The Relationship of Ketogenic Diet with Neurodegenerative and Psychiatric Diseases: A Scoping Review from Basic Research to Clinical Practice DOI Open Access

Maria Mentzelou,

Antonios Dakanalis,

Georgios K. Vasios

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(10), P. 2270 - 2270

Published: May 11, 2023

The ketogenic diet (KD) has become widespread for the therapy of epileptic pathology in childhood and adulthood. In last few decades, current re-emergence its popularity focused on treatment obesity diabetes mellitus. KD also exerts anti-inflammatory neuroprotective properties, which could be utilized neurodegenerative psychiatric disorders.This is a thorough, scoping review that aims to summarize scrutinize currently available basic research performed vitro vivo settings, as well clinical evidence potential beneficial effects against diseases. This was conducted systematically map this area identify gaps knowledge.We thoroughly explored most accurate scientific web databases, e.g., PubMed, Scopus, Web Science, Google Scholar, obtain recent data from animal studies human surveys twenty years, applying effective characteristic keywords.Basic revealed multiple molecular mechanisms through can exert effects, such neuroinflammation inhibition, decreased reactive oxygen species (ROS) production, amyloid plaque deposition microglial activation, protection dopaminergic neurons, tau hyper-phosphorylation suppression, stimulating mitochondrial biogenesis, enhancing gut microbial diversity, restoration histone acetylation, neuron repair promotion. On other hand, remains scarce. Most existing are modest, frequently uncontrolled, merely assess short-term impacts KD. Moreover, several had large dropout rates considerable lack compliance assessment, an increased level heterogeneity study design methodology.KD substantial via various pathological states. Large, long-term, randomized, double-blind, controlled trials with prospective strongly recommended delineate whether may attenuate or even treat disease development, progression, symptomatology.

Language: Английский

The Potential Health Benefits of the Ketogenic Diet: A Narrative Review DOI Open Access

Kathryn Dowis,

Simran Banga

Nutrients, Journal Year: 2021, Volume and Issue: 13(5), P. 1654 - 1654

Published: May 13, 2021

Considering the lack of a comprehensive, multi-faceted overview ketogenic diet (KD) in relation to health issues, we compiled evidence related use its impact on microbiome, epigenome, diabetes, weight loss, cardiovascular health, and cancer. The KD could potentially increase genetic diversity microbiome ratio Bacteroidetes Firmicutes. epigenome might be positively affected by since it creates signaling molecule known as β-hydroxybutyrate (BHB). has helped patients with diabetes reduce their HbA1c need for insulin. There is suggest that can help visceral adiposity, appetite control. also suggests eating high-fat improves lipid profiles lowering low-density lipoprotein (LDL), increasing high-density (HDL), triglycerides (TG). Due Warburg effect, used an adjuvant treatment starve cancer cells, making them more vulnerable chemotherapy radiation. potential positive impacts each these areas warrant further analysis, improved studies, well-designed randomized controlled trials illuminate therapeutic possibilities provided this dietary intervention.

Language: Английский

Citations

158
3-Hydroxybutyrate as a Metabolite and a Signal Molecule Regulating Processes of Living Organisms DOI Creative Commons
Justyna Mierziak, Marta Burgberger, Wioleta Wojtasik

et al.

Biomolecules, Journal Year: 2021, Volume and Issue: 11(3), P. 402 - 402

Published: March 9, 2021

3-hydroxybutyrate (3-HB) as a very important metabolite occurs in animals, bacteria and plants. It is well known that 3-HB formed product of the normal metabolism fatty acid oxidation can therefore be used an energy source absence sufficient blood glucose. In microorganisms, mainly serves substrate for synthesis polyhydroxybutyrate, which reserve material. Recent studies show plants, acts regulatory molecule most likely influences expression genes involved DNA methylation, thereby altering methylation levels. Additionally, not only intermediate metabolite, but also influence gene expression, lipid metabolism, neuronal function, overall metabolic rate. Some these effects are direct itself, while others indirect effects, regulated by metabolites into converted. One functions inhibition activity histone deacetylases thus epigenetic regulation many genes. Due to number this compound, it shows promising therapeutic properties.

