Effects of repetitive transcranial magnetic stimulation combined with repetitive peripheral magnetic stimulation on upper limb motor function after stroke: a systematic review and meta-analysis DOI Creative Commons

Shanshan Luo,

Wen Zhu,

Ying Liu

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 12, 2024

Objective To evaluate the effectiveness of repetitive transcranial magnetic stimulation (rTMS) combined with peripheral (rPMS) on upper limb motor dysfunction after stroke. Methods We systematically searched databases up to May 2024, including PubMed, Embase, Cochrane Library, Web Science, CNKI, VIP, Wanfang, and CBM. Randomized controlled trials (RCTs) examining application rTMS rPMS stroke were included based predefined inclusion criteria. used Risk Bias 2 tool assess bias risk RCTs. Meta-analysis was conducted using RevMan 5.4 Stata 17.0 software. Results A total 9 RCTs involving 483 participants in this study. Compared control groups that either conventional therapy or alone, experimental group showed significant improvements patients' function [MD = 3.65, 95% CI (2.75, 4.54), P < 0.05], ability daily living 4.50, (3.50, 5.50), spasticity –0.34, (−0.48, −0.20), 0.05]. Meanwhile, terms neurophysiological indicators, differences found both for evoked potential latency −1.77, (−3.19, −0.35), 0.05] amplitude 0.25, (0.01, 0.49), Conclusion This study provides low-level evidence LF-rTMS HF-rTMS can improve patients. However, given low quality evaluation results, further from high-quality studies is needed substantiate conclusion. Systematic review registration https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024539195 , PROSPERO Platform [CRD42024539195].

Language: Английский

Frontotemporal dementia. How to deal with its diagnostic complexity? DOI Creative Commons
Annibale Antonioni,

Emanuela Maria Raho,

Enrico Granieri

et al.

Expert Review of Neurotherapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Frontotemporal dementia (FTD) encompasses a group of heterogeneous neurodegenerative disorders. Aside from genetic cases, its diagnosis is challenging, particularly in the early stages when symptoms are ambiguous, and structural neuroimaging does not reveal characteristic patterns. The authors performed comprehensive literature search through MEDLINE, Scopus, Web Science databases to gather evidence aid diagnostic process for suspected FTD patients, phases, even sporadic ranging established promising tools. Blood-based biomarkers might help identify very neuropathological guide further evaluations. Subsequently, neurophysiological measures reflecting functional changes cortical excitatory/inhibitory circuits, along with assessing brain network, connectivity, metabolism, perfusion alterations, could detect specific associated decades before symptom onset. As advances, cognitive-behavioral profiles atrophy patterns emerge, distinguishing subtypes. Emerging disease-modifying therapies require patient enrollment. Therefore, paradigm shift needed - relying on typical cognitive advanced cases widely applicable biomarkers, primarily fluid and, subsequently, where appropriate. Additionally, exploring subjective complaints behavioral detected by home-based technologies be crucial diagnosis.

Language: Английский

Citations

2
Cortico–Cortical Paired Associative Stimulation (ccPAS) in Ageing and Alzheimer’s Disease: A Quali-Quantitative Approach to Potential Therapeutic Mechanisms and Applications DOI Creative Commons
Chiara Di Fazio, Marco Tamietto, Mario Stanziano

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 237 - 237

Published: Feb. 24, 2025

Background/Objectives: Cognitive decline and Alzheimer’s disease (AD) pose a major challenge for the ageing population, with impaired synaptic plasticity playing central role in their pathophysiology. This article explores hypothesis that cortico–cortical paired associative stimulation (ccPAS), non-invasive brain technique, can restore function by targeting spike-timing-dependent (STDP), key mechanism disrupted AD. Methods: We reviewed existing studies investigating effects of ccPAS on neuroplasticity both AD populations. Results: Findings suggest age-specific effects, improving motor performance young adults but showing limited efficacy older adults, likely due to age-related declines cortical excitability. In AD, reveal significant impairments long-term potentiation (LTP)-like plasticity, while depression (LTD)-like mechanisms appear relatively preserved, emphasising need targeted neuromodulation approaches. Conclusions: Despite promising preliminary results, evidence remains largely focused function, impact cognitive domains still underexplored. To bridge this gap, future research should focus larger more diverse cohorts optimise protocols populations investigate its potential enhancing function. By refining parameters integrating neuroimageing-based personalisation strategies, may represent novel therapeutic approach mitigating deficits neurodegenerative conditions.

