Cellular senescence: the good, the bad and the unknown

Nature Reviews Nephrology, Journal Year: 2022, Volume and Issue: 18(10), P. 611 - 627

Published: Aug. 3, 2022

Language: Английский

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Assessment of metabolic syndrome predictors in relation to inflammation and visceral fat tissue in older adults

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Jan. 3, 2023

The diagnosis of metabolic syndrome (MetS) focuses on the assessment risk factors such as insulin resistance, dyslipidemia, central adiposity and elevated blood pressure. Evidence suggests that markers systemic inflammation may also be included in definition MetS play some role its pathogenesis. study was designed to evaluate low-grade status older adults with relation increased body fat tissue an attempt made new predictors for through analysis ROC Curve. Ninety-six middle-aged (69.2 ± 4.9) individuals from University Third Age (women n = 75 men 21) were allocated two groups: without (n 37) 59) according International Diabetes Federation criteria agreement American Heart Association/National Heart, Lung Blood Institute 2009. Participants' current health assessed using medical records a routine follow-up visit primary care physician. Statistical performed R studio software. Depending normal distribution, ANOVA or Kruskal-Wallis test used. optimal threshold value clinical stratification (cut-off value) obtained by calculating Youden index. AUC observed highest anthropometric index i.e. lipid accumulation product (0.820). Low-grade dominated group (BMI 28.0 4.4 kg/m2, WHR 0.9 0.1, FM 24.7 7.9 kg) where significantly higher values TNF-α (p 0.027) HGMB-1 protein 0.011) recorded.The immunological indices were: 93.4 TNF-α, 88.2 1992.75 ghrelin. High these additionally confirmed their high diagnostic usefulness MetS.

Language: Английский

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Mechanisms and Strategies of Immunosenescence Effects on Non-Small Cell Lung Cancer (NSCLC) Treatment: A Comprehensive Analysis and Future Directions

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: 109, P. 44 - 66

Published: Jan. 9, 2025

Language: Английский

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Physical Activity and Nutritional Influence on Immune Function: An Important Strategy to Improve Immunity and Health Status

Frontiers in Physiology, Journal Year: 2021, Volume and Issue: 12

Published: Oct. 8, 2021

Physical activity (PA) and nutrition are the essential components of a healthy lifestyle, as they can influence energy balance, promote functional ability various systems improve immunity. Infections their associated symptoms common frequent challenges to human health that causing severe economic social consequences around world. During aging, immune system undergoes dramatic aging-related changes/dysfunctions known immunosenescence. Clinically, immunosenescence refers gradual deterioration increases exposure infections, reduces vaccine efficacy. Such phenomenon is linked impaired responses lead dysfunction multiple organs, while lack physical activity, progressive loss muscle mass, concomitant decline in strength facilitate inflammation. In present review, we have discussed role PA, which boost alone synergistically. Evidence suggests long-term PA beneficial improving preventing infections. We further several nutritional strategies for system. Unfortunately, available evidence shows conflicting results. terms interaction with food intake, does not tend increase intake during short time course. However, overcoming deficiencies appears be most practical recommendation. Through balanced nutritious diet one fulfill bodily requirement optimal significantly impacts Supplementation single nutrient generally advisable. Rather incorporating fruits vegetables, whole grains, proteins probiotics may ensure adequate intake. Therefore, multi-nutrient supplements benefit people having deficiency spite sufficient diet. Along supplementation probiotics, bovine colostrum, plant-derived products foods provide additional benefits

Language: Английский

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Immune system and sarcopenia: Presented relationship and future perspective

Experimental Gerontology, Journal Year: 2022, Volume and Issue: 164, P. 111823 - 111823

Published: April 30, 2022

Language: Английский

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The Impact of Exercise on Immunity, Metabolism, and Atherosclerosis

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3394 - 3394

Published: Feb. 8, 2023

Physical exercise represents an effective preventive and therapeutic strategy beneficially modifying the course of multiple diseases. The protective mechanisms are manifold; primarily, they elicited by alterations in metabolic inflammatory pathways. Exercise intensity duration strongly influence provoked response. This narrative review aims to provide comprehensive up-to-date insights into beneficial effects physical illustrating impact moderate vigorous on innate adaptive immunity. Specifically, we describe qualitative quantitative changes different leukocyte subsets while distinguishing between acute chronic effects. Further, elaborate how modifies progression atherosclerosis, leading cause death worldwide, representing a prime example disease triggered Here, counteracts causal contributors thereby improves outcomes. In addition, identify gaps that still need be addressed future.

