The gut microbiota in anxiety and depression – A systematic review

Clinical Psychology Review, Journal Year: 2020, Volume and Issue: 83, P. 101943 - 101943

Published: Oct. 29, 2020

Language: Английский

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Colorectal Cancer: A Review of Carcinogenesis, Global Epidemiology, Current Challenges, Risk Factors, Preventive and Treatment Strategies

Cancers, Journal Year: 2022, Volume and Issue: 14(7), P. 1732 - 1732

Published: March 29, 2022

Colorectal cancer (CRC) is the second most deadly cancer. Global incidence and mortality are likely to be increased in coming decades. Although deaths associated with CRC very high high-income countries, fatalities related growing developing countries too. detected early entirely curable by surgery subsequent medications. However, recurrence rate high, drug resistance increases treatment failure rate. Access diagnosis of for survival somewhat possible developed countries. these facilities rarely available Highlighting current status CRC, its development, risk factors, management crucial creating public awareness. Therefore, this review, we have comprehensively discussed global epidemiology, resistance, challenges, preventive strategies CRC. Additionally, there a brief discussion on development pathways recommendations preventing treating

Language: Английский

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Environmental factors shaping the gut microbiome in a Dutch population

Nature, Journal Year: 2022, Volume and Issue: 604(7907), P. 732 - 739

Published: April 13, 2022

Language: Английский

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Carbohydrate-active enzymes (CAZymes) in the gut microbiome

Nature Reviews Microbiology, Journal Year: 2022, Volume and Issue: 20(9), P. 542 - 556

Published: March 28, 2022

Language: Английский

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Herb and Spices in Colorectal Cancer Prevention and Treatment: A Narrative Review

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: June 30, 2022

Colorectal cancer (CRC) is the second most deadly worldwide. CRC management challenging due to late detection, high recurrence rate, and multi-drug resistance. Herbs spices used in cooking, practised for generations, have been shown contain protective effect or even be useful as an anti-CRC adjuvant therapy when doses. many bioactive compounds possess beneficial health effects. The chemopreventive properties of these herbs are mainly mediated by BCL-2, K-ras, MMP pathways, caspase activation, extrinsic apoptotic pathway, regulation ER-stress-induced apoptosis. As a safer natural alternative, could good candidates chemotherapeutic agents because their antiproliferative action on colorectal carcinoma cells inhibitory activity angiogenesis. Therefore, this narrative review, six different herbs: ginger ( Zingiber officinale Roscoe), turmeric Curcuma longa L.), garlic Allium sativum fenugreek Trigonella foenum-graecum sesame Sesamum indicum flaxseed Linum usitatissimum L.) daily cuisine were selected study analyzed chemoprotective roles with underlying molecular mechanisms actions. Initially, comprehensively discussed basis development, followed culinary traditional uses, current scientific research, publications cancers. Lead each herb spice, including phytoconstituents, antioxidant activities, anti-inflammatory properties, finally, effects treatment mechanisms. Future possible works suggested where applicable.

Language: Английский

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Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health

Advances in Nutrition, Journal Year: 2020, Volume and Issue: 12(4), P. 1239 - 1285

Published: Dec. 22, 2020

Language: Английский

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The Role of the Gut Microbiota in the Relationship Between Diet and Human Health

Annual Review of Physiology, Journal Year: 2022, Volume and Issue: 85(1), P. 449 - 468

Published: Nov. 14, 2022

The interplay between diet, the gut microbiome, and host health is complex. Diets associated with have many similarities: high fiber, unsaturated fatty acids, polyphenols while being low in saturated fats, sodium, refined carbohydrates. Over past several decades, dietary patterns changed significantly Westernized nations increased consumption of calorically dense ultraprocessed foods fiber salt, carbohydrates, leading to numerous negative consequences including obesity, metabolic syndrome, cardiovascular disease. microbiota an environmental factor that interacts diet may also impact on outcomes, which involve metabolites produced by from components can host. This review focuses our current understanding complex relationship microbiota, health, examples how support increase individual's risk for disease, be used as a therapy specific diseases.

Language: Английский

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Nutrition and Frailty: Opportunities for Prevention and Treatment

Nutrients, Journal Year: 2021, Volume and Issue: 13(7), P. 2349 - 2349

Published: July 9, 2021

Frailty is a syndrome of growing importance given the global ageing population. While frailty multifactorial process, poor nutritional status considered key contributor to its pathophysiology. As nutrition modifiable risk factor for frailty, strategies prevent and treat should consider dietary change. Observational evidence linking with appears most robust quality: example, patterns such as Mediterranean diet appear be protective. In addition, research on specific foods, higher consumption fruit vegetables lower ultra-processed foods are consistent, healthier profiles linked risk. Few intervention studies have been conducted date, although number trials that combine supplementation exercise training suggest multi-domain approach may more effective. This review based an interdisciplinary workshop, held in November 2020, synthesises current understanding influences focusing opportunities prevention treatment. Longer term prospective well-designed needed determine causal effects progression how change can used and/or future.

Language: Английский

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Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: May 13, 2023

Abstract In the past period, due to rapid development of next-generation sequencing technology, accumulating evidence has clarified complex role human microbiota in cancer and therapeutic response. More importantly, available seems indicate that modulating composition gut improve efficacy anti-cancer drugs may be feasible. However, intricate complexities exist, a deep comprehensive understanding how interacts with is critical realize its full potential treatment. The purpose this review summarize initial clues on molecular mechanisms regarding mutual effects between development, highlight relationship microbes immunotherapy, chemotherapy, radiation therapy surgery, which provide insights into formulation individualized strategies for management. addition, current emerging microbial interventions as well their clinical applications are summarized. Although many challenges remain now, great importance cannot overstated strategies, it necessary explore holistic approach incorporates modulation cancer.

Language: Английский

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Dynamics of Insect–Microbiome Interaction Influence Host and Microbial Symbiont

Frontiers in Microbiology, Journal Year: 2020, Volume and Issue: 11

Published: June 26, 2020

Insects share an intimate relationship with their gut microflora and this symbiotic association has developed into essential evolutionary outcome intended for survival through extreme environmental conditions. While it been clearly established that insects, very few exceptions, associate several microbes during life cycle, information regarding aspects of these associations is yet to be fully unraveled. Acquisition bacteria by insects marks the onset microbial symbiosis, which followed adaptation bacterial species environment prolonged sustenance successful transmission across generations. Although insect-microbiome have reported each distinctive features, diversifications specializations, still unclear as what led diversifications. Recent studies indicated involvement various processes operating within insect body govern transition a free-living microbe obligate or facultative symbiont eventually leading establishment diversification relationships. Data from studies, summarized in review, indicate partners i.e. undergo genetic, biochemical physiological changes profound influence on cycle biology. An interesting insect-microbe interaction compliance partner its eventual genome reduction. Endosymbionts possess smaller compared forms, thus raising question reductive evolution partner? This review attempts highlight fate implications both host. discussion specific would too voluminous outside scope we present overview some recent contribute better understanding trajectory dynamics speculate that, future, nature could pave path sustainable environmentally safe way controlling economically important pests crop plants.

Language: Английский

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