Case Report: Neuro Radiological Screening of First Episode Psychosis Patient Followed up for 3 Years DOI Open Access

Mohammed Allam,

Khaled Hamolila,

Yahya Tikriti

et al.

American Journal of Psychiatry and Neuroscience, Journal Year: 2022, Volume and Issue: 10(2), P. 77 - 77

Published: Jan. 1, 2022

This is a case report of 21 years old female patient with first episode psychosis fulfilling the DSM 5 criteria for paranoid schizophrenia an interesting neuro-radiological finding found during routine screening psychosis. The large right lateral intraventricular thin walled cyst and signs obstruction foramen Monro. objective this paper to present review different correlates in light theories etiology included disorders. Etiology has including infectious theory relevance viral infections such as Herpes Simples Virus Cytomegalovirus also non-viral Toxoplasmosis. Additional findings have suggested that increased susceptibility multiple pathogens schizophrenic patients, rather than specific agent, may play role development schizophrenia. these agents proposed be disrupting neurodevelopment brain critical phases genetically predisposed individuals. On other hand, Monro becomes clinically significant when it obstructed causing non communicating obstruction. Stenosis been attributed origins particularly TORCH inflammation scarring region (Toxoplasmosis, Other agents, Rubella, Simples). Etiologies includes congenital atresia, vascular malformations, neoplastic processes. There are views regards significance MRI case. Some bases related clinical experience directly managing similar cases documented outcome intervention whether pharmacological or neurosurgical. believe particular incidental no causal relationships supporting references below. In same context we discussed overlap between two disorders one theoretically possible pertinent both which one.

Language: Английский

Sex differences in the blood–brain barrier: Implications for mental health DOI Creative Commons
Laurence Dion‐Albert, Luisa Bandeira Binder, Béatrice Daigle

et al.

Frontiers in Neuroendocrinology, Journal Year: 2022, Volume and Issue: 65, P. 100989 - 100989

Published: March 8, 2022

Prevalence of mental disorders, including major depressive disorder (MDD), bipolar (BD) and schizophrenia (SZ) are increasing at alarming rates in our societies. Growing evidence points toward sex differences these conditions, high treatment resistance support the need to consider novel biological mechanisms outside neuronal function gain mechanistic insights that could lead innovative therapies. Blood-brain barrier alterations have been reported MDD, BD SZ. Here, we provide an overview sex-specific immune, endocrine, vascular transcriptional-mediated changes affect neurovascular integrity possibly contribute pathogenesis disorders. We also identify pitfalls current literature highlight promising biomarkers. Better understanding how adaptations can health status is essential not only context SZ but cardiovascular diseases stroke which associated with higher prevalence conditions.

Language: Английский

Citations

63
Association of In Utero Antipsychotic Medication Exposure With Risk of Congenital Malformations in Nordic Countries and the US DOI
Krista F. Huybrechts, Loreen Straub, Pär Karlsson

et al.

JAMA Psychiatry, Journal Year: 2022, Volume and Issue: 80(2), P. 156 - 156

Published: Dec. 7, 2022

Psychiatric disorders are common among female individuals of reproductive age. While antipsychotic medication use is increasing, the safety such medications in pregnancy an area with large evidence gaps.To evaluate risk first-trimester exposure respect to congenital malformations, focusing on individual drugs and specific malformation subtypes.This cohort study used data from nationwide health registers 5 Nordic countries US spanned 1996 2018. The included all pregnancies resulting singleton live-born infants, consisted publicly insured mothers linked their infants nested Medicaid Analytic eXtract. Data were analyzed November 2020 April 2022.One or more dispensing any atypical, typical, drugs.Any major subtypes previously suggested be associated utero: cardiovascular oral clefts, neural tube defects, hip dysplasia, limb reduction anorectal atresia/stenosis, gastroschisis, hydrocephalus, other brain anomalies, esophageal disorders. Propensity score stratification was control for potential confounders. Pooled adjusted estimates calculated using indirect standardization.A total 6 455 324 unexposed (mean maternal age range across countries: 24-31 years), 21 751 exposed atypical range, 26-31 6371 typical 27-32 years) cohort. Prevalence 2.7% (95% CI, 2.7%-2.8%) 4.3% 4.1%-4.6%) drug exposure, 3.1% 2.7%-3.5%) utero. Among most prevalent exposure-outcome combinations, relative risks (aRR) generally close null. One exception olanzapine cleft (aRR, 2.1 [95% 1.1-4.3]); however, varied sensitivity analyses. moderately increased observed gastroschisis anomalies after 1.5 0.8-2.6] 1.9 1.1-3.0]) cardiac malformations chlorprothixene 1.6 1.0-2.7]). association direction consistent analyses, confidence intervals wide, prohibiting firm conclusions.In this study, considering primary analyses inevitable statistical noise very rare utero not meaningfully malformations. clefts olanzapine, antipsychotics requires confirmation as continues accumulate.