Language: Английский

Citations

132
Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment DOI Creative Commons
Wen Li, Feifei Li,

Xia Zhang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: Dec. 20, 2021

More and more in-depth studies have revealed that the occurrence development of tumors depend on gene mutation tumor heterogeneity. The most important manifestation heterogeneity is dynamic change microenvironment (TME) This depends not only cells themselves in where infiltrating immune matrix together forming an antitumor and/or pro-tumor network. TME has resulted novel therapeutic interventions as a place beyond beds. malignant cancer cells, infiltrate angiogenic vascular lymphatic endothelial cancer-associated fibroblastic released factors including intracellular metabolites, hormonal signals inflammatory mediators all contribute actively to progression. Protein post-translational modification (PTM) often regarded degradative mechanism protein destruction or turnover maintain physiological homeostasis. Advances quantitative transcriptomics, proteomics, nuclease-based editing are now paving global ways for exploring PTMs. In this review, we focus recent developments PTM area speculate their importance critical functional readout regulation TME. A wealth information been emerging prove useful search conventional therapies strategies.

Language: Английский

Citations

131
Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle DOI
Saravana Babu Chidambaram, Musthafa Mohamed Essa,

Annan Gopinath Rathipriya

et al.

Pharmacology & Therapeutics, Journal Year: 2021, Volume and Issue: 231, P. 107988 - 107988

Published: Sept. 16, 2021

Language: Английский

Citations

126
Metabolic landscape in cardiac aging: insights into molecular biology and therapeutic implications DOI Creative Commons

Saiyang Xie,

Si‐Chi Xu,

Wei Deng

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: March 14, 2023

Abstract Cardiac aging is evident by a reduction in function which subsequently contributes to heart failure. The metabolic microenvironment has been identified as hallmark of malignancy, but recent studies have shed light on its role cardiovascular diseases (CVDs). Various pathways cardiomyocytes and noncardiomyocytes determine cellular senescence the heart. Metabolic alteration common process throughout cardiac degeneration. Importantly, involvement injuries, including failure myocardial ischemia infarction, reported. However, complexity among human hearts hinders development strategies that targets susceptibility. Advances over past decade linked with their reprogramming pathway aging, autophagy, oxidative stress, epigenetic modifications, chronic inflammation, myocyte systolic phenotype regulation. In addition, status involved crucial aspects biology, from fibrosis hypertrophy inflammation. further elucidation metabolism degeneration still needed. Thus, deciphering mechanisms underlying how impacts thought contribute novel interventions protect or even restore hearts. Here, we summarize emerging concepts about landscapes specific focuses why profile alters during could utilize current knowledge improve management aging.

Language: Английский

Citations

80
The Impact of Ketogenic Nutrition on Obesity and Metabolic Health: Mechanisms and Clinical Implications DOI Creative Commons

Marta Biesiekierska,

Maura Strigini, Agnieszka Śliwińska

et al.

Nutrition Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

The ketogenic diet (KD) has recently gained increasing popularity. This high-fat, adequate-protein, and carbohydrate-poor eating pattern leads to nutritional ketosis. KD long been known for its antidiabetic antiepileptic effects used therapeutically in these contexts. Recently, the KD, due effectiveness inducing weight loss, also proposed as a possible approach treat obesity. Likewise, is currently explored supporting element treatment of obesity-associated metabolic disorders certain forms cancer. Here, we discuss biochemical mechanisms at play during shift metabolism fatty acids acid-derived ketone bodies main fuel molecules, substitution carbohydrates, nutrition. Different sources KDs alternatives glucose carbohydrates energy substrates are discussed, together with an attempt weigh benefits risks posed by chronic use context considering molecular that exert on endocrine system.

Language: Английский

Citations

4
Ketogenesis impact on liver metabolism revealed by proteomics of lysine β-hydroxybutyrylation DOI Creative Commons
Kevin B. Koronowski, Carolina M. Greco, He Huang

et al.

