Potassium Intake and Blood Pressure: A Dose‐Response Meta‐Analysis of Randomized Controlled Trials

Journal of the American Heart Association, Journal Year: 2020, Volume and Issue: 9(12)

Published: June 5, 2020

Background Epidemiologic studies, including trials, suggest an association between potassium intake and blood pressure (BP). However, the strength shape of this relationship is uncertain. Methods Results We performed a meta-analysis to explore dose-response supplementation BP in randomized-controlled trials with duration ≥4 weeks using recently developed 1-stage cubic spline regression model. This model allows use at least 2 exposure categories. identified 32 eligible trials. Most were conducted adults hypertension crossover design doses that ranged from 30 140 mmol/d. observed U-shaped 24-hour active control arm differences excretion levels, weakening reduction effect above mmol/d increase ≈80 Achieved analysis also relationship. The BP-lowering effects stronger participants higher levels sodium intake. high was noted antihypertensive drug-treated but not their untreated counterparts. Conclusions nonlinear both systolic diastolic BP, although estimates for intakes should be interpreted caution because limited availability Our findings indicate adequate desirable achieve lower level excessive avoided, particularly specific subgroups.

Language: Английский

---

The Ketogenic Diet and Cardiovascular Diseases

Nutrients, Journal Year: 2023, Volume and Issue: 15(15), P. 3368 - 3368

Published: July 28, 2023

The most common and increasing causes of death worldwide are cardiovascular diseases (CVD). Taking into account the fact that diet is a key factor, it worth exploring this aspect CVD prevention therapy. aim article to assess potential ketogenic in treatment CVD. comprehensive, meticulous analysis literature area, taking recent studies currently available. has been shown have multifaceted effect on Among other aspects, beneficial blood lipid profile, even compared diets. It shows strong anti-inflammatory cardioprotective potential, which due, among factors, properties state ketosis, elimination simple sugars, restriction total carbohydrates supply omega-3 fatty acids. In addition, ketone bodies provide "rescue fuel" for diseased heart by affecting its metabolism. They also function vascular endothelium, including improving inhibiting premature ageing. pressure risk factors through, weight loss. evidence cited often superior standard diets, making likely advantages over dietary models diseases. There legitimate need further research area.

Language: Английский

---

Valorisation of By-Products from Soybean (Glycine max (L.) Merr.) Processing

Molecules, Journal Year: 2020, Volume and Issue: 25(9), P. 2129 - 2129

Published: May 1, 2020

In recent years, increased awareness of the health benefits associated with consuming soy-based foods, knowledge milk-related allergies and a move towards more sustainable food production have led to an increase in number available products. The biggest producers world, USA, South America China, are from Pacific region. This enormous is accompanied by accumulation related by-products, particular, substance that known as okara. Okara paste rich fibre (50%), protein (25%), fat (10%), vitamins trace elements. Its proper use would lead economic advantages reduction potential for polluting environment. high content low costs mean it could also be used dietary supplement prevent diabetes, obesity hyperlipidaemia. Chemical or enzymatic treatment, fermentation, extrusion, pressure micronisation can all soluble content, thus improve nutritional quality processing properties. However, product degrades rapidly due its moisture (70–80%), which makes difficult handle expensive dry conventional means. aim this paper therefore thoroughly study existing literature on subject order develop general protocol okara exploitation valorisation. A cost/benefit analysis drive design eco-friendly, protocols preparation high-value

Language: Английский

---

Non‐pharmacological management of hypertension

Journal of Clinical Hypertension, Journal Year: 2021, Volume and Issue: 23(7), P. 1275 - 1283