Language: Английский

Citations

40
Psychedelic Drugs in Mental Disorders: Current Clinical Scope and Deep Learning‐Based Advanced Perspectives DOI Creative Commons
Sung‐Hyun Kim, Sumin Yang,

Jeehye Jung

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Mental disorders are a representative type of brain disorder, including anxiety, major depressive depression (MDD), and autism spectrum disorder (ASD), that caused by multiple etiologies, genetic heterogeneity, epigenetic dysregulation, aberrant morphological biochemical conditions. Psychedelic drugs such as psilocybin lysergic acid diethylamide (LSD) have been renewed fascinating treatment options gradually demonstrated potential therapeutic effects in mental disorders. However, the multifaceted conditions psychiatric resulting from individuality, complex interplay, intricate neural circuits impact systemic pharmacology psychedelics, which disturbs integration mechanisms may result dissimilar medicinal efficiency. The precise prescription psychedelic remains unclear, advanced approaches needed to optimize drug development. Here, recent studies demonstrating diverse pharmacological psychedelics reviewed, emerging perspectives on structural function, microbiota-gut-brain axis, transcriptome discussed. Moreover, applicability deep learning is highlighted for development basis big data. These provide insight into interindividual factors enhance discovery precision medicine.

Language: Английский

Citations

0
Comparative modelling of foetal exposure to maternal long-acting injectable versus oral daily antipsychotics DOI Creative Commons

Philip Bediako-Kakari,

Mariella Monyo,

Shakir Atoyebi

et al.

npj Women s Health, Journal Year: 2025, Volume and Issue: 3(1)

Published: May 15, 2025

This study employed physiologically based pharmacokinetic (PBPK) modelling to compare the extent of foetal exposure between oral and long-acting injectable (LAI) aripiprazole olanzapine. Adult pregnancy PBPK models were developed validated with relevant clinical data. Relevant indices during predicted from concentration-time data at steady-state dosing for both LAI formulations. Foetal Cmax was 59-78% higher than oral, 68-181% olanzapine formulation. Predicted cord:maternal ratios (range) 0.59-0.69 0.61-0.66 aripiprazole, 0.34-0.64 0.89-0.96 Also, cumulative over 28 days formulations generally be lower compared their therapeutic-equivalent LAI. As in utero maternal drugs does not necessarily translate risk, these should interpreted a broader context that includes benefit-risk assessments.

Language: Английский

Citations

0
Management of Acute Onset Catatonia Postpartum in a Patient With a History of Major Depressive Disorder With Psychotic Features: A Case Report DOI Open Access
Evan Silverstein,

Tajudeen Basiru,

Maninder Aulakh

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

Language: Английский

Citations

0
Advances in Psychotropic Treatment for Pregnant Women: Efficacy, Adverse Outcomes, and Therapeutic Monitoring DOI Open Access
Bárbara Costa, Nuno Vale

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(15), P. 4398 - 4398

Published: July 27, 2024

Advancements in psychotropic therapy for pregnant women are pivotal addressing maternal mental health during the perinatal period. Screening mood and anxiety symptoms pregnancy is recommended to enable early intervention. Psychotropic medications, including antidepressants, benzodiazepines, antipsychotics, stabilizers, commonly used, but challenges remain regarding their safety efficacy pregnancy. Pregnancy induces significant changes pharmacokinetics, necessitating personalized dosing strategies careful monitoring. Real-time monitoring technologies, such as smartphone-integrated platforms home-based monitoring, enhance accessibility accuracy. Prospective studies collaboration among healthcare providers essential evidence-based guidelines optimal treatment strategies. Reducing stigma around crucial ensure seek help discuss options, promoting understanding acceptance within community.

