Recent developments in the probiotics as live biotherapeutic products (LBPs) as modulators of gut brain axis related neurological conditions DOI Creative Commons
Duygu Ağagündüz, Feray Gençer Bingöl, Elif Çelik

et al.

Journal of Translational Medicine, Journal Year: 2022, Volume and Issue: 20(1)

Published: Oct. 8, 2022

Abstract Probiotics have been defined as “living microorganisms that create health benefits in the host when taken sufficient amounts. Recent developments understanding of relationship between microbiom and its shown evidence about promising potential probiotics to improve certain problems. However, today, there are some confusions traditional new generation foods containing probiotics, naming classifications them scientific studies also their marketing. To clarify this confusion, Food Drug Administration (FDA) declared it has made a category definition called "live biotherapeutic products" (LBPs). Accordingly, FDA designated LBPs “ biological product that: i)contains live organisms, such bacteria; ii)is applicable prevention, treatment, or cure disease/condition human beings; iii) is not vaccine ”. The accumulated literature focused on determine effective strains disease, often obesity, diabetes, diseases like inflammatory bowel disease (IBD).However, microbiome play an important role pathogenesis age day by modern world via gut-brain axis. Herein, we discuss novel roles axis related conditions light recent studies. This article may be interest broad readership including those interested LBPs, effects safety,

Language: Английский

Gut–Brain Axis: Role of Gut Microbiota on Neurological Disorders and How Probiotics/Prebiotics Beneficially Modulate Microbial and Immune Pathways to Improve Brain Functions DOI Open Access

Suganya Kanmani,

Byung‐Soo Koo

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(20), P. 7551 - 7551

Published: Oct. 13, 2020

The gut microbiome acts as an integral part of the gastrointestinal tract (GIT) that has largest and vulnerable surface with desirable features to observe foods, nutrients, environmental factors, well differentiate commensals, invading pathogens, others. It is well-known a strong connection central nervous system (CNS) in context health disease. A healthy diverse microbes vital for normal brain functions emotional behaviors. In addition, CNS controls most aspects GI physiology. molecular interaction between gut/microbiome complex bidirectional, ensuring maintenance homeostasis proper digestion. Besides this, several mechanisms have been proposed, including endocrine, neuronal, toll-like receptor, metabolites-dependent pathways. Changes bidirectional relationship GIT are linked pathogenesis neurological disorders; therefore, microbiota/gut-and-brain axis emerging widely accepted concept. this review, we summarize recent findings supporting role microbiota immune on development disorders. highlight advances improving diseases by probiotics/prebiotics/synbiotics fecal transplantation via concept gut–brain axis.

Language: Английский

Citations

244
Probiotics and fructo-oligosaccharide intervention modulate the microbiota-gut brain axis to improve autism spectrum reducing also the hyper-serotonergic state and the dopamine metabolism disorder DOI
Ying Wang, Ning Li, Junjie Yang

et al.

Pharmacological Research, Journal Year: 2020, Volume and Issue: 157, P. 104784 - 104784

Published: April 17, 2020

Language: Английский

Citations

229
The food-gut axis: lactic acid bacteria and their link to food, the gut microbiome and human health DOI Creative Commons
Francesca De Filippis, Edoardo Pasolli, Danilo Ercolini

et al.

FEMS Microbiology Reviews, Journal Year: 2020, Volume and Issue: 44(4), P. 454 - 489

Published: May 20, 2020

ABSTRACT Lactic acid bacteria (LAB) are present in foods, the environment and animal gut, although fermented foods (FFs) recognized as primary niche of LAB activity. Several strains have been studied for their health-promoting properties employed probiotics. FFs potential beneficial effects, which we review this article. They also an important source LAB, ingested daily upon FF consumption. In review, describe diversity occurrence food well gut microbiome. We discuss opportunities to study functional by considering availability both genomic metagenomic data public repositories, different latest computational tools analysis. addition, role probiotics reporting prevalence key features genomes surveying outcomes use clinical trials involving human subjects. Finally, highlight need further studies aimed at improving our knowledge link between LAB-fermented from perspective health promotion.

Language: Английский

Citations

208
The role of the microbiota-gut-brain axis in neuropsychiatric disorders DOI Creative Commons
Jaqueline S. Generoso, Vijayasree V. Giridharan, June‐Young Lee

et al.

Brazilian Journal of Psychiatry, Journal Year: 2020, Volume and Issue: 43(3), P. 293 - 305

Published: July 12, 2020

The microbiota-gut-brain axis is a bidirectional signaling mechanism between the gastrointestinal tract and central nervous system. complexity of intestinal ecosystem extraordinary; it comprises more than 100 trillion microbial cells that inhabit small large intestine, this interaction microbiota epithelium can cause physiological changes in brain influence mood behavior. Currently, there has been an emphasis on how such interactions affect mental health. Evidence indicates are involved neurological psychiatric disorders. This review covers evidence for gut behavior Alzheimer disease, dementia, anxiety, autism spectrum disorder, bipolar major depressive Parkinson's schizophrenia. primary focus pathways metabolites origin, including short-chain fatty acids, tryptophan metabolites, bacterial components activate host's immune We also list clinical regarding prebiotics, probiotics, fecal transplantation as adjuvant therapies neuropsychiatric

Language: Английский

Citations

157
Gut microbiome and human health: Exploring how the probiotic genus Lactobacillus modulate immune responses DOI Creative Commons

