Epidemiological trends of subarachnoid hemorrhage at global, regional, and national level: a trend analysis study from 1990 to 2021

Military Medical Research, Journal Year: 2024, Volume and Issue: 11(1)

Published: July 11, 2024

Abstract Background Subarachnoid hemorrhage (SAH) is a subtype of hemorrhagic stroke characterized by high mortality and low rates full recovery. This study aimed to investigate the epidemiological characteristics SAH between 1990 2021. Methods Data on incidence, mortality, disability-adjusted life-years (DALYs) from 2021 were obtained Global Burden Disease Study (GBD) Estimated annual percentage changes (EAPCs) calculated evaluate in age-standardized rate (ASR) incidence as well trends burden. The relationship disease burden sociodemographic index (SDI) was also analyzed. Results In 2021, found be 37.09% higher than that 1990; however, (ASIRs) showed decreased [EAPC: -1.52; 95% uncertainty interval (UI) -1.66 -1.37]. Furthermore, both number deaths DALYs over time. It observed females had lower compared males. Among all regions, high-income Asia Pacific region exhibited highest ASIR (14.09/100,000; UI 12.30/100,000 − 16.39/100,000) with an EPAC for < 0 indicating decreasing trend time ASIR. Oceania recorded (ASMRs) among regions at values respectively 8.61 (95% 6.03 11.95) 285.62 209.42 379.65). associated primarily affected individuals aged 50 69 years old. Metabolic risks particularly elevated systolic blood pressure identified main risk factors contributing towards increased when against environmental or occupational behavioral evaluated within GBD framework. Conclusions varies gender, age group, geographical region. Although ASRs have shown decline time, remains significant, especially middle low-middle SDI levels. High stands out key factor SAH. More specific supportive measures are necessary alleviate global

Language: Английский

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Non‐pharmacological management of hypertension

Journal of Clinical Hypertension, Journal Year: 2021, Volume and Issue: 23(7), P. 1275 - 1283

Published: March 18, 2021

Abstract Hypertension is an insidious disease which predisposes to cardiovascular complications and if not treated properly can lead various serious complications. Economic limitations, having additional benefits with few or almost no side effects have made non‐pharmacological management of hypertension attractive approach for dealing hypertension, in developed developing countries alike. A MEDLINE search was done relevant references emphasis on original studies, randomized controlled trials, meta‐analyses this review paper. Lifestyle modifications including changes the dietary pattern, adopting special diets low sodium, saturated fat high calcium, magnesium potassium trying new methods like time restricted meal intake work tandem circadian rhythm are opening vistas field hypertension. that effectively lower blood pressure increased physical activity, weight loss, limited alcohol consumption, relaxation techniques Yoga, Acupuncture, Tai chi, mindfulness‐based stress‐reduction program, Transcendental Meditation. Air pollution surrounding air linked poor health outcomes a major contributor global burden disease. Fine particulate matter <2.5 μm diameter (PM2.5) strongly associated morbidity mortality. Short‐term PM exposure (hours weeks) increases likelihood adverse events myocardial infarction, stroke, heart failure, longer‐term multiplies risk. Non‐pharmacological should be initiated early phase continued medication.

Language: Английский

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Hemp seed protein and its hydrolysate compared with casein protein consumption in adults with hypertension: a double-blind crossover study

American Journal of Clinical Nutrition, Journal Year: 2024, Volume and Issue: 120(1), P. 56 - 65

Published: May 4, 2024

The effects of consuming hemp seed protein (HSP) as well its hydrolysate-derived bioactive peptide (HSP+) on blood pressure (BP) has not to our knowledge been investigated in humans. We aimed investigate how consumption HSP and hydrolysate modulates 24-hr systolic diastolic BP (24-hrSBP 24-hrDBP) plasma biomarkers compared casein. In a double-blind, randomized, cross-over design trial, 35 adults who had mild hypertension with SBP between 130 160 millimeters mercury (mmHg), DBP ≤110 mmHg were recruited. Participants randomly assigned varying sequences three 6-week treatments, 50 g/d casein, HSP, 45 plus derived peptides (HSP+), 5 separated by 2-week washout period. Treatment assessed linear mixed model repeated measures. Compared after HSP+ consumption, 24hrSBP 24hrDBP decreased from 135.1 80.0 128.1 ± 1.6 (P<.0001) 76.0 1.4 respectively whereas these values 133.5 78.9 (P<.0001). There no differences the angiotensin converting enzyme (ACE) activity, renin or Nitric oxide (NO) concentrations. However, two treatments able lower both ACE activities raise NO concentration These results suggest that combination peptides, may have role dietary management hypertension. This trial was registered at clinicaltrials.gov NCT03508895.