Published: March 18, 2021

Abstract Hypertension is an insidious disease which predisposes to cardiovascular complications and if not treated properly can lead various serious complications. Economic limitations, having additional benefits with few or almost no side effects have made non‐pharmacological management of hypertension attractive approach for dealing hypertension, in developed developing countries alike. A MEDLINE search was done relevant references emphasis on original studies, randomized controlled trials, meta‐analyses this review paper. Lifestyle modifications including changes the dietary pattern, adopting special diets low sodium, saturated fat high calcium, magnesium potassium trying new methods like time restricted meal intake work tandem circadian rhythm are opening vistas field hypertension. that effectively lower blood pressure increased physical activity, weight loss, limited alcohol consumption, relaxation techniques Yoga, Acupuncture, Tai chi, mindfulness‐based stress‐reduction program, Transcendental Meditation. Air pollution surrounding air linked poor health outcomes a major contributor global burden disease. Fine particulate matter <2.5 μm diameter (PM2.5) strongly associated morbidity mortality. Short‐term PM exposure (hours weeks) increases likelihood adverse events myocardial infarction, stroke, heart failure, longer‐term multiplies risk. Non‐pharmacological should be initiated early phase continued medication.

Language: Английский

---

Magnesium and Hypertension in Old Age

Nutrients, Journal Year: 2020, Volume and Issue: 13(1), P. 139 - 139

Published: Dec. 31, 2020

Hypertension is a complex condition in which various actors and mechanisms combine, resulting cardiovascular cerebrovascular complications that today represent the most frequent causes of mortality, morbidity, disability, health expenses worldwide. In last decades, there has been an exceptional amount experimental, epidemiological, clinical studies confirming close relationship between magnesium deficit high blood pressure. Multiple may help to explain bulk evidence supporting protective effect against hypertension its complications. increases sharply with advancing age, hence older persons are those affected by negative consequences. They also more frequently at risk deficiency multiple mechanisms, may, least part, higher frequency long-term The for favorable on emphasizes importance broadly encouraging intake foods such as vegetables, nuts, whole cereals legumes, optimal dietary sources magnesium, avoiding processed food, very poor other fundamental nutrients, order prevent hypertension. some cases, when diet not enough maintain adequate status, supplementation be benefit shown well tolerated.

Language: Английский

---

Nutraceuticals and blood pressure control: a European Society of Hypertension position document

Journal of Hypertension, Journal Year: 2020, Volume and Issue: 38(5), P. 799 - 812

Published: Jan. 24, 2020

: High-normal blood pressure (BP) is associated with an increased risk of cardiovascular disease, however the cost-benefit ratio use antihypertensive treatment in these patients not yet clear. Some dietary components and natural products seems to be able significantly lower BP without significant side effects. The aim this position document highlight which have most clinically action wheter they could suggested high-normal BP. Among foods, beetroot juice has covincing evidence effect. Antioxidant-rich beverages (teas, coffee) considered. nutrients, magnesium, potassium vitamin C supplements improve nonnutrient-nutraceuticals, soy isoflavones perimenopausal women, resveratrol insulin-resistant patients, melatonin study participants night hypertension. In any case, nutracutical approach never substitute drug treatment, when needed.

Language: Английский

---

Impact of Micronutrients on Hypertension: Evidence from Clinical Trials with a Special Focus on Meta-Analysis

Nutrients, Journal Year: 2021, Volume and Issue: 13(2), P. 588 - 588

Published: Feb. 10, 2021

Hypertension (HT) is one of the pivotal risk factors for various detrimental diseases like cardiovascular (CVDs), cerebrovascular disease, and renal dysfunction. Currently, many researchers are paying immense attention to diet formula (dietary approach) with a special focus on micro macronutrients along modified lifestyle standard anti-hypertensive drugs. Micronutrients (minerals/vitamins) play central role in regulation blood pressure (BP) as they aid function also improve functions some agents. Even though several studies have demonstrated beneficial effects micronutrients controlling BP, still ambiguity exists among nutritionists/doctors, which combination or individual mineral contributes better BP regulation. Therefore, this critical review article was attempted delineate underlying (minerals vitamins) management prevention delaying HT their related complications strong affirmation from clinical trials well its mechanism BP. Moreover, major source recommended daily allowance (RDA) included guiding common readers (especially subjects) dieticians choose/recommend micronutrient combinations (other nutrients drugs) lowering co-morbid conditions CVDs.