Language: Английский

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Deciphering the mechanisms, biochemistry, physiology, and social habits in the process of aging

Archives of Gerontology and Geriatrics Plus, Journal Year: 2023, Volume and Issue: 1(1), P. 100003 - 100003

Published: Dec. 25, 2023

Aging is a complex journey shaped by interactions among mechanisms, biochemistry, physiology, and social habits. This review explores aging's core facets uncovering the mechanisms driving cellular senescence, oxidative stress, telomere shortening, mitochondrial dysfunction. The also delves into biochemistry physiology of aging, shedding light on hormonal shifts, genetic influences, immune system modifications that contribute to aging process. It navigates terrain habits linked considering profound impact dietary choices, physical activity, engagement, stress management. These elements intricately intertwine, emphasizing holistic nature aging. interplay between underscores need for comprehensive understanding transcends single disciplines. Deciphering these factors significance personalized approaches healthy Tailoring interventions individual genetics, lifestyles, health needs emerges as critical strategy optimizing well-being in later life. In conclusion, this illuminates multifaceted urging embrace complexity interdependence. By fostering holistic, approach, individuals can navigate with grace, vitality, resilience.

Language: Английский

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Age-related changes in peripheral T-cell subpopulations in elderly individuals: An observational study

Open Life Sciences, Journal Year: 2023, Volume and Issue: 18(1)

Published: Jan. 1, 2023

Abstract The age-related decline in T-cell function among elderly individuals remains unclear. We thus investigated the interrelationship between subsets and age to identify changes phenotypes develop an prediction model for population. A total of 127 aged >60 years were divided into three groups (youngest-old group, 61–70 years, n = 34; middle-old 71–80 53; oldest-old ≥ 81 40). percentage CD8+CD28− cells ( P 0.001) was highest group then followed by while youngest-old lowest. Both females males demonstrated significant decreases absolute counts CD4+CD45RA+ 0.020; 0.002) CD8+CD28+ 0.015; 0.005) with age. Multivariate linear regression showed that < independent predictor aging after adjusting sex, body mass index, hospitalization duration, smoking, drinking, chronic medical illness, medications at admission. In conclusion, our results suggest is accompanied a decrease subpopulations. may be potential targets antiaging-related immunosenescence.

Language: Английский

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Inflammatory Trajectory of Type 2 Diabetes: Novel Opportunities for Early and Late Treatment

Cells, Journal Year: 2024, Volume and Issue: 13(19), P. 1662 - 1662

Published: Oct. 8, 2024

Low-grade inflammation (LGI) represents a key driver of type 2 diabetes (T2D) and its associated cardiovascular diseases (CVDs). Indeed, inflammatory markers such as hs-CRP IL-6 predict the development T2D complications, suggesting that LGI already increases before diagnosis remains elevated even after treatment. Overnutrition, unhealthy diets, physical inactivity, obesity, aging are all recognized triggers LGI, promoting insulin resistance sustaining pathogenesis T2D. Once developed, frank appearance, people with undergo pathological metabolic remodeling, an alteration multiple CVD risk factors, i.e., glycemia, lipids, blood pressure, renal function. In turn, variables foster range pathways mechanisms, e.g., immune cell stimulation, accrual senescent cells, long-lasting epigenetic changes, trained immunity, which held to chronically fuel at systemic tissue levels. Targeting factors partially ameliorates LGI. However, some unaffected by common therapies, burden is still increased in many patients, phenomenon possibly underlying residual (i.e., having > mg/dL despite optimal LDL cholesterol control). On other hand, selected disease-modifying drugs, GLP-1RA, seem also act on T2D, curbing trajectory disease preventing it if introduced early. addition, trials demonstrated potential canonical anti-inflammatory therapies reducing rate CVDs patients this condition or high for it, whom had Since colchicine, inhibitor activation, now approved prevention CVDs, might be worth exploring possible therapeutic paradigm identify subjects treat them drug. Upcoming studies will reveal whether drugs reverse early suppressing sources colchicine has broad benefit condition.

Language: Английский

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The Association of Anti-Inflammatory Diet Ingredients and Lifestyle Exercise with Inflammaging

Nutrients, Journal Year: 2021, Volume and Issue: 13(11), P. 3696 - 3696

Published: Oct. 21, 2021

One of the latest theories on ageing focuses immune response, and considers activation subclinical chronic inflammation. The study was designed to explain whether anti-inflammatory diet lifestyle exercise affect an inflammatory profile in Polish elderly population. Sixty individuals (80.2 ± 7.9 years) were allocated a low-grade inflammation (LGI n = 33) or high-grade (HGI 27) group, based C-reactive protein concentration (<3 ≥3 mg/L) as conventional marker systemic Diet analysis focused vitamins D, C, E, A, β-carotene, n-3 n-6 PUFA using single 24-h dietary recall. LGI demonstrated lower n-6/n-3 but higher vitamin D intake than HGI. Physical performance 6-min walk test (6MWT) classified physically inactive, whereby significantly gait speed (1.09 0.26 m/s) HGI (0.72 0.28 m/s). Circulating interleukins IL-1β, IL-6, IL-13, TNFα cfDNA high concentrations with low 6MWT, confirming impairment physical by persistent These findings reveal that increased ingredients activity sustained throughout life attenuate progression inflammaging indicate potential therapeutic strategies counteract pathophysiological effects ageing.

Language: Английский

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