Quercetin Nanoemulsion Ameliorates Neuronal Dysfunction in Experimental Alzheimer’s Disease Model DOI Creative Commons
Nouf K. Alaqeel, Mona Hmoud AlSheikh, Mohammed Al-Hariri

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(10), P. 1986 - 1986

Published: Oct. 5, 2022

Aluminum is the most abundant metal that can get admission to human through several means include our food, drinking water, cans, drugs, and deodorants, causing neurodegenerative diseases such as Alzheimer's disease (AD). The present study aims evaluate role of quercetin nanoemulsion (QCNE) in attenuating neuronal dysfunction aluminum chloride (AlCl3)-induced experimental AD. All animals were classified into six groups including negative control group (I): received a vehicle; QC group: intraperitoneal (IP) injection QC; AlCl3 orally; treated orally IP (II): (III): QCNE. At end period (30 days), brain was used biochemical parameters (measurement neurotransmitters (serotonin, dopamine, norepinephrine), oxidant/antioxidant (reduced glutathione, malondialdehyde, superoxide dismutase, advanced oxidation protein product), inflammatory markers (adiponectin, interleukin 1β, plasma tumor necrosis factor-alpha)), while another part for immune-histochemical analysis (study cyclooxygenases (COX-1 COX-2)). Results showed mean value oxidative stress significantly increased AD well biomarkers all neurotransmitters, whereas these attenuated groups, especially those immunohistochemistry findings confirm results. Both approaches (QC QCNE) succeeded retracting impact AlCl3. Meanwhile, effect QCNE more potent mitigating mediated by animals. In conclusion, treatment mainly has huge potential protecting against AlCl3-induced dysfunction, shown results elevation antioxidant/anti-inflammatory activities neurotransmitter levels mending histopathological changes animal models.

Language: Английский

Anti-inflammatory effects of flavonoids DOI
Soheila J. Maleki,

Jesús F. Crespo,

Beatriz Cabanillas

et al.

Food Chemistry, Journal Year: 2019, Volume and Issue: 299, P. 125124 - 125124

Published: July 3, 2019

Language: Английский

Citations

1008
Polyphenols: A concise overview on the chemistry, occurrence, and human health DOI
Alessandra Durazzo, Massimo Lucarini, Eliana B. Souto

et al.

Phytotherapy Research, Journal Year: 2019, Volume and Issue: 33(9), P. 2221 - 2243

Published: July 29, 2019

This review gives an updated picture of each class phenolic compounds and their properties. The most common classification implies the subdivision phenolics in two main groups: flavonoids (e.g., anthocyanins, flavanols, flavanones, flavonols, flavonones, isoflavones) non‐flavonoids acids, xanthones, stilbens, lignans, tannins) polyphenols. great interest polyphenols is associated with high potential application for food preservation therapeutic beneficial use. relationship between polyphenol intake human health has been exploited special reference to cardiovascular diseases, hypertension, diabetes, metabolic syndrome, obesity, cancer. use current existing databases bioactive including described as key tools research.

Language: Английский

Citations

656
The Effects of Flavonoids in Cardiovascular Diseases DOI Creative Commons

Lorena Ciumărnean,

Mircea Vasile Milaciu,

Octavia Runcan

et al.

Molecules, Journal Year: 2020, Volume and Issue: 25(18), P. 4320 - 4320

Published: Sept. 21, 2020

Flavonoids are metabolites of plants and fungus. Flavonoid research has been paid special attention to in recent times after the observation their beneficial effects on cardiovascular system. These favorable exerted by flavonoids mainly due antioxidant properties, which result from ability decrease oxidation low-density lipoproteins, thus improving lipid profiles. The other positive effect system is produce vasodilation regulate apoptotic processes endothelium. Researchers suggested that these effects, including anti-inflammatory function, consequences flavonoids’ potent but studies have shown multiple signaling pathways linked them, suggesting there more mechanisms involved human body. This review aims present latest data classification substances, main action body, physiological pathological status

Language: Английский

Citations

319
Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies DOI Open Access

Gopalsamy Rajiv Gandhi,

Alan Bruno Silva Vasconcelos, Ding‐Tao Wu

et al.

Nutrients, Journal Year: 2020, Volume and Issue: 12(10), P. 2907 - 2907

Published: Sept. 23, 2020

The consumption of plant-based food is important for health promotion, especially concerning the prevention and management chronic diseases. Flavonoids are main bioactive compounds in citrus fruits, with multiple beneficial effects, antidiabetic effects. We systematically review potential action molecular mechanisms flavonoids based on vitro vivo studies. A search PubMed, EMBASE, Scopus, Web Science Core Collection databases articles published since 2010 was carried out using keywords citrus, flavonoid, diabetes. All identified were analyzed, data extracted a standardized form. 38 articles, which reported that 19 flavonoids, including 8-prenylnaringenin, cosmosiin, didymin, diosmin, hesperetin, hesperidin, isosiennsetin, naringenin, naringin, neohesperidin, nobiletin, poncirin, quercetin, rhoifolin, rutin, sineesytin, sudachitin, tangeretin, xanthohumol, have potential. These regulated biomarkers glycemic control, lipid profiles, renal function, hepatic enzymes, antioxidant modulated signaling pathways related to glucose uptake insulin sensitivity involved pathogenesis diabetes its complications. Citrus therefore, promising candidates, while their effects remain be verified forthcoming human