Language: Английский

---

Effects of the Mediterranean diet on the components of metabolic syndrome.

PubMed, Journal Year: 2022, Volume and Issue: 63(2 Suppl 3), P. E56 - E64

Published: June 1, 2022

Metabolic syndrome, also as known Syndrome X or Insulin Resistance Syndrome, is a complex health problem featuring visceral obesity (the main diagnostic criterion), insulin resistance, dyslipidemia and high blood pressure. Currently, this condition has gained momentum globally while raising concerns among health-related communities. The World Health Organization, American Heart Association International Diabetes Federation have formulated criteria for metabolic syndrome. Diet nutrition can influence syndrome: example, the Western diet associated with increased risk of whereas Nordic Mediterranean diets Dietary Approach to Stop Hypertension are potentially beneficial. affect components syndrome due its dietary fiber, omega 3 9 fatty acids, carbohydrates, antioxidants, minerals, vitamins bioactive substances, such polyphenols. These nutrients substances combat obesity, dyslipidemia, hypertension diabetes mellitus. mechanisms by which they do so generally related oxidative stress, inflammation most common factors syndrome) gastrointestinal function. literature shows examples positive effects on In review literature, we shed light effects, dynamic relationship between

Language: Английский

---

Challenges of Changing Water Sources for Human Wellbeing in the Arctic Zone of Western Siberia

Water, Journal Year: 2023, Volume and Issue: 15(8), P. 1577 - 1577

Published: April 18, 2023

The availability of clean drinking water impacts the quality life Arctic populations and is affected by climate change. We provide perceptions based on: (1) a study accessibility natural surface to nomadic settled Indigenous inhabitants living in rural areas (in settlements remote camps) zone Western Siberia during change industrial development; (2) an assessment impact consuming different resources on human health. include primary data sources from medical examinations surveys collected regions between rivers Ob, Nadym, Taz, Yenisey 2012, 2014–2019, 2022 whereas chemical analysis waters region was previous research. A total 552 local residents participated study. discuss how high-quality limited for them due climatic anthropogenic risks, despite abundant resources. consumption river associated with high health risks since it contains heavy metals (Pb, Cd, Mn, Fe), lake ice melt likely affects because low concentrations beneficial ions.

Language: Английский

---

Electrolyte Imbalances and Metabolic Emergencies in Obesity: Mechanisms and Clinical Implications

Diseases, Journal Year: 2025, Volume and Issue: 13(3), P. 69 - 69

Published: Feb. 24, 2025

Electrolyte imbalances are a frequently overlooked yet critical component of obesity-related metabolic dysfunction, contributing to an increased risk cardiovascular disease, kidney impairment, and emergencies such as diabetic ketoacidosis (DKA), hyperosmolar hyperglycemic state (HHS), acute injury (AKI). These disturbances arise from insulin resistance, chronic inflammation, hormonal dysregulation, renal leading sodium retention, potassium depletion, deficiencies in calcium magnesium homeostasis. Managing electrolyte is essential obesity management, exacerbate hypertension, acidosis, neuromuscular complications, resistance. This review explores the pathophysiology their impact on fluid balance, acid–base status, health. Effective management strategies include individualized monitoring, dietary restriction, supplementation, vitamin D correction, pharmacologic interventions targeting renin–angiotensin–aldosterone system (RAAS) activity Additionally, lifestyle interventions, including modification, weight loss strategies, hydration optimization, play key role preventing complications. Future research should investigate long-term obesity, emerging therapies, how can optimize homeostasis outcomes. A personalized, multidisciplinary approach integrating endocrinology, nephrology, clinical nutrition improving prevention obese individuals.

Language: Английский

---