The challenges associated with a ketogenic diet: a narrative review DOI Creative Commons
Xin Qi, Richard F. Tester

Published: Jan. 16, 2025

The so-called ‘ketogenic diet’ aimed to limit energy derived from carbohydrates, has many variations which cause confusion in the literature and beyond. For ‘intractable’ epilepsy (when seizures cannot be managed completely by drug therapy, also referred as ‘refractory’, ‘uncontrolled’ or ‘drug-resistant’ epilepsy) dietary fat carbohydrate plus protein ratio is held at a of 4:1 3:1. Thus promoting metabolism ketone bodies primary source. This intervention limits glucose availability consequently neural ‘excitability’ seizures. Overall, diet high-fat, low-carbohydrate, restricted design. generally accepted clinical approach (which based on essentially fasting, historically) was applied recorded back 1920s (for patient with diabetic ketoacidosis). That observation (and others) initiated applications for thereafter (or perhaps parallel with) both (i) weight management (especially ‘Atkin’s diet) (ii) enhanced sport performance. Products loss tend high-fat but not ratios anticipated seizure management, where, perhaps, brands have been developed that are more cognisant consumer demands desirable sensory characteristics than specific nutrient ratios. Whilst ketogenic type diets discussed context different within literature, challenges associated making utilising products applications/needs (with compliance) addressed. review addresses some creating consuming products, especially restrict control carbohydrates. It aims contextualise issues faced this significance individuals interested regulation, most health professionals people involved nutrition.

Language: Английский

Nutrition, longevity and disease: From molecular mechanisms to interventions DOI Creative Commons
Valter D. Longo, Rozalyn M. Anderson

Cell, Journal Year: 2022, Volume and Issue: 185(9), P. 1455 - 1470

Published: April 1, 2022

Diet as a whole, encompassing food composition, calorie intake, and the length frequency of fasting periods, affects time span in which health functional capacity are maintained. Here, we analyze aging nutrition studies simple organisms, rodents, monkeys, humans to link longevity conserved growth metabolic pathways outline their role age-related disease. We focus on feasible nutritional strategies shown delay and/or prevent diseases through epidemiological, model organism, clinical, centenarian underline need avoid malnourishment frailty. These findings integrated define diet based multi-pillar approach adjusted for age status optimize lifespan healthspan humans.

Language: Английский

Citations

224
A review of healthy role of dietary fiber in modulating chronic diseases DOI

Mengyuan Li,

Sen Ma

Food Research International, Journal Year: 2024, Volume and Issue: 191, P. 114682 - 114682

Published: June 27, 2024

Language: Английский

Citations

35
Tea polyphenol and epigallocatechin gallate ameliorate hyperlipidemia via regulating liver metabolism and remodeling gut microbiota DOI
Jia-Jia Wen, Mingzhi Li, Chunhua Chen

et al.

Food Chemistry, Journal Year: 2022, Volume and Issue: 404, P. 134591 - 134591

Published: Oct. 14, 2022

Language: Английский

Citations

51
Ceramides and ceramide synthases in cancer: Focus on apoptosis and autophagy DOI Creative Commons
Javad Alizadeh, Simone C. da Silva Rosa, Xiaohui Weng

et al.

European Journal of Cell Biology, Journal Year: 2023, Volume and Issue: 102(3), P. 151337 - 151337

Published: June 26, 2023

Different studies corroborate a role for ceramide synthases and their downstream products, ceramides, in modulation of apoptosis autophagy the context cancer. These mechanisms regulation, however, appear to be dependent terms ceramides' fatty acid chain length, subcellular localization, presence or absence targets. Our current understanding ceramides regulation could harnessed pioneer development new treatments activate inhibit single type synthase, thereby regulating induction cross talk cancer cells. Moreover, apoptotic function suggests that analogues can pave way novel treatments. Therefore, review paper we discuss impact different types cancers. We also briefly introduce latest information on synthase inhibitors, application diseases including therapy, approaches drug discovery field inhibitors. finally discussed strategies developing use lipids analysis biological fluids early biomarkers

Language: Английский

Citations

39
Determining the metabolic effects of dietary fat, sugars and fat-sugar interaction using nutritional geometry in a dietary challenge study with male mice DOI Creative Commons
Jibran A. Wali, Duan Ni,

Harrison J. W. Facey

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: July 21, 2023

The metabolic effects of sugars and fat lie at the heart "carbohydrate vs fat" debate on global obesity epidemic. Here, we use nutritional geometry to systematically investigate interaction between dietary major monosaccharides, fructose glucose, their impact body composition health. Male mice (n = 245) are maintained one 18 isocaloric diets for 18-19 weeks status is assessed through in vivo procedures by vitro assays involving harvested tissue samples. We find that setting low medium content, a 50:50 mixture glucose (similar high-fructose corn syrup) more obesogenic metabolically adverse than when either monosaccharide consumed alone. With increasing sugar become less pronounced. Moreover, higher intake harmful tolerance insulin sensitivity irrespective mix consumed. type (soy oil lard) does not modify these outcomes. Our work shows both can lead outcomes, depending context. This study how principles two seemingly conflicting models (the "energy balance model" model") be valid, it will help progressing towards unified model obesity. main limitations this include male single strain, testing via sugary drinks, which strongly linked human

Language: Английский

Citations

23
Development of sugar- and fat-reduced pulse cookies with improved predicted glycemic behavior DOI Creative Commons
Xinying Suo, Marianna Tagliasco,

Matteo Bonfini

et al.