Language: Английский

Citations

206
Role of Phenylpropanoids and Flavonoids in Plant Resistance to Pests and Diseases DOI Creative Commons
Marie‐Louisa Ramaroson,

Claude Koutouan,

Jean‐Jacques Hélesbeux

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(23), P. 8371 - 8371

Published: Nov. 30, 2022

Phenylpropanoids and flavonoids are specialized metabolites frequently reported as involved in plant defense to biotic or abiotic stresses. Their biosynthetic accumulation may be constitutive and/or induced response external stimuli. They participate signaling driving responses, act a physical chemical barrier prevent invasion, direct toxic weapon against microbial insect targets. protective action is described the combinatory effect of their localization during host’s interaction with aggressors, sustained availability, predominance specific compounds synergy others. biosynthesis regulation partly deciphered; however, lot gaps knowledge remain filled. mode on microorganisms insects probably arises from an interference important cellular machineries structures, yet this not fully understood for all type pests pathogens. We present here overview advances state art both phenylpropanoids objective paving way breeders looking natural sources resistance improve varieties. Examples provided types that targeted crop protection. For purpose, fields phytopathology, phytochemistry, human health were explored.

Language: Английский

Citations

145
The potential of anthocyanins in smart, active, and bioactive eco-friendly polymer-based films: A review DOI Creative Commons
Josemar Gonçalves de Oliveira Filho, Anna Rafaela Cavalcante Braga,

Bianca Ribeiro de Oliveira

et al.

Food Research International, Journal Year: 2021, Volume and Issue: 142, P. 110202 - 110202

Published: Feb. 10, 2021

Language: Английский

Citations

144
Unique roles in health promotion of dietary flavonoids through gut microbiota regulation: Current understanding and future perspectives DOI
Zhanming Li, Zhongyang Ren, Lin Zhao

et al.

Food Chemistry, Journal Year: 2022, Volume and Issue: 399, P. 133959 - 133959

Published: Aug. 18, 2022

Language: Английский

Citations

74
Polyphenols: Secondary Metabolites with a Biological Impression DOI Open Access
Ecem Bolat, Sümeyye Sarıtaş, Hatice Duman

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(15), P. 2550 - 2550

Published: Aug. 3, 2024

Polyphenols are natural compounds which plant-based bioactive molecules, and have been the subject of growing interest in recent years. Characterized by multiple varieties, polyphenols mostly found fruits vegetables. Currently, many diseases waiting for a cure or solution to reduce their symptoms. However, drug other chemical strategies limitations using treatment agent still detection tool diseases, thus researchers need investigate preventive improving treatment. Therefore, it is elucidate polyphenols, bioactivity effects, supplementation, consumption. The disadvantage that they limited bioavailability, although beneficial outcomes with roles. In this context, several different developed improve particularly liposomal nanoparticles. As nutrition one most important factors health, inclusion molecules daily diet significant continues be enthusiastically researched. Nutrition, individuals all ages, key polyphenols.

Language: Английский

Citations

21
Dietary flavonoid actions on senescence, aging, and applications for health DOI
Bruce A. Watkins, Alyson E. Mitchell, Andrew C. Shin

et al.

The Journal of Nutritional Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 109862 - 109862

Published: Feb. 1, 2025

Language: Английский

Citations

3
Flavonoids and Mitochondria: Activation of Cytoprotective Pathways? DOI Creative Commons
Anna Kicińska, Wiesława Jarmuszkiewicz

Molecules, Journal Year: 2020, Volume and Issue: 25(13), P. 3060 - 3060

Published: July 4, 2020

A large number of diverse mechanisms that lead to cytoprotection have been described date. Perhaps, not surprisingly, the role mitochondria in these phenomena is notable. In addition being metabolic centers, due their cell catabolism, ATP synthesis, and biosynthesis organelles are triggers and/or end-effectors a signaling pathways. Their regulation intrinsic apoptotic pathway, calcium homeostasis, reactive oxygen species well documented. this review, we aim characterize prospects influencing cytoprotective mitochondrial routes by natural substances plant origin, namely, flavonoids (e.g., flavanones, flavones, flavonols, flavan-3-ols, anthocyanidins, isoflavones). Flavonoids family widely distributed secondary metabolites known for beneficial effects on human health applied traditional medicine. pharmacological characteristics include antioxidative, anticarcinogenic, anti-inflammatory, antibacterial, antidiabetic properties. Here, focus presenting mitochondria-mediated against various insults. Thus, as antioxidants modulators antioxidant cellular response, apoptosis, biogenesis, autophagy, fission fusion reported. Finally, an emerging field flavonoid-mediated changes activity ion channels outlined.

Language: Английский

Citations

91