Language: Английский

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Designing a meditation module to affect etiological and preventive factors in primary hypertensive patients—A pilot study

Physiological Reports, Journal Year: 2025, Volume and Issue: 13(3)

Published: Feb. 1, 2025

The aim of the present pilot study is to design, validate, and check feasibility efficacy designed meditation module on etiological preventive factors in primary hypertensive patients (PHP). systematic detailed was formulated prevent complications hypertension. validated by 5 subject experts field complementary alternative therapy research. Content Validity Ratio (CVR), Average Congruency Percentage (ACP), Index were calculated. intervention given for days a week 4 weeks, 9 PHP analyzing biochemical psychological parameters. A randomized controlled trial planned ahead with this as intervention. had 19 concepts CVR >0.49 ACP > 90% which retained, 2 modified (CVR 0.6, 80) 1 deleted <0.49 < 70%. test mean 93.33 ± 8.66 tested increase brain-derived neurotrophic factor (BDNF) (p = 0.022) decrease anxiety perceived stress 0.016), improvement emotional quotient 0.011), mental state 0.044), quality sleep 0.001), life happiness 0.003). found valid experts, feasible patients, efficient improving parameters among affect progress disorder. Trial Registration: CTRI/2022/09/045421.

Language: Английский

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The potential impact of a probiotic: Akkermansia muciniphila in the regulation of blood pressure—the current facts and evidence

Journal of Translational Medicine, Journal Year: 2022, Volume and Issue: 20(1)

Published: Sept. 24, 2022

Abstract Akkermansia muciniphila ( A. ) is present in the human gut microbiota from infancy and gradually increases adulthood. The potential impact of abundance has been studied major cardiovascular diseases including elevated blood pressure or hypertension (HTN). HTN a factor premature death worldwide, approximately 1.28 billion adults aged 30–79 years have hypertension. being considered next-generation probiotic though numerous studies had highlighted positive role lowering/controlling HTN, however, few negative increased management HTN. Thus, review, we aimed to discuss current facts, evidence, controversy about A . pathophysiology its effect on management/regulation, which could be beneficial identifying drug target for

Language: Английский

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The effect of physical activity intervention on blood pressure in 18 low and middle-income countries: a systematic review and meta-analysis of randomized controlled trials

Clinical Hypertension, Journal Year: 2024, Volume and Issue: 30(1)

Published: Aug. 1, 2024

Abstract Background In especially, low and middle-income nations (LMICs), where healthcare access may be restricted, high blood pressure (BP) is a major risk factor for cardiovascular disease stroke, both of which can even lead to death. Altering one's lifestyle, in conjunction with medical therapy, has been demonstrated effective lowering BP. Recent research shown that physical activity (PA), variety guises varying degrees, an means Objective The purpose this meta-analysis systematic review was evaluate the impact PA plays development hypertension LMICs nations. Methods An exhaustive search available carried out order locate studies were pertinent. We searched number online databases, such as SCOPUS, Medline, Web Science, looking clinical trials published before March 2023. Studies only considered inclusion if they randomized controlled (RCTs), reported on association between BP, countries. Results This incorporated comprehensive collection 60 studies, encompassing total 11,002 people, consisting 5,630 cases 5372 controls. findings indicate engaging had notable decreasing systolic (SBP), seen by weighted mean difference (WMD) -7.70 mmHg, 95% confidence interval (CI) ranging from -9.50 -5.91 ( p < 0.001). Additionally, found have significant influence reducing diastolic (DBP), indicated WMD -3.60 CI -4.48to -2.73( subgroup analysis observed results remained statistically when considering individuals baseline SBP 120 mmHg or lower DBP 80 lower. Conclusion incorporation significantly contribute mitigation BP within Additional investigation required ascertain most form amount mitigate levels these specific individuals. Graphical

Language: Английский

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Development of a Health Behavioral Digital Intervention for Patients With Hypertension Based on an Intelligent Health Promotion System and WeChat: Randomized Controlled Trial

JMIR mhealth and uhealth, Journal Year: 2024, Volume and Issue: 12, P. e53006 - e53006

