Genetic and epigenetic correlation between diabetic retinopathy and polycystic ovarian syndrome: in-silico analyses-experimental research

Annals of Medicine and Surgery, Journal Year: 2025, Volume and Issue: 87(3), P. 1295 - 1300

Published: Feb. 5, 2025

Introduction: Metabolic disorders, such as diabetes, can give rise to complications like diabetic retinopathy and polycystic ovarian syndrome, which have emerged a primary concern among healthcare systems. This study aims explore the genetic epigenetic associations between syndrome. Methods: Gene expression data were retrieved from Expression Omnibus database. Common genes identified using Venn diagrams, while Enrichment Analysis Resource database pinpointed shared signaling pathways. Additionally, microRNAs circular RNAs MiRmap Circaintractome databases investigate potential links two conditions. Results: of datasets Series Accession 53 257 54 248 revealed eight genes. These are involved in pathways related glycine, serine, threonine metabolism, tRNA biosynthesis, DNA repair. Furthermore, associated with miRNA (6 cases) (12 identified. molecular factors play key roles critical biological processes insulin secretion, adiponectin regulation, electron transport respiratory chain. Conclusion: highlights genetic, epigenetic, metabolic demonstrating that disruptions these may exacerbate complications. Identifying common provides avenues for clinical management treatment disorders.

Language: Английский

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Prevalence of Sleep Disorders and Association With Mortality: Results From the NHANES 2009–2010

The Laryngoscope, Journal Year: 2020, Volume and Issue: 131(3), P. 686 - 689

Published: July 18, 2020

Objectives To determine the prevalence of sleep disorders in United States and association between all‐cause mortality. Methods A cross‐sectional analysis 2009 to 2010 National Health Nutrition Examination Survey (NHANES) 2015 Death Index (NDI) was performed. The NHANES national household survey for adults ≥ 18 years examined as well standard demographics presence comorbidities (coronary artery disease [CAD], stroke, emphysema). This dataset linked NDI associate with 5‐year Results study sample had a mean age 46.1 old, 48.3% male, an average body mass index (BMI) 28.7 (28.4–28.9). 7.1% (6.5%–7.7%) reported being diagnosed disorder, which represents estimated 15.9 million (13.2–18.6) patients. mortality rate those having disorder 9.3% (7.2%–11.9%) compared 5.2% (4.5%–5.9%) without (odds ratio 1.89, P = <.001). After adjusting age, sex, BMI, CAD, emphysema, remained significant predictor increased (hazard ratio, 1.5 [1.02–2.18], .042). Conclusion reports high self‐reported but physician‐diagnosed disorders; however, this likely underestimate. Given mortality, there is need recognition undiagnosed within States. Level Evidence 2b Laryngoscope , 131:686–689, 2021

Language: Английский

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Sleep and Metabolic Syndrome

Nursing Clinics of North America, Journal Year: 2021, Volume and Issue: 56(2), P. 203 - 217

Published: March 11, 2021

Language: Английский

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High Triglyceride-Glucose Index is Associated with Poor Cardiovascular Outcomes in Nondiabetic Patients with ACS with LDL-C below 1.8 mmol/L

Journal of Atherosclerosis and Thrombosis, Journal Year: 2021, Volume and Issue: 29(2), P. 268 - 281

Published: Feb. 2, 2021

Aim: To evaluate the prognostic value of triglyceride-glucose (TyG) index in nondiabetic patients with acute coronary syndrome (ACS) low-density lipoprotein cholesterol (LDL-C) below 1.8 mmol/L.

Language: Английский

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The relationship between sleep health and multimorbidity in community dwelling populations: Systematic review and global perspectives

Sleep Medicine, Journal Year: 2023, Volume and Issue: 109, P. 270 - 284

Published: July 14, 2023

Language: Английский

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Joint and interactive effects of metal mixtures on liver damage: Epidemiological evidence from repeated-measures study

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 274, P. 116178 - 116178

Published: March 11, 2024

The impact of heavy metals on liver function has been examined in numerous epidemiological studies. However, these findings lack consistency and longitudinal validation.

