Physical Exercise and Immune System in the Elderly: Implications and Importance in COVID-19 Pandemic Period

Frontiers in Psychology, Journal Year: 2020, Volume and Issue: 11

Published: Nov. 19, 2020

Physical exercise is seen as the main ally for health promotion, preventing and protecting organism from several diseases. According to WHO, there a tendency of constant growth in elderly population coming years. The regular practice exercises by becomes relevant minimize deleterious effects aging process increase fitness index. Recently, world started confrontation against Corona Virus Disease (COVID-19), which most significant public challenge globally. Although social isolation reasonable measure an attempt stop contamination COVID-19, this has limited ability individuals outdoors or gyms clubs, increased risk developing chronic illnesses related sedentary lifestyle. critical point that recent recommendations on prescription combat potentially harmful COVID-19 failure adequately address resistance interventions home-based strategy. Thus, paper, we discussed physical medicine if training status enough protect infection, about role activity immunosuppression. Possible risks old methods, such no-load possible strategies high-intensity interval training, new proposals interventions, could perform during current pandemic.

Language: Английский

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Thymus involution sets the clock of the aging T-cell landscape: Implications for declined immunity and tissue repair

Ageing Research Reviews, Journal Year: 2020, Volume and Issue: 65, P. 101231 - 101231

Published: Nov. 25, 2020

Aging is generally characterized as a gradual increase in tissue damage, which associated with senescence and chronic systemic inflammation evident variety of age-related diseases. The extent to such damage result decline immune regulation, consequently compromises the capacity body repair damages, has not been fully explored. Whereas CD4 T lymphocytes play critical role orchestration immunity, thymus involution initiates changes T-cell landscape, may significantly compromise repair. In this review, we describe lifespan accumulation specific dysregulated subsets their coevolution process declined immunity age. Then, discuss involution—which appears be most pronounced around puberty—as possible driver aging landscape. Finally, identify individualized cell-based early diagnostic biomarkers therapeutic strategies for

Language: Английский

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To stress or not to stress: Brain-behavior-immune interaction may weaken or promote the immune response to SARS-CoV-2

Neurobiology of Stress, Journal Year: 2021, Volume and Issue: 14, P. 100296 - 100296

Published: Jan. 27, 2021

The COVID-19 pandemic continues to strongly affect people with health disadvantages, creating a heavy burden on medical systems and societies worldwide. Research is growing rapidly recently revealed that stress-related factors such as socio-economic status, may also play pivotal role. However, stress research investigating the underlying psychoneuroimmune interactions missing. Here we address question whether stress-associated neuroendocrine-immune mechanisms can possibly contribute an increase in SARS-CoV-2 infections influence course of disease. Additionally, discuss not all forms (e.g. acute versus chronic) are detrimental some types could attenuate infection-risk -progression. overall aim this review motivate future efforts clarify psychosocial interventions have potential optimize responses against respiratory viral during beyond pandemic. current state different summarized comprehensive narrative promote understanding how its mediators cortisol, (nor)adrenaline, neuropeptides neurotrophins shape immune defense diseases. Based understanding, describe high be identified, which behaviors optimal management, knowledge used improve adequate care for other patients infections.

Language: Английский

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Lifestyle exercise attenuates immunosenescence; flow cytometry analysis

BMC Geriatrics, Journal Year: 2021, Volume and Issue: 21(1)

Published: March 22, 2021

Abstract Background Interaction of physical activity and overall immune profile is very complex depends on the intensity, duration frequency undertaken activity, exposure to cytomegalovirus (CMV) infection age-related changes in system. Daily which particularly influences immunity, declines dramatically with age. Therefore, aim study was explain whether sustained throughout life can attenuate or reverse immunosenescence. Methods Ninety-nine older adults (60–90 years) were recruited for study. According 6-min walk test (6WMT), Åstrand-Ryhming bike (VO 2 max) Community Healthy Activities Model Program Seniors (CHAMPS) questionnaire, individuals classified as physically active ( n = 34) inactive 20) groups. The analysis T lymphocytes between vs. participants performed using eight-parameter flow cytometry. Results Analysis baseline peripheral naïve memory showed a significant relationship lifestyle exercise CD4/CD8 ratio. Above 50% demonstrated ratio ≥ 1 ≤ 2.5 contrary group who < 1. result 6WMT > 1.3 m/s VO max 35 mL/kg/min had significantly higher CD4 + CD45RA lymphocyte percentage also /CD4 CD45RO . Interestingly, IgG CMV 30) count than 20). Conclusion Based cytometry analysis, we concluded that could lead rejuvenation system by increasing reducing tendency inverse

Language: Английский

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Deciphering the mechanisms, biochemistry, physiology, and social habits in the process of aging

Archives of Gerontology and Geriatrics Plus, Journal Year: 2023, Volume and Issue: 1(1), P. 100003 - 100003

Published: Dec. 25, 2023

Aging is a complex journey shaped by interactions among mechanisms, biochemistry, physiology, and social habits. This review explores aging's core facets uncovering the mechanisms driving cellular senescence, oxidative stress, telomere shortening, mitochondrial dysfunction. The also delves into biochemistry physiology of aging, shedding light on hormonal shifts, genetic influences, immune system modifications that contribute to aging process. It navigates terrain habits linked considering profound impact dietary choices, physical activity, engagement, stress management. These elements intricately intertwine, emphasizing holistic nature aging. interplay between underscores need for comprehensive understanding transcends single disciplines. Deciphering these factors significance personalized approaches healthy Tailoring interventions individual genetics, lifestyles, health needs emerges as critical strategy optimizing well-being in later life. In conclusion, this illuminates multifaceted urging embrace complexity interdependence. By fostering holistic, approach, individuals can navigate with grace, vitality, resilience.

Language: Английский

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