Effects of Time-Restricted Eating on Weight Loss and Other Metabolic Parameters in Women and Men With Overweight and Obesity

JAMA Internal Medicine, Journal Year: 2020, Volume and Issue: 180(11), P. 1491 - 1491

Published: Sept. 28, 2020

The efficacy and safety of time-restricted eating have not been explored in large randomized clinical trials.

Language: Английский

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Effectiveness of Intermittent Fasting and Time-Restricted Feeding Compared to Continuous Energy Restriction for Weight Loss

Nutrients, Journal Year: 2019, Volume and Issue: 11(10), P. 2442 - 2442

Published: Oct. 14, 2019

The current obesity epidemic is staggering in terms of its magnitude and public health impact. Current guidelines recommend continuous energy restriction (CER) along with a comprehensive lifestyle intervention as the cornerstone treatment, yet this approach produces modest weight loss on average. Recently, there has been increased interest identifying alternative dietary strategies that involve restricting intake to certain periods day or prolonging fasting interval between meals (i.e., intermittent restriction, IER). These include (IMF; >60% 2-3 days per week, alternate days) time-restricted feeding (TRF; limiting daily period food 8-10 h less most week). Here, we summarize evidence for IER regimens treatments overweight obesity. Specifically, review randomized trials ≥8 weeks duration performed adults (BMI ≥ 25 kg/m2) which an paradigm (IMF TRF) was compared CER, primary outcome being loss. Overall, available suggests paradigms produce equivalent when 9 out 11 studies reviewed showing no differences groups body fat

Language: Английский

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Time‐Restricted Eating Effects on Body Composition and Metabolic Measures in Humans who are Overweight: A Feasibility Study

Obesity, Journal Year: 2020, Volume and Issue: 28(5), P. 860 - 869

Published: April 9, 2020

In contrast to intentionally restricting energy intake, the eating window may be an option for treating obesity. By comparing time-restricted (TRE) with unrestricted (non-TRE) control, it was hypothesized that TRE facilitates weight loss, alters body composition, and improves metabolic measures.Participants (17 women 3 men; mean [SD]: 45.5 [12.1] years; BMI 34.1 [7.5] kg/m2 ) a prolonged (15.4 [0.9] hours) were randomized (n = 11: 8-hour window, within window) versus non-TRE 9: eating) 12 weeks. Weight, composition (dual x-ray absorptiometry), lipids, blood pressure, 2-hour oral glucose tolerance, 2-week continuous monitoring, physical activity (actigraphy assessed) measured during pre- end-intervention periods.The group significantly reduced (end-intervention window: 9.9 [2.0] compared 15.1 [1.1] (P < 0.01). Compared non-TRE, decreased number of occasions, weight, lean mass, visceral fat (all P ≤ 0.05). preintervention measures, occasions (-21.9% [30.1%]) (-3.7% [1.8%]), mass (-4% [2.9%]), (-3.0% [2.7%]), (-11.1% [13.4%]) Physical measures remained unchanged.In setting trial, presents simplified view food intake reduces weight.

Language: Английский

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Time-restricted Eating for the Prevention and Management of Metabolic Diseases

Endocrine Reviews, Journal Year: 2021, Volume and Issue: 43(2), P. 405 - 436

Published: Sept. 22, 2021

Time-restricted feeding (TRF, animal-based studies) and time-restricted eating (TRE, humans) are an emerging behavioral intervention approach based on the understanding of role circadian rhythms in physiology metabolism. In this approach, all calorie intake is restricted within a consistent interval less than 12 hours without overtly attempting to reduce calories. This article will summarize origin TRF/TRE starting with concept chronic rhythm disruption increasing risk for metabolic diseases. Circadian usually perceived as sleep-wake cycle dependent arising from central nervous system. However, recent discovery peripheral organs plasticity these response changes nutrition availability raised possibility that adopting daily short window can sustain robust rhythm. Preclinical animal studies have demonstrated proof identified potential mechanisms driving TRF-related benefits. Pilot human reported promising results reducing obesity, diabetes, cardiovascular Epidemiological indicated maintaining long overnight fast, which similar TRE, significantly risks Despite early successes, more clinical mechanistic needed implement TRE alone or adjuvant lifestyle prevention management

Language: Английский

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Autophagy and the hallmarks of aging

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 72, P. 101468 - 101468

Published: Sept. 24, 2021

Language: Английский

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Beneficial Effects of Time-Restricted Eating on Metabolic Diseases: A Systemic Review and Meta-Analysis