Language: Английский

Citations

3
Endocrine factors associated with infertility in women: an updated review DOI
Marcio José Concepción‐Zavaleta, Julia Arroyo, Juan Eduardo Quiroz‐Aldave

et al.

Expert Review of Endocrinology & Metabolism, Journal Year: 2023, Volume and Issue: 18(5), P. 399 - 417

Published: Sept. 3, 2023

ABSTRACTIntroduction Infertility is defined as the inability to conceive after unprotected sexual intercourse for at least 12 consecutive months. Our objective present an updated narrative review on endocrine causes of infertility in women.Areas covered A comprehensive was conducted using Scielo, Scopus, and EMBASE databases, comprising 245 articles. The pathophysiology women described, including endocrinopathies such hypothalamic amenorrhea, hyperprolactinemia, polycystic ovary syndrome, primary ovarian insufficiency, obesity, thyroid dysfunction, adrenal disorders. diagnostic approach outlined, emphasizing necessity hormonal studies response assessments. Additionally, treatment plan presented, commencing with non-pharmacological interventions, encompassing adoption a Mediterranean diet, vitamin supplementation, moderate exercise, maintaining healthy weight. Subsequently, pharmacological discussed, focusing management associated disorders ovulatory dysfunction.Expert opinion This highlights impact fertility women, providing therapeutic algorithms. Despite remaining knowledge gaps that hinder more effective treatments, ongoing research advancements show promise improved success rates within next five years. Enhanced comprehension behind progress genetic will facilitate delivery personalized thus enhancing rates.KEYWORDS: Fertilityfemale infertilityanovulationreproductive healthovarian reservehormones Article Correcting underlying abnormalities enhances most patients.Polycystic syndrome common cause anovulation.Hormonal evaluation crucial assessment female causes.Ovarian reserve should be evaluated antimüllerian hormone imaging.Healthy lifestyles contribute improving fertility.Declaration interestThe authors have no relevant affiliations or financial involvement any organization entity interest conflict subject matter materials discussed manuscript. includes employment, consultancies, honoraria, stock ownership options, expert testimony, grants patents received pending, royalties.Reviewer disclosuresPeer reviewers this manuscript other relationships disclose.Author contribution statementJEQA MJCZ designed outline article review. JEQA, JCA, MCDV, ERGO, JSR, SPIN LPRR were main writers performed literature JPI prepared All read approved final manuscript.Additional informationFundingThis paper not funded.

Language: Английский

Citations

6
Consequences of the exposome to gestational diabetes mellitus DOI
Marilza Vieira Cunha Rudge, Fernanda Cristina Bérgamo Alves,

Raghavendra L.S. Hallur

et al.

Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2022, Volume and Issue: 1867(2), P. 130282 - 130282

Published: Nov. 25, 2022

Language: Английский

Citations

7
Grappling with Issues of Motherhood for Women with Schizophrenia DOI Open Access
Mary V. Seeman

Healthcare, Journal Year: 2023, Volume and Issue: 11(21), P. 2882 - 2882

Published: Nov. 2, 2023

Despite the fact that most persons with schizophrenia find steady employment difficult to sustain, many women this diagnosis embrace and fulfill task of all—motherhood. The aim paper is specify challenges motherhood in population review treatment strategies needed keep mothers children safe, protecting health fostering growth. addresses concerns had been brought author’s earlier attention during her clinical involvement an outpatient clinic for psychosis. It is, thus, a non-systematic, narrative topic areas subjectively assessed as essential “good enough” mothering context schizophrenia. Questions explored are stigma against population, mothers’ painful choices, issues contraception, abortion, child custody, foster care kin placement children, effects antipsychotics, specific perinatal delusional syndromes, and, finally, availability parental support. This intended clinicians. Recommendations providers work collaboratively mothers, take note their strengths well failings, offer wide array family services, monitor households closely safety adherence, appreciating face daily.

Language: Английский

Citations

4
Outcomes of long-acting injectable antipsychotics use in pregnancy: A literature review DOI Open Access
Ana V. Pejčić, Srđjan Stefanović, Miloš Milosavljević

et al.

World Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 14(4), P. 582 - 599

Published: April 16, 2024

Women with a history of serious psychotic disorders are at increased risk disease relapse during pregnancy. Long-acting injectable (LAI) antipsychotics have been widely used to improve adherence and prevent in patients various severe disorders, but there is lack high-quality data from previous research on the safety LAI

Language: Английский

Citations

1