Cell Reports, Journal Year: 2021, Volume and Issue: 36(5), P. 109487 - 109487

Published: Aug. 1, 2021

Ketone bodies are bioactive metabolites that function as energy substrates, signaling molecules, and regulators of histone modifications. β-hydroxybutyrate (β-OHB) is utilized in lysine β-hydroxybutyrylation (Kbhb) histones, associates with starvation-responsive genes, effectively coupling ketogenic metabolism gene expression. The emerging diversity the acylation landscape prompted us to investigate full proteomic impact Kbhb. Global protein Kbhb induced a tissue-specific manner by variety interventions evoke β-OHB. Mass spectrometry analysis β-hydroxybutyrylome mouse liver revealed 891 sites within 267 proteins enriched for fatty acid, amino detoxification, one-carbon metabolic pathways. inhibits S-adenosyl-L-homocysteine hydrolase (AHCY), rate-limiting enzyme methionine cycle, parallel altered metabolite levels. Our results illuminate role hepatic under conditions demonstrate functional consequence this modification on central enzyme.

Language: Английский

Citations

94
Ketogenic Diet in Cancer Prevention and Therapy: Molecular Targets and Therapeutic Opportunities DOI Creative Commons
Wamidh H. Talib, Asma Ismail Mahmod,

Ayah Kamal

et al.

Current Issues in Molecular Biology, Journal Year: 2021, Volume and Issue: 43(2), P. 558 - 589

Published: July 3, 2021

Although cancer is still one of the most significant global challenges facing public health, world lacks complementary approaches that would significantly enhance efficacy standard anticancer therapies. One essential strategies during treatment following a healthy diet program. The ketogenic (KD) has recently emerged as metabolic therapy in treatment, targeting cell metabolism rather than conventional dietary approach. (KD), high-fat and very-low-carbohydrate with adequate amounts protein, shown antitumor effects by reducing energy supplies to cells. This low supply inhibits tumor growth, explaining diet’s therapeutic mechanisms treatment. review highlights crucial explain potential effects, which probably produces an unfavorable environment for cells can be used promising adjuvant therapy. Studies discussed this provide solid background researchers physicians design new combination therapies based on KD

Language: Английский

Citations

90
β-hydroxybutyrate as an Anti-Aging Metabolite DOI Open Access
Lian Wang, Peijie Chen, Weihua Xiao

et al.

Nutrients, Journal Year: 2021, Volume and Issue: 13(10), P. 3420 - 3420

Published: Sept. 28, 2021

The ketone bodies, especially β-hydroxybutyrate (β-HB), derive from fatty acid oxidation and alternatively serve as a fuel source for peripheral tissues including the brain, heart, skeletal muscle. β-HB is currently considered not solely an energy substrate maintaining metabolic homeostasis but also acts signaling molecule of modulating lipolysis, oxidative stress, neuroprotection. Besides, it serves epigenetic regulator in terms histone methylation, acetylation, β-hydroxybutyrylation to delay various age-related diseases. In addition, studies support endogenous administration or exogenous supplementation effective strategies induce state nutritional ketosis. purpose this review article provide overview metabolism its relationship application Future are needed reveal whether has potential adjunctive therapy aging.

Language: Английский

Citations

79
Short-Term Physiological Effects of a Very Low-Calorie Ketogenic Diet: Effects on Adiponectin Levels and Inflammatory States DOI Open Access
Vincenzo Monda, Rita Polito,

Annarita Lovino

et al.

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(9), P. 3228 - 3228

Published: May 2, 2020

Adipose tissue is a multifunctional organ involved in many physiological and metabolic processes through the production of adipokines and, particular, adiponectin. Caloric restriction one most important strategies against obesity today. The very low-calorie ketogenic diet (VLCKD) represents type caloric with or extremely low daily food energy consumption. This study aimed to investigate effects VLCKD on anthropometric biochemical parameters such as adiponectin levels, well analyzing oligomeric profiles cytokine serum levels obese subjects before after VLCKD. Twenty were enrolled. At baseline eight weeks intervention, parameters, recorded. Our findings showed significant change these We found negative correlation between lipid profile, visceral adipose (VAT), C-reactive protein (CRP), pro-inflammatory cytokines tumor necrosis factor-α (TNF-α), which confirmed involvement inflammatory diseases. demonstrated beneficial short-term not only treatment but also establishment obesity-correlated

Language: Английский

Citations

73