions.In this study, considering primary analyses inevitable statistical noise very rare utero not meaningfully malformations. clefts olanzapine, antipsychotics requires confirmation as continues accumulate.

Language: Английский

Citations

40
Psychedelic Drugs in Mental Disorders: Current Clinical Scope and Deep Learning‐Based Advanced Perspectives DOI Creative Commons
Sung‐Hyun Kim, Sumin Yang,

Jeehye Jung

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Mental disorders are a representative type of brain disorder, including anxiety, major depressive depression (MDD), and autism spectrum disorder (ASD), that caused by multiple etiologies, genetic heterogeneity, epigenetic dysregulation, aberrant morphological biochemical conditions. Psychedelic drugs such as psilocybin lysergic acid diethylamide (LSD) have been renewed fascinating treatment options gradually demonstrated potential therapeutic effects in mental disorders. However, the multifaceted conditions psychiatric resulting from individuality, complex interplay, intricate neural circuits impact systemic pharmacology psychedelics, which disturbs integration mechanisms may result dissimilar medicinal efficiency. The precise prescription psychedelic remains unclear, advanced approaches needed to optimize drug development. Here, recent studies demonstrating diverse pharmacological psychedelics reviewed, emerging perspectives on structural function, microbiota-gut-brain axis, transcriptome discussed. Moreover, applicability deep learning is highlighted for development basis big data. These provide insight into interindividual factors enhance discovery precision medicine.

Language: Английский

Citations

0
Comparative modelling of foetal exposure to maternal long-acting injectable versus oral daily antipsychotics DOI Creative Commons

Philip Bediako-Kakari,

Mariella Monyo,

Shakir Atoyebi

et al.

npj Women s Health, Journal Year: 2025, Volume and Issue: 3(1)

Published: May 15, 2025

This study employed physiologically based pharmacokinetic (PBPK) modelling to compare the extent of foetal exposure between oral and long-acting injectable (LAI) aripiprazole olanzapine. Adult pregnancy PBPK models were developed validated with relevant clinical data. Relevant indices during predicted from concentration-time data at steady-state dosing for both LAI formulations. Foetal Cmax was 59-78% higher than oral, 68-181% olanzapine formulation. Predicted cord:maternal ratios (range) 0.59-0.69 0.61-0.66 aripiprazole, 0.34-0.64 0.89-0.96 Also, cumulative over 28 days formulations generally be lower compared their therapeutic-equivalent LAI. As in utero maternal drugs does not necessarily translate risk, these should interpreted a broader context that includes benefit-risk assessments.

Language: Английский

Citations

0
Advances in Psychotropic Treatment for Pregnant Women: Efficacy, Adverse Outcomes, and Therapeutic Monitoring DOI Open Access
Bárbara Costa, Nuno Vale

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(15), P. 4398 - 4398

Published: July 27, 2024

Advancements in psychotropic therapy for pregnant women are pivotal addressing maternal mental health during the perinatal period. Screening mood and anxiety symptoms pregnancy is recommended to enable early intervention. Psychotropic medications, including antidepressants, benzodiazepines, antipsychotics, stabilizers, commonly used, but challenges remain regarding their safety efficacy pregnancy. Pregnancy induces significant changes pharmacokinetics, necessitating personalized dosing strategies careful monitoring. Real-time monitoring technologies, such as smartphone-integrated platforms home-based monitoring, enhance accessibility accuracy. Prospective studies collaboration among healthcare providers essential evidence-based guidelines optimal treatment strategies. Reducing stigma around crucial ensure seek help discuss options, promoting understanding acceptance within community.

Language: Английский

Citations

2
Endocrine factors associated with infertility in women: an updated review DOI
Marcio José Concepción‐Zavaleta, Julia Arroyo, Juan Eduardo Quiroz‐Aldave

et al.

Expert Review of Endocrinology & Metabolism, Journal Year: 2023, Volume and Issue: 18(5), P. 399 - 417