Nutrients, Journal Year: 2020, Volume and Issue: 12(5), P. 1267 - 1267

Published: April 29, 2020

Various behavioral and physiological pathways follow a pre-determined, 24 hour cycle known as the circadian rhythm. Metabolic homeostasis is regulated by Time-restricted eating (TRE) type of intermittent fasting based on In this study, we aim to analyze systemically effects TRE body weight, composition, other metabolic parameters. We reviewed articles from PubMed, EMBASE, Cochrane Library identify clinical trials that compared regular diet. included 19 studies for meta-analysis. Participants following showed significantly reduced weight (mean difference (MD), −0.90; 95% confidence interval (CI): −1.71 −0.10) fat mass (MD: −1.58, CI: −2.64 −0.51), while preserving fat-free (MD, −0.24; −1.15 0.67). also beneficial cardiometabolic parameters such blood pressure (systolic BP, MD, −3.07; −5.76 −0.37), glucose concentration −2.96; CI, −5.60 −0.33), cholesterol profiles (triglycerides, MD: −11.60, −23.30 −0.27). conclusion, promising therapeutic strategy controlling improving dysfunctions in those who are overweight or obese. Further large-scale needed confirm these findings usefulness TRE.

Language: Английский

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Randomized controlled trial for time-restricted eating in healthy volunteers without obesity

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Feb. 22, 2022

Time-restricted feeding (TRF) improves metabolic health. Both early TRF (eTRF, food intake restricted to the part of day) and mid-day (mTRF, middle have been shown benefits. However, two regimens yet be thoroughly compared. We conducted a five-week randomized trial compare effects in healthy individuals without obesity (ChiCTR2000029797). The has completed. Ninety participants were eTRF (n=30), mTRF or control groups (n=30) using computer-based random-number generator. Eighty-two completed entire analyzed (28 eTRF, 26 mTRF, 28 groups). primary outcome was change insulin resistance. Researchers who assessed outcomes blinded group assignment, but care givers not. Here we show that more effective than at improving sensitivity. Furthermore, not improved fasting glucose, reduced total body mass adiposity, ameliorated inflammation, increased gut microbial diversity. No serious adverse events reported during trial. In conclusion, showed greater benefits for resistance related parameters compared with mTRF. Clinical Trial Registration URL: http://www.chictr.org.cn/showproj.aspx?proj=49406 .

Language: Английский

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Feeding Rhythms and the Circadian Regulation of Metabolism

Frontiers in Nutrition, Journal Year: 2020, Volume and Issue: 7

Published: April 17, 2020

The molecular circadian clock regulates metabolic processes within the cell, and alignment of these clocks between tissues is essential for maintenance homeostasis. possibility misalignment arises from differential responsiveness to environmental cues that synchronize (zeitgebers). Although light dominant cue master suprachiasmatic nucleus, many other are sensitive feeding fasting. When rhythms behaviour altered, example by shift work or constant availability highly palatable foods, strong feedback sent peripheral clocks. Varying degrees phase can cause systemic processes. Moreover, when there a endogenous in physiology inputs, such as during inactive phase, body's ability maintain homeostasis impaired. loss coordination organism environment, well internal tissues, produce cardiometabolic disease consequence. aim this review synthesize on mechanisms effects misalignment. timing food intake highlighted powerful with potential destroy restore synchrony metabolism.

Language: Английский

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Time-Restricted Eating: Benefits, Mechanisms, and Challenges in Translation

iScience, Journal Year: 2020, Volume and Issue: 23(6), P. 101161 - 101161

Published: May 15, 2020

Eating out of phase with daily circadian rhythms induces metabolic desynchrony in peripheral organs and may increase chronic disease risk. Time-restricted eating (TRE) is a dietary approach that consolidates all calorie intake to 6- 10-h periods during the active day, without necessarily altering diet quality quantity. TRE reduces body weight, improves glucose tolerance, protects from hepatosteatosis, increases flexibility, atherogenic lipids blood pressure, gut function cardiometabolic health preclinical studies. This review discusses importance meal timing on system, benefits models humans, possible mechanisms action, challenges we face implementing consequences delaying initiation TRE.

Language: Английский

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Effects of time-restricted feeding on body weight and metabolism. A systematic review and meta-analysis

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2019, Volume and Issue: 21(1), P. 17 - 33

Published: Dec. 6, 2019

Language: Английский

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