Published: Feb. 27, 2024

Background The effectiveness of timely medication, physical activity (PA), a healthy diet, and blood pressure (BP) monitoring for promoting health outcomes behavioral changes among patients with hypertension is supported by substantial amount literature, “adherence” playing pivotal role. Nevertheless, there lack consistent evidence regarding whether digital interventions can improve adherence to behaviors individuals hypertension. Objective aim was develop intervention hypertensive (HBDIHP) based on an intelligent promotion system WeChat following the behavior change wheel (BCW) theory micro-intervention care (DMIC) model assess its efficacy in controlling BP improving adherence. Methods A 2-arm, randomized trial design used. We randomly assigned 68 aged >60 years 1:1 ratio either control or experimental group. established through steps: (1) developing education materials focused exercise prescriptions, Dietary Approaches Stop Hypertension (DASH), prescribed BP; (2) using BCW select techniques; (3) constructing intervention's logic guidelines DMIC model; (4) creating manual including aforementioned elements. Prior experiment, participants underwent examinations at community service center's cabin received personalized recommendations. group 12-week via WeChat, while routine self-management manual. primary included indicators. Data analysis performed SPSS, independent sample t tests, chi-square paired McNemar tests. P value <.05 considered statistically significant. Results final 54 mean age 67.24 (SD 4.19) (n=23 group, n=31 group). had improvements systolic (–7.36 mm Hg, P=.002), time (856.35 metabolic equivalent [MET]-min/week, P<.001), medication (0.56, P=.001), frequency (P=.02), learning performance (3.23, P<.001). Both groups experienced weight reduction (experimental: 1.2 kg, P=.002; control: 1.11 P=.009) after intervention. diet types quantities both (P<.001) as well subendocardial viability (0.16, P=.01) showed significant improvement. However, were no other outcomes. Conclusions observations suggest our program may have enhanced specific older adults longer-term, larger-scale necessary validate effectiveness. Trial Registration Chinese Clinical Registry ChiCTR2200062643; https://www.chictr.org.cn/showprojEN.html?proj=172782 International Registered Report Identifier (IRRID) RR2-10.2196/46883

Language: Английский

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Association between dietary flavonoid intake and hypertension among U.S. adults

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 3, 2024

Background Hypertension is one of the major risk factors for cardiovascular disease. Dietary flavonoids have been reported to reduce inflammation, protect against oxidative stress, vascular endothelium, and improve health. However, relationship between dietary flavonoid intake prevalence hypertension remains controversial. Methods This study included 8010 adults from 2007-2010 2017-2018 National Health Nutrition Examination Surveys (NHANES). The was explored by weighted logistic regression restricted cubic spline. Results We found an inverse total anthocyanin in fourth quartile compared with first [0.81(0.66,0.99), p = 0.04]. Moreover, tended decrease increasing participants over 60 years age. In addition, we a U-shaped flavan-3-ol intake. Total inversely associated third [0.79 (0.63,0.99), there significant negative association when below 48.26 mg/day. Conclusion Our moderate anthocyanins flavan-3-ols provides evidence population-based hypertension.

Language: Английский

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Tagetes erecta L. flowers, a medicinal plant traditionally used to promote diuresis, induced diuretic and natriuretic effects in normotensive and hypertensive rats

Journal of Ethnopharmacology, Journal Year: 2021, Volume and Issue: 279, P. 114393 - 114393

Published: July 3, 2021

Language: Английский

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The critical issue linking lipids and inflammation: Clinical utility of stopping oxidative stress

Frontiers in Cardiovascular Medicine, Journal Year: 2022, Volume and Issue: 9

Published: Nov. 9, 2022

The formation of an atheroma begins when lipoproteins become trapped in the intima. Entrapped oxidized and activate innate immune system. This immunity represents primary association between lipids inflammation. When trapping continues, link inflammation becomes chronic detrimental, resulting atherosclerosis. entrapment ceases, is temporary healthy, atherogenic process halts. Therefore, depends upon lipoprotein retention due to electrostatic forces uniting apolipoprotein B polysaccharide chains on intimal proteoglycans. genetic transformation contractile smooth muscle cells media into migratory secretory produces protein, platelet-derived growth factor produced by activated platelets, stimulus for this change. Oxidative stress main platelets. minimizing oxidative would significantly reduce lipoproteins. Less decreases More importantly, it halt atherogenesis. review will analyze as critical lipids, inflammation, pathogenesis Through perspective, we discuss stopping disrupt a harmful Numerous therapeutic options be discussed mitigate stress. paper add new meaning Morse code distress signal SOS-stopping

Language: Английский

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