Published: Sept. 3, 2023

ABSTRACTIntroduction Infertility is defined as the inability to conceive after unprotected sexual intercourse for at least 12 consecutive months. Our objective present an updated narrative review on endocrine causes of infertility in women.Areas covered A comprehensive was conducted using Scielo, Scopus, and EMBASE databases, comprising 245 articles. The pathophysiology women described, including endocrinopathies such hypothalamic amenorrhea, hyperprolactinemia, polycystic ovary syndrome, primary ovarian insufficiency, obesity, thyroid dysfunction, adrenal disorders. diagnostic approach outlined, emphasizing necessity hormonal studies response assessments. Additionally, treatment plan presented, commencing with non-pharmacological interventions, encompassing adoption a Mediterranean diet, vitamin supplementation, moderate exercise, maintaining healthy weight. Subsequently, pharmacological discussed, focusing management associated disorders ovulatory dysfunction.Expert opinion This highlights impact fertility women, providing therapeutic algorithms. Despite remaining knowledge gaps that hinder more effective treatments, ongoing research advancements show promise improved success rates within next five years. Enhanced comprehension behind progress genetic will facilitate delivery personalized thus enhancing rates.KEYWORDS: Fertilityfemale infertilityanovulationreproductive healthovarian reservehormones Article Correcting underlying abnormalities enhances most patients.Polycystic syndrome common cause anovulation.Hormonal evaluation crucial assessment female causes.Ovarian reserve should be evaluated antimüllerian hormone imaging.Healthy lifestyles contribute improving fertility.Declaration interestThe authors have no relevant affiliations or financial involvement any organization entity interest conflict subject matter materials discussed manuscript. includes employment, consultancies, honoraria, stock ownership options, expert testimony, grants patents received pending, royalties.Reviewer disclosuresPeer reviewers this manuscript other relationships disclose.Author contribution statementJEQA MJCZ designed outline article review. JEQA, JCA, MCDV, ERGO, JSR, SPIN LPRR were main writers performed literature JPI prepared All read approved final manuscript.Additional informationFundingThis paper not funded.

Language: Английский

Citations

6
Grappling with Issues of Motherhood for Women with Schizophrenia DOI Open Access
Mary V. Seeman

Healthcare, Journal Year: 2023, Volume and Issue: 11(21), P. 2882 - 2882

Published: Nov. 2, 2023

Despite the fact that most persons with schizophrenia find steady employment difficult to sustain, many women this diagnosis embrace and fulfill task of all—motherhood. The aim paper is specify challenges motherhood in population review treatment strategies needed keep mothers children safe, protecting health fostering growth. addresses concerns had been brought author’s earlier attention during her clinical involvement an outpatient clinic for psychosis. It is, thus, a non-systematic, narrative topic areas subjectively assessed as essential “good enough” mothering context schizophrenia. Questions explored are stigma against population, mothers’ painful choices, issues contraception, abortion, child custody, foster care kin placement children, effects antipsychotics, specific perinatal delusional syndromes, and, finally, availability parental support. This intended clinicians. Recommendations providers work collaboratively mothers, take note their strengths well failings, offer wide array family services, monitor households closely safety adherence, appreciating face daily.

Language: Английский

Citations

4
Consequences of the exposome to gestational diabetes mellitus DOI
Marilza Vieira Cunha Rudge, Fernanda Cristina Bérgamo Alves,

Raghavendra L.S. Hallur

et al.

Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2022, Volume and Issue: 1867(2), P. 130282 - 130282

Published: Nov. 25, 2022

Language: Английский

Citations

7
Outcomes of long-acting injectable antipsychotics use in pregnancy: A literature review DOI Open Access
Ana V. Pejčić, Srđjan Stefanović, Miloš Milosavljević

et al.

World Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 14(4), P. 582 - 599

Published: April 16, 2024

Women with a history of serious psychotic disorders are at increased risk disease relapse during pregnancy. Long-acting injectable (LAI) antipsychotics have been widely used to improve adherence and prevent in patients various severe disorders, but there is lack high-quality data from previous research on the safety LAI

Language: Английский

Citations

1
Neutrophil–Lymphocyte Ratio Values in Schizophrenia: A Comparison between Oral and Long-Acting Antipsychotic Therapies DOI Creative Commons
A. Messina, Fabrizio Bella,

Giuliana Maccarone

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(6), P. 602 - 602

Published: June 14, 2024

Background: Schizophrenia is a mental disorder affecting approximately 0.32% of the global population, according to World Health Organization. Antipsychotic medications are used treat this condition by inhibiting D2 dopamine and 5HT2 serotonin receptors. The selection appropriate mode delivery for these drugs based on factors such as patient adherence, clinical presentation, preferences. However, additional drivers treatment required in practice. Mounting evidence suggests that neuroinflammation plays crucial role pathogenesis schizophrenia. NLR, cost-effective biomarker inflammation, has increased several psychiatric conditions may represent valid method studying inflammatory stage schizophrenia, relapse, first episode psychosis. aim study evaluate whether there any variations NLR values between patients given oral antipsychotics those long-acting antipsychotics. Methods: included 50 individuals with either acute or follow-up phase. was obtained calculating ratio absolute neutrophil count (cells/μL) lymphocyte (cells/μL). Results: Patients exhibited significantly lower mean scores (1.5 ± 0.7) compared (2.2 1.3) (p < 0.05). Conclusions: appears promising neuroinflammatory biomarker. This reveals antipsychotics, which signify reduced systemic inflammation improved adherence.

Language: Английский

Citations

1