Sonakshi Rastogi,

Aditi Singh

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 24, 2022

The highest density of microbes resides in human gastrointestinal tract, known as “Gut microbiome”. Of note, the members genus Lactobacillus that belong to phyla Firmicutes are most important probiotic bacteria gut microbiome. These gut-residing species not only communicate with each other but also epithelial lining balance barrier integrity, mucosal defence and ameliorate host immune responses. body suffers from several inflammatory diseases affecting gut, lungs, heart, bone or neural tissues. Mounting evidence supports significant role spp. their components (such metabolites, peptidoglycans, and/or surface proteins) modulatingimmune responses, primarily through exchange immunological signals between tract distant organs. This bidirectional crosstalk which is mediated by promotes anti-inflammatory response, thereby supporting improvement symptoms pertaining asthma, chronic obstructive pulmonary disease (COPD), neuroinflammatory multiple sclerosis, alzheimer’s disease, parkinson’s disease), cardiovascular diseases, bowel (IBD) infections patients. metabolic disorders, obesity diabetes characterized a low-grade inflammation. Genus alleviates disorders regulating oxidative stress response pathways. Osteoporosis associated inflammation resorption. metabolites act powerful cell controllers exhibit regulatory resorption formation, health. Thus, this review demonstrated mechanisms summarized benefit alleviating different organs animal clinical trials. present narrative explores detail complex interactions gut-dwelling promote host’s

Language: Английский

Citations

139
Health-Promoting Role of Lactiplantibacillus plantarum Isolated from Fermented Foods DOI Creative Commons
Natalia García-González, Natalia Battista, Roberta Prete

et al.

Microorganisms, Journal Year: 2021, Volume and Issue: 9(2), P. 349 - 349

Published: Feb. 10, 2021

Fermentation processes have been used for centuries food production and preservation. Besides the contribution of fermentation to quality, recently, scientific interest in beneficial nature fermented foods as a reservoir probiotic candidates is increasing. Fermented microbes are gaining attention their health-promoting potential being genetically related human bacteria. Among them,

Language: Английский

Citations

136
Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications DOI Creative Commons

Chen-Chen Jiang,

Lishan Lin,

Sen Long

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: July 11, 2022

Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental which has strong genetic basis. Despite the rapidly rising incidence of autism, little known about its aetiology, risk factors, disease progression. There are currently neither validated biomarkers for diagnostic screening nor specific medication autism. Over last two decades, there have been remarkable advances in genetics, with hundreds genes identified as being associated high The convergence neuroscience methods becoming more widely recognized significance elucidating pathological mechanisms Efforts devoted to exploring behavioural functions, key potential treatments Here, we highlight this review, emerging evidence shows that signal transduction molecular events involved processes such transcription, translation, synaptic transmission, epigenetics immunoinflammatory responses. This involvement important implications discovery precise targets Moreover, review recent insights into clinical autism from molecular, cellular, neural circuit, neurobehavioural aspects. Finally, challenges future perspectives discussed regard novel strategies predicated on biological features

Language: Английский

Citations

132
Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle DOI
Saravana Babu Chidambaram, Musthafa Mohamed Essa,

Annan Gopinath Rathipriya

et al.

Pharmacology & Therapeutics, Journal Year: 2021, Volume and Issue: 231, P. 107988 - 107988

Published: Sept. 16, 2021

Language: Английский

Citations

124
The Role of Microbiome in Brain Development and Neurodegenerative Diseases DOI Creative Commons

Varsha Nandwana,

Nitesh Kumar Nandwana,

Yogarupa Das

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(11), P. 3402 - 3402

Published: May 25, 2022

Hundreds of billions commensal microorganisms live in and on our bodies, most which colonize the gut shortly after birth stay there for rest lives. In animal models, bidirectional communications between central nervous system microbiota (Gut-Brain Axis) have been extensively studied, it is clear that changes composition play a vital role pathogenesis various neurodevelopmental neurodegenerative disorders, such as Autism Spectrum Disorder, Alzheimer's disease, Parkinson's Multiple Sclerosis, Amyotrophic Lateral anxiety, stress, so on. The makeup microbiome impacted by variety factors, genetics, health status, method delivery, environment, nutrition, exercise, present understanding its metabolites preservation brain functioning development aforementioned neurological illnesses summarized this review article. Furthermore, we discuss current breakthroughs use probiotics, prebiotics, synbiotics to address illnesses. Moreover, also discussed boron-based diet memory, boron relation, anti-inflammatory agents, diseases. addition, coming years, reagents will significant improve dysbiosis open new areas researchers.

Language: Английский

Citations

78
Next-Generation Probiotics as Novel Therapeutics for Improving Human Health: Current Trends and Future Perspectives DOI Creative Commons
Mohamed E. Abouelela, Yosra A. Helmy

Microorganisms, Journal Year: 2024, Volume and Issue: 12(3), P. 430 - 430

Published: Feb. 20, 2024

Next-generation probiotics (NGPs) represent an innovative group of beneficial bacteria that are currently undergoing research and development. NGPs designed not only for conventional use as foods or dietary supplements but also tailored pharmaceutical applications. Research indicates show therapeutic promise in addressing various chronic ailments. Offering multiple advantages over probiotics, present opportunities personalized probiotic therapies, involvement synthetic biology gene editing, participation combination targeted delivery methods, application settings. Our review discusses the potential effect NGPs, covering diverse trajectories including their identification, characterization, delivery. Furthermore, this elucidates influence on critical aspects human health, specifically, gut immune function, broader health outcomes. Mechanistic insights encompass production bioactive compounds, competitive interactions with pathogenic bacteria, modulation cell activity, reinforcement barrier. What is noteworthy current points out prevalent NGP strains sources, providing a highlight comprehensive framework understanding applications future benefits domain advanced therapeutics.

Language: Английский

Citations

55