Applied Food Research, Journal Year: 2025, Volume and Issue: 5(1), P. 100761 - 100761

Published: Feb. 7, 2025

Language: Английский

Citations

1
Prophylactic effects of nutrition, dietary strategies, exercise, lifestyle and environment on nonalcoholic fatty liver disease DOI Creative Commons
Xiangyong Hao, Hao Song, Xin Su

et al.

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: Feb. 12, 2025

Background Nonalcoholic fatty liver disease (NAFLD) is a chronic and its prevalence has risen sharply. However, whether nutrition, dietary strategies, exercise, lifestyle environment have preventive value for NAFLD remains unclear.

Language: Английский

Citations

1
Dual Effects of Lipid Metabolism on Osteoblast Function DOI Creative Commons

Nathalie S. Alekos,

Megan C. Moorer, Ryan C. Riddle

et al.

Frontiers in Endocrinology, Journal Year: 2020, Volume and Issue: 11

Published: Sept. 23, 2020

The skeleton is a dynamic and metabolically active organ with the capacity to influence whole body metabolism. This newly recognized function has propagated interest in connection between bone health metabolic dysfunction. Osteoblasts, specialized mesenchymal cells responsible for production of matrix mineralization, rely on multiple fuel sources. utilization glucose by osteoblasts long been focus research, however, lipids their derivatives, are increasingly as vital energy source. Osteoblasts possess necessary receptors catabolic enzymes internalization circulating lipids. Disruption these processes can impair osteoblast function, resulting skeletal deficits while simultaneously altering lipid homeostasis. article provides an overview metabolism postprandial stored osteoblast's ability acquire utilize molecules. We requirement fatty acid oxidation pathways regulating this well negative impact dyslipidemia health. These findings provide key insights into nuances influencing homeostasis which critical appreciate extent role

Language: Английский

Citations

60
Diabetes: Risk factor and translational therapeutic implications for Alzheimer's disease DOI Creative Commons
Jeffrey L. Cummings, Andrew A. Ortiz, Janelle Castellino

et al.

European Journal of Neuroscience, Journal Year: 2022, Volume and Issue: 56(9), P. 5727 - 5757

Published: Feb. 7, 2022

Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) commonly co-occur. T2DM increases the risk for AD by approximately twofold. Animal models provide one means of interrogating relationship to investigating brain insulin resistance in pathophysiology AD. show that persistent hyperglycaemia results chronic low-grade inflammation may contribute development neuroinflammation accelerate pathobiology Epidemiological studies suggest patients with who received treatment specific anti-diabetic agents have a decreased occurrence all-cause dementia. Agents such as metformin ameliorate other important systemic effects lower Glucagon-like peptide 1 (GLP-1) agonists been associated T2DM. Both non-insulin treatments evaluated clinical trials. In most cases, included trials features but do not Many were conducted prior use diagnostic biomarkers Trials had wide range durations population sizes. used treat cross blood barrier, are posited occur via lowering peripheral reduction central inflammation. Clinical ongoing will insight into therapeutic utility these agents.

Language: Английский

Citations

32
The Role of Gut Microbiota in High-Fat-Diet-Induced Diabetes: Lessons from Animal Models and Humans DOI Open Access
Yue Qi, Xiaofei Wang

Nutrients, Journal Year: 2023, Volume and Issue: 15(4), P. 922 - 922

Published: Feb. 12, 2023

The number of diabetes mellitus patients is increasing rapidly worldwide. Diet and nutrition are strongly believed to play a significant role in the development mellitus. However, specific dietary factors detailed mechanisms its have not been clearly elucidated. Increasing evidence indicates intestinal microbiota becoming abundantly apparent progression prevention insulin resistance diabetes. Differences gut composition, particularly butyrate-producing bacteria, observed preclinical animal models as well human compared healthy controls. Gut dysbiosis may disrupt barrier functions alter host metabolic pathways, directly or indirectly relating resistance. In this article, we focus on fat, diabetes, microbiome characterization. promising probiotic prebiotic approaches by favorably modifying composition microbial community, warrant further investigation through well-designed clinical studies.

Language: Английский

Citations

18