Language: Английский

Citations

2
The cerebellum and the Mirror Neuron System: A matter of inhibition? From neurophysiological evidence to neuromodulatory implications. A narrative review DOI Creative Commons
Annibale Antonioni,

Emanuela Maria Raho,

Sofía Straudi

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 164, P. 105830 - 105830

Published: July 26, 2024

Mirror neurons show activity during both the execution (AE) and observation of actions (AO). The Neuron System (MNS) could be involved motor imagery (MI) as well. Extensive research suggests that cerebellum is interconnected with MNS may critically in its activities. We gathered evidence on cerebellum's role functions, theoretically experimentally. Evidence shows plays a major AO MI lesions impair functions likely because, by modulating cortical inhibitory interneurons mirror properties, contribute to visuomotor matching, which fundamental for shaping properties. Indeed, strengthen sensory-motor patterns minimise discrepancy between predicted actual outcome, AE AO. Furthermore, through connections hippocampus, might internal simulations programs MI. Finally, cerebellar neuromodulation improve impact activity, we explored potential neurophysiological neurorehabilitation implications.

Language: Английский

Citations

16
Visuomotor paired associative stimulation enhances corticospinal excitability in post-stroke patients with upper-limb hemiparesis DOI Creative Commons
Michela Picardi, Giacomo Guidali, Antonio Caronni

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 1, 2025

Language: Английский

Citations

0
The cerebellum in frontotemporal dementia: from neglected bystander to potential neuromodulatory target. A narrative review DOI Creative Commons
Annibale Antonioni,

Emanuela Maria Raho,

Danny Spampinato

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: 174, P. 106194 - 106194

Published: May 3, 2025

Though cortical changes in frontotemporal dementia (FTD) are well-documented, the cerebellum's role, closely linked to these areas, remains unclear. To provide evidence on cerebellar involvement FTD across clinical, genetic, imaging, neuropathological, and neurophysiological perspectives. Additionally, we sought supporting application of non-invasive brain stimulation (NIBS) for both diagnostic therapeutic purposes. We performed a literature review using MEDLINE (via PubMed), Scopus, Web Science databases. emphasized specific regions which differentiate each subtypes may account some characteristic symptoms. Furthermore, highlighted peculiarities genetic alterations. Finally, outlined role cerebellum pathogenesis. The is critically involved spectrum. Moreover, it can be speculated that modulation, as already shown other neurodegenerative disorders, could restore interneuronal intracortical circuits typically impaired patients, providing clinical improvements fundamental outcome measures trials.

Language: Английский

Citations

0
Visuomotor paired associative stimulation for post-stroke hand motor impairments DOI Creative Commons
Michela Picardi, Giacomo Guidali, Antonio Caronni

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

ABSTRACT Objectives We assess the effectiveness of a visuomotor paired associative stimulation (vm-PAS) protocol targeting Action Observation Network (AON) in patients with chronic post-stroke upper-limb hemiparesis. Vm-PAS consisted hand-grasping action observation stimuli repeatedly transcranial magnetic (TMS) pulses over ipsilesional primary motor cortex (M1). Methods Fifteen underwent session vm-PAS and, as control, standard excitatory PAS (M1-PAS), during which slow-rate electrical paretic limb was M1-TMS. Before and after each PAS, we assessed corticospinal excitability (CSE), short-interval intracortical inhibition (SICI), wrist’s voluntary movements. Results The two protocols induce distinct muscle-specific CSE enhancements: increases motor- evoked potentials (MEPs) recorded from first dorsal interosseous muscle. Conversely, M1-PAS MEPs electrically stimulated extensor carpi radialis efficacy correlates hemiparesis chronicity: higher time elapsed since stroke, greater effects on CSE. Neither affected SICI or wrist Conclusion leads to enhancements patients, highlighting its potential for driving recovery. Significance Our findings show cross-modal AON an injured system.

Language: Английский

Citations

1
Effects of repetitive transcranial magnetic stimulation combined with repetitive peripheral magnetic stimulation on upper limb motor function after stroke: a systematic review and meta-analysis DOI Creative Commons

Shanshan Luo,

Wen Zhu,

Ying Liu

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 12, 2024

Objective To evaluate the effectiveness of repetitive transcranial magnetic stimulation (rTMS) combined with peripheral (rPMS) on upper limb motor dysfunction after stroke. Methods We systematically searched databases up to May 2024, including PubMed, Embase, Cochrane Library, Web Science, CNKI, VIP, Wanfang, and CBM. Randomized controlled trials (RCTs) examining application rTMS rPMS stroke were included based predefined inclusion criteria. used Risk Bias 2 tool assess bias risk RCTs. Meta-analysis was conducted using RevMan 5.4 Stata 17.0 software. Results A total 9 RCTs involving 483 participants in this study. Compared control groups that either conventional therapy or alone, experimental group showed significant improvements patients' function [MD = 3.65, 95% CI (2.75, 4.54), P < 0.05], ability daily living 4.50, (3.50, 5.50), spasticity –0.34, (−0.48, −0.20), 0.05]. Meanwhile, terms neurophysiological indicators, differences found both for evoked potential latency −1.77, (−3.19, −0.35), 0.05] amplitude 0.25, (0.01, 0.49), Conclusion This study provides low-level evidence LF-rTMS HF-rTMS can improve patients. However, given low quality evaluation results, further from high-quality studies is needed substantiate conclusion. Systematic review registration https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024539195 , PROSPERO Platform [CRD42024539195].

Language: Английский

Citations

0