Cell Host & Microbe,
Journal Year:
2024,
Volume and Issue:
32(4), P. 506 - 526.e9
Published: March 12, 2024
To
understand
the
dynamic
interplay
between
human
microbiome
and
host
during
health
disease,
we
analyzed
microbial
composition,
temporal
dynamics,
associations
with
multi-omics,
immune,
clinical
markers
of
microbiomes
from
four
body
sites
in
86
participants
over
6
years.
We
found
that
stability
individuality
are
body-site
specific
heavily
influenced
by
host.
The
stool
oral
more
stable
than
skin
nasal
microbiomes,
possibly
due
to
their
interaction
environment.
identify
individual-specific
commonly
shared
bacterial
taxa,
individualized
taxa
showing
greater
stability.
Interestingly,
dynamics
correlate
across
sites,
suggesting
systemic
host-microbial-environment
interactions.
Notably,
insulin-resistant
individuals
show
altered
among
microbiome,
molecular
markers,
features,
disrupted
metabolic
disease.
Our
study
offers
comprehensive
views
multi-site
relationship
Nature Medicine,
Journal Year:
2022,
Volume and Issue:
28(11), P. 2333 - 2343
Published: Oct. 10, 2022
The
levels
of
the
thousands
metabolites
in
human
plasma
metabolome
are
strongly
influenced
by
an
individual's
genetics
and
composition
their
diet
gut
microbiome.
Here,
assessing
1,183
1,368
extensively
phenotyped
individuals
from
Lifelines
DEEP
Genome
Netherlands
cohorts,
we
quantified
proportion
inter-individual
variation
explained
different
factors,
characterizing
610,
85
38
as
dominantly
associated
with
diet,
microbiome
genetics,
respectively.
Moreover,
a
quality
score
derived
metabolite
was
significantly
quality,
assessed
detailed
food
frequency
questionnaire.
Through
Mendelian
randomization
mediation
analyses,
revealed
putative
causal
relationships
between
metabolites.
For
example,
analyses
support
potential
effect
Eubacterium
rectale
decreasing
hydrogen
sulfite-a
toxin
that
affects
cardiovascular
function.
Lastly,
based
on
analysis
311
at
two
time
points
separated
4
years,
observed
positive
correlation
stability
amount
variance
could
be
our
analysis.
Altogether,
characterization
factors
explain
can
help
design
approaches
for
modulating
or
to
shape
healthy
metabolome.
Trends in Microbiology,
Journal Year:
2022,
Volume and Issue:
30(10), P. 940 - 947
Published: May 13, 2022
Bifidobacteria
are
among
the
earliest
and
most
abundant
bacterial
colonizers
of
neonatal
gut
in
many
mammals,
where
they
elicit
purported
host
health
benefits.
While
early
life-associated
dynamics
diversity,
as
well
metabolic
beneficial
activities,
Bifidobacterium
species
have
been
studied,
functional
contributions
bifidobacteria
to
well-being
adults
remain
less
explored.
In
this
opinion
piece,
we
discuss
current
knowledge
regarding
relevance
endogenous
associated
with
adulthood.
We
identify
gaps
opportunities
for
microbiota
enrichment
rationally
selected
strains
more
adapted
adult
host.
propose
that
future
studies
area
will
help
us
better
understand
ecological,
metabolic,
roles
played
by
ecosystem
across
various
ages.
BMC Medicine,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: May 11, 2023
Oxidative
stress
(OS)
is
a
key
pathophysiological
mechanism
in
Crohn's
disease
(CD).
OS-related
genes
can
be
affected
by
environmental
factors,
intestinal
inflammation,
gut
microbiota,
and
epigenetic
changes.
However,
the
role
of
OS
as
potential
CD
etiological
factor
or
triggering
unknown,
differentially
expressed
either
cause
subsequent
change
inflammation.
Herein,
we
used
multi-omics
summary
data-based
Mendelian
randomization
(SMR)
approach
to
identify
putative
causal
effects
underlying
mechanisms
CD.
Science,
Journal Year:
2023,
Volume and Issue:
380(6649)
Published: June 8, 2023
Antibiotics
(ABX)
compromise
the
efficacy
of
programmed
cell
death
protein
1
(PD-1)
blockade
in
cancer
patients,
but
mechanisms
underlying
their
immunosuppressive
effects
remain
unknown.
By
inducing
down-regulation
mucosal
addressin
adhesion
molecule
(MAdCAM-1)
ileum,
post-ABX
gut
recolonization
by
Enterocloster
species
drove
emigration
enterotropic
α4β7+CD4+
regulatory
T
17
cells
into
tumor.
These
deleterious
ABX
were
mimicked
oral
gavage
species,
genetic
deficiency,
or
antibody-mediated
neutralization
MAdCAM-1
and
its
receptor,
α4β7
integrin.
contrast,
fecal
microbiota
transplantation
interleukin-17A
prevented
ABX-induced
immunosuppression.
In
independent
lung,
kidney,
bladder
patient
cohorts,
low
serum
levels
soluble
had
a
negative
prognostic
impact.
Thus,
MAdCAM-1-α4β7
axis
constitutes
an
actionable
immune
checkpoint
immunosurveillance.
Psychological Medicine,
Journal Year:
2022,
Volume and Issue:
52(7), P. 1222 - 1242
Published: May 1, 2022
Abstract
Major
depressive
disorder
(MDD),
bipolar
(BD)
and
schizophrenia-spectrum
disorders
(SSD)
are
heterogeneous
psychiatric
disorders,
which
place
significant
burden
on
patient's
well-being
global
health.
Disruptions
in
the
gut-microbiome
may
play
a
role
these
disorders.
This
review
presents
current
data
composition
of
human
gastrointestinal
microbiota,
its
interaction
mechanisms
gut–brain
axis
MDD,
BD
SSD.
Diversity
metrics
microbial
relative
abundance
differed
across
studies.
More
studies
reported
inconsistent
findings
(
n
=
7)
or
no
differences
8)
than
who
lower
α
-diversity
5).
The
most
consistent
were
higher
abundances
genera
Streptococcus
,
Lactobacillus
Eggerthella
butyrate
producing
Faecalibacterium
patients
with
All
three
increased
associated
symptom
severity.
Confounders,
such
as
medication
use
life
style
have
not
been
accounted
for.
So
far,
results
probiotics
trials
inconsistent.
Most
traditional
widely
used
(consisting
Bifidobacterium
spp.
spp.)
safe,
however,
they
do
correct
potential
microbiota
disbalances
Findings
prebiotics
faecal
transplantation
(FMT)
too
limited
to
draw
definitive
conclusions.
Disease-specific
pro/prebiotic
treatment
even
FMT
could
be
auspicious
interventions
for
prevention
therapy
should
investigated
future
trials.