Language: Английский

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Sleep deprivation detected by voice analysis

PLoS Computational Biology, Journal Year: 2024, Volume and Issue: 20(2), P. e1011849 - e1011849

Published: Feb. 5, 2024

Sleep deprivation has an ever-increasing impact on individuals and societies. Yet, to date, there is no quick objective test for sleep deprivation. Here, we used automated acoustic analyses of the voice detect Building current machine-learning approaches, focused interpretability by introducing two novel ideas: use a fully generic auditory representation as input feature space, combined with interpretation technique based reverse correlation. The consisted spectro-temporal modulation analysis derived from neurophysiology. method aimed reveal regions that supported classifiers' decisions. Results showed features could be successfully, accuracy comparable state-of-the-art speech features. Furthermore, revealed distinct effects voice: changes in slow temporal modulations related prosody spectral quality. Importantly, relative balance varied widely across individuals, even though amount was controlled, thus confirming need characterize at individual level. Moreover, while factor correlated subjective sleepiness reports, quality did not, consistent presence both explicit implicit consequences Overall, findings show may observed vocal biomarkers. Future investigations correlating such markers physiological measures enable "sleep stethoscopes" cost-effective diagnosis

Language: Английский

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Physical behaviors and chronotype in people with type 2 diabetes

BMJ Open Diabetes Research & Care, Journal Year: 2020, Volume and Issue: 8(1), P. e001375 - e001375

Published: July 1, 2020

Introduction Previous investigations have suggested that evening chronotypes may be more susceptible to obesity-related metabolic alterations. However, whether device-measured physical behaviors differ by chronotype in those with type 2 diabetes (T2DM) remains unknown. Research design and methods This analysis reports data from the ongoing Chronotype of Patients Type Diabetes Effect on Glycaemic Control (CODEC) observational study. Eligible participants were recruited both primary secondary care settings Midlands area, UK. Participants asked wear an accelerometer (GENEActiv, ActivInsights, Kimbolton, UK) their non-dominant wrist for 7 days quantify different (sleep, sedentary, light, moderate-to-vigorous activity (MVPA), intensity gradient, average acceleration above which most active continuous 2, 10, 30 60 min are accumulated). preference (morning, intermediate or evening) was assessed using Morningness-Eveningness Questionnaire. Multiple linear regression analyses associated timing. Evening considered as reference group. Results 635 included (age=63.8±8.4 years, 34.6% female, body mass index=30.9±5.1 kg/m ). 25% (n=159) cohort morning chronotypes, 52% (n=330) 23% (n=146) chronotypes. had higher sedentary time (28.7 min/day, 95% CI 8.6 48.3) lower MVPA levels (–9.7 –14.9 –4.6) compared The 2-60 day, gradient timing also differed across displaying a later sleep onset consistently time. Conclusions People T2DM lead lifestyle characterized insufficient MVPA. exacerbated ‘eveningness’ (ie, go bed late get up late).

Language: Английский

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Prevalence and factors associated with sleep disturbance in adult patients with psoriasis

Journal of the European Academy of Dermatology and Venereology, Journal Year: 2022, Volume and Issue: 36(5), P. 688 - 697

Published: Jan. 12, 2022

Sleep, which is crucial for restoring of physiological functions and health, reportedly impaired in psoriasis. The role different potential sleep confounding factors, including detailed pruritus characteristics, the complex interplay between psychological variables (anxiety depression), disturbance psoriasis remain insufficiently investigated.To investigate characteristics to identify clinical, demographic factors associated with psoriasis.This cross-sectional study included 334 patients (response rate 86%) 126 control subjects 82%). Measures quality [Pittsburgh Sleep Quality Index (PSQI)], severity, average intensity [visual analogue scale (VAS)], severity comorbidities, anxiety depression (Hospital Anxiety Depression Scale - HADS) life (Dermatology Life DLQI, Short Form 12 SF12).Fifty-nine per cent 34% (P < 0.001) suffered from (PSQI > 5). Patients slept 1 h less than (median 6 vs. 7 h, P 0.001). without had (global PSQI) strong very (HADS-A) (HADS-D) levels were strongest predictors impairment, followed by exacerbation at night, age, female sex, morning, (VAS), diagnosed gastroesophageal reflux disease, altogether explaining 32%-37% variance global quality. Both significant mediators association (VAS) impairment 42% 37% respectively.Sleep highly prevalent. should be assessed pruritus, depression. Reduction considered as an important therapeutic goal, along therapies aimed reducing

Language: Английский

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Associations of metals and metals mixture with lipid profiles: A repeated-measures study of older adults in Beijing

Chemosphere, Journal Year: 2023, Volume and Issue: 319, P. 137833 - 137833

Published: Jan. 21, 2023

Language: Английский

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